PRO_ID
type: ObjectProperty
comment: PRO identifier, mandatory.

Object_term
type: ObjectProperty
comment: Name of the PRO term, Mandatory, cardinality 1.

Object_synonym
type: ObjectProperty
comment: Other names by which the described object is known, Optional field. Cardinality 0, 1 or >1. Separated by | (e.g. smad5beta|smad5b).

Modifier
type: ObjectProperty
comment: Modifiers are used within an annotation to modify a relation between a PRO term (protein) and another term (which can be internal or external to PRO). It includes the qualifiers used by GO: NOT, and contributes_to. And also includes decreased, increased and altered (see table 2 below for more information). This field is not mandatory; cardinality 0, 1, >1; for cardinality >1 use a pipe to separate entries (e.g. NOT|contributes_to).

Relation
type: ObjectProperty
comment: Relation to the corresponding annotation. For the list of relations used in PRO see table 3 below. Mandatory, cardinality 1.

Ontology_ID
type: ObjectProperty
comment: ID for the corresponding annotation. Mandatory, cardinality 1.

Ontology_term
type: ObjectProperty
comment: Term name for the corresponding ontology ID. Mandatory, cardinality 1.

Relative_to
type: ObjectProperty
comment: Contains a PRO identifier. Modifiers increased, decreased and altered require an entry in this column to indicate what the change is relative to.

Interaction_with
type: ObjectProperty
comment: To indicate binding partner. For GO component complex and GO function protein binding. If possible indicate the most exact protein object by using PRO ID. If part of a complex please add the GO ID for the corresponding one. Not mandatory, cardinality 0 or 1.

Evidence_source
type: ObjectProperty
comment: Pubmed ID or database source for the evidence. Mandatory, cardinality 1. (or >1?)

Evidence_code
type: ObjectProperty
comment: At the ProEvo level, the evidence code is ISS (inferred by sequence and/or structural similarity) At the protein form level only experimental evidence codes are allowed. If no expertise in evidence code assignation please use EXP (experimental evidence) as a general code. For GO term protein binding, the evidence code should be IPI. From GOA source: see the GO evidence code guide for the list of valid evidence codes for GO annotations. This field is mandatory for GO terms, cardinality 1.

Taxon
type: ObjectProperty
comment: Taxon identifier for the species that the annotation is extracted from. Related to column 9. Not mandatory, cardinality 0 or 1.

Inferred_from
type: ObjectProperty
comment: This field is used only for certain types of evidence code: IPI and ISS for PRO. Cardinality 0, 1, >1; for cardinality >1 use a pipe to separate entries (e.g. PANTHER:PTHR13703:SF17|PIRSF:PIRSF500500).

DB_ID
type: ObjectProperty
comment: GOA Source:one or more unique identifiers for a single source cited as an authority for the attribution of the ontology ID to the DB_Object_ID. This may be a literature reference or a database record. The syntax is DB:accession_number.

Date
type: ObjectProperty
comment: From GOA source: Date on which the annotation was made; format is YYYY-MM-DD this field is mandatory, cardinality 1.

Assigned_by
type: ObjectProperty
comment: The database which made the annotation. This field is mandatory, cardinality 1. Format: Source DB:curator initials.

Comments
type: ObjectProperty
comment: Curator comment for some annotations.

PR_000000002
type: Class
Object_term: E3 ubiquitin ligase SFC complex Skp1 subunit

subject: PR_000000002
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01466
  Ontology_term: Skp1 family, dimerisation domain
Evidence_source: PIRSF:PIRSF028729
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF028729
DB_ID: PIRSF:PIRSF028729
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000002
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03931
  Ontology_term: Skp1 family, tetramerisation domain
Evidence_source: PIRSF:PIRSF028729
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF028729
DB_ID: PIRSF:PIRSF028729
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000002
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0019005
  Ontology_term: SCF ubiquitin ligase complex
Evidence_source: PIRSF:PIRSF028729
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF028729
DB_ID: PIRSF:PIRSF028729
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000002
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006511
  Ontology_term: ubiquitin-dependent protein catabolic process
Evidence_source: PIRSF:PIRSF028729
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF028729
DB_ID: PIRSF:PIRSF028729
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000003
type: Class
Object_term: HLH DNA-binding protein inhibitor
Object_synonym: bHLH clade D
Object_synonym: bHLH class V
Object_synonym: DNA-binding protein inhibitor ID
Object_synonym: ID protein

subject: PR_000000003
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PIRSF:PIRSF005808
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005808
DB_ID: PIRSF:PIRSF005808
Date: 2015-08-20
Assigned_by: PRO:CNA

subject: PR_000000003
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00010
  Ontology_term: Helix-loop-helix DNA-binding domain
Evidence_source: PIRSF:PIRSF005808
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005808
DB_ID: PIRSF:PIRSF005808
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000003
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of transcription, DNA-templated
Evidence_source: PIRSF:PIRSF005808
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005808
DB_ID: PIRSF:PIRSF005808
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000004
type: Class
Object_term: RING-box protein

subject: PR_000000004
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004842
  Ontology_term: ubiquitin-protein transferase activity
Evidence_source: PIRSF:PIRSF016237
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF016237
DB_ID: PIRSF:PIRSF016237
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000004
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF016237
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF016237
DB_ID: PIRSF:PIRSF016237
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000004
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00097
  Ontology_term: Zinc finger, C3HC4 type (RING finger)
Evidence_source: PIRSF:PIRSF016237
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF016237
DB_ID: PIRSF:PIRSF016237
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000004
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0016567
  Ontology_term: protein ubiquitination
Evidence_source: PIRSF:PIRSF016237
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF016237
DB_ID: PIRSF:PIRSF016237
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000005
type: Class
Object_term: TGF-beta receptor type-2
Object_synonym: TbetaR-II
Object_synonym: TGF-beta receptor type II
Object_synonym: TGF-beta type II receptor
Object_synonym: TGFBR2
Object_synonym: TGFR-2
Object_synonym: transforming growth factor-beta receptor type II

subject: PR_000000005
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000005
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000005
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000005
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08917
  Ontology_term: Transforming growth factor beta receptor 2 ectodomain
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000005
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000005
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000005
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0042127
  Ontology_term: regulation of cell proliferation
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000006
type: Class
Object_term: TGF-beta superfamily receptor type-1
Object_synonym: TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I (PTHR23255:SF15)

subject: PR_000000006
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005025
  Ontology_term: transforming growth factor beta receptor activity, type I
Evidence_source: PIRSF:PIRSF037391
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037391
DB_ID: PIRSF:PIRSF037391
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000006
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0019838
  Ontology_term: growth factor binding
Interaction_with: PR_000000046
Evidence_source: PANTHER:PTHR23255:SF14
Evidence_source: PIRSF:PIRSF037391
Evidence_code: ISS
Inferred_from: PANTHER:PTHR23255:SF14
Inferred_from: PIRSF:PIRSF037391
DB_ID: PANTHER:PTHR23255:SF14
DB_ID: PIRSF:PIRSF037391
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000000006
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Evidence_source: PIRSF:PIRSF037391
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037391
DB_ID: PIRSF:PIRSF037391
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000006
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01064
  Ontology_term: Activin types I and II receptor domain
Evidence_source: PIRSF:PIRSF037391
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037391
DB_ID: PIRSF:PIRSF037391
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000006
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08515
  Ontology_term: Transforming growth factor beta type I GS-motif
Evidence_source: PIRSF:PIRSF037391
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037391
DB_ID: PIRSF:PIRSF037391
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000006
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007178
  Ontology_term: transmembrane receptor protein serine/threonine kinase signaling pathway
Evidence_source: PIRSF:PIRSF037391
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037391
DB_ID: PIRSF:PIRSF037391
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000007
type: Class
Object_term: TGF-beta superfamily receptor type-2 with activin receptor domain

subject: PR_000000007
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Evidence_source: PIRSF:PIRSF000627
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000627
DB_ID: PIRSF:PIRSF000627
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000007
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF000627
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000627
DB_ID: PIRSF:PIRSF000627
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000007
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Evidence_source: PIRSF:PIRSF000627
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000627
DB_ID: PIRSF:PIRSF000627
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000007
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01064
  Ontology_term: Activin types I and II receptor domain
Evidence_source: PIRSF:PIRSF000627
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000627
DB_ID: PIRSF:PIRSF000627
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000007
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PIRSF:PIRSF000627
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000627
DB_ID: PIRSF:PIRSF000627
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000007
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007178
  Ontology_term: transmembrane receptor protein serine/threonine kinase signaling pathway
Evidence_source: PIRSF:PIRSF000627
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000627
DB_ID: PIRSF:PIRSF000627
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000008
type: Class
Object_term: TGF-beta-like cystine-knot cytokine
Object_synonym: TGF-beta superfamily

subject: PR_000000008
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00019
  Ontology_term: Transforming growth factor beta like domain
Evidence_source: PIRSF:PIRSF800009
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF800009
DB_ID: PIRSF:PIRSF800009
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000009
type: Class
Object_term: anti-Muellerian hormone type-2 receptor
Object_synonym: AMH type II receptor
Object_synonym: AMHR
Object_synonym: AMHR2
Object_synonym: anti-Muellerian hormone type II receptor
Object_synonym: MIS type II receptor
Object_synonym: MISR2
Object_synonym: MISRII
Object_synonym: MRII

subject: PR_000000009
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Evidence_source: PIRSF:PIRSF037392
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037392
DB_ID: PIRSF:PIRSF037392
DB_ID: UniProtKB:Q16671
DB_ID: UniProtKB:Q8K592
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000009
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007178
  Ontology_term: transmembrane receptor protein serine/threonine kinase signaling pathway
Evidence_source: PIRSF:PIRSF037392
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037392
DB_ID: PIRSF:PIRSF037392
DB_ID: UniProtKB:Q16671
DB_ID: UniProtKB:Q8K592
Date: 2015-08-20
Assigned_by: PRO:CNA

subject: PR_000000009
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007548
  Ontology_term: sex differentiation
Evidence_source: PIRSF:PIRSF037392
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037392
DB_ID: PIRSF:PIRSF037392
DB_ID: UniProtKB:Q16671
DB_ID: UniProtKB:Q8K592
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000010
type: Class
Object_term: chordin
Object_synonym: CHRD
Object_synonym: UNQ217/PRO243

subject: PR_000000010
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF002496
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002496
DB_ID: PIRSF:PIRSF002496
DB_ID: UniProtKB:Q9H2X0
DB_ID: UniProtKB:Q9Z0E2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000010
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008201
  Ontology_term: heparin binding
Evidence_source: PIRSF:PIRSF002496
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002496
DB_ID: PIRSF:PIRSF002496
DB_ID: UniProtKB:Q9H2X0
DB_ID: UniProtKB:Q9Z0E2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000010
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0045545
  Ontology_term: syndecan binding
Evidence_source: PIRSF:PIRSF002496
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002496
DB_ID: PIRSF:PIRSF002496
DB_ID: UniProtKB:Q9H2X0
DB_ID: UniProtKB:Q9Z0E2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000010
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00093
  Ontology_term: von Willebrand factor type C domain
Evidence_source: PIRSF:PIRSF002496
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002496
DB_ID: PIRSF:PIRSF002496
DB_ID: UniProtKB:Q9H2X0
DB_ID: UniProtKB:Q9Z0E2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000010
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07452
  Ontology_term: CHRD domain
Evidence_source: PIRSF:PIRSF002496
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002496
DB_ID: PIRSF:PIRSF002496
DB_ID: UniProtKB:Q9H2X0
DB_ID: UniProtKB:Q9Z0E2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000010
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030510
  Ontology_term: regulation of BMP signaling pathway
Evidence_source: PIRSF:PIRSF002496
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002496
DB_ID: PIRSF:PIRSF002496
DB_ID: UniProtKB:Q9H2X0
DB_ID: UniProtKB:Q9Z0E2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000011
type: Class
Object_term: class 1 small leucine-rich proteoglycan

subject: PR_000000011
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005201
  Ontology_term: extracellular matrix structural constituent
Evidence_source: PIRSF:PIRSF002490
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002490
DB_ID: PIRSF:PIRSF002490
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000011
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00560
  Ontology_term: Leucine Rich Repeat
Evidence_source: PIRSF:PIRSF002490
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002490
DB_ID: PIRSF:PIRSF002490
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000011
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01462
  Ontology_term: Leucine rich repeat N-terminal domain
Evidence_source: PIRSF:PIRSF002490
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002490
DB_ID: PIRSF:PIRSF002490
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000013
type: Class
Object_term: cullin

subject: PR_000000013
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00888
  Ontology_term: Cullin family
Evidence_source: PIRSF:PIRSF017874
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF017874
DB_ID: PIRSF:PIRSF017874
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000013
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0031461
  Ontology_term: cullin-RING ubiquitin ligase complex
Evidence_source: PIRSF:PIRSF017874
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF017874
DB_ID: PIRSF:PIRSF017874
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000014
type: Class
Object_term: cyclin-dependent kinase inhibitor

subject: PR_000000014
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004861
  Ontology_term: cyclin-dependent protein serine/threonine kinase inhibitor activity
Evidence_source: PIRSF:PIRSF036346
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036346
DB_ID: PIRSF:PIRSF036346
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000014
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00023
  Ontology_term: Ankyrin repeat
Evidence_source: PIRSF:PIRSF036346
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036346
DB_ID: PIRSF:PIRSF036346
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000014
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0000079
  Ontology_term: regulation of cyclin-dependent protein serine/threonine kinase activity
Evidence_source: PIRSF:PIRSF036346
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036346
DB_ID: PIRSF:PIRSF036346
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000014
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007050
  Ontology_term: cell cycle arrest
Evidence_source: PIRSF:PIRSF036346
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036346
DB_ID: PIRSF:PIRSF036346
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000014
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0008285
  Ontology_term: negative regulation of cell proliferation
Evidence_source: PIRSF:PIRSF036346
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036346
DB_ID: PIRSF:PIRSF036346
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000015
type: Class
Object_term: follistatin
Object_synonym: activin-binding protein
Object_synonym: FS
Object_synonym: FST

subject: PR_000000015
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00050
  Ontology_term: Kazal-type serine protease inhibitor domain
Evidence_source: PIRSF:PIRSF002278
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002278
DB_ID: PIRSF:PIRSF002278
DB_ID: UniProtKB:P19883
DB_ID: UniProtKB:P47931
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000015
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0032926
  Ontology_term: negative regulation of activin receptor signaling pathway
Evidence_source: PIRSF:PIRSF002278
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002278
DB_ID: PIRSF:PIRSF002278
DB_ID: UniProtKB:P19883
DB_ID: UniProtKB:P47931
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000016
type: Class
Object_term: HECT domain-containing E3 ubiquitin-protein ligase with WW domains

subject: PR_000000016
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004842
  Ontology_term: ubiquitin-protein transferase activity
Evidence_source: PIRSF:PIRSF001569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001569
DB_ID: PIRSF:PIRSF001569
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000016
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00168
  Ontology_term: C2 domain
Evidence_source: PIRSF:PIRSF001569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001569
DB_ID: PIRSF:PIRSF001569
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000016
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00397
  Ontology_term: WW domain
Evidence_source: PIRSF:PIRSF001569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001569
DB_ID: PIRSF:PIRSF001569
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000016
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00632
  Ontology_term: HECT-domain (ubiquitin-transferase)
Evidence_source: PIRSF:PIRSF001569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001569
DB_ID: PIRSF:PIRSF001569
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000017
type: Class
Object_term: interferon gamma
Object_synonym: IFN-gamma
Object_synonym: IFNG
Object_synonym: immune interferon

subject: PR_000000017
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00714
  Ontology_term: Interferon gamma
Evidence_source: PIRSF:PIRSF001936
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001936
DB_ID: PIRSF:PIRSF001936
DB_ID: UniProtKB:P01579
DB_ID: UniProtKB:P01580
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000017
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006955
  Ontology_term: immune response
Evidence_source: PIRSF:PIRSF001936
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001936
DB_ID: PIRSF:PIRSF001936
DB_ID: UniProtKB:P01579
DB_ID: UniProtKB:P01580
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000017
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0045080
  Ontology_term: positive regulation of chemokine biosynthetic process
Evidence_source: PIRSF:PIRSF001936
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001936
DB_ID: PIRSF:PIRSF001936
DB_ID: UniProtKB:P01579
DB_ID: UniProtKB:P01580
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000018
type: Class
Object_term: latent TGF-beta-binding protein

subject: PR_000000018
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0019838
  Ontology_term: growth factor binding
Interaction_with: PR_000000046
Evidence_source: PIRSF:PIRSF037569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037569
DB_ID: PIRSF:PIRSF037569
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000018
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00008
  Ontology_term: EGF-like domain
Evidence_source: PIRSF:PIRSF037569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037569
DB_ID: PIRSF:PIRSF037569
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000018
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07974
  Ontology_term: EGF-like domain 2
Evidence_source: PIRSF:PIRSF037569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037569
DB_ID: PIRSF:PIRSF037569
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000018
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PIRSF:PIRSF037569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037569
DB_ID: PIRSF:PIRSF037569
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000019
type: Class
Object_term: mitogen-activated protein kinase
Object_synonym: kinase-related transforming protein
Object_synonym: MAPK

subject: PR_000000019
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PIRSF:PIRSF501110
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501110
DB_ID: PIRSF:PIRSF501110
Date: 2009-06-01
Assigned_by: PRO:CNA

subject: PR_000000019
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Evidence_source: PIRSF:PIRSF501110
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501110
DB_ID: PIRSF:PIRSF501110
Date: 2009-06-01
Assigned_by: PRO:CNA

subject: PR_000000019
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PIRSF:PIRSF501110
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501110
DB_ID: PIRSF:PIRSF501110
Date: 2009-06-01
Assigned_by: PRO:CNA

PR_000000020
type: Class
Object_term: Myc protein
Object_synonym: bHLH clade B
Object_synonym: bHLH class III

subject: PR_000000020
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Evidence_source: PIRSF:PIRSF001705
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001705
DB_ID: PIRSF:PIRSF001705
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000020
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF001705
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001705
DB_ID: PIRSF:PIRSF001705
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000020
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00010
  Ontology_term: Helix-loop-helix DNA-binding domain
Evidence_source: PIRSF:PIRSF001705
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001705
DB_ID: PIRSF:PIRSF001705
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000020
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01056
  Ontology_term: Myc amino-terminal region
Evidence_source: PIRSF:PIRSF001705
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001705
DB_ID: PIRSF:PIRSF001705
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000020
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02344
  Ontology_term: Myc leucine zipper domain
Evidence_source: PIRSF:PIRSF001705
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001705
DB_ID: PIRSF:PIRSF001705
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000020
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0042127
  Ontology_term: regulation of cell proliferation
Evidence_source: PIRSF:PIRSF001705
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001705
DB_ID: PIRSF:PIRSF001705
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000021
type: Class
Object_term: noggin
Object_synonym: NOG

subject: PR_000000021
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF05806
  Ontology_term: Noggin
Evidence_source: PANTHER:PTHR10494:SF2
Evidence_source: PIRSF:PIRSF008129
Evidence_code: ISS
Inferred_from: PANTHER:PTHR10494:SF2
Inferred_from: PIRSF:PIRSF008129
DB_ID: PANTHER:PTHR10494:SF2
DB_ID: PIRSF:PIRSF008129
DB_ID: UniProtKB:P97466
DB_ID: UniProtKB:Q13253
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000021
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007275
  Ontology_term: multicellular organism development
Evidence_source: PANTHER:PTHR10494:SF2
Evidence_source: PIRSF:PIRSF008129
Evidence_source: UniProtKB:P97466
Evidence_source: UniProtKB:Q13253
Evidence_code: ISS
Inferred_from: PANTHER:PTHR10494:SF2
Inferred_from: PIRSF:PIRSF008129
Inferred_from: UniProtKB:P97466
Inferred_from: UniProtKB:Q13253
DB_ID: PANTHER:PTHR10494:SF2
DB_ID: PIRSF:PIRSF008129
DB_ID: UniProtKB:P97466
DB_ID: UniProtKB:Q13253
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000021
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030509
  Ontology_term: BMP signaling pathway
Evidence_source: PANTHER:PTHR10494:SF2
Evidence_source: PIRSF:PIRSF008129
Evidence_source: UniProtKB:P97466
Evidence_source: UniProtKB:Q13253
Evidence_code: ISS
Inferred_from: PANTHER:PTHR10494:SF2
Inferred_from: PIRSF:PIRSF008129
Inferred_from: UniProtKB:P97466
Inferred_from: UniProtKB:Q13253
DB_ID: PANTHER:PTHR10494:SF2
DB_ID: PIRSF:PIRSF008129
DB_ID: UniProtKB:P97466
DB_ID: UniProtKB:Q13253
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000021
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030514
  Ontology_term: negative regulation of BMP signaling pathway
Evidence_source: PANTHER:PTHR10494:SF2
Evidence_source: PIRSF:PIRSF008129
Evidence_source: UniProtKB:P97466
Evidence_source: UniProtKB:Q13253
Evidence_code: ISS
Inferred_from: PANTHER:PTHR10494:SF2
Inferred_from: PIRSF:PIRSF008129
Inferred_from: UniProtKB:P97466
Inferred_from: UniProtKB:Q13253
DB_ID: PANTHER:PTHR10494:SF2
DB_ID: PIRSF:PIRSF008129
DB_ID: UniProtKB:P97466
DB_ID: UniProtKB:Q13253
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000022
type: Class
Object_term: ptx homeobox protein

subject: PR_000000022
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PIRSF:PIRSF000563
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000563
DB_ID: PIRSF:PIRSF000563
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000022
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00046
  Ontology_term: Homeodomain
Evidence_source: PIRSF:PIRSF000563
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000563
DB_ID: PIRSF:PIRSF000563
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000022
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03826
  Ontology_term: OAR domain
Evidence_source: PIRSF:PIRSF000563
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000563
DB_ID: PIRSF:PIRSF000563
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000022
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of transcription, DNA-templated
Evidence_source: PIRSF:PIRSF000563
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000563
DB_ID: PIRSF:PIRSF000563
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000022
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007275
  Ontology_term: multicellular organism development
Evidence_source: PIRSF:PIRSF000563
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000563
DB_ID: PIRSF:PIRSF000563
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000023
type: Class
Object_term: retinoblastoma-like protein

subject: PR_000000023
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF037408
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037408
DB_ID: PIRSF:PIRSF037408
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000023
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01857
  Ontology_term: Retinoblastoma-associated protein B domain
Evidence_source: PIRSF:PIRSF037408
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037408
DB_ID: PIRSF:PIRSF037408
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000023
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01858
  Ontology_term: Retinoblastoma-associated protein A domain
Evidence_source: PIRSF:PIRSF037408
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037408
DB_ID: PIRSF:PIRSF037408
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000023
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0051726
  Ontology_term: regulation of cell cycle
Evidence_source: PIRSF:PIRSF037408
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037408
DB_ID: PIRSF:PIRSF037408
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000024
type: Class
Object_term: Rho-associated protein kinase
Object_synonym: RHO-ASSOCIATED, COILED-COIL CONTAINING PROTEIN KINASE (PTHR22988:SF3)

subject: PR_000000024
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00130
  Ontology_term: Phorbol esters/diacylglycerol binding domain (C1 domain)
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00169
  Ontology_term: PH domain
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00433
  Ontology_term: Protein kinase C terminal domain
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08912
  Ontology_term: Rho Binding
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007266
  Ontology_term: Rho protein signal transduction
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000025
type: Class
Object_term: ribosomal protein S6 kinase beta

subject: PR_000000025
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PANTHER:PTHR24351:SF83
Evidence_source: PIRSF:PIRSF000605
Evidence_code: ISS
Inferred_from: PANTHER:PTHR24351:SF83
Inferred_from: PIRSF:PIRSF000605
DB_ID: PANTHER:PTHR24351:SF83
DB_ID: PIRSF:PIRSF000605
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000025
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004711
  Ontology_term: ribosomal protein S6 kinase activity
Evidence_source: PANTHER:PTHR24351:SF83
Evidence_source: PIRSF:PIRSF000605
Evidence_code: ISS
Inferred_from: PANTHER:PTHR24351:SF83
Inferred_from: PIRSF:PIRSF000605
DB_ID: PANTHER:PTHR24351:SF83
DB_ID: PIRSF:PIRSF000605
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000025
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Evidence_source: PANTHER:PTHR24351:SF83
Evidence_source: PIRSF:PIRSF000605
Evidence_code: ISS
Inferred_from: PANTHER:PTHR24351:SF83
Inferred_from: PIRSF:PIRSF000605
DB_ID: PANTHER:PTHR24351:SF83
DB_ID: PIRSF:PIRSF000605
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000025
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00433
  Ontology_term: Protein kinase C terminal domain
Evidence_source: PANTHER:PTHR24351:SF83
Evidence_source: PIRSF:PIRSF000605
Evidence_code: ISS
Inferred_from: PANTHER:PTHR24351:SF83
Inferred_from: PIRSF:PIRSF000605
DB_ID: PANTHER:PTHR24351:SF83
DB_ID: PIRSF:PIRSF000605
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000025
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PANTHER:PTHR24351:SF83
Evidence_source: PIRSF:PIRSF000605
Evidence_code: ISS
Inferred_from: PANTHER:PTHR24351:SF83
Inferred_from: PIRSF:PIRSF000605
DB_ID: PANTHER:PTHR24351:SF83
DB_ID: PIRSF:PIRSF000605
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000026
type: Class
Object_term: sara-type zinc finger FYVE domain-containing protein

subject: PR_000000026
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01363
  Ontology_term: FYVE zinc finger
Evidence_source: PIRSF:PIRSF037289
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037289
DB_ID: PIRSF:PIRSF037289
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000026
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0008104
  Ontology_term: protein localization
Evidence_source: PIRSF:PIRSF037289
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037289
DB_ID: PIRSF:PIRSF037289
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000027
type: Class
Object_term: smad protein

subject: PR_000000027
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF037286
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037286
DB_ID: PIRSF:PIRSF037286
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000027
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03165
  Ontology_term: MH1 domain
Evidence_source: PIRSF:PIRSF037286
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037286
DB_ID: PIRSF:PIRSF037286
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000027
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03166
  Ontology_term: MH2 domain
Evidence_source: PIRSF:PIRSF037286
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037286
DB_ID: PIRSF:PIRSF037286
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000027
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of transcription, DNA-templated
Evidence_source: PIRSF:PIRSF037286
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037286
DB_ID: PIRSF:PIRSF037286
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000027
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PIRSF:PIRSF037286
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037286
DB_ID: PIRSF:PIRSF037286
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000028
type: Class
Object_term: small GTPase

subject: PR_000000028
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00071
  Ontology_term: Ras family
Evidence_source: PIRSF:PIRSF001710
Evidence_source: PIRSF:PIRSF037165
Evidence_source: PIRSF:PIRSF037166
Evidence_source: PIRSF:PIRSF037169
Evidence_source: PIRSF:PIRSF037502
Evidence_source: PIRSF:PIRSF037527
Evidence_source: PIRSF:PIRSF038017
Evidence_source: PIRSF:PIRSF038482
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001710
Inferred_from: PIRSF:PIRSF037165
Inferred_from: PIRSF:PIRSF037166
Inferred_from: PIRSF:PIRSF037169
Inferred_from: PIRSF:PIRSF037502
Inferred_from: PIRSF:PIRSF037527
Inferred_from: PIRSF:PIRSF038017
Inferred_from: PIRSF:PIRSF038482
DB_ID: PIRSF:PIRSF001710
DB_ID: PIRSF:PIRSF037165
DB_ID: PIRSF:PIRSF037166
DB_ID: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037502
DB_ID: PIRSF:PIRSF037527
DB_ID: PIRSF:PIRSF038017
DB_ID: PIRSF:PIRSF038482
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000029
type: Class
Object_term: thrombospondin subgroup A

subject: PR_000000029
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004866
  Ontology_term: endopeptidase inhibitor activity
Evidence_source: PIRSF:PIRSF002478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002478
DB_ID: PIRSF:PIRSF002478
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000029
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008201
  Ontology_term: heparin binding
Evidence_source: PIRSF:PIRSF002478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002478
DB_ID: PIRSF:PIRSF002478
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000029
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00008
  Ontology_term: EGF-like domain
Evidence_source: PIRSF:PIRSF002478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002478
DB_ID: PIRSF:PIRSF002478
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000029
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00093
  Ontology_term: von Willebrand factor type C domain
Evidence_source: PIRSF:PIRSF002478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002478
DB_ID: PIRSF:PIRSF002478
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000029
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02412
  Ontology_term: Thrombospondin type 3 repeat
Evidence_source: PIRSF:PIRSF002478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002478
DB_ID: PIRSF:PIRSF002478
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000029
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF05735
  Ontology_term: Thrombospondin C-terminal region
Evidence_source: PIRSF:PIRSF002478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002478
DB_ID: PIRSF:PIRSF002478
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000029
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0016525
  Ontology_term: negative regulation of angiogenesis
Evidence_source: PIRSF:PIRSF002478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002478
DB_ID: PIRSF:PIRSF002478
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000030
type: Class
Object_term: thrombospondin subgroup B

subject: PR_000000030
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008201
  Ontology_term: heparin binding
Evidence_source: PIRSF:PIRSF002479
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002479
DB_ID: PIRSF:PIRSF002479
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000030
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02412
  Ontology_term: Thrombospondin type 3 repeat
Evidence_source: PIRSF:PIRSF002479
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002479
DB_ID: PIRSF:PIRSF002479
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000030
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF05735
  Ontology_term: Thrombospondin C-terminal region
Evidence_source: PIRSF:PIRSF002479
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002479
DB_ID: PIRSF:PIRSF002479
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000031
type: Class
Object_term: transcription adapter with TAZ, KIX and bromo-domains
Object_synonym: fam:CBP-p300

subject: PR_000000031
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004402
  Ontology_term: histone acetyltransferase activity
Evidence_source: PANTHER:PTHR13808
Evidence_source: PIRSF:PIRSF036333
Evidence_code: ISS
Inferred_from: PANTHER:PTHR13808
Inferred_from: PIRSF:PIRSF036333
DB_ID: PANTHER:PTHR13808
DB_ID: PIRSF:PIRSF036333
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000031
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00439
  Ontology_term: Bromodomain
Evidence_source: PANTHER:PTHR13808
Evidence_source: PIRSF:PIRSF036333
Evidence_code: ISS
Inferred_from: PANTHER:PTHR13808
Inferred_from: PIRSF:PIRSF036333
DB_ID: PANTHER:PTHR13808
DB_ID: PIRSF:PIRSF036333
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000031
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00569
  Ontology_term: Zinc finger, ZZ type
Evidence_source: PANTHER:PTHR13808
Evidence_source: PIRSF:PIRSF036333
Evidence_code: ISS
Inferred_from: PANTHER:PTHR13808
Inferred_from: PIRSF:PIRSF036333
DB_ID: PANTHER:PTHR13808
DB_ID: PIRSF:PIRSF036333
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000031
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02135
  Ontology_term: TAZ zinc finger
Evidence_source: PANTHER:PTHR13808
Evidence_source: PIRSF:PIRSF036333
Evidence_code: ISS
Inferred_from: PANTHER:PTHR13808
Inferred_from: PIRSF:PIRSF036333
DB_ID: PANTHER:PTHR13808
DB_ID: PIRSF:PIRSF036333
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000031
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02172
  Ontology_term: KIX domain
Evidence_source: PANTHER:PTHR13808
Evidence_source: PIRSF:PIRSF036333
Evidence_code: ISS
Inferred_from: PANTHER:PTHR13808
Inferred_from: PIRSF:PIRSF036333
DB_ID: PANTHER:PTHR13808
DB_ID: PIRSF:PIRSF036333
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000031
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF09030
  Ontology_term: Creb binding
Evidence_source: PANTHER:PTHR13808
Evidence_source: PIRSF:PIRSF036333
Evidence_code: ISS
Inferred_from: PANTHER:PTHR13808
Inferred_from: PIRSF:PIRSF036333
DB_ID: PANTHER:PTHR13808
DB_ID: PIRSF:PIRSF036333
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000031
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0016573
  Ontology_term: histone acetylation
Evidence_source: PANTHER:PTHR13808
Evidence_source: PIRSF:PIRSF036333
Evidence_code: ISS
Inferred_from: PANTHER:PTHR13808
Inferred_from: PIRSF:PIRSF036333
DB_ID: PANTHER:PTHR13808
DB_ID: PIRSF:PIRSF036333
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000032
type: Class
Object_term: transcription factor Sp

subject: PR_000000032
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Evidence_source: PIRSF:PIRSF037570
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037570
DB_ID: PIRSF:PIRSF037570
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000032
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PIRSF:PIRSF037570
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037570
DB_ID: PIRSF:PIRSF037570
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000032
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00096
  Ontology_term: Zinc finger, C2H2 type
Evidence_source: PIRSF:PIRSF037570
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037570
DB_ID: PIRSF:PIRSF037570
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000032
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of transcription, DNA-templated
Evidence_source: PIRSF:PIRSF037570
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037570
DB_ID: PIRSF:PIRSF037570
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000033
type: Class
Object_term: tumor necrosis factor, TNF-like

subject: PR_000000033
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005125
  Ontology_term: cytokine activity
Evidence_source: PIRSF:PIRSF001873
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001873
DB_ID: PIRSF:PIRSF001873
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000033
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00229
  Ontology_term: TNF(Tumour Necrosis Factor) family
Evidence_source: PIRSF:PIRSF001873
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001873
DB_ID: PIRSF:PIRSF001873
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000033
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006915
  Ontology_term: apoptotic process
Evidence_source: PIRSF:PIRSF001873
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001873
DB_ID: PIRSF:PIRSF001873
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000033
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PIRSF:PIRSF001873
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001873
DB_ID: PIRSF:PIRSF001873
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000034
type: Class
Object_term: BMP

subject: PR_000000034
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005102
  Ontology_term: signaling receptor binding
Evidence_source: PIRSF:PIRSF037272
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037272
DB_ID: PIRSF:PIRSF037272
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000034
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005125
  Ontology_term: cytokine activity
Evidence_source: PIRSF:PIRSF037272
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037272
DB_ID: PIRSF:PIRSF037272
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000034
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Evidence_source: PIRSF:PIRSF037272
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037272
DB_ID: PIRSF:PIRSF037272
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000034
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PIRSF:PIRSF037272
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037272
DB_ID: PIRSF:PIRSF037272
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000037
type: Class
Object_term: BMP receptor type-2
Object_synonym: BMP type II receptor
Object_synonym: BMP type-2 receptor
Object_synonym: BMPR-2
Object_synonym: BMPR-II
Object_synonym: BMPR2
Object_synonym: bone morphogenetic protein receptor type II
Object_synonym: BRK-3
Object_synonym: PPH1

subject: PR_000000037
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030509
  Ontology_term: BMP signaling pathway
Evidence_source: PIRSF:PIRSF500434
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500434
DB_ID: PIRSF:PIRSF500434
DB_ID: UniProtKB:O35607
DB_ID: UniProtKB:Q13873
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000038
type: Class
Object_term: BMP receptor-regulated smad protein
Object_synonym: R-SMAD(BMP)

subject: PR_000000038
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030509
  Ontology_term: BMP signaling pathway
Evidence_source: PANTHER:PTHR13703:SF19
Evidence_source: PIRSF:PIRSF500500
Evidence_code: ISS
Inferred_from: PANTHER:PTHR13703:SF19
Inferred_from: PIRSF:PIRSF500500
DB_ID: PANTHER:PTHR13703:SF19
DB_ID: PIRSF:PIRSF500500
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000039
type: Class
Object_term: DNA-binding protein inhibitor ID-1
Object_synonym: BHLHB24
Object_synonym: bHLHb24
Object_synonym: class B basic helix-loop-helix protein 24
Object_synonym: ID
Object_synonym: Id-1
Object_synonym: ID1
Object_synonym: Idb1
Object_synonym: inhibitor of differentiation 1
Object_synonym: inhibitor of DNA binding 1

subject: PR_000000039
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0046983
  Ontology_term: protein dimerization activity
Evidence_source: PANTHER:PTHR11723:SF4
Evidence_source: PIRSF:PIRSF500477
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11723:SF4
Inferred_from: PIRSF:PIRSF500477
DB_ID: PANTHER:PTHR11723:SF4
DB_ID: PIRSF:PIRSF500477
DB_ID: UniProtKB:P20067
DB_ID: UniProtKB:P41134
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000040
type: Class
Object_term: DNA-binding protein inhibitor ID-2
Object_synonym: BHLHB26
Object_synonym: bHLHb26
Object_synonym: class B basic helix-loop-helix protein 26
Object_synonym: Id-2
Object_synonym: ID2
Object_synonym: Idb2
Object_synonym: inhibitor of differentiation 2
Object_synonym: inhibitor of DNA binding 2

subject: PR_000000040
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of transcription, DNA-templated
Evidence_source: PIRSF:PIRSF500478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500478
Inferred_from: UniProtKB:P41136
Inferred_from: UniProtKB:Q02363
Inferred_from: UniProtKB:Q545T4
DB_ID: PIRSF:PIRSF500478
DB_ID: UniProtKB:P41136
DB_ID: UniProtKB:Q02363
DB_ID: UniProtKB:Q545T4
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000041
type: Class
Object_term: DNA-binding protein inhibitor ID-3
Object_synonym: 1R21
Object_synonym: BHLHB25
Object_synonym: bHLHb25
Object_synonym: class B basic helix-loop-helix protein 25
Object_synonym: HEIR1
Object_synonym: helix-loop-helix protein HEIR-1
Object_synonym: Hlh462
Object_synonym: Id-3
Object_synonym: ID-like protein inhibitor HLH 1R21
Object_synonym: ID-like protein inhibitor HLH 462
Object_synonym: ID3
Object_synonym: Idb3
Object_synonym: inhibitor of differentiation 3
Object_synonym: inhibitor of DNA binding 3

subject: PR_000000041
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of transcription, DNA-templated
Evidence_source: PIRSF:PIRSF500479
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500479
Inferred_from: UniProtKB:P41133
Inferred_from: UniProtKB:Q02535
Inferred_from: UniProtKB:Q545W1
DB_ID: PIRSF:PIRSF500479
DB_ID: UniProtKB:P41133
DB_ID: UniProtKB:Q02535
DB_ID: UniProtKB:Q545W1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000042
type: Class
Object_term: DNA-binding protein inhibitor ID-4
Object_synonym: BHLHB27
Object_synonym: bHLHb27
Object_synonym: class B basic helix-loop-helix protein 27
Object_synonym: Id-4
Object_synonym: ID4
Object_synonym: Idb4
Object_synonym: inhibitor of differentiation 4
Object_synonym: inhibitor of DNA binding 4

subject: PR_000000042
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of transcription, DNA-templated
Evidence_source: PIRSF:PIRSF500478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500478
Inferred_from: UniProtKB:P41139
Inferred_from: UniProtKB:P47928
Inferred_from: UniProtKB:Q544D2
DB_ID: PIRSF:PIRSF500478
DB_ID: UniProtKB:P41139
DB_ID: UniProtKB:P47928
DB_ID: UniProtKB:Q544D2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000043
type: Class
Object_term: E3 ubiquitin-protein ligase RBX1
Object_synonym: E3 ubiquitin-protein transferase RBX1
Object_synonym: protein ZYP
Object_synonym: RBX1
Object_synonym: rbx1
Object_synonym: regulator of cullins 1
Object_synonym: RING finger protein 75
Object_synonym: RING-box protein 1
Object_synonym: RNF75
Object_synonym: ROC1

subject: PR_000000043
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0019005
  Ontology_term: SCF ubiquitin ligase complex
Evidence_source: PIRSF:PIRSF500724
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500724
Inferred_from: UniProtKB:P62877
Inferred_from: UniProtKB:P62878
DB_ID: PIRSF:PIRSF500724
DB_ID: UniProtKB:P62877
DB_ID: UniProtKB:P62878
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000043
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0031146
  Ontology_term: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Evidence_source: PIRSF:PIRSF500724
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500724
Inferred_from: UniProtKB:P62877
Inferred_from: UniProtKB:P62878
DB_ID: PIRSF:PIRSF500724
DB_ID: UniProtKB:P62877
DB_ID: UniProtKB:P62878
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000044
type: Class
Object_term: RING-box protein 2
Object_synonym: CKBBP1
Object_synonym: CKII beta-binding protein 1
Object_synonym: RBX2
Object_synonym: rbx2
Object_synonym: regulator of cullins 2
Object_synonym: RING finger protein 7
Object_synonym: RNF7
Object_synonym: ROC2
Object_synonym: SAG
Object_synonym: sensitive to apoptosis gene protein

subject: PR_000000044
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0019005
  Ontology_term: SCF ubiquitin ligase complex
Evidence_source: PIRSF:PIRSF500725
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500725
Inferred_from: UniProtKB:Q9UBF6
Inferred_from: UniProtKB:Q9WTZ1
DB_ID: PIRSF:PIRSF500725
DB_ID: UniProtKB:Q9UBF6
DB_ID: UniProtKB:Q9WTZ1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000044
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0031146
  Ontology_term: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Evidence_source: PIRSF:PIRSF500725
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500725
Inferred_from: UniProtKB:Q9UBF6
Inferred_from: UniProtKB:Q9WTZ1
DB_ID: PIRSF:PIRSF500725
DB_ID: UniProtKB:Q9UBF6
DB_ID: UniProtKB:Q9WTZ1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000046
type: Class
Object_term: TGF-beta
Object_synonym: transforming growth factor beta

subject: PR_000000046
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005160
  Ontology_term: transforming growth factor beta receptor binding
Evidence_source: PIRSF:PIRSF001787
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001787
DB_ID: PIRSF:PIRSF001787
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000046
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Evidence_source: PIRSF:PIRSF001787
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001787
DB_ID: PIRSF:PIRSF001787
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000046
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PIRSF:PIRSF001787
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001787
DB_ID: PIRSF:PIRSF001787
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000046
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PIRSF:PIRSF001787
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001787
DB_ID: PIRSF:PIRSF001787
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000046
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0042127
  Ontology_term: regulation of cell proliferation
Evidence_source: PIRSF:PIRSF001787
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001787
DB_ID: PIRSF:PIRSF001787
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000050
type: Class
Object_term: TGF-beta receptor type-2 sequence variant L308P (human)
Object_synonym: hTGFBR2/var:L308P
Object_synonym: TGF-beta receptor type-2 sequence variant 1 (human)
Object_synonym: UniProtKB:P37173-1, Leu-308, CHEBI:50342

subject: PR_000000050
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022351
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000050
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: NOT
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022351
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000051
type: Class
Object_term: TGF-beta receptor type-2 sequence variant R460H (human)
Object_synonym: hTGFBR2/var:R460H
Object_synonym: TGF-beta receptor type-2 sequence variant 10 (human)
Object_synonym: UniProtKB:P37173-1, Arg-460, CHEBI:29979

subject: PR_000000051
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029761
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000052
type: Class
Object_term: TGF-beta receptor type-2 sequence variant R460C (human)
Object_synonym: hTGFBR2/var:R460C
Object_synonym: TGF-beta receptor type-2 sequence variant 11 (human)
Object_synonym: UniProtKB:P37173-1, Arg-460, CHEBI:29950

subject: PR_000000052
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029760
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000053
type: Class
Object_term: TGF-beta receptor type-2 sequence variant E526Q (human)
Object_synonym: hTGFBR2/var:E526Q
Object_synonym: TGF-beta receptor type-2 sequence variant 12 (human)
Object_synonym: UniProtKB:P37173-1, Glu-526, CHEBI:30011

subject: PR_000000053
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:3748
  Ontology_term: esophagus squamous cell carcinoma
Evidence_source: PMID:10789724
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015816
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000053
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: NOT
Evidence_source: PMID:10789724
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015816
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000054
type: Class
Object_term: TGF-beta receptor type-2 sequence variant R528C (human)
Object_synonym: hTGFBR2/var:R528C
Object_synonym: TGF-beta receptor type-2 sequence variant 13 (human)
Object_synonym: UniProtKB:P37173-1, Arg-528, CHEBI:29950

subject: PR_000000054
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022360
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000055
type: Class
Object_term: TGF-beta receptor type-2 sequence variant R528H (human)
Object_synonym: hTGFBR2/var:R528H
Object_synonym: TGF-beta receptor type-2 sequence variant 14 (human)
Object_synonym: UniProtKB:P37173-1, Arg-528, CHEBI:29979

subject: PR_000000055
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022361
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000056
type: Class
Object_term: TGF-beta receptor type-2 sequence variant R537C (human)
Object_synonym: hTGFBR2/var:R537C
Object_synonym: TGF-beta receptor type-2 sequence variant 15 (human)
Object_synonym: UniProtKB:P37173-1, Arg-537, CHEBI:29950

subject: PR_000000056
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022362
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000056
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: NOT
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022362
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000057
type: Class
Object_term: TGF-beta receptor type-2 sequence variant G357W (human)
Object_synonym: hTGFBR2/var:G357W
Object_synonym: TGF-beta receptor type-2 sequence variant 16 (human)
Object_synonym: UniProtKB:P37173-1, Gly-357, CHEBI:29954

subject: PR_000000057
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022354
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000058
type: Class
Object_term: TGF-beta receptor type-2 sequence variant T315M (human)
Object_synonym: hTGFBR2/var:T315M
Object_synonym: TGF-beta receptor type-2 sequence variant 2 (human)
Object_synonym: UniProtKB:P37173-1, Thr-315, CHEBI:16044

subject: PR_000000058
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:3883
  Ontology_term: Lynch syndrome
Evidence_source: PMID:9590282
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008156
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000058
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0008284
  Ontology_term: positive regulation of cell proliferation
Evidence_source: PMID:9590282
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008156
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000059
type: Class
Object_term: TGF-beta receptor type-2 sequence variant Y336N (human)
Object_synonym: hTGFBR2/var:Y336N
Object_synonym: TGF-beta receptor type-2 sequence variant 3 (human)
Object_synonym: UniProtKB:P37173-1, Tyr-336, CHEBI:50347

subject: PR_000000059
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022352
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000060
type: Class
Object_term: TGF-beta receptor type-2 sequence variant A355P (human)
Object_synonym: hTGFBR2/var:A355P
Object_synonym: TGF-beta receptor type-2 sequence variant 4 (human)
Object_synonym: UniProtKB:P37173-1, Ala-355, CHEBI:50342

subject: PR_000000060
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022353
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000060
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0016021
  Ontology_term: integral component of membrane
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022353
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000060
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022353
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000061
type: Class
Object_term: TGF-beta receptor type-2 sequence variant V387M (human)
Object_synonym: hTGFBR2/var:V387M
Object_synonym: TGF-beta receptor type-2 sequence variant 5 (human)
Object_synonym: UniProtKB:P37173-1, Val-387, CHEBI:16044

subject: PR_000000061
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0016021
  Ontology_term: integral component of membrane
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022355
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000061
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022355
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000061
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: decreased
Relative_to: PR_000000409
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022355
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000062
type: Class
Object_term: TGF-beta receptor type-2 sequence variant N435S (human)
Object_synonym: hTGFBR2/var:N435S
Object_synonym: TGF-beta receptor type-2 sequence variant 6 (human)
Object_synonym: UniProtKB:P37173-1, Asn-435, CHEBI:29999

subject: PR_000000062
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022356
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000062
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: decreased
Relative_to: PR_000000409
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022356
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000063
type: Class
Object_term: TGF-beta receptor type-2 sequence variant V447A (human)
Object_synonym: hTGFBR2/var:V447A
Object_synonym: TGF-beta receptor type-2 sequence variant 7 (human)
Object_synonym: UniProtKB:P37173-1, Val-447, CHEBI:46217

subject: PR_000000063
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0016021
  Ontology_term: integral component of membrane
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022357
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000063
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022357
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000063
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: decreased
Relative_to: PR_000000409
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022357
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000064
type: Class
Object_term: TGF-beta receptor type-2 sequence variant S449F (human)
Object_synonym: hTGFBR2/var:S449F
Object_synonym: TGF-beta receptor type-2 sequence variant 8 (human)
Object_synonym: UniProtKB:P37173-1, Ser-449, CHEBI:29997

subject: PR_000000064
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022358
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000064
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: NOT
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022358
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000065
type: Class
Object_term: TGF-beta receptor type-2 sequence variant L452M (human)
Object_synonym: hTGFBR2/var:L452M
Object_synonym: TGF-beta receptor type-2 sequence variant 9 (human)
Object_synonym: UniProtKB:P37173-1, Leu-452, CHEBI:16044

subject: PR_000000065
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022359
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000065
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: decreased
Relative_to: PR_000000409
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022359
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000066
type: Class
Object_term: TGF-beta receptor-regulated smad protein
Object_synonym: R-SMAD(TGFB)

subject: PR_000000066
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PIRSF:PIRSF500455
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500455
DB_ID: PIRSF:PIRSF500455
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000066
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007183
  Ontology_term: SMAD protein complex assembly
Evidence_source: PIRSF:PIRSF500455
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500455
DB_ID: PIRSF:PIRSF500455
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000070
type: Class
Object_term: activin receptor type-2A
Object_synonym: activin receptor type IIA
Object_synonym: ACTR-IIA
Object_synonym: ACTRIIA
Object_synonym: ACVR2
Object_synonym: ACVR2A

subject: PR_000000070
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0048185
  Ontology_term: activin binding
Evidence_source: PIRSF:PIRSF500457
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500457
Inferred_from: UniProtKB:P27037
Inferred_from: UniProtKB:P27038
Inferred_from: UniProtKB:Q8BRV4
DB_ID: PIRSF:PIRSF500457
DB_ID: UniProtKB:P27037
DB_ID: UniProtKB:P27038
DB_ID: UniProtKB:Q8BRV4
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000070
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0032924
  Ontology_term: activin receptor signaling pathway
Evidence_source: PIRSF:PIRSF500457
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500457
Inferred_from: UniProtKB:P27037
Inferred_from: UniProtKB:P27038
Inferred_from: UniProtKB:Q8BRV4
DB_ID: PIRSF:PIRSF500457
DB_ID: UniProtKB:P27037
DB_ID: UniProtKB:P27038
DB_ID: UniProtKB:Q8BRV4
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000071
type: Class
Object_term: activin receptor type-2B
Object_synonym: activin receptor type IIB
Object_synonym: ACTR-IIB
Object_synonym: ACVR2B

subject: PR_000000071
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0048185
  Ontology_term: activin binding
Evidence_source: PIRSF:PIRSF500456
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500456
Inferred_from: UniProtKB:P27040
Inferred_from: UniProtKB:Q13705
Inferred_from: UniProtKB:Q3KQI1
DB_ID: PIRSF:PIRSF500456
DB_ID: UniProtKB:P27040
DB_ID: UniProtKB:Q13705
DB_ID: UniProtKB:Q3KQI1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000071
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0032924
  Ontology_term: activin receptor signaling pathway
Evidence_source: PIRSF:PIRSF500456
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500456
Inferred_from: UniProtKB:P27040
Inferred_from: UniProtKB:Q13705
Inferred_from: UniProtKB:Q3KQI1
DB_ID: PIRSF:PIRSF500456
DB_ID: UniProtKB:P27040
DB_ID: UniProtKB:Q13705
DB_ID: UniProtKB:Q3KQI1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000072
type: Class
Object_term: activin/inhibin beta subunit

subject: PR_000000072
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005102
  Ontology_term: signaling receptor binding
Evidence_source: PIRSF:PIRSF037268
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037268
DB_ID: PIRSF:PIRSF037268
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000073
type: Class
Object_term: Muellerian-inhibiting factor
Object_synonym: AMH
Object_synonym: anti-Muellerian hormone
Object_synonym: MIF
Object_synonym: MIS
Object_synonym: Muellerian-inhibiting substance

subject: PR_000000073
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005102
  Ontology_term: signaling receptor binding
Evidence_source: PIRSF:PIRSF037270
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037270
DB_ID: PIRSF:PIRSF037270
DB_ID: UniProtKB:P03971
DB_ID: UniProtKB:P27106
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000073
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005179
  Ontology_term: hormone activity
Evidence_source: PIRSF:PIRSF037270
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037270
DB_ID: PIRSF:PIRSF037270
DB_ID: UniProtKB:P03971
DB_ID: UniProtKB:P27106
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000073
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007548
  Ontology_term: sex differentiation
Evidence_source: PIRSF:PIRSF037270
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037270
DB_ID: PIRSF:PIRSF037270
DB_ID: UniProtKB:P03971
DB_ID: UniProtKB:P27106
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000073
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0008406
  Ontology_term: gonad development
Evidence_source: PIRSF:PIRSF037270
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037270
DB_ID: PIRSF:PIRSF037270
DB_ID: UniProtKB:P03971
DB_ID: UniProtKB:P27106
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000075
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant R54C (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 1 (human)
Object_synonym: hAMHR2/var:R54C
Object_synonym: UniProtKB:Q16671-1, Arg-54, CHEBI:29950

subject: PR_000000075
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015525
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000076
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant G142V (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 2 (human)
Object_synonym: hAMHR2/var:G142V
Object_synonym: UniProtKB:Q16671-1, Gly-142, CHEBI:30015

subject: PR_000000076
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015526
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000077
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant H282Q (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 3 (human)
Object_synonym: hAMHR2/var:H282Q
Object_synonym: UniProtKB:Q16671-1, His-282, CHEBI:30011

subject: PR_000000077
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015527
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000078
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant R406Q (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 4 (human)
Object_synonym: hAMHR2/var:R406Q
Object_synonym: UniProtKB:Q16671-1, Arg-406, CHEBI:30011

subject: PR_000000078
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:11549681
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015528
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000079
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant D426G (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 5 (human)
Object_synonym: hAMHR2/var:D426G
Object_synonym: UniProtKB:Q16671-1, Asp-426, CHEBI:29947

subject: PR_000000079
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015529
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000080
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant V458A (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 6 (human)
Object_synonym: hAMHR2/var:V458A
Object_synonym: UniProtKB:Q16671-1, Val-458, CHEBI:46217

subject: PR_000000080
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015530
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000081
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant D491H (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 7 (human)
Object_synonym: hAMHR2/var:D491H
Object_synonym: UniProtKB:Q16671-1, Asp-491, CHEBI:29979

subject: PR_000000081
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015531
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000082
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant R504C (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 8 (human)
Object_synonym: hAMHR2/var:R504C
Object_synonym: UniProtKB:Q16671-1, Arg-504, CHEBI:29950

subject: PR_000000082
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015532
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000087
type: Class
Object_term: chordin isoform 2
Object_synonym: CHRD/iso:2
Object_synonym: P-CR1

subject: PR_000000087
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07452
  Ontology_term: CHRD domain
Modifier: NOT
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000092
type: Class
Object_term: fungal/metazoan cullin-1
Object_synonym: CUL-1
Object_synonym: CUL1

subject: PR_000000092
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0019005
  Ontology_term: SCF ubiquitin ligase complex
Evidence_source: PANTHER:PTHR11932:SF19
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11932:SF19
DB_ID: PANTHER:PTHR11932:SF19
DB_ID: UniProtKB:Q13616
DB_ID: UniProtKB:Q9WTX6
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000092
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0031146
  Ontology_term: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Evidence_source: PANTHER:PTHR11932:SF19
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11932:SF19
DB_ID: PANTHER:PTHR11932:SF19
DB_ID: UniProtKB:Q13616
DB_ID: UniProtKB:Q9WTX6
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000093
type: Class
Object_term: cyclin-dependent kinase 4 inhibitor B
Object_synonym: CDKN2B
Object_synonym: MTS-2
Object_synonym: MTS2
Object_synonym: multiple tumor suppressor 2
Object_synonym: p14-INK4b
Object_synonym: p15-INK4b
Object_synonym: p15INK4B

subject: PR_000000093
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0051726
  Ontology_term: regulation of cell cycle
Evidence_source: PANTHER:PTHR24144:SF138
Evidence_code: ISS
Inferred_from: PANTHER:PTHR24144:SF138
DB_ID: PANTHER:PTHR24144:SF138
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000095
type: Class
Object_term: tumor necrosis factor ligand superfamily member 6
Object_synonym: apoptosis antigen ligand
Object_synonym: APT1LG1
Object_synonym: APTL
Object_synonym: CD178
Object_synonym: CD95 ligand
Object_synonym: CD95-L
Object_synonym: CD95L
Object_synonym: fas antigen ligand
Object_synonym: fas ligand
Object_synonym: fas ligand, TNF-like
Object_synonym: FASL
Object_synonym: FASLG
Object_synonym: gld
Object_synonym: TNFSF6

subject: PR_000000095
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007267
  Ontology_term: cell-cell signaling
Evidence_source: PANTHER:PTHR11471:SF7
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11471:SF7
DB_ID: PANTHER:PTHR11471:SF7
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000099
type: Class
Object_term: inhibitory smad protein

subject: PR_000000099
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0009968
  Ontology_term: negative regulation of signal transduction
Evidence_source: PIRSF:PIRSF500412
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500412
DB_ID: PIRSF:PIRSF500412
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000099
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PIRSF:PIRSF500412
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500412
DB_ID: PIRSF:PIRSF500412
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000099
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030514
  Ontology_term: negative regulation of BMP signaling pathway
Evidence_source: PIRSF:PIRSF500412
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500412
DB_ID: PIRSF:PIRSF500412
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000102
type: Class
Object_term: lefty protein

subject: PR_000000102
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007275
  Ontology_term: multicellular organism development
Evidence_source: PIRSF:PIRSF037402
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037402
DB_ID: PIRSF:PIRSF037402
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000105
type: Class
Object_term: nodal protein
Object_synonym: NODAL

subject: PR_000000105
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0016015
  Ontology_term: morphogen activity
Evidence_source: PIRSF:PIRSF037400
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037400
DB_ID: PIRSF:PIRSF037400
DB_ID: UniProtKB:P43021
DB_ID: UniProtKB:Q96S42
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000105
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007368
  Ontology_term: determination of left/right symmetry
Evidence_source: PIRSF:PIRSF037400
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037400
DB_ID: PIRSF:PIRSF037400
DB_ID: UniProtKB:P43021
DB_ID: UniProtKB:Q96S42
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000107
type: Class
Object_term: noggin sequence variant P35S (human)
Object_synonym: hNOG/var:P35S
Object_synonym: noggin sequence variant 1 (human)
Object_synonym: UniProtKB:Q13253, Pro-35, CHEBI:29999

subject: PR_000000107
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:11857750
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_018324
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000108
type: Class
Object_term: noggin sequence variant P223L (human)
Object_synonym: hNOG/var:P223L
Object_synonym: noggin sequence variant 10 (human)
Object_synonym: UniProtKB:Q13253, Pro-223, CHEBI:30006

subject: PR_000000108
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:10080184
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011367
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000109
type: Class
Object_term: noggin sequence variant P35R (human)
Object_synonym: hNOG/var:P35R
Object_synonym: noggin sequence variant 2 (human)
Object_synonym: UniProtKB:Q13253, Pro-35, CHEBI:29952

subject: PR_000000109
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:11545688
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011361
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000109
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050789
  Ontology_term: tarsal-carpal coalition syndrome
Evidence_source: PMID:11545688
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011361
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000110
type: Class
Object_term: noggin sequence variant C184Y (human)
Object_synonym: hNOG/var:C184Y
Object_synonym: noggin sequence variant 3 (human)
Object_synonym: UniProtKB:Q13253, Cys-184, CHEBI:46858

subject: PR_000000110
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:11846737
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_018325
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000111
type: Class
Object_term: noggin sequence variant G189C (human)
Object_synonym: hNOG/var:G189C
Object_synonym: noggin sequence variant 4 (human)
Object_synonym: UniProtKB:Q13253, Gly-189, CHEBI:29950

subject: PR_000000111
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:99178269
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011362
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000112
type: Class
Object_term: noggin sequence variant R204L (human)
Object_synonym: hNOG/var:R204L
Object_synonym: noggin sequence variant 5 (human)
Object_synonym: UniProtKB:Q13253, Arg-204, CHEBI:30006

subject: PR_000000112
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050789
  Ontology_term: tarsal-carpal coalition syndrome
Evidence_source: PMID:11545688
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011326
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000113
type: Class
Object_term: noggin sequence variant W217G (human)
Object_synonym: hNOG/var:W217G
Object_synonym: noggin sequence variant 6 (human)
Object_synonym: UniProtKB:Q13253, Trp-217, CHEBI:29947

subject: PR_000000113
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:10080184
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011363
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000114
type: Class
Object_term: noggin sequence variant I220N (human)
Object_synonym: hNOG/var:I220N
Object_synonym: noggin sequence variant 7 (human)
Object_synonym: UniProtKB:Q13253, Ile-220, CHEBI:50347

subject: PR_000000114
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:10080184
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011364
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000115
type: Class
Object_term: noggin sequence variant Y222C (human)
Object_synonym: hNOG/var:Y222C
Object_synonym: noggin sequence variant 8 (human)
Object_synonym: UniProtKB:Q13253, Tyr-222, CHEBI:29950

subject: PR_000000115
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:11545688
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011365
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000115
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050789
  Ontology_term: tarsal-carpal coalition syndrome
Evidence_source: PMID:10080184
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011365
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000116
type: Class
Object_term: noggin sequence variant Y222D (human)
Object_synonym: hNOG/var:Y222D
Object_synonym: noggin sequence variant 9 (human)
Object_synonym: UniProtKB:Q13253, Tyr-222, CHEBI:29958

subject: PR_000000116
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:10080184
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011366
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000122
type: Class
Object_term: Rho-related small GTPase

subject: PR_000000122
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003924
  Ontology_term: GTPase activity
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000122
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000122
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005525
  Ontology_term: GTP binding
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000122
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0000902
  Ontology_term: cell morphogenesis
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000122
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007264
  Ontology_term: small GTPase mediated signal transduction
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000122
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007266
  Ontology_term: Rho protein signal transduction
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000125
type: Class
Object_term: sara
Object_synonym: Madh-interacting protein
Object_synonym: MADHIP
Object_synonym: mothers against decapentaplegic homolog-interacting protein
Object_synonym: novel serine protease
Object_synonym: NSP
Object_synonym: receptor activation anchor
Object_synonym: SARA
Object_synonym: smad anchor for receptor activation
Object_synonym: SMADIP
Object_synonym: ZFYVE9

subject: PR_000000125
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007178
  Ontology_term: transmembrane receptor protein serine/threonine kinase signaling pathway
Evidence_source: PANTHER:PTHR22835:SF7
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22835:SF7
DB_ID: PANTHER:PTHR22835:SF7
DB_ID: UniProtKB:A2A8R0
DB_ID: UniProtKB:O95405
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000127
type: Class
Object_term: smad ubiquitination regulatory factor
Object_synonym: smurf

subject: PR_000000127
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006511
  Ontology_term: ubiquitin-dependent protein catabolic process
Evidence_source: PIRSF:PIRSF500454
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500454
DB_ID: PIRSF:PIRSF500454
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000127
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007398
  Ontology_term: ectoderm development
Evidence_source: PIRSF:PIRSF500454
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500454
DB_ID: PIRSF:PIRSF500454
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000127
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0009968
  Ontology_term: negative regulation of signal transduction
Evidence_source: PIRSF:PIRSF500454
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500454
DB_ID: PIRSF:PIRSF500454
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000129
type: Class
Object_term: thrombospondin-1
Object_synonym: glycoprotein G
Object_synonym: THBS1
Object_synonym: TSP
Object_synonym: TSP1

subject: PR_000000129
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007596
  Ontology_term: blood coagulation
Evidence_source: PANTHER:PTHR10199:SF37
Evidence_code: ISS
Inferred_from: PANTHER:PTHR10199:SF37
Inferred_from: UniProtKB:P07996
Inferred_from: UniProtKB:P35441
Inferred_from: UniProtKB:Q80YQ1
Inferred_from: UniProtKB:Q8CGB2
DB_ID: PANTHER:PTHR10199:SF37
DB_ID: UniProtKB:P07996
DB_ID: UniProtKB:P35441
DB_ID: UniProtKB:Q80YQ1
DB_ID: UniProtKB:Q8CGB2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000137
type: Class
Object_term: BMP receptor type-1A sequence variant Y62D (human)
Object_synonym: BMP receptor type-1A sequence variant 1 (human)
Object_synonym: hBMPR1A/var:Y62D
Object_synonym: UniProtKB:P36894, Tyr-62, CHEBI:29958

subject: PR_000000137
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12417513
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022828
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000138
type: Class
Object_term: BMP receptor type-1A sequence variant C82Y (human)
Object_synonym: BMP receptor type-1A sequence variant 2 (human)
Object_synonym: hBMPR1A/var:C82Y
Object_synonym: UniProtKB:P36894, Cys-82, CHEBI:46858

subject: PR_000000138
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12417513
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022829
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000139
type: Class
Object_term: BMP receptor type-1A sequence variant C124R (human)
Object_synonym: BMP receptor type-1A sequence variant 3 (human)
Object_synonym: hBMPR1A/var:C124R
Object_synonym: UniProtKB:P36894, Cys-124, CHEBI:29952

subject: PR_000000139
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:11536076
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015533
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000140
type: Class
Object_term: BMP receptor type-1A sequence variant C130R (human)
Object_synonym: BMP receptor type-1A sequence variant 4 (human)
Object_synonym: hBMPR1A/var:C130R
Object_synonym: UniProtKB:P36894, Cys-130, CHEBI:29952

subject: PR_000000140
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12136244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022830
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000141
type: Class
Object_term: BMP receptor type-1A sequence variant A338D (human)
Object_synonym: BMP receptor type-1A sequence variant 5 (human)
Object_synonym: hBMPR1A/var:A338D
Object_synonym: UniProtKB:P36894, Ala-338, CHEBI:29958

subject: PR_000000141
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:6457
  Ontology_term: Cowden syndrome
Evidence_source: PMID:11536076
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015534
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000142
type: Class
Object_term: BMP receptor type-1A sequence variant C376Y (human)
Object_synonym: BMP receptor type-1A sequence variant 6 (human)
Object_synonym: hBMPR1A/var:C376Y
Object_synonym: UniProtKB:P36894, Cys-376, CHEBI:46858

subject: PR_000000142
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:11536076
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015535
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000143
type: Class
Object_term: BMP receptor type-1A sequence variant R443C (human)
Object_synonym: BMP receptor type-1A sequence variant 7 (human)
Object_synonym: hBMPR1A/var:R443C
Object_synonym: UniProtKB:P36894, Arg-443, CHEBI:29950

subject: PR_000000143
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12417513
Evidence_source: PMID:17344846
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022831
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000144
type: Class
Object_term: BMP receptor type-1A sequence variant M470T (human)
Object_synonym: BMP receptor type-1A sequence variant 8 (human)
Object_synonym: hBMPR1A/var:M470T
Object_synonym: UniProtKB:P36894, Met-470, CHEBI:30013

subject: PR_000000144
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12630959
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022832
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000146
type: Class
Object_term: BMP receptor type-1B sequence variant I200K (human)
Object_synonym: BMP receptor type-1B sequence variant 1 (human)
Object_synonym: hBMPR1B/var:I200K
Object_synonym: UniProtKB:O00238-1, Ile-200, CHEBI:29967

subject: PR_000000146
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050581
  Ontology_term: brachydactyly
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023819
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000146
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023819
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000146
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023819
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000147
type: Class
Object_term: BMP receptor type-1B sequence variant R486W (human)
Object_synonym: BMP receptor type-1B sequence variant 2 (human)
Object_synonym: hBMPR1B/var:R486W
Object_synonym: UniProtKB:O00238-1, Arg-486, CHEBI:29954

subject: PR_000000147
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050581
  Ontology_term: brachydactyly
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023820
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000147
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023820
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000147
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023820
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000149
type: Class
Object_term: BMP receptor type-2 sequence variant C60Y (human)
Object_synonym: BMP receptor type-2 sequence variant 1 (human)
Object_synonym: hBMPR2/var:C60Y
Object_synonym: UniProtKB:Q13873-1, Cys-60, CHEBI:46858

subject: PR_000000149
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11015450
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013670
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000150
type: Class
Object_term: BMP receptor type-2 sequence variant D485G (human)
Object_synonym: BMP receptor type-2 sequence variant 10 (human)
Object_synonym: hBMPR2/var:D485G
Object_synonym: UniProtKB:Q13873-1, Asp-485, CHEBI:29947

subject: PR_000000150
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:10973254
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013679
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000151
type: Class
Object_term: BMP receptor type-2 sequence variant R491Q (human)
Object_synonym: BMP receptor type-2 sequence variant 11 (human)
Object_synonym: hBMPR2/var:R491Q
Object_synonym: UniProtKB:Q13873-1, Arg-491, CHEBI:30011

subject: PR_000000151
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:10903931
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013680
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000152
type: Class
Object_term: BMP receptor type-2 sequence variant R491W (human)
Object_synonym: BMP receptor type-2 sequence variant 12 (human)
Object_synonym: hBMPR2/var:R491W
Object_synonym: UniProtKB:Q13873-1, Arg-491, CHEBI:29954

subject: PR_000000152
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:10903931
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013681
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000153
type: Class
Object_term: BMP receptor type-2 sequence variant K512T (human)
Object_synonym: BMP receptor type-2 sequence variant 13 (human)
Object_synonym: hBMPR2/var:K512T
Object_synonym: UniProtKB:Q13873-1, Lys-512, CHEBI:30013

subject: PR_000000153
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11115378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013682
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000154
type: Class
Object_term: BMP receptor type-2 sequence variant N519K (human)
Object_synonym: BMP receptor type-2 sequence variant 14 (human)
Object_synonym: hBMPR2/var:N519K
Object_synonym: UniProtKB:Q13873-1, Asn-519, CHEBI:29967

subject: PR_000000154
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: UniProtKB_VAR:VAR_013683
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013683
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000155
type: Class
Object_term: BMP receptor type-2 sequence variant C117Y (human)
Object_synonym: BMP receptor type-2 sequence variant 2 (human)
Object_synonym: hBMPR2/var:C117Y
Object_synonym: UniProtKB:Q13873-1, Cys-117, CHEBI:46858

subject: PR_000000155
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11015450
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013671
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000156
type: Class
Object_term: BMP receptor type-2 sequence variant C118W (human)
Object_synonym: BMP receptor type-2 sequence variant 3 (human)
Object_synonym: hBMPR2/var:C118W
Object_synonym: UniProtKB:Q13873-1, Cys-118, CHEBI:29954

subject: PR_000000156
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:10973254
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013672
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000157
type: Class
Object_term: BMP receptor type-2 sequence variant C123R (human)
Object_synonym: BMP receptor type-2 sequence variant 4 (human)
Object_synonym: hBMPR2/var:C123R
Object_synonym: UniProtKB:Q13873-1, Cys-123, CHEBI:29952

subject: PR_000000157
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11115378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013673
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000158
type: Class
Object_term: BMP receptor type-2 sequence variant C123S (human)
Object_synonym: BMP receptor type-2 sequence variant 5 (human)
Object_synonym: hBMPR2/var:C123S
Object_synonym: UniProtKB:Q13873-1, Cys-123, CHEBI:29999

subject: PR_000000158
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11115378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013674
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000159
type: Class
Object_term: BMP receptor type-2 sequence variant E224D (human)
Object_synonym: BMP receptor type-2 sequence variant 6 (human)
Object_synonym: hBMPR2/var:E224D
Object_synonym: UniProtKB:Q13873-1, Glu-224, CHEBI:29958

subject: PR_000000159
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11115378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013675
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000160
type: Class
Object_term: BMP receptor type-2 sequence variant C347Y (human)
Object_synonym: BMP receptor type-2 sequence variant 7 (human)
Object_synonym: hBMPR2/var:C347Y
Object_synonym: UniProtKB:Q13873-1, Cys-347, CHEBI:46858

subject: PR_000000160
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:10973254
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013676
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000161
type: Class
Object_term: BMP receptor type-2 sequence variant C420R (human)
Object_synonym: BMP receptor type-2 sequence variant 8 (human)
Object_synonym: hBMPR2/var:C420R
Object_synonym: UniProtKB:Q13873-1, Cys-420, CHEBI:29952

subject: PR_000000161
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11115378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013677
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000162
type: Class
Object_term: BMP receptor type-2 sequence variant C483R (human)
Object_synonym: BMP receptor type-2 sequence variant 9 (human)
Object_synonym: hBMPR2/var:C483R
Object_synonym: UniProtKB:Q13873-1, Cys-483, CHEBI:29952

subject: PR_000000162
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11015450
Evidence_source: PMID:12358323
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013678
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000164
type: Class
Object_term: BMP2
Object_synonym: BMP-2
Object_synonym: BMP-2A
Object_synonym: BMP2
Object_synonym: BMP2A
Object_synonym: bone morphogenetic protein 2A

subject: PR_000000164
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0001501
  Ontology_term: skeletal system development
Evidence_source: PANTHER:PTHR11848:SF50
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF50
DB_ID: PANTHER:PTHR11848:SF50
DB_ID: UniProtKB:P12643
DB_ID: UniProtKB:P21274
DB_ID: UniProtKB:Q3V1I4
DB_ID: UniProtKB:Q497W8
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000164
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007267
  Ontology_term: cell-cell signaling
Evidence_source: PANTHER:PTHR11848:SF50
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF50
DB_ID: PANTHER:PTHR11848:SF50
DB_ID: UniProtKB:P12643
DB_ID: UniProtKB:P21274
DB_ID: UniProtKB:Q3V1I4
DB_ID: UniProtKB:Q497W8
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000164
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030509
  Ontology_term: BMP signaling pathway
Evidence_source: PANTHER:PTHR11848:SF50
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF50
DB_ID: PANTHER:PTHR11848:SF50
DB_ID: UniProtKB:P12643
DB_ID: UniProtKB:P21274
DB_ID: UniProtKB:Q3V1I4
DB_ID: UniProtKB:Q497W8
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000165
type: Class
Object_term: BMP4
Object_synonym: BMP-2B
Object_synonym: BMP-4
Object_synonym: BMP2B
Object_synonym: BMP4
Object_synonym: bone morphogenetic protein 2B
Object_synonym: Dvr-4
Object_synonym: DVR4

subject: PR_000000165
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0001501
  Ontology_term: skeletal system development
Evidence_source: PANTHER:PTHR11848:SF49
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF49
DB_ID: PANTHER:PTHR11848:SF49
DB_ID: UniProtKB:P12644
DB_ID: UniProtKB:P21275
DB_ID: UniProtKB:Q3ULR1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000182
type: Class
Object_term: TGF-beta 1
Object_synonym: TGF-beta-1
Object_synonym: TGFB
Object_synonym: TGFB1

subject: PR_000000182
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0008283
  Ontology_term: cell proliferation
Evidence_source: PANTHER:PTHR11848:SF32
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF32
DB_ID: PANTHER:PTHR11848:SF32
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000182
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030154
  Ontology_term: cell differentiation
Evidence_source: PANTHER:PTHR11848:SF32
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF32
DB_ID: PANTHER:PTHR11848:SF32
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000183
type: Class
Object_term: TGF-beta 2
Object_synonym: BSC-1 cell growth inhibitor
Object_synonym: cetermin
Object_synonym: G-TSF
Object_synonym: glioblastoma-derived T-cell suppressor factor
Object_synonym: polyergin
Object_synonym: TGF-beta-2
Object_synonym: TGFB2

subject: PR_000000183
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0008283
  Ontology_term: cell proliferation
Evidence_source: PANTHER:PTHR11848:SF33
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF33
DB_ID: PANTHER:PTHR11848:SF33
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000186
type: Class
Object_term: TGF-beta receptor type-1 sequence variant T200I (human)
Object_synonym: hTGFBR1/var:T200I
Object_synonym: TGF-beta receptor type-1 sequence variant 1 (human)
Object_synonym: UniProtKB:P36897-1, Thr-200, CHEBI:30009

subject: PR_000000186
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022344
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000187
type: Class
Object_term: TGF-beta receptor type-1 sequence variant 10 (human)
Object_synonym: hTGFBR1/var:10
Object_synonym: TGFBR1*10A

subject: PR_000000187
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001605
  Ontology_term: amino_acid_insertion
Evidence_source: PMID:9661882
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022343
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000188
type: Class
Object_term: TGF-beta receptor type-1 sequence variant 11 (human)
Object_synonym: hTGFBR1/var:11
Object_synonym: TGFBR1*6A (human)
Object_synonym: UniProtKB:P36897-1, 1-23, 27-503

subject: PR_000000188
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:9661882
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022342
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000188
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:9661882
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022342
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000189
type: Class
Object_term: TGF-beta receptor type-1 sequence variant K232E (human)
Object_synonym: hTGFBR1/var:K232E
Object_synonym: TGF-beta receptor type-1 sequence variant 2 (human)
Object_synonym: UniProtKB:P36897-1, Lys-232, CHEBI:29972

subject: PR_000000189
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:16928994
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029481
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000190
type: Class
Object_term: TGF-beta receptor type-1 sequence variant S241L (human)
Object_synonym: hTGFBR1/var:S241L
Object_synonym: TGF-beta receptor type-1 sequence variant 3 (human)
Object_synonym: UniProtKB:P36897-1, Ser-241, CHEBI:30006

subject: PR_000000190
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:16596670
Evidence_source: PMID:16791849
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029482
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000191
type: Class
Object_term: TGF-beta receptor type-1 sequence variant N267H (human)
Object_synonym: hTGFBR1/var:N267H
Object_synonym: TGF-beta receptor type-1 sequence variant 4 (human)
Object_synonym: UniProtKB:P36897-1, Asn-267, CHEBI:29979

subject: PR_000000191
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:16791849
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029483
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000192
type: Class
Object_term: TGF-beta receptor type-1 sequence variant M318R (human)
Object_synonym: hTGFBR1/var:M318R
Object_synonym: TGF-beta receptor type-1 sequence variant 5 (human)
Object_synonym: UniProtKB:P36897-1, Met-318, CHEBI:29952

subject: PR_000000192
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022345
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000193
type: Class
Object_term: TGF-beta receptor type-1 sequence variant D400G (human)
Object_synonym: hTGFBR1/var:D400G
Object_synonym: TGF-beta receptor type-1 sequence variant 6 (human)
Object_synonym: UniProtKB:P36897-1, Asp-400, CHEBI:29947

subject: PR_000000193
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022346
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000194
type: Class
Object_term: TGF-beta receptor type-1 sequence variant R487P (human)
Object_synonym: hTGFBR1/var:R487P
Object_synonym: TGF-beta receptor type-1 sequence variant 7 (human)
Object_synonym: UniProtKB:P36897-1, Arg-487, CHEBI:50342

subject: PR_000000194
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14756
  Ontology_term: autosomal dominant type IV Ehlers-Danlos syndrome
Evidence_source: PMID:15731757
Evidence_source: PMID:16928994
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022347
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000195
type: Class
Object_term: TGF-beta receptor type-1 sequence variant R487E (human)
Object_synonym: hTGFBR1/var:R487E
Object_synonym: TGF-beta receptor type-1 sequence variant 8 (human)
Object_synonym: UniProtKB:P36897-1, Arg-487, CHEBI:29972

subject: PR_000000195
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:16791849
Evidence_source: PMID:16928994
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029484
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000196
type: Class
Object_term: TGF-beta receptor type-1 sequence variant R487W (human)
Object_synonym: hTGFBR1/var:R487W
Object_synonym: TGF-beta receptor type-1 sequence variant 9 (human)
Object_synonym: UniProtKB:P36897-1, Arg-487, CHEBI:29954

subject: PR_000000196
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14756
  Ontology_term: autosomal dominant type IV Ehlers-Danlos syndrome
Evidence_source: PMID:16928994
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029485
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000200
type: Class
Object_term: activin receptor type-1 sequence variant R206H (human)
Object_synonym: activin receptor type-1 sequence variant 1 (human)
Object_synonym: hACVR1/var:R206H
Object_synonym: UniProtKB:Q04771, Arg-206, CHEBI:29979

subject: PR_000000200
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13374
  Ontology_term: fibrodysplasia ossificans progressiva
Evidence_source: PMID:8397373
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_028244
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000200
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005887
  Ontology_term: integral component of plasma membrane
Evidence_source: PMID:8397373
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_028444
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000214
type: Class
Object_term: activin receptor type-2B sequence variant R40H (human)
Object_synonym: activin receptor type-2B sequence variant 1 (human)
Object_synonym: hACVR2B/var:R40H
Object_synonym: UniProtKB:Q13705-1, Arg-40, CHEBI:29979

subject: PR_000000214
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050545
  Ontology_term: visceral heterotaxy
Evidence_source: PMID:9916847
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013281
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000215
type: Class
Object_term: activin receptor type-2B sequence variant V494I (human)
Object_synonym: activin receptor type-2B sequence variant 2 (human)
Object_synonym: hACVR2B/var:V494I
Object_synonym: UniProtKB:Q13705-1, Val-494, CHEBI:30009

subject: PR_000000215
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050545
  Ontology_term: visceral heterotaxy
Evidence_source: PMID:9916847
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013282
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000221
type: Class
Object_term: Muellerian-inhibiting factor sequence variant V12G (human)
Object_synonym: anti-Muellerian hormone sequence variant 1 (human)
Object_synonym: hAMH/var:V12G
Object_synonym: UniProtKB:P03971, Val-12, CHEBI:29947

subject: PR_000000221
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007483
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000222
type: Class
Object_term: Muellerian-inhibiting factor sequence variant L70P (human)
Object_synonym: anti-Muellerian hormone sequence variant 2 (human)
Object_synonym: hAMH/var:L70P
Object_synonym: UniProtKB:P03971, Leu-70, CHEBI:50342

subject: PR_000000222
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007485
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000223
type: Class
Object_term: Muellerian-inhibiting factor sequence variant G101V (human)
Object_synonym: anti-Muellerian hormone sequence variant 3 (human)
Object_synonym: hAMH/var:G101V
Object_synonym: UniProtKB:P03971, Gly-101, CHEBI:30015

subject: PR_000000223
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007486
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000224
type: Class
Object_term: Muellerian-inhibiting factor sequence variant R123W (human)
Object_synonym: anti-Muellerian hormone sequence variant 4 (human)
Object_synonym: hAMH/var:R123W
Object_synonym: UniProtKB:P03971, Arg-123, CHEBI:29954

subject: PR_000000224
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007487
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000225
type: Class
Object_term: Muellerian-inhibiting factor sequence variant Y167C (human)
Object_synonym: anti-Muellerian hormone sequence variant 5 (human)
Object_synonym: hAMH/var:Y167C
Object_synonym: UniProtKB:P03971, Tyr-167, CHEBI:29950

subject: PR_000000225
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007488
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000226
type: Class
Object_term: Muellerian-inhibiting factor sequence variant R194C (human)
Object_synonym: anti-Muellerian hormone sequence variant 6 (human)
Object_synonym: hAMH/var:R194C
Object_synonym: UniProtKB:P03971, Arg-194, CHEBI:29950

subject: PR_000000226
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:14673134
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007490
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000226
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001555
  Ontology_term: decreased_translational_product_level
Evidence_source: PMID:14673134
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007490
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000226
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001558
  Ontology_term: polypeptide_localization_variant
Evidence_source: PMID:14673134
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007490
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000226
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0044424
  Ontology_term: intracellular part
Evidence_source: PMID:14673134
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007490
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000227
type: Class
Object_term: Muellerian-inhibiting factor sequence variant V477A (human)
Object_synonym: anti-Muellerian hormone sequence variant 7 (human)
Object_synonym: hAMH/var:V477A
Object_synonym: UniProtKB:P03971, Val-477, CHEBI:46217

subject: PR_000000227
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001558
  Ontology_term: polypeptide_localization_variant
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007492
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000227
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0044424
  Ontology_term: intracellular part
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007492
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000231
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant P276R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 1 (human)
Object_synonym: hCOMP/var:P276R
Object_synonym: UniProtKB:P49747-1, Pro-276, CHEBI:29952

subject: PR_000000231
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:11565064
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026239
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000232
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant C387G (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 10 (human)
Object_synonym: hCOMP/var:C387G
Object_synonym: UniProtKB:P49747-1, Cys-387, CHEBI:29947

subject: PR_000000232
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007625
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007625
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000233
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D408Y (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 11 (human)
Object_synonym: hCOMP/var:D408Y
Object_synonym: UniProtKB:P49747-1, Asp-408, CHEBI:46858

subject: PR_000000233
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007627
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000234
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D420A (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 12 (human)
Object_synonym: hCOMP/var:D420A
Object_synonym: UniProtKB:P49747-1, Asp-420, CHEBI:46217

subject: PR_000000234
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:11565064
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026240
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000235
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant G440E (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 13 (human)
Object_synonym: hCOMP/var:G440E
Object_synonym: UniProtKB:P49747-1, Gly-440, CHEBI:29972

subject: PR_000000235
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007628
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007628
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000236
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant G440R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 14 (human)
Object_synonym: hCOMP/var:G440R
Object_synonym: UniProtKB:P49747-1, Gly-440, CHEBI:29952

subject: PR_000000236
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007629
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000237
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant N453S (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 15 (human)
Object_synonym: hCOMP/var:N453S
Object_synonym: UniProtKB:P49747-1, Asn-453, CHEBI:29999

subject: PR_000000237
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: UniProtKB_VAR:VAR_007630
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007630
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000238
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D439V (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 16 (human)
Object_synonym: hCOMP/var:D439V
Object_synonym: UniProtKB:P49747-1, Asp-439, CHEBI:30015

subject: PR_000000238
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007618
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007618
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000239
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant C468Y (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 17 (human)
Object_synonym: hCOMP/var:C468Y
Object_synonym: UniProtKB:P49747-1, Cys-468, CHEBI:46858

subject: PR_000000239
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:7670471
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007632
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000240
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D472Y (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 18 (human)
Object_synonym: hCOMP/var:D472Y
Object_synonym: UniProtKB:P49747-1, Asp-472, CHEBI:46858

subject: PR_000000240
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:7670471
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007634
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000241
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D473G (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 19 (human)
Object_synonym: hCOMP/var:D473G
Object_synonym: UniProtKB:P49747-1, Asp-473, CHEBI:29947

subject: PR_000000241
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007635
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007635
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000242
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D290N (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 2 (human)
Object_synonym: hCOMP/var:D290N
Object_synonym: UniProtKB:P49747-1, Asp-290, CHEBI:50347

subject: PR_000000242
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007614
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007614
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000243
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D482G (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 20 (human)
Object_synonym: hCOMP/var:D482G
Object_synonym: UniProtKB:P49747-1, Asp-482, CHEBI:29947

subject: PR_000000243
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:9452063
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007637
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000244
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D518N (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 21 (human)
Object_synonym: hCOMP/var:D518N
Object_synonym: UniProtKB:P49747-1, Asp-518, CHEBI:50347

subject: PR_000000244
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007639
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007639
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000245
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant G719D (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 22 (human)
Object_synonym: hCOMP/var:G719D
Object_synonym: UniProtKB:P49747-1, Gly-719, CHEBI:29958

subject: PR_000000245
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:11746044
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017103
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000246
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant N523K (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 23 (human)
Object_synonym: hCOMP/var:N523K
Object_synonym: UniProtKB:P49747-1, Asn-523, CHEBI:29967

subject: PR_000000246
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:9021009
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007640
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000247
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant T585M (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 24 (human)
Object_synonym: hCOMP/var:T585M

subject: PR_000000247
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:11565064
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007641
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000247
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:11565064
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007641
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000248
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant T585R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 25 (human)
Object_synonym: hCOMP/var:T585R
Object_synonym: UniProtKB:P49747-1, Thr-585, CHEBI:29952

subject: PR_000000248
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: UniProtKB_VAR:VAR_007642
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007642
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000249
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant 26 (human)
Object_synonym: hCOMP/var:26

subject: PR_000000249
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007626
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007626
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000250
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D372del (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 27 (human)
Object_synonym: hCOMP/var:D372del
Object_synonym: UniProtKB:P49747-1, 21-371, 373-757

subject: PR_000000250
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007623
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007623
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000251
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D374del (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 28 (human)
Object_synonym: hCOMP/var:D374del
Object_synonym: UniProtKB:P49747-1, 21-373, 375-757

subject: PR_000000251
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007624
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007624
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000252
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant S459del (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 29 (human)
Object_synonym: hCOMP/var:S459del
Object_synonym: UniProtKB:P49747-1, 21-458, 460-757

subject: PR_000000252
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007631
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007631
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000253
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant G299R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 3 (human)
Object_synonym: hCOMP/var:G299R
Object_synonym: UniProtKB:P49747-1, Gly-299, CHEBI:29952

subject: PR_000000253
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007615
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007615
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000254
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D469del (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 30 (human)
Object_synonym: hCOMP/var:D469del
Object_synonym: UniProtKB:P49747-1, 21-468, 470-757

subject: PR_000000254
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007633
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007633
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000255
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D473del (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 31 (human)
Object_synonym: hCOMP/var:D473del
Object_synonym: UniProtKB:P49747-1, 21-472, 474-757

subject: PR_000000255
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007636
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007636
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000256
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant 32 (human)
Object_synonym: hCOMP/var:32
Object_synonym: UniProtKB:P49747-1, 21-366, 369-757

subject: PR_000000256
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: UniProtKB_VAR:VAR_007621
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007621
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000257
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant 33 (human)
Object_synonym: hCOMP/var:33
Object_synonym: UniProtKB:P49747-1, 21-512, 517-757

subject: PR_000000257
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007638
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007638
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000258
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant C328R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 4 (human)
Object_synonym: hCOMP/var:C328R
Object_synonym: UniProtKB:P49747-1, Cys-328, CHEBI:29952

subject: PR_000000258
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007616
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007616
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000259
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D342Y (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 5 (human)
Object_synonym: hCOMP/var:D342Y
Object_synonym: UniProtKB:P49747-1, Asp-342, CHEBI:46858

subject: PR_000000259
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:7670472
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007617
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000260
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant C348R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 6 (human)
Object_synonym: hCOMP/var:C348R
Object_synonym: UniProtKB:P49747-1, Cys-348, CHEBI:29952

subject: PR_000000260
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:11746045
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017102
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000261
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D361V (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 7 (human)
Object_synonym: hCOMP/var:D361V
Object_synonym: UniProtKB:P49747-1, Asp-361, CHEBI:30015

subject: PR_000000261
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: UniProtKB_VAR:VAR_007619
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007619
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000262
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D361Y (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 8 (human)
Object_synonym: hCOMP/var:D361Y
Object_synonym: UniProtKB:P49747-1, Asp-361, CHEBI:46858

subject: PR_000000262
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007620
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000263
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant C371S (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 9 (human)
Object_synonym: hCOMP/var:C371S
Object_synonym: UniProtKB:P49747-1, Cys-371, CHEBI:29999

subject: PR_000000263
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:9184241
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007622
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000266
type: Class
Object_term: CREB-binding protein sequence variant R1378P (human)
Object_synonym: CREB-binding protein sequence variant 1 (human)
Object_synonym: hCREBBP/var:R1378P
Object_synonym: UniProtKB:Q92793-1, Arg-1378, CHEBI:50342

subject: PR_000000266
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1933
  Ontology_term: Rubinstein-Taybi syndrome
Evidence_source: PMID:11331617
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015578
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000266
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:11331617
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015578
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000266
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004402
  Ontology_term: histone acetyltransferase activity
Modifier: NOT
Evidence_source: PMID:11331617
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015578
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000281
type: Class
Object_term: growth/differentiation factor 5
Object_synonym: BMP-14
Object_synonym: BMP14
Object_synonym: bone morphogenetic protein 14
Object_synonym: Bp
Object_synonym: cartilage-derived morphogenetic protein 1
Object_synonym: CDMP-1
Object_synonym: CDMP1
Object_synonym: GDF-5
Object_synonym: GDF5
Object_synonym: radotermin

subject: PR_000000281
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030326
  Ontology_term: embryonic limb morphogenesis
Evidence_source: PANTHER:PTHR11848:SF44
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF44
DB_ID: PANTHER:PTHR11848:SF44
DB_ID: UniProtKB:P43026
DB_ID: UniProtKB:P43027
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000282
type: Class
Object_term: growth/differentiation factor 7
Object_synonym: GDF-7
Object_synonym: GDF7

subject: PR_000000282
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007154
  Ontology_term: cell communication
Evidence_source: PANTHER:PTHR11848:SF42
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF42
DB_ID: PANTHER:PTHR11848:SF42
DB_ID: UniProtKB:P43029
DB_ID: UniProtKB:Q7Z4P5
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000292
type: Class
Object_term: nodal protein sequence variant R183Q (human)
Object_synonym: hNODAL/var:R183Q
Object_synonym: nodal protein sequence variant 1 (human)
Object_synonym: UniProtKB:Q96S42, Arg-183, CHEBI:30011

subject: PR_000000292
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050545
  Ontology_term: visceral heterotaxy
Evidence_source: PMID:9354794
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015111
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000297
type: Class
Object_term: pituitary homeobox 2 isoform 4
Object_synonym: PITX2/iso:4
Object_synonym: pitx2D

subject: PR_000000297
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00046
  Ontology_term: Homeodomain
Modifier: NOT
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000298
type: Class
Object_term: pituitary homeobox 2 sequence variant R89W (human)
Object_synonym: hPITX2/var:R89W
Object_synonym: pituitary homeobox 2 sequence variant 1 (human)
Object_synonym: UniProtKB:Q99697-1, Arg-89, CHEBI:29954

subject: PR_000000298
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050786
  Ontology_term: iridogoniodysgenesis syndrome
Evidence_source: PMID:9437321
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_003762
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000299
type: Class
Object_term: pituitary homeobox 2 sequence variant L100Q (human)
Object_synonym: hPITX2/var:L100Q
Object_synonym: pituitary homeobox 2 sequence variant 2 (human)
Object_synonym: UniProtKB:Q99697-1, Leu-100, CHEBI:30011

subject: PR_000000299
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14686
  Ontology_term: Axenfeld-Rieger syndrome
Evidence_source: PMID:8944018
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_003763
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000300
type: Class
Object_term: pituitary homeobox 2 sequence variant T114P (human)
Object_synonym: hPITX2/var:T114P
Object_synonym: pituitary homeobox 2 sequence variant 3 (human)
Object_synonym: UniProtKB:Q99697-1, Thr-114, CHEBI:50342

subject: PR_000000300
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14686
  Ontology_term: Axenfeld-Rieger syndrome
Evidence_source: PMID:8944018
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_003764
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000301
type: Class
Object_term: pituitary homeobox 2 sequence variant R115H (human)
Object_synonym: hPITX2/var:R115H
Object_synonym: pituitary homeobox 2 sequence variant 4 (human)
Object_synonym: UniProtKB:Q99697-1, Arg-115, CHEBI:29979

subject: PR_000000301
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050786
  Ontology_term: iridogoniodysgenesis syndrome
Evidence_source: PMID:9618168
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_003765
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000302
type: Class
Object_term: pituitary homeobox 2 sequence variant R137P (human)
Object_synonym: hPITX2/var:R137P
Object_synonym: pituitary homeobox 2 sequence variant 5 (human)
Object_synonym: UniProtKB:Q99697-1, Arg-137, CHEBI:50342

subject: PR_000000302
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14686
  Ontology_term: Axenfeld-Rieger syndrome
Evidence_source: PMID:8944018
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_003766
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000317
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant G48R (human)
Object_synonym: hACVRL1/var:G48R
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 1 (human)
Object_synonym: UniProtKB:P37023, Gly-48, CHEBI:29952

subject: PR_000000317
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026785
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000318
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant E215K (human)
Object_synonym: hACVRL1/var:E215K
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 10 (human)
Object_synonym: UniProtKB:P37023, Glu-215, CHEBI:29967

subject: PR_000000318
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026789
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000319
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant H222del (human)
Object_synonym: hACVRL1/var:H222del
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 11 (human)
Object_synonym: UniProtKB:P37023, 22-221, 223-503

subject: PR_000000319
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: UniProtKB_VAR:VAR_006209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006209
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000319
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005887
  Ontology_term: integral component of plasma membrane
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006209
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000320
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant S233del (human)
Object_synonym: hACVRL1/var:S233del
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 12 (human)
Object_synonym: UniProtKB:P37023, 22-232, 234-503

subject: PR_000000320
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: UniProtKB_VAR:VAR_026792
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026792
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000321
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant G223R (human)
Object_synonym: hACVRL1/var:G223R
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 13 (human)
Object_synonym: UniProtKB:P37023, Gly-223, CHEBI:29952

subject: PR_000000321
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026790
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000322
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant K229R (human)
Object_synonym: hACVRL1/var:K229R
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 14 (human)
Object_synonym: UniProtKB:P37023, Lys-229, CHEBI:29952

subject: PR_000000322
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026791
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000323
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant D254del (human)
Object_synonym: hACVRL1/var:D254del
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 15 (human)
Object_synonym: UniProtKB:P37023, 22-253, 255-503

subject: PR_000000323
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: UniProtKB_VAR:VAR_026793
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026793
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000323
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026793
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000323
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026793
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000324
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant M376V (human)
Object_synonym: hACVRL1/var:M376V
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 16 (human)
Object_synonym: UniProtKB:P37023, Met-376, CHEBI:30015

subject: PR_000000324
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026801
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000325
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant L285F (human)
Object_synonym: hACVRL1/var:L285F
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 17 (human)
Object_synonym: UniProtKB:P37023, Leu-285, CHEBI:29997

subject: PR_000000325
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026794
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000326
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant A306P (human)
Object_synonym: hACVRL1/var:A306P
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 18 (human)
Object_synonym: UniProtKB:P37023, Ala-306, CHEBI:50342

subject: PR_000000326
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026795
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000327
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant H314Y (human)
Object_synonym: hACVRL1/var:H314Y
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 19 (human)
Object_synonym: UniProtKB:P37023, His-314, CHEBI:46858

subject: PR_000000327
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026796
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000328
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant W50C (human)
Object_synonym: hACVRL1/var:W50C
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 2 (human)
Object_synonym: UniProtKB:P37023, Trp-50, CHEBI:29950

subject: PR_000000328
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10767348
Evidence_source: PMID:14684682
Evidence_source: PMID:9245985
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006204
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000328
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006204
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000328
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006204
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000329
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant S333I (human)
Object_synonym: hACVRL1/var:S333I
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 20 (human)
Object_synonym: UniProtKB:P37023, Ser-333, CHEBI:30009

subject: PR_000000329
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10767348
Evidence_source: PMID:14684682
Evidence_source: PMID:9245985
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006210
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000329
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006210
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000329
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006210
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000330
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant L337P (human)
Object_synonym: hACVRL1/var:L337P
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 21 (human)
Object_synonym: UniProtKB:P37023, Leu-337, CHEBI:50342

subject: PR_000000330
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026797
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000331
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant C344Y (human)
Object_synonym: hACVRL1/var:C344Y
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 22 (human)
Object_synonym: UniProtKB:P37023, Cys-344, CHEBI:46858

subject: PR_000000331
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10767348
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026798
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000331
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026798
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000331
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026798
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000332
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant A347P (human)
Object_synonym: hACVRL1/var:A347P
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 23 (human)
Object_synonym: UniProtKB:P37023, Ala-347, CHEBI:50342

subject: PR_000000332
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026799
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000333
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant R374Q (human)
Object_synonym: hACVRL1/var:R374Q
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 24 (human)
Object_synonym: UniProtKB:P37023, Arg-374, CHEBI:30011

subject: PR_000000333
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026800
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000333
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026800
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000333
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026800
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000334
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant R374W (human)
Object_synonym: hACVRL1/var:R374W
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 25 (human)
Object_synonym: UniProtKB:P37023, Arg-374, CHEBI:29954

subject: PR_000000334
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11170071
Evidence_source: PMID:14684682
Evidence_source: PMID:15712270
Evidence_source: PMID:9245985
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006211
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000335
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant P378L (human)
Object_synonym: hACVRL1/var:P378L
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 26 (human)
Object_synonym: UniProtKB:P37023, Pro-378, CHEBI:30006

subject: PR_000000335
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026802
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000335
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026802
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000335
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026802
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000336
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant E379K (human)
Object_synonym: hACVRL1/var:E379K
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 27 (human)
Object_synonym: UniProtKB:P37023, Glu-379, CHEBI:29967

subject: PR_000000336
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_source: PMID:15712270
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026803
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000337
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant M376R (human)
Object_synonym: hACVRL1/var:M376R
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 28 (human)
Object_synonym: UniProtKB:P37023, Met-376, CHEBI:29952

subject: PR_000000337
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:8640225
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006212
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000338
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant D397G (human)
Object_synonym: hACVRL1/var:D397G
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 29 (human)
Object_synonym: UniProtKB:P37023, Asp-397, CHEBI:29947

subject: PR_000000338
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026804
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000339
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant C51Y (human)
Object_synonym: hACVRL1/var:C51Y
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 3 (human)
Object_synonym: UniProtKB:P37023, Cys-51, CHEBI:46858

subject: PR_000000339
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11170071
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006205
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000340
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant I398N (human)
Object_synonym: hACVRL1/var:I398N
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 30 (human)
Object_synonym: UniProtKB:P37023, Ile-398, CHEBI:50347

subject: PR_000000340
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11170071
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026805
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000341
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant W399S (human)
Object_synonym: hACVRL1/var:W399S
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 31 (human)
Object_synonym: UniProtKB:P37023, Trp-399, CHEBI:29999

subject: PR_000000341
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11170071
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026806
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000342
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant E407D (human)
Object_synonym: hACVRL1/var:E407D
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 32 (human)
Object_synonym: UniProtKB:P37023, Glu-407, CHEBI:29958

subject: PR_000000342
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10767348
Evidence_source: PMID:15712270
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026807
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000343
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant R411P (human)
Object_synonym: hACVRL1/var:R411P
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 33 (human)
Object_synonym: UniProtKB:P37023, Arg-411, CHEBI:50342

subject: PR_000000343
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026808
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000344
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant R411Q (human)
Object_synonym: hACVRL1/var:R411Q
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 34 (human)
Object_synonym: UniProtKB:P37023, Arg-411, CHEBI:30011

subject: PR_000000344
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_source: PMID:15024723
Evidence_source: PMID:8640225
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006213
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000344
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006213
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000344
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006213
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000345
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant R411W (human)
Object_synonym: hACVRL1/var:R411W
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 35 (human)
Object_synonym: UniProtKB:P37023, Arg-411, CHEBI:29954

subject: PR_000000345
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11484689
Evidence_source: PMID:15024723
Evidence_source: PMID:15712270
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026809
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000346
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant P424T (human)
Object_synonym: hACVRL1/var:P424T
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 36 (human)
Object_synonym: UniProtKB:P37023, Pro-424, CHEBI:30013

subject: PR_000000346
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:9245985
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006214
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000347
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant F425L (human)
Object_synonym: hACVRL1/var:F425L
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 37 (human)
Object_synonym: UniProtKB:P37023, Phe-425, CHEBI:30006

subject: PR_000000347
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026810
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000348
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant F425V (human)
Object_synonym: hACVRL1/var:F425V
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 38 (human)
Object_synonym: UniProtKB:P37023, Phe-425, CHEBI:30015

subject: PR_000000348
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15712270
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026811
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000349
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant F425del (human)
Object_synonym: hACVRL1/var:F425del
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 39 (human)
Object_synonym: UniProtKB:P37023, 22-423, 425-503

subject: PR_000000349
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: UniProtKB_VAR:VAR_026812
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026812
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000350
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant R67Q (human)
Object_synonym: hACVRL1/var:R67Q
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 4 (human)
Object_synonym: UniProtKB:P37023, Arg-67, CHEBI:30011

subject: PR_000000350
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_source: PMID:9245985
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006206
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000350
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006206
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000350
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006206
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000351
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant R479L (human)
Object_synonym: hACVRL1/var:R479L
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 40 (human)
Object_synonym: UniProtKB:P37023, Arg-479, CHEBI:30006

subject: PR_000000351
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026813
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000352
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant A482V (human)
Object_synonym: hACVRL1/var:A482V
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 41 (human)
Object_synonym: UniProtKB:P37023, Ala-482, CHEBI:30015

subject: PR_000000352
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026814
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000353
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant R484W (human)
Object_synonym: hACVRL1/var:R484W
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 42 (human)
Object_synonym: UniProtKB:P37023, Arg-484, CHEBI:29954

subject: PR_000000353
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11484689
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026815
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000354
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant K487T (human)
Object_synonym: hACVRL1/var:K487T
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 43 (human)
Object_synonym: UniProtKB:P37023, Lys-487, CHEBI:30013

subject: PR_000000354
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026816
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000354
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005887
  Ontology_term: integral component of plasma membrane
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026816
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000355
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant GA48/49EP (human)
Object_synonym: hACVRL1/var:GA48/49EP
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 44 (human)
Object_synonym: UniProtKB:P37023, Gly-48, CHEBI:29972
Object_synonym: Ala-49, CHEBI:46217

subject: PR_000000355
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: UniProtKB_VAR:VAR_026784
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026784
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000356
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant R67W (human)
Object_synonym: hACVRL1/var:R67W
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 5 (human)
Object_synonym: UniProtKB:P37023, Arg-67, CHEBI:29954

subject: PR_000000356
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15712270
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026786
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000357
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant C77W (human)
Object_synonym: hACVRL1/var:C77W
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 6 (human)
Object_synonym: UniProtKB:P37023, Cys-77, CHEBI:29954

subject: PR_000000357
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10694922
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006207
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000357
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006207
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000357
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006207
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000358
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant N96D (human)
Object_synonym: hACVRL1/var:N96D
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 7 (human)
Object_synonym: UniProtKB:P37023, Asn-96, CHEBI:29958

subject: PR_000000358
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10694922
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006208
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000359
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant D179A (human)
Object_synonym: hACVRL1/var:D179A
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 8 (human)
Object_synonym: UniProtKB:P37023, Asp-179, CHEBI:46217

subject: PR_000000359
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026787
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000359
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026787
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000360
type: Class
Object_term: serine/threonine-protein kinase receptor R3 sequence variant G211D (human)
Object_synonym: hACVRL1/var:G211D
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 9 (human)
Object_synonym: UniProtKB:P37023, Gly-211, CHEBI:29958

subject: PR_000000360
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026788
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000360
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026788
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000360
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026788
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000367
type: Class
Object_term: smad4 sequence variant E330G (human)
Object_synonym: hSMAD4/var:E330G
Object_synonym: smad4 sequence variant 1 (human)
Object_synonym: UniProtKB:Q13485, Glu-330, CHEBI:29947

subject: PR_000000367
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12417513
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022833
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000368
type: Class
Object_term: smad4 sequence variant G352R (human)
Object_synonym: hSMAD4/var:G352R
Object_synonym: smad4 sequence variant 2 (human)
Object_synonym: UniProtKB:Q13485, Gly-352, CHEBI:29952

subject: PR_000000368
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12417513
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019571
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000368
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4905
  Ontology_term: pancreatic carcinoma
Evidence_source: PMID:12417513
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019571
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000369
type: Class
Object_term: smad4 sequence variant R361C (human)
Object_synonym: hSMAD4/var:R361C
Object_synonym: smad4 sequence variant 3 (human)
Object_synonym: UniProtKB:Q13485, Arg-361, CHEBI:29950

subject: PR_000000369
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:9811934
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019572
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000370
type: Class
Object_term: smad4 sequence variant G386D (human)
Object_synonym: hSMAD4/var:G386D
Object_synonym: smad4 sequence variant 4 (human)
Object_synonym: UniProtKB:Q13485, Gly-386, CHEBI:29958

subject: PR_000000370
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:15031030
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019573
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000371
type: Class
Object_term: smad4 sequence variant D493H (human)
Object_synonym: hSMAD4/var:D493H
Object_synonym: smad4 sequence variant 5 (human)
Object_synonym: UniProtKB:Q13485, Asp-493, CHEBI:29979

subject: PR_000000371
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4905
  Ontology_term: pancreatic carcinoma
Evidence_source: PMID:8553070
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011380
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000398
type: Class
Object_term: TGF-beta 1 sequence variant L10P (human)
Object_synonym: hTGFB1/var:L10P
Object_synonym: TGF-beta 1 sequence variant 1 (human)
Object_synonym: UniProtKB:P01137, Leu-10, CHEBI:50342

subject: PR_000000398
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:9783545
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_016171
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000399
type: Class
Object_term: TGF-beta 1 sequence variant T81H (human)
Object_synonym: hTGFB1/var:T81H
Object_synonym: TGF-beta 1 sequence variant 2 (human)
Object_synonym: UniProtKB:P01137, Tyr-81, CHEBI:29979

subject: PR_000000399
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4997
  Ontology_term: Camurati-Engelmann disease
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000399
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001558
  Ontology_term: polypeptide_localization_variant
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000399
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0044424
  Ontology_term: intracellular part
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000399
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11062463
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000400
type: Class
Object_term: TGF-beta 1 sequence variant R218C (human)
Object_synonym: hTGFB1/var:R218C
Object_synonym: TGF-beta 1 sequence variant 3 (human)
Object_synonym: UniProtKB:P01137, Arg-218, CHEBI:29950

subject: PR_000000400
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4997
  Ontology_term: Camurati-Engelmann disease
Evidence_source: PMID:10973241
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000400
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000400
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000400
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000002555
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000401
type: Class
Object_term: TGF-beta 1 sequence variant R218H (human)
Object_synonym: hTGFB1/var:R218H
Object_synonym: TGF-beta 1 sequence variant 4 (human)
Object_synonym: UniProtKB:P01137, Arg-218, CHEBI:29979

subject: PR_000000401
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4997
  Ontology_term: Camurati-Engelmann disease
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000402
type: Class
Object_term: TGF-beta 1 sequence variant H222D (human)
Object_synonym: hTGFB1/var:H222D
Object_synonym: TGF-beta 1 sequence variant 5 (human)
Object_synonym: UniProtKB:P01137, His-222, CHEBI:29958

subject: PR_000000402
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4997
  Ontology_term: Camurati-Engelmann disease
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000402
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000402
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000403
type: Class
Object_term: TGF-beta 1 sequence variant C225R (human)
Object_synonym: hTGFB1/var:C225R
Object_synonym: TGF-beta 1 sequence variant 6 (human)
Object_synonym: UniProtKB:P01137, Cys-225, CHEBI:29952

subject: PR_000000403
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4997
  Ontology_term: Camurati-Engelmann disease
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000403
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000403
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000403
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000403
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000002555
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000437
type: Class
Object_term: growth/differentiation factor 5 sequence variant C400Y (human)
Object_synonym: growth/differentiation factor 5 sequence variant 1 (human)
Object_synonym: hGDF5/var:C400Y
Object_synonym: UniProtKB:P43026, Cys-400, CHEBI:46858

subject: PR_000000437
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080052
  Ontology_term: acromesomelic dysplasia, Grebe type
Evidence_source: UniProtKB_VAR:VAR_017407
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017407
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000437
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR_000000164
Evidence_source: PMID:9288098
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017407
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000437
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005622
  Ontology_term: intracellular
Evidence_source: PMID:9288098
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017407
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000437
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: NOT
Evidence_source: PMID:9288098
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017407
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000438
type: Class
Object_term: growth/differentiation factor 5 sequence variant R438L (human)
Object_synonym: growth/differentiation factor 5 sequence variant 2 (human)
Object_synonym: hGDF5/var:R438L
Object_synonym: UniProtKB:P43026, Arg-438, CHEBI:30006

subject: PR_000000438
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050794
  Ontology_term: multiple synostoses syndrome
Evidence_source: PMID:16532400
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026545
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000438
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:16532400
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026545
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000439
type: Class
Object_term: growth/differentiation factor 5 sequence variant L441P (human)
Object_synonym: growth/differentiation factor 5 sequence variant 3 (human)
Object_synonym: hGDF5/var:L441P
Object_synonym: UniProtKB:P43026, Leu-441, CHEBI:50342

subject: PR_000000439
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050790
  Ontology_term: fibular hypoplasia and complex brachydactyly
Evidence_source: UniProtKB_VAR:VAR_017408
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017408
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000441
type: Class
Object_term: growth/differentiation factor 5 sequence variant 5 (mouse)
Object_synonym: mGDF5/var:5

subject: PR_000000441
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: MP:0006279
  Ontology_term: abnormal limb development
Evidence_source: PMID:8145850
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000452
type: Class
Object_term: lefty 2 sequence variant S342N (human)
Object_synonym: hLEFTY2/var:S342N
Object_synonym: lefty 2 sequence variant 1 (human)
Object_synonym: UniProtKB:O00292-1, Ser-342, CHEBI:50347

subject: PR_000000452
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050545
  Ontology_term: visceral heterotaxy
Evidence_source: PMID:10053005
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010385
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000470
type: Class
Object_term: smad2 sequence variant R133C (human)
Object_synonym: hSMAD2/var:R133C
Object_synonym: smad2 sequence variant 1 (human)
Object_synonym: UniProtKB:Q15796-1, Arg-133, CHEBI:29950

subject: PR_000000470
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:5672
  Ontology_term: large intestine cancer
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011375
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000470
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011375
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000470
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011375
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000471
type: Class
Object_term: smad2 sequence variant L440R (human)
Object_synonym: hSMAD2/var:L440R
Object_synonym: smad2 sequence variant 2 (human)
Object_synonym: UniProtKB:Q15796-1, Leu-440, CHEBI:29952

subject: PR_000000471
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:5672
  Ontology_term: large intestine cancer
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011377
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000472
type: Class
Object_term: smad2 sequence variant P445H (human)
Object_synonym: hSMAD2/var:P445H
Object_synonym: smad2 sequence variant 3 (human)
Object_synonym: UniProtKB:Q15796-1, Pro-445, CHEBI:29979

subject: PR_000000472
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:5672
  Ontology_term: large intestine cancer
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011378
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000472
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011378
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000473
type: Class
Object_term: smad2 sequence variant D450E (human)
Object_synonym: hSMAD2/var:D450E
Object_synonym: smad2 sequence variant 4 (human)
Object_synonym: UniProtKB:Q15796-1, Asp-450, CHEBI:29972

subject: PR_000000473
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:5672
  Ontology_term: large intestine cancer
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011379
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000473
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011379
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000474
type: Class
Object_term: smad2 sequence variant 5 (human)
Object_synonym: hSMAD2/var:5
Object_synonym: UniProtKB:Q15796-1, 2-343, 359-467

subject: PR_000000474
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:5672
  Ontology_term: large intestine cancer
Evidence_source: PMID:8673135
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011376
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000474
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:8673135
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011376
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000619
type: Class
Object_term: TGF-beta 1 sequence variant T81H cleaved 1 (human)
Object_synonym: hTGFB1/var:T81H/Clv:1
Object_synonym: TGF-beta 1 sequence variant 2 cleaved 1 (human)
Object_synonym: UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979

subject: PR_000000619
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001558
  Ontology_term: polypeptide_localization_variant
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000619
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0044424
  Ontology_term: intracellular part
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000620
type: Class
Object_term: TGF-beta 1 sequence variant T81H cleaved 2 (human)
Object_synonym: hTGFB1/var:T81H/Clv:2
Object_synonym: TGF-beta 1 sequence variant 2 cleaved 2 (human)
Object_synonym: UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979

subject: PR_000000620
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000621
type: Class
Object_term: TGF-beta 1 sequence variant R218C cleaved 1 (human)
Object_synonym: hTGFB1/var:R218C/Clv:1
Object_synonym: TGF-beta 1 sequence variant 3 cleaved 1 (human)
Object_synonym: UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950

subject: PR_000000621
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005160
  Ontology_term: transforming growth factor beta receptor binding
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000621
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000621
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000621
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000621
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000000616
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000622
type: Class
Object_term: TGF-beta 1 sequence variant R218C cleaved 2 (human)
Object_synonym: hTGFB1/var:R218C/Clv:2
Object_synonym: TGF-beta 1 sequence variant 3 cleaved 2 (human)
Object_synonym: UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950

subject: PR_000000622
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000623
type: Class
Object_term: TGF-beta 1 sequence variant H222D cleaved 1 (human)
Object_synonym: hTGFB1/var:H222D/Clv:1
Object_synonym: TGF-beta 1 sequence variant 5 cleaved 1 (human)
Object_synonym: UniProtKB:P01137, 279-390, His-222, CHEBI:29958

subject: PR_000000623
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000623
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000623
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000623
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000000616
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000624
type: Class
Object_term: TGF-beta 1 sequence variant H222D cleaved 2 (human)
Object_synonym: hTGFB1/var:H222D/Clv:2
Object_synonym: TGF-beta 1 sequence variant 5 cleaved 2 (human)
Object_synonym: UniProtKB:P01137, 30-278, His-222, CHEBI:29958

subject: PR_000000624
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000624
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001601
  Ontology_term: conformational_change_variant
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000625
type: Class
Object_term: TGF-beta 1 sequence variant C225R cleaved 1 (human)
Object_synonym: hTGFB1/var:C225R/Clv:1
Object_synonym: TGF-beta 1 sequence variant 6 cleaved 1 (human)
Object_synonym: UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952

subject: PR_000000625
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000625
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000000616
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000626
type: Class
Object_term: TGF-beta 1 sequence variant C225R cleaved 2 (human)
Object_synonym: hTGFB1/var:C225R/Clv:2
Object_synonym: TGF-beta 1 sequence variant 6 cleaved 2 (human)
Object_synonym: UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952

subject: PR_000000626
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000627
type: Class
Object_term: TGF-beta 1 sequence variant R218H cleaved 1 (human)
Object_synonym: hTGFB1/var:R218H/Clv:1
Object_synonym: TGF-beta 1 sequence variant 4 cleaved 1 (human)
Object_synonym: UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979

subject: PR_000000627
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005160
  Ontology_term: transforming growth factor beta receptor binding
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000627
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000627
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000627
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000627
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000000616
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000628
type: Class
Object_term: TGF-beta 1 sequence variant R218H cleaved 2 (human)
Object_synonym: hTGFB1/var:R218H/Clv:2
Object_synonym: TGF-beta 1 sequence variant 4 cleaved 2 (human)
Object_synonym: UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979

subject: PR_000000628
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000628
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001601
  Ontology_term: conformational_change_variant
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000647
type: Class
Object_term: smad1 isoform 1 phosphorylated 1
Object_synonym: BMP receptor-activated smad1
Object_synonym: SMAD1/iso:1/Phos:1

subject: PR_000000647
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005072
  Ontology_term: transforming growth factor beta receptor, cytoplasmic mediator activity
Evidence_source: PMID:10708949
Evidence_code: TAS
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000668
type: Class
Object_term: calcium-activated calmodulin-binding potassium channel alpha subunit

subject: PR_000000668
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02888
  Ontology_term: Calmodulin binding domain
Evidence_source: PIRSF:PIRSF038511
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038511
DB_ID: PIRSF:PIRSF038511
Date: 2008-09-15
Assigned_by: PRO:CNA

subject: PR_000000668
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03530
  Ontology_term: Calcium-activated SK potassium channel
Evidence_source: PIRSF:PIRSF038511
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038511
DB_ID: PIRSF:PIRSF038511
Date: 2008-09-15
Assigned_by: PRO:CNA

subject: PR_000000668
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07885
  Ontology_term: Ion channel
Evidence_source: PIRSF:PIRSF038511
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038511
DB_ID: PIRSF:PIRSF038511
Date: 2008-09-15
Assigned_by: PRO:CNA

PR_000000673
type: Class
Object_term: cyclic nucleotide-gated channel alpha subunit

subject: PR_000000673
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00027
  Ontology_term: Cyclic nucleotide-binding domain
Evidence_source: PIRSF:PIRSF002403
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002403
DB_ID: PIRSF:PIRSF002403
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000673
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF002403
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002403
DB_ID: PIRSF:PIRSF002403
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000674
type: Class
Object_term: cyclic nucleotide-gated channel beta subunit

subject: PR_000000674
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00027
  Ontology_term: Cyclic nucleotide-binding domain
Evidence_source: PIRSF:PIRSF038515
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038515
DB_ID: PIRSF:PIRSF038515
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000674
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF038515
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038515
DB_ID: PIRSF:PIRSF038515
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000675
type: Class
Object_term: platelet-derived growth factor with CUB domain

subject: PR_000000675
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00341
  Ontology_term: PDGF/VEGF domain
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000675
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00431
  Ontology_term: CUB domain
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000676
type: Class
Object_term: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
Object_synonym: f-channel
Object_synonym: HCN

subject: PR_000000676
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00027
  Ontology_term: Cyclic nucleotide-binding domain
Evidence_source: PIRSF:PIRSF038514
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038514
DB_ID: PIRSF:PIRSF038514
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000676
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF038514
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038514
DB_ID: PIRSF:PIRSF038514
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000676
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08412
  Ontology_term: Ion transport protein N-terminal
Evidence_source: PIRSF:PIRSF038514
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038514
DB_ID: PIRSF:PIRSF038514
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000677
type: Class
Object_term: shab-related voltage-gated potassium channel alpha subunit
Object_synonym: fam:Kchan_shab_sub-a
Object_synonym: Kv2 channel

subject: PR_000000677
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF038520
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038520
DB_ID: PIRSF:PIRSF038520
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000677
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02214
  Ontology_term: BTB/POZ domain
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000677
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03521
  Ontology_term: Kv2 voltage-gated K+ channel
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000678
type: Class
Object_term: sodium leak channel non-selective protein
Object_synonym: CanIon
Object_synonym: NALCN
Object_synonym: VGCNL1
Object_synonym: voltage gated channel-like protein 1

subject: PR_000000678
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF038547
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038547
DB_ID: PIRSF:PIRSF038547
DB_ID: UniProtKB:Q8BXR5
DB_ID: UniProtKB:Q8IZF0
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000678
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006811
  Ontology_term: ion transport
Evidence_source: PIRSF:PIRSF038547
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038547
DB_ID: PIRSF:PIRSF038547
DB_ID: UniProtKB:Q8BXR5
DB_ID: UniProtKB:Q8IZF0
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000678
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005216
  Ontology_term: ion channel activity
Modifier: contributes_to
Evidence_source: PIRSF:PIRSF038547
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038547
DB_ID: PIRSF:PIRSF038547
DB_ID: UniProtKB:Q8BXR5
DB_ID: UniProtKB:Q8IZF0
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000679
type: Class
Object_term: transient receptor potential cation channel TRPA
Object_synonym: fam:TRPA

subject: PR_000000679
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00023
  Ontology_term: Ankyrin repeat
Evidence_source: PIRSF:PIRSF038535
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038535
DB_ID: PIRSF:PIRSF038535
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000000679
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF038535
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038535
DB_ID: PIRSF:PIRSF038535
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000000680
type: Class
Object_term: transient receptor potential cation channel TRPC
Object_synonym: fam:TRPC

subject: PR_000000680
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00023
  Ontology_term: Ankyrin repeat
Evidence_source: PIRSF:PIRSF005528
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005528
DB_ID: PIRSF:PIRSF005528
Date: 2008-07-01
Assigned_by: PRO:CNA

subject: PR_000000680
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF005528
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005528
DB_ID: PIRSF:PIRSF005528
Date: 2008-07-01
Assigned_by: PRO:CNA

subject: PR_000000680
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08344
  Ontology_term: Transient receptor ion channel II
Evidence_source: PIRSF:PIRSF005528
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005528
DB_ID: PIRSF:PIRSF005528
Date: 2008-07-01
Assigned_by: PRO:CNA

PR_000000681
type: Class
Object_term: transient receptor potential cation channel TRPV
Object_synonym: fam:TRPV

subject: PR_000000681
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00023
  Ontology_term: Ankyrin repeat
Evidence_source: PIRSF:PIRSF038527
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038527
DB_ID: PIRSF:PIRSF038527
Date: 2008-10-15
Assigned_by: PRO:CNA

subject: PR_000000681
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF038527
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038527
DB_ID: PIRSF:PIRSF038527
Date: 2008-10-15
Assigned_by: PRO:CNA

PR_000000682
type: Class
Object_term: voltage-gated potassium channel alpha subunit with PAS domain
Object_synonym: fam:Kchan_sub-a_PAS

subject: PR_000000682
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00027
  Ontology_term: Cyclic nucleotide-binding domain
Evidence_source: PIRSF:PIRSF038287
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038287
DB_ID: PIRSF:PIRSF038287
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000682
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF038287
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038287
DB_ID: PIRSF:PIRSF038287
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000682
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00989
  Ontology_term: PAS fold
Evidence_source: PIRSF:PIRSF038287
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038287
DB_ID: PIRSF:PIRSF038287
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000682
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PIRSF:PIRSF038287
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038287
DB_ID: PIRSF:PIRSF038287
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000682
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: contributes_to
Evidence_source: PIRSF:PIRSF038287
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038287
DB_ID: PIRSF:PIRSF038287
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000683
type: Class
Object_term: voltage-gated potassium channel alpha subunit KCNA4
Object_synonym: HPCN2
Object_synonym: KCNA4
Object_synonym: KCNA4L
Object_synonym: voltage-gated K(+) channel HuKII
Object_synonym: voltage-gated potassium channel HBK4
Object_synonym: voltage-gated potassium channel HK1
Object_synonym: voltage-gated potassium channel subunit Kv1.4

subject: PR_000000683
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF038521
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038521
DB_ID: PIRSF:PIRSF038521
DB_ID: UniProtKB:P22459
DB_ID: UniProtKB:Q61423
DB_ID: UniProtKB:Q8CBF8
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000683
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02214
  Ontology_term: BTB/POZ domain
Evidence_source: PIRSF:PIRSF038521
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038521
DB_ID: PIRSF:PIRSF038521
DB_ID: UniProtKB:P22459
DB_ID: UniProtKB:Q61423
DB_ID: UniProtKB:Q8CBF8
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000683
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07941
  Ontology_term: Potassium channel Kv1.4 tandem inactivation domain
Evidence_source: PIRSF:PIRSF038521
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038521
DB_ID: PIRSF:PIRSF038521
DB_ID: UniProtKB:P22459
DB_ID: UniProtKB:Q61423
DB_ID: UniProtKB:Q8CBF8
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000684
type: Class
Object_term: voltage-gated potassium channel subunit KQT
Object_synonym: fam:Kchan_sub-KQT

subject: PR_000000684
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF038513
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038513
DB_ID: PIRSF:PIRSF038513
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000684
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03520
  Ontology_term: KCNQ voltage-gated potassium channel
Evidence_source: PIRSF:PIRSF038513
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038513
DB_ID: PIRSF:PIRSF038513
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000684
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PIRSF:PIRSF038513
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038513
DB_ID: PIRSF:PIRSF038513
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000684
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: contributes_to
Evidence_source: PIRSF:PIRSF038513
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038513
DB_ID: PIRSF:PIRSF038513
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000685
type: Class
Object_term: voltage-gated potassium channel alpha subunit
Object_synonym: fam:Kchan_sub-a

subject: PR_000000685
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF002449
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002449
DB_ID: PIRSF:PIRSF002449
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000685
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02214
  Ontology_term: BTB/POZ domain
Evidence_source: PIRSF:PIRSF002449
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002449
DB_ID: PIRSF:PIRSF002449
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000685
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PIRSF:PIRSF002449
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002449
DB_ID: PIRSF:PIRSF002449
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000685
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: contributes_to
Evidence_source: PIRSF:PIRSF002449
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002449
DB_ID: PIRSF:PIRSF002449
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000701
type: Class
Object_term: modulatory voltage-gated potassium channel subunit KCNG
Object_synonym: fam:Kchan_sub-KCNG
Object_synonym: silent subunit

subject: PR_000000701
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0015459
  Ontology_term: potassium channel regulator activity
Evidence_source: PIRSF:PIRSF500980
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500980
DB_ID: PIRSF:PIRSF500980
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000702
type: Class
Object_term: modulatory voltage-gated potassium channel subunit KCNS
Object_synonym: fam:Kchan_sub-KCNS
Object_synonym: silent subunit

subject: PR_000000702
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0015459
  Ontology_term: potassium channel regulator activity
Evidence_source: PIRSF:PIRSF500981
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500981
DB_ID: PIRSF:PIRSF500981
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000717
type: Class
Object_term: sodium leak channel non-selective protein isoform 3
Object_synonym: NALCN/iso:3
Object_synonym: sodium leak channel non-selective protein isoform 4

subject: PR_000000717
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Modifier: NOT
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000724
type: Class
Object_term: voltage-gated potassium channel KCNF1
Object_synonym: KCNF1
Object_synonym: kH1
Object_synonym: voltage-gated potassium channel subunit Kv5.1

subject: PR_000000724
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0015459
  Ontology_term: potassium channel regulator activity
Evidence_source: PMID:9696692
Evidence_code: IDA
DB_ID: UniProtKB:Q7TSH7
DB_ID: UniProtKB:Q9H3M0
Date: 2008-06-01
Assigned_by: PRO:CNA
Comments: Note=The organism source is uncertain.

subject: PR_000000724
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PMID:9696692
Evidence_code: IDA
DB_ID: UniProtKB:Q7TSH7
DB_ID: UniProtKB:Q9H3M0
Date: 2008-06-01
Assigned_by: PRO:CNA
Comments: Note=The organism source is uncertain.

subject: PR_000000724
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: contributes_to
Evidence_source: PMID:9696692
Evidence_code: IDA
DB_ID: UniProtKB:Q7TSH7
DB_ID: UniProtKB:Q9H3M0
Date: 2008-06-01
Assigned_by: PRO:CNA
Comments: Note=The organism source is uncertain.

PR_000000725
type: Class
Object_term: voltage-gated potassium channel KCNV1
Object_synonym: KCNV1
Object_synonym: neuronal potassium channel alpha subunit HNKA
Object_synonym: voltage-gated potassium channel subunit Kv8.1

subject: PR_000000725
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0015459
  Ontology_term: potassium channel regulator activity
Evidence_source: PANTHER:PTHR11537:SF38
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11537:SF38
DB_ID: PANTHER:PTHR11537:SF38
DB_ID: UniProtKB:Q6PIU1
DB_ID: UniProtKB:Q8BZN2
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000726
type: Class
Object_term: voltage-gated potassium channel KCNV2
Object_synonym: KCNV2
Object_synonym: voltage-gated potassium channel subunit Kv8.2

subject: PR_000000726
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0015459
  Ontology_term: potassium channel regulator activity
Evidence_source: PANTHER:PTHR11537:SF40
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11537:SF39
DB_ID: PANTHER:PTHR11537:SF39
DB_ID: UniProtKB:Q8CFS6
DB_ID: UniProtKB:Q8TDN2
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000738
type: Class
Object_term: cGMP-gated cation channel alpha-1 sequence variant S320F (human)
Object_synonym: cGMP-gated cation channel alpha-1 sequence variant 1 (human)
Object_synonym: hCNGA1/var:S320F
Object_synonym: UniProtKB:P29973-1, Ser-320, CHEBI:29997

subject: PR_000000738
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10584
  Ontology_term: retinitis pigmentosa
Evidence_source: PMID:7479749
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009297
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000738
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005887
  Ontology_term: integral component of plasma membrane
Modifier: NOT
Evidence_source: PMID:7479749
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009297
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000741
type: Class
Object_term: cyclic nucleotide-gated cation channel alpha-3 sequence variant R283Q (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 1 (human)
Object_synonym: hCNGA3/var:R283Q
Object_synonym: UniProtKB:Q16281-1, Arg-283, CHEBI:30011

subject: PR_000000741
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010904
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000742
type: Class
Object_term: cyclic nucleotide-gated cation channel alpha-3 sequence variant T291R (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 2 (human)
Object_synonym: hCNGA3/var:T291R
Object_synonym: UniProtKB:Q16281-1, Thr-291, CHEBI:29952

subject: PR_000000742
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010906
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000743
type: Class
Object_term: cyclic nucleotide-gated cation channel alpha-3 sequence variant G557R (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 3 (human)
Object_synonym: hCNGA3/var:G557R
Object_synonym: UniProtKB:Q16281-1, Gly-557, CHEBI:29952

subject: PR_000000743
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010909
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000744
type: Class
Object_term: cyclic nucleotide-gated cation channel alpha-3 sequence variant V529M (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 4 (human)
Object_synonym: hCNGA3/var:V529M
Object_synonym: UniProtKB:Q16281-1, Val-529, CHEBI:16044

subject: PR_000000744
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010907
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000745
type: Class
Object_term: cyclic nucleotide-gated cation channel alpha-3 sequence variant R283W (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 5 (human)
Object_synonym: hCNGA3/var:R283W
Object_synonym: UniProtKB:Q16281-1, Arg-283, CHEBI:29954

subject: PR_000000745
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010905
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000746
type: Class
Object_term: cyclic nucleotide-gated cation channel alpha-3 sequence variant F547L (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 6 (human)
Object_synonym: hCNGA3/var:F547L
Object_synonym: UniProtKB:Q16281-1, Phe-547, CHEBI:30006

subject: PR_000000746
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010908
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000747
type: Class
Object_term: cyclic nucleotide-gated cation channel alpha-3 sequence variant R410W (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 7 (human)
Object_synonym: hCNGA3/var:R410W
Object_synonym: UniProtKB:Q16281-1, Arg-410, CHEBI:29954

subject: PR_000000747
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010910
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000748
type: Class
Object_term: cyclic nucleotide-gated cation channel alpha-3 sequence variant P163L (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 8 (human)
Object_synonym: hCNGA3/var:P163L
Object_synonym: UniProtKB:Q16281-1, Pro-163, CHEBI:30006

subject: PR_000000748
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010903
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000752
type: Class
Object_term: cyclic nucleotide-gated cation channel beta-3 sequence variant S435F (human)
Object_synonym: cyclic nucleotide-gated cation channel beta-3 sequence variant 1 (human)
Object_synonym: hCNGB3/var:S435F
Object_synonym: UniProtKB:Q9NQW8-1, Ser-435, CHEBI:29997

subject: PR_000000752
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:10888875
Evidence_source: PMID:10958649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_018111
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000759
type: Class
Object_term: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human)
Object_synonym: hHCN4/var:D553N
Object_synonym: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 1 (human)
Object_synonym: UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347

subject: PR_000000759
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13884
  Ontology_term: sick sinus syndrome
Evidence_source: PMID:15123648
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026534
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000759
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Modifier: NOT
Evidence_source: PMID:15123648
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026534
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000760
type: Class
Object_term: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human)
Object_synonym: hHCN4/var:S672R
Object_synonym: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 2 (human)
Object_synonym: UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952

subject: PR_000000760
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13884
  Ontology_term: sick sinus syndrome
Evidence_source: PMID:16407510
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026535
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000760
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005222
  Ontology_term: intracellular cAMP-activated cation channel activity
Evidence_source: PMID:16407510
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026535
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000760
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0022843
  Ontology_term: voltage-gated cation channel activity
Modifier: altered
Relative_to: PR_000002604
Evidence_source: PMID:16407510
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026535
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000772
type: Class
Object_term: small conductance calcium-activated potassium channel protein 2 isoform 2
Object_synonym: KCNN2/iso:2

subject: PR_000000772
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03530
  Ontology_term: Calcium-activated SK potassium channel
Modifier: NOT
DB_ID: UniProtKB:Q6PJI0-1
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000803
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant G459D (human)
Object_synonym: hKCNV2/var:G459D
Object_synonym: UniProtKB:Q8TDN2, Gly-459, CHEBI:29958
Object_synonym: voltage-gated potassium channel KCNV2 sequence variant 1 (human)

subject: PR_000000803
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027637
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000804
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant A259V (human)
Object_synonym: hKCNV2/var:A259V
Object_synonym: UniProtKB:Q8TDN2, Ala-259, CHEBI:30015
Object_synonym: voltage-gated potassium channel KCNV2 sequence variant 2 (human)

subject: PR_000000804
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027635
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000805
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant L126Q (human)
Object_synonym: hKCNV2/var:L126Q
Object_synonym: UniProtKB:Q8TDN2, Leu-126, CHEBI:30011
Object_synonym: voltage-gated potassium channel KCNV2 sequence variant 3 (human)

subject: PR_000000805
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027632
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000806
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant 4 (human)
Object_synonym: hKCNV2/var:4
Object_synonym: UniProtKB:Q8TDN2, 1-338, 342-545

subject: PR_000000806
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027636
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000807
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant S256W (human)
Object_synonym: hKCNV2/var:S256W
Object_synonym: UniProtKB:Q8TDN2, Ser-256, CHEBI:29954
Object_synonym: voltage-gated potassium channel KCNV2 sequence variant 5 (human)

subject: PR_000000807
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027634
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000808
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant W188C (human)
Object_synonym: hKCNV2/var:W188C
Object_synonym: UniProtKB:Q8TDN2, Trp-188, CHEBI:29950
Object_synonym: voltage-gated potassium channel KCNV2 sequence variant 6 (human)

subject: PR_000000808
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027633
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000817
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant T587M (human)
Object_synonym: hKCNQ1/var:T587M
Object_synonym: UniProtKB:P51787-1, Thr-587, CHEBI:16044
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 1 (human)

subject: PR_000000817
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10024302
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008951
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000818
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant S373P (human)
Object_synonym: hKCNQ1/var:S373P
Object_synonym: UniProtKB:P51787-1, Ser-373, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 10 (human)

subject: PR_000000818
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008127
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000819
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R243C (human)
Object_synonym: hKCNQ1/var:R243C
Object_synonym: UniProtKB:P51787-1, Arg-243, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 11 (human)

subject: PR_000000819
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10409658
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010933
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000819
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: altered
Relative_to: PR_000002622
Evidence_source: PMID:10409658
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010933
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000820
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant D317N (human)
Object_synonym: hKCNQ1/var:D317N
Object_synonym: UniProtKB:P51787-1, Asp-317, CHEBI:50347
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 12 (human)

subject: PR_000000820
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9302275
Evidence_source: PMID:9482580
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001534
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000821
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant V310I (human)
Object_synonym: hKCNQ1/var:V310I
Object_synonym: UniProtKB:P51787-1, Val-310, CHEBI:30009
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 13 (human)

subject: PR_000000821
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009926
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000822
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant S566F (human)
Object_synonym: hKCNQ1/var:S566F
Object_synonym: UniProtKB:P51787-1, Ser-566, CHEBI:29997
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 14 (human)

subject: PR_000000822
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009932
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000823
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant Y315C (human)
Object_synonym: hKCNQ1/var:Y315C
Object_synonym: UniProtKB:P51787-1, Tyr-315, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 15 (human)

subject: PR_000000823
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9693036
Evidence_source: PMID:9927399
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008946
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000824
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant S225L (human)
Object_synonym: hKCNQ1/var:S225L
Object_synonym: UniProtKB:P51787-1, Ser-225, CHEBI:30006
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 16 (human)

subject: PR_000000824
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9927399
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009923
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000825
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A178P (human)
Object_synonym: hKCNQ1/var:A178P
Object_synonym: UniProtKB:P51787-1, Ala-178, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 17 (human)

subject: PR_000000825
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001518
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000825
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001518
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000825
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: NOT|contributes_to
Evidence_source: PMID:10704188
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001518
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000826
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A178T (human)
Object_synonym: hKCNQ1/var:A178T
Object_synonym: UniProtKB:P51787-1, Ala-178, CHEBI:30013
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 18 (human)

subject: PR_000000826
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9024139
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009920
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000827
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G189R (human)
Object_synonym: hKCNQ1/var:G189R
Object_synonym: UniProtKB:P51787-1, Gly-189, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 19 (human)

subject: PR_000000827
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001519
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000828
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant P448R (human)
Object_synonym: hKCNQ1/var:P448R
Object_synonym: UniProtKB:P51787-1, Pro-448, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 2 (human)

subject: PR_000000828
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009931
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000829
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant T309R (human)
Object_synonym: hKCNQ1/var:T309R
Object_synonym: UniProtKB:P51787-1, Thr-309, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 20 (human)

subject: PR_000000829
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001529
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000830
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R591H (human)
Object_synonym: hKCNQ1/var:R591H
Object_synonym: UniProtKB:P51787-1, Arg-591, CHEBI:29979
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 21 (human)

subject: PR_000000830
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10024302
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008953
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000831
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R366W (human)
Object_synonym: hKCNQ1/var:R366W
Object_synonym: UniProtKB:P51787-1, Arg-366, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 22 (human)

subject: PR_000000831
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9693036
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008948
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000832
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant I313M (human)
Object_synonym: hKCNQ1/var:I313M
Object_synonym: UniProtKB:P51787-1, Ile-313, CHEBI:16044
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 23 (human)

subject: PR_000000832
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9024139
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001531
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000833
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant Y111C (human)
Object_synonym: hKCNQ1/var:Y111C
Object_synonym: UniProtKB:P51787-1, Tyr-111, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 24 (human)

subject: PR_000000833
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009918
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000834
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R533W (human)
Object_synonym: hKCNQ1/var:R533W
Object_synonym: UniProtKB:P51787-1, Arg-533, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 25 (human)

subject: PR_000000834
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008949
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000834
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: altered
Relative_to: PR_000002622
Evidence_source: PMID:10704188
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008949
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000835
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G168R (human)
Object_synonym: hKCNQ1/var:G168R
Object_synonym: UniProtKB:P51787-1, Gly-168, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 26 (human)

subject: PR_000000835
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9693036
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001516
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000836
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant E261D (human)
Object_synonym: hKCNQ1/var:E261D
Object_synonym: UniProtKB:P51787-1, Glu-261, CHEBI:29958
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 27 (human)

subject: PR_000000836
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2842
  Ontology_term: Jervell-Lange Nielsen syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008944
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000837
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A371T (human)
Object_synonym: hKCNQ1/var:A371T
Object_synonym: UniProtKB:P51787-1, Ala-371, CHEBI:30013
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 28 (human)

subject: PR_000000837
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001544
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000838
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant 29 (human)
Object_synonym: hKCNQ1/var:29
Object_synonym: UniProtKB:P49747-1, 21-70, 74-757

subject: PR_000000838
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10511610
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009917
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000839
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A341V (human)
Object_synonym: hKCNQ1/var:A341V
Object_synonym: UniProtKB:P51787-1, Ala-341, CHEBI:30015
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 3 (human)

subject: PR_000000839
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:8818942
Evidence_source: PMID:8872472
Evidence_source: PMID:9570196
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001539
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000840
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant L250H (human)
Object_synonym: hKCNQ1/var:L250H
Object_synonym: UniProtKB:P51787-1, Leu-250, CHEBI:29979
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 30 (human)

subject: PR_000000840
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008943
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000841
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant S349W (human)
Object_synonym: hKCNQ1/var:S349W
Object_synonym: UniProtKB:P51787-1, Ser-349, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 31 (human)

subject: PR_000000841
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009928
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000842
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant T391I (human)
Object_synonym: hKCNQ1/var:T391I
Object_synonym: UniProtKB:P51787-1, Thr-391, CHEBI:30009
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 32 (human)

subject: PR_000000842
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009930
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000843
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant K318N (human)
Object_synonym: hKCNQ1/var:K318N
Object_synonym: UniProtKB:P51787-1, Lys-318, CHEBI:50347
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 33 (human)

subject: PR_000000843
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9693036
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008947
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000844
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A344V (human)
Object_synonym: hKCNQ1/var:A344V
Object_synonym: UniProtKB:P51787-1, Ala-344, CHEBI:30015
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 34 (human)

subject: PR_000000844
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001541
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000845
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A525T (human)
Object_synonym: hKCNQ1/var:A525T
Object_synonym: UniProtKB:P51787-1, Ala-525, CHEBI:30013
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 35 (human)

subject: PR_000000845
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10482963
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009181
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000846
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A341E (human)
Object_synonym: hKCNQ1/var:A341E
Object_synonym: UniProtKB:P51787-1, Ala-341, CHEBI:29972
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 36 (human)

subject: PR_000000846
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001538
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000846
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: MP:0003233
  Ontology_term: prolonged QT interval
Evidence_source: PMID:15498462
Evidence_code: IMP
Taxon: NCBITaxon:10090
DB_ID: MGI:3056651
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000847
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R583C (human)
Object_synonym: hKCNQ1/var:R583C
Object_synonym: UniProtKB:P51787-1, Arg-583, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 37 (human)

subject: PR_000000847
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009933
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000848
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant D242N (human)
Object_synonym: hKCNQ1/var:D242N
Object_synonym: UniProtKB:P51787-1, Asp-242, CHEBI:50347
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 38 (human)

subject: PR_000000848
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008940
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000849
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant L342F (human)
Object_synonym: hKCNQ1/var:L342F
Object_synonym: UniProtKB:P51787-1, Leu-342, CHEBI:29997
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 39 (human)

subject: PR_000000849
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001540
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000850
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G306R (human)
Object_synonym: hKCNQ1/var:G306R
Object_synonym: UniProtKB:P51787-1, Gly-306, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 4 (human)

subject: PR_000000850
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001528
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000851
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant S140G (human)
Object_synonym: hKCNQ1/var:S140G
Object_synonym: UniProtKB:P51787-1, Ser-140, CHEBI:29947
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 40 (human)

subject: PR_000000851
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050650
  Ontology_term: familial atrial fibrillation
Evidence_source: PMID:12522251
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015742
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000851
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001557
  Ontology_term: polypeptide_gain_of_function_variant
Evidence_source: PMID:12522251
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015742
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000851
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005267
  Ontology_term: potassium channel activity
Modifier: increased
Relative_to: PR_000002622
Evidence_source: PMID:12522251
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015742
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000852
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G269S (human)
Object_synonym: hKCNQ1/var:G269S
Object_synonym: UniProtKB:P51787-1, Gly-269, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 41 (human)

subject: PR_000000852
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009925
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000853
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R555C (human)
Object_synonym: hKCNQ1/var:R555C
Object_synonym: UniProtKB:P51787-1, Arg-555, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 42 (human)

subject: PR_000000853
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001545
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000854
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R539W (human)
Object_synonym: hKCNQ1/var:R539W
Object_synonym: UniProtKB:P51787-1, Arg-539, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 43 (human)

subject: PR_000000854
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008950
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000854
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: altered
Relative_to: PR_000002622
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008950
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000854
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Modifier: altered
Relative_to: PR_000002622
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008950
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000855
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant Y315S (human)
Object_synonym: hKCNQ1/var:Y315S
Object_synonym: UniProtKB:P51787-1, Tyr-315, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 44 (human)

subject: PR_000000855
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001533
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000856
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R174H (human)
Object_synonym: hKCNQ1/var:R174H
Object_synonym: UniProtKB:P51787-1, Arg-174, CHEBI:29979
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 45 (human)

subject: PR_000000856
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10367071
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008939
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000857
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A194P (human)
Object_synonym: hKCNQ1/var:A194P
Object_synonym: UniProtKB:P51787-1, Ala-194, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 46 (human)

subject: PR_000000857
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009922
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000858
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant Y184S (human)
Object_synonym: hKCNQ1/var:Y184S
Object_synonym: UniProtKB:P51787-1, Tyr-184, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 47 (human)

subject: PR_000000858
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008125
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000859
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G345E (human)
Object_synonym: hKCNQ1/var:G345E
Object_synonym: UniProtKB:P51787-1, Gly-345, CHEBI:29972
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 48 (human)

subject: PR_000000859
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001542
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000860
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R190Q (human)
Object_synonym: hKCNQ1/var:R190Q
Object_synonym: UniProtKB:P51787-1, Arg-190, CHEBI:30011
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 49 (human)

subject: PR_000000860
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001520
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000860
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:10704188
Evidence_source: PMID:9482580
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001520
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000860
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Modifier: NOT
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001520
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000860
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: NOT|contributes_to
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001520
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000861
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant T311I (human)
Object_synonym: hKCNQ1/var:T311I
Object_synonym: UniProtKB:P51787-1, Thr-311, CHEBI:30009
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 5 (human)

subject: PR_000000861
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9482580
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009927
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000862
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G314S (human)
Object_synonym: hKCNQ1/var:G314S
Object_synonym: UniProtKB:P51787-1, Gly-314, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 50 (human)

subject: PR_000000862
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:8872472
Evidence_source: PMID:9693036
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001532
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000863
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant W248R (human)
Object_synonym: hKCNQ1/var:W248R
Object_synonym: UniProtKB:P51787-1, Trp-248, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 51 (human)

subject: PR_000000863
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10409658
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008942
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000863
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:10409658
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008942
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000863
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008942
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000863
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: altered|contributes_to
Relative_to: PR_000002622
Evidence_source: PMID:10409658
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008942
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000864
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R366P (human)
Object_synonym: hKCNQ1/var:R366P
Object_synonym: UniProtKB:P51787-1, Arg-366, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 52 (human)

subject: PR_000000864
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9024139
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001543
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000865
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R366Q (human)
Object_synonym: hKCNQ1/var:R366Q
Object_synonym: UniProtKB:P51787-1, Arg-366, CHEBI:30011
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 53 (human)

subject: PR_000000865
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009929
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000866
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant E160K (human)
Object_synonym: hKCNQ1/var:E160K
Object_synonym: UniProtKB:P51787-1, Glu-160, CHEBI:29967
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 54 (human)

subject: PR_000000866
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009919
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000867
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant V254M (human)
Object_synonym: hKCNQ1/var:V254M
Object_synonym: UniProtKB:P51787-1, Val-254, CHEBI:16044
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 55 (human)

subject: PR_000000867
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001522
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000868
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G345R (human)
Object_synonym: hKCNQ1/var:G345R
Object_synonym: UniProtKB:P51787-1, Gly-345, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 56 (human)

subject: PR_000000868
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008126
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000869
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant E261K (human)
Object_synonym: hKCNQ1/var:E261K
Object_synonym: UniProtKB:P51787-1, Glu-261, CHEBI:29967
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 57 (human)

subject: PR_000000869
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10409658
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001523
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000869
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Modifier: NOT
Evidence_source: PMID:8900283
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001523
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000869
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: NOT|contributes_to
Evidence_source: PMID:8900283
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001523
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000870
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant V307L (human)
Object_synonym: hKCNQ1/var:V307L
Object_synonym: UniProtKB:P51787-1, Val-307, CHEBI:30006
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 58 (human)

subject: PR_000000870
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050793
  Ontology_term: short QT syndrome
Evidence_source: PMID:15159330
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023841
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000870
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001557
  Ontology_term: polypeptide_gain_of_function_variant
Evidence_source: PMID:15159330
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023841
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000870
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005267
  Ontology_term: potassium channel activity
Modifier: increased
Relative_to: PR_000002622
Evidence_source: PMID:15159330
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023841
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000871
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant F339del (human)
Object_synonym: deltaF339
Object_synonym: hKCNQ1/var:F339del
Object_synonym: UniProtKB:P49747-1, 21-338, 340-757
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 59 (human)

subject: PR_000000871
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:15159330
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001537
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000872
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R243H (human)
Object_synonym: hKCNQ1/var:R243H
Object_synonym: UniProtKB:P51787-1, Arg-243, CHEBI:29979
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 6 (human)

subject: PR_000000872
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2842
  Ontology_term: Jervell-Lange Nielsen syndrome
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008941
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000872
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008941
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000872
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: decreased|contributes_to
Relative_to: PR_000002622
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008941
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000873
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G179S (human)
Object_synonym: hKCNQ1/var:G179S
Object_synonym: UniProtKB:P51787-1, Gly-179, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 60 (human)

subject: PR_000000873
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009921
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000874
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A300T (human)
Object_synonym: hKCNQ1/var:A300T
Object_synonym: UniProtKB:P51787-1, Ala-300, CHEBI:30013
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 61 (human)

subject: PR_000000874
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9641694
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001526
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000874
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: contributes_to
Evidence_source: PMID:9641694
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001526
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000875
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R174C (human)
Object_synonym: hKCNQ1/var:R174C
Object_synonym: UniProtKB:P51787-1, Arg-174, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 62 (human)

subject: PR_000000875
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001517
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000876
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant W305S (human)
Object_synonym: hKCNQ1/var:W305S
Object_synonym: UniProtKB:P51787-1, Trp-305, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 63 (human)

subject: PR_000000876
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2842
  Ontology_term: Jervell-Lange Nielsen syndrome
Evidence_source: PMID:9781056
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001527
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000877
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant L266P (human)
Object_synonym: hKCNQ1/var:L266P
Object_synonym: UniProtKB:P51787-1, Leu-266, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 64 (human)

subject: PR_000000877
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009924
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000878
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R594Q (human)
Object_synonym: hKCNQ1/var:R594Q
Object_synonym: UniProtKB:P51787-1, Arg-594, CHEBI:30011
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 65 (human)

subject: PR_000000878
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009934
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000879
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant L273F (human)
Object_synonym: hKCNQ1/var:L273F
Object_synonym: UniProtKB:P51787-1, Leu-273, CHEBI:29997
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 66 (human)

subject: PR_000000879
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001525
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000879
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001525
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000879
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: contributes_to
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001525
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000880
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant Y281C (human)
Object_synonym: hKCNQ1/var:Y281C
Object_synonym: UniProtKB:P51787-1, Tyr-281, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 67 (human)

subject: PR_000000880
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9927399
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008945
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000881
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant P320A (human)
Object_synonym: hKCNQ1/var:P320A
Object_synonym: UniProtKB:P51787-1, Pro-320, CHEBI:46217
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 68 (human)

subject: PR_000000881
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001535
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000882
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant F157C (human)
Object_synonym: hKCNQ1/var:F157C
Object_synonym: UniProtKB:P51787-1, Phe-157, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 69 (human)

subject: PR_000000882
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220146
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008124
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000883
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant L353P (human)
Object_synonym: hKCNQ1/var:L353P
Object_synonym: UniProtKB:P51787-1, Leu-353, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 7 (human)

subject: PR_000000883
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9693036
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009180
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000884
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G325R (human)
Object_synonym: hKCNQ1/var:G325R
Object_synonym: UniProtKB:P51787-1, Gly-325, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 70 (human)

subject: PR_000000884
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9024139
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001536
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000885
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant W392R (human)
Object_synonym: hKCNQ1/var:W392R
Object_synonym: UniProtKB:P51787-1, Trp-392, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 71 (human)

subject: PR_000000885
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008128
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000886
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G269D (human)
Object_synonym: hKCNQ1/var:G269D
Object_synonym: UniProtKB:P51787-1, Gly-269, CHEBI:29958
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 72 (human)

subject: PR_000000886
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001524
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000887
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G589D (human)
Object_synonym: hKCNQ1/var:G589D
Object_synonym: UniProtKB:P51787-1, Gly-589, CHEBI:29958
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 73 (human)

subject: PR_000000887
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008952
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000888
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G216R (human)
Object_synonym: hKCNQ1/var:G216R
Object_synonym: UniProtKB:P51787-1, Gly-216, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 74 (human)

subject: PR_000000888
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9272155
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001521
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000889
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant V417M (human)
Object_synonym: hKCNQ1/var:V417M
Object_synonym: UniProtKB:P51787-1, Val-417, CHEBI:16044
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 8 (human)

subject: PR_000000889
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010934
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000890
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant T312I (human)
Object_synonym: hKCNQ1/var:T312I
Object_synonym: UniProtKB:P51787-1, Thr-312, CHEBI:30009
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 9 (human)

subject: PR_000000890
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10409658
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001530
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000890
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:10409658
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001530
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000890
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: NOT|contributes_to
Evidence_source: PMID:10409658
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001530
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000907
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant S247W (human)
Object_synonym: hKCNQ2/var:S247W
Object_synonym: UniProtKB:O43526-1, Ser-247, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 1 (human)

subject: PR_000000907
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:12742592
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026991
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000907
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: decreased
Relative_to: PR_000002632
Evidence_source: PMID:12742592
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026991
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000908
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant H228Q (human)
Object_synonym: hKCNQ2/var:H228Q
Object_synonym: UniProtKB:O43526-1, His-228, CHEBI:30011
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 10 (human)

subject: PR_000000908
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:14534157
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026989
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000909
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant R207W (human)
Object_synonym: hKCNQ2/var:R207W
Object_synonym: UniProtKB:O43526-1, Arg-207, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 2 (human)

subject: PR_000000909
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:11572947
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026987
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000909
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: decreased
Relative_to: PR_000002632
Evidence_source: PMID:11572947
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026987
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000910
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant L243F (human)
Object_synonym: hKCNQ2/var:L243F
Object_synonym: UniProtKB:O43526-1, Leu-243, CHEBI:29997
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 3 (human)

subject: PR_000000910
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:14534157
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026990
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000911
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant 4 (human)
Object_synonym: hKCNQ2/var:4
Object_synonym: UniProtKB:O43526-1, Arg-214, CHEBI:29954

subject: PR_000000911
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:11175290
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010929
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000912
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant Y284C (human)
Object_synonym: hKCNQ2/var:Y284C
Object_synonym: UniProtKB:O43526-1, Tyr-284, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 5 (human)

subject: PR_000000912
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:10788442
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010930
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000912
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:10788442
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010930
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000913
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant A306T (human)
Object_synonym: hKCNQ2/var:A306T
Object_synonym: UniProtKB:O43526-1, Ala-306, CHEBI:30013
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 6 (human)

subject: PR_000000913
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:10788442
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010931
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000913
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:10788442
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010931
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000914
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant R333Q (human)
Object_synonym: hKCNQ2/var:R333Q
Object_synonym: UniProtKB:O43526-1, Arg-333, CHEBI:30011
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 7 (human)

subject: PR_000000914
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:14534157
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026992
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000915
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant M208V (human)
Object_synonym: hKCNQ2/var:M208V
Object_synonym: UniProtKB:O43526-1, Met-208, CHEBI:30015
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 8 (human)

subject: PR_000000915
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:14534157
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026988
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000916
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant K526N (human)
Object_synonym: hKCNQ2/var:K526N
Object_synonym: UniProtKB:O43526-3, Lys-526, CHEBI:50347
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 9 (human)

subject: PR_000000916
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:15249611
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026993
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000920
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant G285C (human)
Object_synonym: hKCNQ4/var:G285C
Object_synonym: UniProtKB:P56696-1, Gly-285, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 1 (human)

subject: PR_000000920
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10369879
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008727
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000920
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: altered
Relative_to: PR_000000918
Evidence_source: PMID:10369879
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008727
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000921
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant L274H (human)
Object_synonym: hKCNQ4/var:L274H
Object_synonym: UniProtKB:P56696-1, Leu-274, CHEBI:29979
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 2 (human)

subject: PR_000000921
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10925378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010936
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000922
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant G285S (human)
Object_synonym: hKCNQ4/var:G285S
Object_synonym: UniProtKB:P56696-1, Gly-285, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 3 (human)

subject: PR_000000922
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10025409
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001547
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000922
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: altered
Relative_to: PR_000000918
Evidence_source: PMID:10025409
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001547
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000923
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant L281S (human)
Object_synonym: hKCNQ4/var:L281S
Object_synonym: UniProtKB:P56696-1, Leu-281, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 4 (human)

subject: PR_000000923
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10571947
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010937
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000924
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant W276S (human)
Object_synonym: hKCNQ4/var:W276S
Object_synonym: UniProtKB:P56696-1, Trp-276, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 5 (human)

subject: PR_000000924
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10369879
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008726
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000925
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant G321S (human)
Object_synonym: hKCNQ4/var:G321S
Object_synonym: UniProtKB:P56696-1, Gly-321, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 6 (human)

subject: PR_000000925
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10369879
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008728
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000929
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ5 isoform 4
Object_synonym: KCNQ5/iso:4

subject: PR_000000929
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03520
  Ontology_term: KCNQ voltage-gated potassium channel
Modifier: NOT
DB_ID: UniProtKB:Q9NR82-4
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000982
type: Class
Object_term: platelet-derived growth factor C isoform 1 cleaved 1
Object_synonym: PDGFC/iso:1/Clv:1

subject: PR_000000982
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00431
  Ontology_term: CUB domain
Modifier: NOT
DB_ID: UniProtKB:Q9NRA1-1
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000001003
type: Class
Object_term: CD34 molecule
Object_synonym: CD34
Object_synonym: hematopoietic progenitor cell antigen CD34

subject: PR_000001003
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF06365
  Ontology_term: CD34/Podocalyxin family
Evidence_source: PIRSF:PIRSF028749
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF028749
DB_ID: PIRSF:PIRSF028749
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000001004
type: Class
Object_term: CD4 molecule
Object_synonym: CD4
Object_synonym: T-cell differentiation antigen L3T4
Object_synonym: T-cell surface antigen T4/Leu-3
Object_synonym: T-cell surface glycoprotein CD4

subject: PR_000001004
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF001977
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001977
DB_ID: PIRSF:PIRSF001977
Date: 2013-02-06
Assigned_by: PRO:CNA

subject: PR_000001004
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF05790
  Ontology_term: Immunoglobulin C2-set domain
Evidence_source: PIRSF:PIRSF001977
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001977
DB_ID: PIRSF:PIRSF001977
Date: 2013-02-06
Assigned_by: PRO:CNA

subject: PR_000001004
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Evidence_source: PIRSF:PIRSF001977
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001977
DB_ID: PIRSF:PIRSF001977
Date: 2013-02-06
Assigned_by: PRO:CNA

subject: PR_000001004
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF09191
  Ontology_term: CD4, extracellular
Evidence_source: PIRSF:PIRSF001977
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001977
DB_ID: PIRSF:PIRSF001977
Date: 2013-02-06
Assigned_by: PRO:CNA

PR_000001005
type: Class
Object_term: integrin alpha with A domain
Object_synonym: integrin alpha with I domain

subject: PR_000001005
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00092
  Ontology_term: von Willebrand factor type A domain
Evidence_source: PIRSF:PIRSF002497
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002497
DB_ID: PIRSF:PIRSF002497
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000001005
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00357
  Ontology_term: Integrin alpha cytoplasmic region
Evidence_source: PIRSF:PIRSF002497
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002497
DB_ID: PIRSF:PIRSF002497
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000001005
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01839
  Ontology_term: FG-GAP repeat
Evidence_source: PIRSF:PIRSF002497
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002497
DB_ID: PIRSF:PIRSF002497
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000001005
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08441
  Ontology_term: Integrin alpha
Evidence_source: PIRSF:PIRSF002497
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002497
DB_ID: PIRSF:PIRSF002497
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000001006
type: Class
Object_term: receptor-type tyrosine-protein phosphatase C
Object_synonym: CD45
Object_synonym: L-CA
Object_synonym: leukocyte common antigen
Object_synonym: ly-5
Object_synonym: lymphocyte antigen 5
Object_synonym: PTPRC
Object_synonym: T200

subject: PR_000001006
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Evidence_source: PIRSF:PIRSF002004
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002004
DB_ID: PIRSF:PIRSF002004
DB_ID: UniProtKB:A1E2H6
DB_ID: UniProtKB:P06800
DB_ID: UniProtKB:P08575
DB_ID: UniProtKB:Q05C79
DB_ID: UniProtKB:Q3U382
DB_ID: UniProtKB:Q5XFY7
DB_ID: UniProtKB:Q64730
DB_ID: UniProtKB:Q8C6Q7
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000001006
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00102
  Ontology_term: Protein-tyrosine phosphatase
Evidence_source: PIRSF:PIRSF002004
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002004
DB_ID: PIRSF:PIRSF002004
DB_ID: UniProtKB:A1E2H6
DB_ID: UniProtKB:P06800
DB_ID: UniProtKB:P08575
DB_ID: UniProtKB:Q05C79
DB_ID: UniProtKB:Q3U382
DB_ID: UniProtKB:Q5XFY7
DB_ID: UniProtKB:Q64730
DB_ID: UniProtKB:Q8C6Q7
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001018
type: Class
Object_term: CD3 subunit with immunoglobulin domain
Object_synonym: CD3 subunit with Ig-like domain

subject: PR_000001018
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF001993
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001993
DB_ID: PIRSF:PIRSF001993
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000001018
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02189
  Ontology_term: Immunoreceptor tyrosine-based activation motif
Evidence_source: PIRSF:PIRSF001993
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001993
DB_ID: PIRSF:PIRSF001993
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000001022
type: Class
Object_term: neural cell adhesion molecule

subject: PR_000001022
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000001022
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000001025
type: Class
Object_term: C-type lectin with multiple lectin domains

subject: PR_000001025
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00040
  Ontology_term: Fibronectin type II domain
Evidence_source: PIRSF:PIRSF002427
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002427
DB_ID: PIRSF:PIRSF002427
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000001025
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00059
  Ontology_term: Lectin C-type domain
Evidence_source: PIRSF:PIRSF002427
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002427
DB_ID: PIRSF:PIRSF002427
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000001027
type: Class
Object_term: CD247
Object_synonym: CD247
Object_synonym: CD3Z
Object_synonym: T-cell receptor T3 eta chain
Object_synonym: T-cell receptor T3 zeta chain
Object_synonym: T3Z
Object_synonym: TCRZ

subject: PR_000001027
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02189
  Ontology_term: Immunoreceptor tyrosine-based activation motif
Evidence_source: PIRSF:PIRSF028738
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF028738
DB_ID: PIRSF:PIRSF028738
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000001030
type: Class
Object_term: erm protein

subject: PR_000001030
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008092
  Ontology_term: cytoskeletal protein binding
Evidence_source: PIRSF:PIRSF002305
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002305
DB_ID: PIRSF:PIRSF002305
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000001030
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00373
  Ontology_term: FERM central domain
Evidence_source: PIRSF:PIRSF002305
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002305
DB_ID: PIRSF:PIRSF002305
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000001030
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00769
  Ontology_term: Ezrin/radixin/moesin family
Evidence_source: PIRSF:PIRSF002305
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002305
DB_ID: PIRSF:PIRSF002305
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001032
type: Class
Object_term: ezrin isoform 1
Object_synonym: EZR/iso:1

subject: PR_000001032
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00373
  Ontology_term: FERM central domain
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001036
type: Class
Object_term: WW domain-containing oxidoreductase
Object_synonym: FOR
Object_synonym: fragile site FRA16D oxidoreductase
Object_synonym: SDR41C1
Object_synonym: WOX1
Object_synonym: WWOX

subject: PR_000001036
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00106
  Ontology_term: short chain dehydrogenase
Evidence_source: PIRSF:PIRSF038706
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038706
DB_ID: PIRSF:PIRSF038706
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000001036
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00397
  Ontology_term: WW domain
Evidence_source: PIRSF:PIRSF038706
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038706
DB_ID: PIRSF:PIRSF038706
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001037
type: Class
Object_term: WW domain-containing oxidoreductase isoform 1
Object_synonym: FOR II
Object_synonym: FOR2
Object_synonym: Wox1
Object_synonym: WWOX v8
Object_synonym: WWOX/iso:1
Object_synonym: WWOXv1

subject: PR_000001037
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00397
  Ontology_term: WW domain
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001043
type: Class
Object_term: Na(+)/H(+) exchange regulatory cofactor with ERM-binding domain
Object_synonym: NHERF

subject: PR_000001043
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00595
  Ontology_term: PDZ domain
Evidence_source: PIRSF:PIRSF037866
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037866
DB_ID: PIRSF:PIRSF037866
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000001043
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF09007
  Ontology_term: EBP50, C-terminal
Evidence_source: PIRSF:PIRSF037866
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037866
DB_ID: PIRSF:PIRSF037866
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001082
type: Class
Object_term: CD160 molecule
Object_synonym: BY55
Object_synonym: CD160
Object_synonym: CD160 antigen
Object_synonym: natural killer cell receptor BY55

subject: PR_000001082
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Evidence_source: PIRSF:PIRSF038702
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038702
DB_ID: PIRSF:PIRSF038702
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001083
type: Class
Object_term: CD2 molecule
Object_synonym: CD2
Object_synonym: erythrocyte receptor
Object_synonym: LFA-2
Object_synonym: LFA-3 receptor
Object_synonym: ly-37
Object_synonym: lymphocyte antigen 37
Object_synonym: rosette receptor
Object_synonym: SRBC
Object_synonym: T-cell surface antigen CD2
Object_synonym: T-cell surface antigen T11/Leu-5
Object_synonym: T-cell surface glycoprotein CD2

subject: PR_000001083
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF05790
  Ontology_term: Immunoglobulin C2-set domain
Evidence_source: PIRSF:PIRSF001984
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001984
DB_ID: PIRSF:PIRSF001984
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001083
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Evidence_source: PIRSF:PIRSF001984
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001984
DB_ID: PIRSF:PIRSF001984
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001084
type: Class
Object_term: T-cell surface glycoprotein CD8 alpha chain
Object_synonym: CD8A
Object_synonym: CD8a
Object_synonym: Lyt-2
Object_synonym: Lyt2
Object_synonym: MAL
Object_synonym: T-cell surface glycoprotein Lyt-2
Object_synonym: T-lymphocyte differentiation antigen T8/Leu-2

subject: PR_000001084
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Evidence_source: PIRSF:PIRSF038778
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038778
DB_ID: PIRSF:PIRSF038778
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001085
type: Class
Object_term: T-cell surface glycoprotein CD8 beta chain
Object_synonym: CD8B
Object_synonym: CD8B1
Object_synonym: Ly-3
Object_synonym: lymphocyte antigen 3
Object_synonym: Lyt-3
Object_synonym: Lyt3
Object_synonym: T-cell membrane glycoprotein Ly-3
Object_synonym: T-cell surface glycoprotein Lyt-3

subject: PR_000001085
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Evidence_source: PIRSF:PIRSF002020
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002020
DB_ID: PIRSF:PIRSF002020
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001086
type: Class
Object_term: VVC2C2C2 Ig-like domain arrangement-containing protein

subject: PR_000001086
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF038703
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038703
DB_ID: PIRSF:PIRSF038703
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001086
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08205
  Ontology_term: CD80-like C2-set immunoglobulin domain
Evidence_source: PIRSF:PIRSF038703
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038703
DB_ID: PIRSF:PIRSF038703
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001087
type: Class
Object_term: adhesion G-protein coupled receptor
Object_synonym: adhesion class GPCR
Object_synonym: fam:adhesion
Object_synonym: secretin receptor-like G-protein coupled receptor
Object_synonym: subfamily B2 G-protein coupled receptor

subject: PR_000001087
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00002
  Ontology_term: 7 transmembrane receptor (Secretin family)
Evidence_source: PMID:12761335
Evidence_code: ISS
Inferred_from: PMID:12761335
DB_ID: PMID:12761335
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001091
type: Class
Object_term: interleukin-1

subject: PR_000001091
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00340
  Ontology_term: Interleukin-1 / 18
Evidence_source: PIRSF:PIRSF001937
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001937
DB_ID: PIRSF:PIRSF001937
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000001091
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02394
  Ontology_term: Interleukin-1 propeptide
Evidence_source: PIRSF:PIRSF001937
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001937
DB_ID: PIRSF:PIRSF001937
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001092
type: Class
Object_term: interleukin-17
Object_synonym: fam:IL-17
Object_synonym: IL17

subject: PR_000001092
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF06083
  Ontology_term: Interleukin-17
Evidence_source: PANTHER:PTHR21295
Evidence_source: PIRSF:PIRSF003430
Evidence_code: ISS
Inferred_from: PANTHER:PTHR21295
Inferred_from: PIRSF:PIRSF003430
DB_ID: PANTHER:PTHR21295
DB_ID: PIRSF:PIRSF003430
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000001092
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0019221
  Ontology_term: cytokine-mediated signaling pathway
Evidence_source: PIRSF:PIRSF003430
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF003430
DB_ID: PIRSF:PIRSF003430
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001094
type: Class
Object_term: rhodopsin-like G-protein coupled receptor
Object_synonym: class 1 G-protein coupled receptor
Object_synonym: class A G-protein coupled receptor
Object_synonym: fam:rhodopsin

subject: PR_000001094
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF800006
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF800006
DB_ID: PIRSF:PIRSF800006
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001095
type: Class
Object_term: secretin-like G-protein coupled receptor
Object_synonym: class 2 G-protein coupled receptor
Object_synonym: class B G-protein coupled receptor
Object_synonym: fam:secretin
Object_synonym: subfamily B1 G-protein coupled receptor

subject: PR_000001095
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00002
  Ontology_term: 7 transmembrane receptor (Secretin family)
Evidence_source: PMID:15862553
Evidence_code: ISS
Inferred_from: PMID:15862553
DB_ID: PMID:15862553
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001096
type: Class
Object_term: Toll-like receptor
Object_synonym: fam:TLR

subject: PR_000001096
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00560
  Ontology_term: Leucine Rich Repeat
Evidence_source: PIRSF:PIRSF800008
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF800008
DB_ID: PIRSF:PIRSF800008
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000001096
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01463
  Ontology_term: Leucine rich repeat C-terminal domain
Evidence_source: PIRSF:PIRSF800008
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF800008
DB_ID: PIRSF:PIRSF800008
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000001096
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01582
  Ontology_term: TIR domain
Evidence_source: PIRSF:PIRSF800008
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF800008
DB_ID: PIRSF:PIRSF800008
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001098
type: Class
Object_term: 5-hydroxytryptamine receptor 1

subject: PR_000001098
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF005474
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005474
DB_ID: PIRSF:PIRSF005474
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001099
type: Class
Object_term: 5-hydroxytryptamine receptor 2

subject: PR_000001099
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038549
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038549
DB_ID: PIRSF:PIRSF038549
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001101
type: Class
Object_term: 5-hydroxytryptamine receptor 5

subject: PR_000001101
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038636
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038636
DB_ID: PIRSF:PIRSF038636
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001105
type: Class
Object_term: C5a anaphylatoxin chemotactic receptor

subject: PR_000001105
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038566
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038566
DB_ID: PIRSF:PIRSF038566
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001107
type: Class
Object_term: D(1)-like dopamine receptor

subject: PR_000001107
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038629
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038629
DB_ID: PIRSF:PIRSF038629
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001108
type: Class
Object_term: D(2)-like dopamine receptor

subject: PR_000001108
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038553
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038553
DB_ID: PIRSF:PIRSF038553
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001112
type: Class
Object_term: G-protein coupled receptor 37-like 1
Object_synonym: endothelin B receptor-like protein 2
Object_synonym: ETBR-LP-2
Object_synonym: ETBRLP2
Object_synonym: GPR37L1
Object_synonym: prosaposin receptor GPR37L1

subject: PR_000001112
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001115
type: Class
Object_term: alpha-1 adrenergic receptor

subject: PR_000001115
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038550
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038550
DB_ID: PIRSF:PIRSF038550
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001116
type: Class
Object_term: alpha-2 adrenergic receptor

subject: PR_000001116
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038554
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038554
DB_ID: PIRSF:PIRSF038554
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001118
type: Class
Object_term: angiotensin II receptor
Object_synonym: angiotensin receptor
Object_synonym: fam:AGTR

subject: PR_000001118
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038557
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038557
DB_ID: PIRSF:PIRSF038557
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001119
type: Class
Object_term: animal opsin
Object_synonym: opsin receptor
Object_synonym: type II opsin

subject: PR_000001119
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038544
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038544
DB_ID: PIRSF:PIRSF038544
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001121
type: Class
Object_term: beta adrenergic receptor

subject: PR_000001121
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038556
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038556
DB_ID: PIRSF:PIRSF038556
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001122
type: Class
Object_term: bombesin receptor

subject: PR_000001122
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038623
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038623
DB_ID: PIRSF:PIRSF038623
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001123
type: Class
Object_term: bradykinin receptor

subject: PR_000001123
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038572
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038572
DB_ID: PIRSF:PIRSF038572
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001124
type: Class
Object_term: calcium-independent alpha-latrotoxin receptor
Object_synonym: latrophilin

subject: PR_000001124
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00002
  Ontology_term: 7 transmembrane receptor (Secretin family)
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2008-09-15
Assigned_by: PRO:CNA

subject: PR_000001124
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01825
  Ontology_term: GPCR proteolysis site, GPS, motif
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2008-09-15
Assigned_by: PRO:CNA

subject: PR_000001124
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02140
  Ontology_term: Galactose binding lectin domain
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2008-09-15
Assigned_by: PRO:CNA

subject: PR_000001124
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02191
  Ontology_term: Olfactomedin-like domain
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2008-09-15
Assigned_by: PRO:CNA

subject: PR_000001124
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02354
  Ontology_term: Latrophilin Cytoplasmic C-terminal region
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2008-09-15
Assigned_by: PRO:CNA

subject: PR_000001124
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02793
  Ontology_term: Hormone receptor domain
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2008-09-15
Assigned_by: PRO:CNA

subject: PR_000001124
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007186
  Ontology_term: G protein-coupled receptor signaling pathway
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2008-09-15
Assigned_by: PRO:CNA

subject: PR_000001124
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0017157
  Ontology_term: regulation of exocytosis
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2008-09-15
Assigned_by: PRO:CNA

PR_000001126
type: Class
Object_term: cannabinoid receptor 2
Object_synonym: CB-2
Object_synonym: CB2
Object_synonym: CB2A
Object_synonym: CB2B
Object_synonym: CNR2
Object_synonym: CX5

subject: PR_000001126
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038633
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038633
DB_ID: PIRSF:PIRSF038633
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001128
type: Class
Object_term: chemokine receptor

subject: PR_000001128
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038545
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038545
DB_ID: PIRSF:PIRSF038545
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001130
type: Class
Object_term: cholecystokinin receptor
Object_synonym: fam:CCK_R

subject: PR_000001130
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038581
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038581
DB_ID: PIRSF:PIRSF038581
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001131
type: Class
Object_term: cysteinyl leukotriene receptor

subject: PR_000001131
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038618
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038618
DB_ID: PIRSF:PIRSF038618
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001133
type: Class
Object_term: endothelin receptor

subject: PR_000001133
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF001842
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001842
DB_ID: PIRSF:PIRSF001842
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001134
type: Class
Object_term: growth hormone secretagogue/motilin receptor

subject: PR_000001134
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038641
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038641
DB_ID: PIRSF:PIRSF038641
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001138
type: Class
Object_term: interleukin-17A
Object_synonym: CTLA-8
Object_synonym: CTLA8
Object_synonym: cytotoxic T-lymphocyte-associated antigen 8
Object_synonym: IL-17
Object_synonym: IL-17A
Object_synonym: IL17
Object_synonym: IL17A

subject: PR_000001138
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF06083
  Ontology_term: Interleukin-17
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001146
type: Class
Object_term: melanocortin receptor

subject: PR_000001146
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF005524
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005524
DB_ID: PIRSF:PIRSF005524
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001147
type: Class
Object_term: adhesion G protein-coupled receptor A1
Object_synonym: ADGRA1
Object_synonym: G-protein coupled receptor 123
Object_synonym: GPR123
Object_synonym: KIAA1828

subject: PR_000001147
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00002
  Ontology_term: 7 transmembrane receptor (Secretin family)
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001148
type: Class
Object_term: prosaposin receptor GPR37
Object_synonym: endothelin B receptor-like protein 1
Object_synonym: ETBR-LP-1
Object_synonym: G-protein coupled receptor 37
Object_synonym: GPR37
Object_synonym: PAELR
Object_synonym: parkin-associated endothelin receptor-like receptor

subject: PR_000001148
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001149
type: Class
Object_term: G-protein coupled receptor 157
Object_synonym: GPR157

subject: PR_000001149
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00002
  Ontology_term: 7 transmembrane receptor (Secretin family)
Evidence_source: PIRSF:PIRSF038116
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038116
DB_ID: PIRSF:PIRSF038116
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001150
type: Class
Object_term: tachykinin receptor

subject: PR_000001150
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF001840
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001840
DB_ID: PIRSF:PIRSF001840
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001197
type: Class
Object_term: chemokine receptor CCR1/3/1L

subject: PR_000001197
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF501024
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501024
DB_ID: PIRSF:PIRSF501024
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001226
type: Class
Object_term: high affinity interleukin-8 receptor

subject: PR_000001226
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF501022
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501022
DB_ID: PIRSF:PIRSF501022
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001237
type: Class
Object_term: melanocortin receptor 4
Object_synonym: MC4-R
Object_synonym: MC4R

subject: PR_000001237
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF501014
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501014
DB_ID: PIRSF:PIRSF501014
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001242
type: Class
Object_term: neuromedin-K receptor
Object_synonym: neurokinin B receptor
Object_synonym: NK-3 receptor
Object_synonym: NK-3R
Object_synonym: NK3R
Object_synonym: NKR
Object_synonym: TAC3R
Object_synonym: tachykinin receptor 3
Object_synonym: TACR3

subject: PR_000001242
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF501016
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501016
DB_ID: PIRSF:PIRSF501016
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001246
type: Class
Object_term: substance-K receptor
Object_synonym: neurokinin A receptor
Object_synonym: NK-2 receptor
Object_synonym: NK-2R
Object_synonym: NK2R
Object_synonym: NKNAR
Object_synonym: SKR
Object_synonym: TAC2R
Object_synonym: tachykinin receptor 2
Object_synonym: TACR2

subject: PR_000001246
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF501017
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501017
DB_ID: PIRSF:PIRSF501017
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001247
type: Class
Object_term: substance-P receptor
Object_synonym: NK-1 receptor
Object_synonym: NK-1R
Object_synonym: NK1R
Object_synonym: SPR
Object_synonym: TAC1R
Object_synonym: tachykinin receptor 1
Object_synonym: TACR1

subject: PR_000001247
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF501015
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501015
DB_ID: PIRSF:PIRSF501015
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001281
type: Class
Object_term: ADP-ribosyl cyclase

subject: PR_000001281
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02267
  Ontology_term: ADP-ribosyl cyclase
Evidence_source: PIRSF:PIRSF005736
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005736
DB_ID: PIRSF:PIRSF005736
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001284
type: Class
Object_term: B- and T-lymphocyte attenuator
Object_synonym: B- and T-lymphocyte-associated protein
Object_synonym: BTLA
Object_synonym: CD272

subject: PR_000001284
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF038341
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038341
DB_ID: PIRSF:PIRSF038341
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001289
type: Class
Object_term: membrane-spanning 4-domains subfamily A member 1
Object_synonym: B-cell differentiation antigen Ly-44
Object_synonym: B-cell surface antigen CD20
Object_synonym: B-lymphocyte antigen CD20
Object_synonym: B-lymphocyte surface antigen B1
Object_synonym: Bp35
Object_synonym: CD20
Object_synonym: leukocyte surface antigen Leu-16
Object_synonym: Ly-44
Object_synonym: lymphocyte antigen 44
Object_synonym: MS4A1
Object_synonym: Ms4a2

subject: PR_000001289
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF04103
  Ontology_term: CD20-like family
Evidence_source: PIRSF:PIRSF001995
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001995
DB_ID: PIRSF:PIRSF001995
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001290
type: Class
Object_term: B7-related protein

subject: PR_000001290
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001290
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08205
  Ontology_term: CD80-like C2-set immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001291
type: Class
Object_term: C-type asialoglycoprotein receptor

subject: PR_000001291
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00059
  Ontology_term: Lectin C-type domain
Evidence_source: PIRSF:PIRSF002424
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002424
DB_ID: PIRSF:PIRSF002424
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001291
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03954
  Ontology_term: Hepatic lectin, N-terminal domain
Evidence_source: PIRSF:PIRSF002424
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002424
DB_ID: PIRSF:PIRSF002424
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001298
type: Class
Object_term: CD180 molecule
Object_synonym: CD180
Object_synonym: CD180 antigen
Object_synonym: ly-78
Object_synonym: LY64
Object_synonym: Ly78
Object_synonym: lymphocyte antigen 64
Object_synonym: lymphocyte antigen 78
Object_synonym: radioprotective 105 kDa protein
Object_synonym: RP105

subject: PR_000001298
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00560
  Ontology_term: Leucine Rich Repeat
Evidence_source: PIRSF:PIRSF038744
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038744
DB_ID: PIRSF:PIRSF038744
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001298
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01463
  Ontology_term: Leucine rich repeat C-terminal domain
Evidence_source: PIRSF:PIRSF038744
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038744
DB_ID: PIRSF:PIRSF038744
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001304
type: Class
Object_term: CD300 molecule-like protein
Object_synonym: CD300 antigen-like protein
Object_synonym: fam:CD300

subject: PR_000001304
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Evidence_source: PIRSF:PIRSF036923
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036923
DB_ID: PIRSF:PIRSF036923
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001305
type: Class
Object_term: CD302 molecule
Object_synonym: C-type lectin BIMLEC
Object_synonym: C-type lectin domain family 13 member A
Object_synonym: CD302
Object_synonym: CD302 antigen
Object_synonym: CLEC13A
Object_synonym: DCL1
Object_synonym: type I transmembrane C-type lectin receptor DCL-1

subject: PR_000001305
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00059
  Ontology_term: Lectin C-type domain
Evidence_source: PIRSF:PIRSF038745
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038745
DB_ID: PIRSF:PIRSF038745
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001306
type: Class
Object_term: CD320 molecule
Object_synonym: 8D6 antigen
Object_synonym: 8D6A
Object_synonym: CD320
Object_synonym: CD320 antigen
Object_synonym: FDC-signaling molecule 8D6
Object_synonym: FDC-SM-8D6
Object_synonym: TCblR
Object_synonym: transcobalamin receptor
Object_synonym: UNQ198/PRO224

subject: PR_000001306
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00057
  Ontology_term: Low-density lipoprotein receptor domain class A
Evidence_source: PIRSF:PIRSF038748
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038748
DB_ID: PIRSF:PIRSF038748
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001308
type: Class
Object_term: CD48 molecule
Object_synonym: B-lymphocyte activation marker BLAST-1
Object_synonym: Bcm-1
Object_synonym: BCM1
Object_synonym: BCM1 surface antigen
Object_synonym: BLAST-1
Object_synonym: BLAST1
Object_synonym: CD48
Object_synonym: CD48 antigen
Object_synonym: HM48-1
Object_synonym: leukocyte antigen MEM-102
Object_synonym: MRC OX-45 surface antigen
Object_synonym: sgp-60
Object_synonym: signaling lymphocytic activation molecule 2
Object_synonym: SLAM family member 2
Object_synonym: SLAMF2
Object_synonym: TCT.1

subject: PR_000001308
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF001973
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001973
DB_ID: PIRSF:PIRSF001973
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001308
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Evidence_source: PIRSF:PIRSF001973
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001973
DB_ID: PIRSF:PIRSF001973
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001313
type: Class
Object_term: E/P-selectin

subject: PR_000001313
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00008
  Ontology_term: EGF-like domain
Evidence_source: PIRSF:PIRSF036331
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036331
DB_ID: PIRSF:PIRSF036331
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001313
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00059
  Ontology_term: Lectin C-type domain
Evidence_source: PIRSF:PIRSF036331
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036331
DB_ID: PIRSF:PIRSF036331
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001313
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00084
  Ontology_term: Sushi repeat (SCR repeat)
Evidence_source: PIRSF:PIRSF036331
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036331
DB_ID: PIRSF:PIRSF036331
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001315
type: Class
Object_term: frizzled-like G-protein coupled receptor
Object_synonym: class F G-protein coupled receptor
Object_synonym: fam:frizzled

subject: PR_000001315
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01392
  Ontology_term: Fz domain
Evidence_source: PIRSF:PIRSF006696
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF006696
DB_ID: PIRSF:PIRSF006696
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001315
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01534
  Ontology_term: Frizzled/Smoothened family membrane region
Evidence_source: PIRSF:PIRSF006696
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF006696
DB_ID: PIRSF:PIRSF006696
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001317
type: Class
Object_term: interleukin-7
Object_synonym: IL-7
Object_synonym: IL7

subject: PR_000001317
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01415
  Ontology_term: Interleukin 7/9 family
Evidence_source: PIRSF:PIRSF001942
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001942
DB_ID: PIRSF:PIRSF001942
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001318
type: Class
Object_term: L-selectin
Object_synonym: CD62 antigen-like family member L
Object_synonym: CD62L
Object_synonym: gp90-MEL
Object_synonym: LAM-1
Object_synonym: LECAM1
Object_synonym: leukocyte adhesion molecule 1
Object_synonym: leukocyte surface antigen Leu-8
Object_synonym: leukocyte-endothelial cell adhesion molecule 1
Object_synonym: LNHR
Object_synonym: ly-22
Object_synonym: Ly22
Object_synonym: LYAM1
Object_synonym: lymph node homing receptor
Object_synonym: lymphocyte antigen 22
Object_synonym: lymphocyte surface MEL-14 antigen
Object_synonym: SELL
Object_synonym: TQ1

subject: PR_000001318
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00008
  Ontology_term: EGF-like domain
Evidence_source: PIRSF:PIRSF002421
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002421
DB_ID: PIRSF:PIRSF002421
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001318
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00059
  Ontology_term: Lectin C-type domain
Evidence_source: PIRSF:PIRSF002421
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002421
DB_ID: PIRSF:PIRSF002421
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001318
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00084
  Ontology_term: Sushi repeat (SCR repeat)
Evidence_source: PIRSF:PIRSF002421
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002421
DB_ID: PIRSF:PIRSF002421
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001318
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07974
  Ontology_term: EGF-like domain
Evidence_source: PIRSF:PIRSF002421
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002421
DB_ID: PIRSF:PIRSF002421
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001320
type: Class
Object_term: alpha-(1,3)-fucosyltransferase

subject: PR_000001320
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00852
  Ontology_term: Glycosyltransferase family 10 (fucosyltransferase) C-term
Evidence_source: PIRSF:PIRSF005726
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005726
DB_ID: PIRSF:PIRSF005726
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001324
type: Class
Object_term: basigin
Object_synonym: 5F7
Object_synonym: basic immunoglobulin superfamily
Object_synonym: BSG
Object_synonym: CD147
Object_synonym: collagenase stimulatory factor
Object_synonym: EMMPRIN
Object_synonym: extracellular matrix metalloproteinase inducer
Object_synonym: HT7 antigen
Object_synonym: leukocyte activation antigen M6
Object_synonym: membrane glycoprotein gp42
Object_synonym: OK blood group antigen
Object_synonym: TCSF
Object_synonym: tumor cell-derived collagenase stimulatory factor
Object_synonym: UNQ6505/PRO21383

subject: PR_000001324
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF001983
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001983
DB_ID: PIRSF:PIRSF001983
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001325
type: Class
Object_term: beta-1,3-glucuronyltransferase

subject: PR_000001325
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03360
  Ontology_term: Glycosyltransferase family 43
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001327
type: Class
Object_term: cadherin

subject: PR_000001327
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00028
  Ontology_term: Cadherin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001327
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01049
  Ontology_term: Cadherin cytoplasmic region
Evidence_source: PIRSF:PIRSF002504
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002504
DB_ID: PIRSF:PIRSF002504
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001333
type: Class
Object_term: cation-independent mannose-6-phosphate receptor
Object_synonym: 300 kDa mannose 6-phosphate receptor
Object_synonym: CD222
Object_synonym: CI Man-6-P receptor
Object_synonym: CI-MPR
Object_synonym: IGF-II receptor
Object_synonym: IGF2R
Object_synonym: insulin-like growth factor 2 receptor
Object_synonym: insulin-like growth factor II receptor
Object_synonym: M6P/IGF2 receptor
Object_synonym: M6P/IGF2R
Object_synonym: M6PR
Object_synonym: MPR 300
Object_synonym: MPRI

subject: PR_000001333
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00040
  Ontology_term: Fibronectin type II domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001333
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00878
  Ontology_term: Cation-independent mannose-6-phosphate receptor repeat
Evidence_source: PIRSF:PIRSF036993
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036993
DB_ID: PIRSF:PIRSF036993
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001335
type: Class
Object_term: class 2 cytokine, IL-10 type

subject: PR_000001335
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00726
  Ontology_term: Interleukin 10
Evidence_source: PIRSF:PIRSF003542
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF003542
DB_ID: PIRSF:PIRSF003542
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001336
type: Class
Object_term: CD55-like protein
Object_synonym: complement decay-accelerating factor like protein

subject: PR_000001336
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00084
  Ontology_term: Sushi repeat (SCR repeat)
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001338
type: Class
Object_term: complement receptor type 2
Object_synonym: C3DR
Object_synonym: CD21
Object_synonym: complement C3d receptor
Object_synonym: CR2
Object_synonym: Cr2
Object_synonym: EBV receptor
Object_synonym: epstein-Barr virus receptor

subject: PR_000001338
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00084
  Ontology_term: Sushi repeat (SCR repeat)
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001339
type: Class
Object_term: cytokine receptor common subunit beta
Object_synonym: Aic2b
Object_synonym: CD131
Object_synonym: CDw131
Object_synonym: CSF2RB
Object_synonym: Csf2rb1
Object_synonym: cytokine receptor common beta chain
Object_synonym: GM-CSF/IL-3/IL-5 receptor common beta subunit
Object_synonym: IL3RB
Object_synonym: Il3rb1
Object_synonym: IL5RB

subject: PR_000001339
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001340
type: Class
Object_term: cytokine receptor common subunit gamma
Object_synonym: CD132
Object_synonym: cytokine receptor common gamma chain
Object_synonym: gammaC
Object_synonym: IL-2 receptor subunit gamma
Object_synonym: IL-2R subunit gamma
Object_synonym: IL-2RG
Object_synonym: IL2RG
Object_synonym: interleukin-2 receptor subunit gamma
Object_synonym: p64

subject: PR_000001340
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001341
type: Class
Object_term: dipeptidyl peptidase IV
Object_synonym: ADABP
Object_synonym: ADCP-2
Object_synonym: ADCP2
Object_synonym: adenosine deaminase complexing protein 2
Object_synonym: CD26
Object_synonym: DPP IV
Object_synonym: DPP4
Object_synonym: T-cell activation antigen CD26
Object_synonym: THAM
Object_synonym: thymocyte-activating molecule
Object_synonym: TP103

subject: PR_000001341
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00326
  Ontology_term: Prolyl oligopeptidase family
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001341
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00930
  Ontology_term: Dipeptidyl peptidase IV (DPP IV) N-terminal region
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001342
type: Class
Object_term: discoidin domain-containing receptor

subject: PR_000001342
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00754
  Ontology_term: F5/8 type C domain
Evidence_source: PIRSF:PIRSF038747
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038747
DB_ID: PIRSF:PIRSF038747
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001342
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001344
type: Class
Object_term: ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Object_synonym: CD203c
Object_synonym: E-NPP 3
Object_synonym: ectonucleotide pyrophosphatase/phosphodiesterase 3
Object_synonym: ENPP3
Object_synonym: PD-Ibeta
Object_synonym: PDNP3
Object_synonym: phosphodiesterase I beta
Object_synonym: phosphodiesterase I/nucleotide pyrophosphatase 3

subject: PR_000001344
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01033
  Ontology_term: Somatomedin B domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001344
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01223
  Ontology_term: DNA/RNA non-specific endonuclease
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001344
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01663
  Ontology_term: Type I phosphodiesterase / nucleotide pyrophosphatase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001345
type: Class
Object_term: endoglin
Object_synonym: CD105
Object_synonym: cell surface MJ7/18 antigen
Object_synonym: Edg
Object_synonym: END
Object_synonym: ENG

subject: PR_000001345
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00100
  Ontology_term: Zona pellucida-like domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001346
type: Class
Object_term: endosialin
Object_synonym: CD164L1
Object_synonym: CD248
Object_synonym: TEM1
Object_synonym: tumor endothelial marker 1

subject: PR_000001346
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00008
  Ontology_term: EGF-like domain
Evidence_source: PIRSF:PIRSF038358
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038358
DB_ID: PIRSF:PIRSF038358
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001346
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00059
  Ontology_term: Lectin C-type domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001346
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07645
  Ontology_term: Calcium-binding EGF domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001348
type: Class
Object_term: erythrocyte membrane protein Rh

subject: PR_000001348
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00909
  Ontology_term: Ammonium Transporter Family
Evidence_source: PIRSF:PIRSF017968
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF017968
DB_ID: PIRSF:PIRSF017968
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001349
type: Class
Object_term: fibroblast growth factor receptor

subject: PR_000001349
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF000628
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000628
DB_ID: PIRSF:PIRSF000628
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001349
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001351
type: Class
Object_term: gamma-glutamyltranspeptidase

subject: PR_000001351
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01019
  Ontology_term: Gamma-glutamyltranspeptidase
Evidence_source: PIRSF:PIRSF000457
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000457
DB_ID: PIRSF:PIRSF000457
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001352
type: Class
Object_term: glycophorin

subject: PR_000001352
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01102
  Ontology_term: Glycophorin A
Evidence_source: PIRSF:PIRSF002466
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002466
DB_ID: PIRSF:PIRSF002466
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001355
type: Class
Object_term: immunoglobulin gamma Fc receptor II/III/IV

subject: PR_000001355
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF001980
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001980
DB_ID: PIRSF:PIRSF001980
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001356
type: Class
Object_term: immunoglobulin gamma Fc receptor I
Object_synonym: Fc-gamma receptor

subject: PR_000001356
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF001981
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001981
DB_ID: PIRSF:PIRSF001981
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001357
type: Class
Object_term: intercellular adhesion molecule 1/3
Object_synonym: ICAM

subject: PR_000001357
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF002510
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002510
DB_ID: PIRSF:PIRSF002510
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001357
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03921
  Ontology_term: Intercellular adhesion molecule (ICAM), N-terminal domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001358
type: Class
Object_term: intercellular adhesion molecule 2
Object_synonym: CD102
Object_synonym: ICAM-2
Object_synonym: ICAM2
Object_synonym: lymphocyte function-associated AG-1 counter-receptor

subject: PR_000001358
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03921
  Ontology_term: Intercellular adhesion molecule (ICAM), N-terminal domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001359
type: Class
Object_term: intercellular adhesion molecule 4
Object_synonym: CD242
Object_synonym: ICAM-4
Object_synonym: ICAM4
Object_synonym: landsteiner-Wiener blood group glycoprotein
Object_synonym: LW
Object_synonym: LW blood group protein

subject: PR_000001359
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03921
  Ontology_term: Intercellular adhesion molecule (ICAM), N-terminal domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001360
type: Class
Object_term: intercellular adhesion molecule 5
Object_synonym: ICAM-5
Object_synonym: Icam3
Object_synonym: ICAM5
Object_synonym: telencephalin
Object_synonym: TLCN
Object_synonym: TLN

subject: PR_000001360
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF038690
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038690
DB_ID: PIRSF:PIRSF038690
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001360
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03921
  Ontology_term: Intercellular adhesion molecule (ICAM), N-terminal domain
Evidence_source: PIRSF:PIRSF038690
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038690
DB_ID: PIRSF:PIRSF038690
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001360
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07679
  Ontology_term: Immunoglobulin I-set domain
Evidence_source: PIRSF:PIRSF038690
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038690
DB_ID: PIRSF:PIRSF038690
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001361
type: Class
Object_term: interferon gamma receptor alpha chain
Object_synonym: CD119
Object_synonym: CDw119
Object_synonym: IFN-gamma receptor 1
Object_synonym: IFN-gamma-R-alpha
Object_synonym: IFN-gamma-R1
Object_synonym: Ifngr
Object_synonym: IFNGR1
Object_synonym: interferon gamma receptor alpha-chain

subject: PR_000001361
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07140
  Ontology_term: Interferon gamma receptor (IFNGR1)
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001366
type: Class
Object_term: interleukin-11
Object_synonym: adipogenesis inhibitory factor
Object_synonym: AGIF
Object_synonym: IL-11
Object_synonym: IL11
Object_synonym: oprelvekin

subject: PR_000001366
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07400
  Ontology_term: Interleukin 11
Evidence_source: PIRSF:PIRSF001944
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001944
DB_ID: PIRSF:PIRSF001944
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001367
type: Class
Object_term: interleukin-12 receptor subunit beta-1
Object_synonym: CD212
Object_synonym: IL-12 receptor beta component
Object_synonym: IL-12 receptor subunit beta-1
Object_synonym: IL-12R subunit beta-1
Object_synonym: IL-12R-beta-1
Object_synonym: IL-12RB1
Object_synonym: IL12R
Object_synonym: IL12RB
Object_synonym: IL12RB1
Object_synonym: interleukin-12 receptor beta 1

subject: PR_000001367
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Evidence_source: PIRSF:PIRSF029027
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF029027
DB_ID: PIRSF:PIRSF029027
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001368
type: Class
Object_term: interleukin-12 subunit alpha
Object_synonym: CLMF p35
Object_synonym: cytotoxic lymphocyte maturation factor 35 kDa subunit
Object_synonym: IL-12 subunit p35
Object_synonym: IL-12A
Object_synonym: IL12A
Object_synonym: NK cell stimulatory factor chain 1
Object_synonym: NKSF1

subject: PR_000001368
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03039
  Ontology_term: Interleukin-12 alpha subunit
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001369
type: Class
Object_term: interleukin-12 subunit beta
Object_synonym: CLMF p40
Object_synonym: cytotoxic lymphocyte maturation factor 40 kDa subunit
Object_synonym: IL-12 subunit p40
Object_synonym: IL-12B
Object_synonym: IL12B
Object_synonym: NK cell stimulatory factor chain 2
Object_synonym: NKSF2

subject: PR_000001369
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Evidence_source: PIRSF:PIRSF038007
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038007
DB_ID: PIRSF:PIRSF038007
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001369
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Evidence_source: PIRSF:PIRSF038007
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038007
DB_ID: PIRSF:PIRSF038007
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001370
type: Class
Object_term: interleukin-13
Object_synonym: IL-13
Object_synonym: IL13
Object_synonym: NC30
Object_synonym: T-cell activation protein P600

subject: PR_000001370
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03487
  Ontology_term: Interleukin-13
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001373
type: Class
Object_term: interleukin-15
Object_synonym: IL-15
Object_synonym: IL15

subject: PR_000001373
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02372
  Ontology_term: Interleukin 15
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001374
type: Class
Object_term: interleukin-16
Object_synonym: IL16

subject: PR_000001374
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00595
  Ontology_term: PDZ domain
Evidence_source: PIRSF:PIRSF038750
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038750
DB_ID: PIRSF:PIRSF038750
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001376
type: Class
Object_term: interleukin-18
Object_synonym: iboctadekin
Object_synonym: IFN-gamma-inducing factor
Object_synonym: IGIF
Object_synonym: IL-1 gamma
Object_synonym: IL-18
Object_synonym: IL18
Object_synonym: IL1F4
Object_synonym: interferon gamma-inducing factor
Object_synonym: interleukin-1 gamma

subject: PR_000001376
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00340
  Ontology_term: Interleukin-1 / 18
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001379
type: Class
Object_term: interleukin-2
Object_synonym: aldesleukin
Object_synonym: IL-2
Object_synonym: IL2
Object_synonym: T-cell growth factor
Object_synonym: TCGF

subject: PR_000001379
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00715
  Ontology_term: Interleukin 2
Evidence_source: PIRSF:PIRSF001938
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001938
DB_ID: PIRSF:PIRSF001938
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001380
type: Class
Object_term: interleukin-2 receptor subunit alpha
Object_synonym: CD25
Object_synonym: IL-2 receptor subunit alpha
Object_synonym: IL-2-RA
Object_synonym: IL-2R subunit alpha
Object_synonym: IL2-RA
Object_synonym: Il2r
Object_synonym: IL2RA
Object_synonym: p55
Object_synonym: TAC antigen

subject: PR_000001380
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00084
  Ontology_term: Sushi repeat (SCR repeat)
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001384
type: Class
Object_term: interleukin-23 subunit alpha
Object_synonym: IL-23 subunit alpha
Object_synonym: IL-23-A
Object_synonym: IL-23p19
Object_synonym: IL23A
Object_synonym: interleukin-23 subunit p19
Object_synonym: SGRF
Object_synonym: UNQ2498/PRO5798

subject: PR_000001384
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00489
  Ontology_term: Interleukin-6/G-CSF/MGF family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001387
type: Class
Object_term: interleukin-3
Object_synonym: Csfmu
Object_synonym: hematopoietic growth factor
Object_synonym: IL-3
Object_synonym: IL3
Object_synonym: mast cell growth factor
Object_synonym: MCGF
Object_synonym: multipotential colony-stimulating factor
Object_synonym: P-cell-stimulating factor

subject: PR_000001387
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02059
  Ontology_term: Interleukin-3
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001392
type: Class
Object_term: interleukin-5
Object_synonym: B-cell differentiation factor I
Object_synonym: B-cell growth factor II
Object_synonym: BCGF-II
Object_synonym: cytotoxic T-lymphocyte inducer
Object_synonym: eosinophil differentiation factor
Object_synonym: IL-5
Object_synonym: IL5
Object_synonym: T-cell replacing factor
Object_synonym: TRF

subject: PR_000001392
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02025
  Ontology_term: Interleukin 5
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001393
type: Class
Object_term: interleukin-6
Object_synonym: B-cell hybridoma growth factor
Object_synonym: B-cell stimulatory factor 2
Object_synonym: BSF-2
Object_synonym: CDF
Object_synonym: CTL differentiation factor
Object_synonym: hybridoma growth factor
Object_synonym: IFN-beta-2
Object_synonym: IFNB2
Object_synonym: IL-6
Object_synonym: IL6
Object_synonym: interferon beta-2
Object_synonym: interleukin HP-1

subject: PR_000001393
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00489
  Ontology_term: Interleukin-6/G-CSF/MGF family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001394
type: Class
Object_term: interleukin-6 receptor subunit alpha
Object_synonym: CD126
Object_synonym: gp80
Object_synonym: IL-6 receptor subunit alpha
Object_synonym: IL-6R 1
Object_synonym: IL-6R subunit alpha
Object_synonym: IL-6R-alpha
Object_synonym: IL-6RA
Object_synonym: IL6R
Object_synonym: Il6ra
Object_synonym: membrane glycoprotein 80

subject: PR_000001394
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001394
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001394
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF09240
  Ontology_term: Interleukin-6 receptor alpha chain, binding
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001395
type: Class
Object_term: interleukin-8
Object_synonym: C-X-C motif chemokine 8
Object_synonym: CXCL8
Object_synonym: emoctakin
Object_synonym: GCP-1
Object_synonym: granulocyte chemotactic protein 1
Object_synonym: IL-8
Object_synonym: IL8
Object_synonym: MDNCF
Object_synonym: MONAP
Object_synonym: monocyte-derived neutrophil chemotactic factor
Object_synonym: monocyte-derived neutrophil-activating peptide
Object_synonym: NAP-1
Object_synonym: neutrophil-activating protein 1
Object_synonym: protein 3-10C
Object_synonym: T-cell chemotactic factor

subject: PR_000001395
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00048
  Ontology_term: Small cytokines (intecrine/chemokine), interleukin-8 like
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001396
type: Class
Object_term: interleukin-9
Object_synonym: cytokine P40
Object_synonym: IL-9
Object_synonym: IL9
Object_synonym: T-cell growth factor P40

subject: PR_000001396
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01415
  Ontology_term: Interleukin 7/9 family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001398
type: Class
Object_term: leukocyte immunoglobulin-like receptor subfamily A member 4
Object_synonym: CD85 antigen-like family member G
Object_synonym: CD85g
Object_synonym: ILT-7
Object_synonym: ILT7
Object_synonym: immunoglobulin-like transcript 7
Object_synonym: LILRA4

subject: PR_000001398
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001399
type: Class
Object_term: CD47 molecule
Object_synonym: antigenic surface determinant protein OA3
Object_synonym: CD47
Object_synonym: IAP
Object_synonym: integrin-associated protein
Object_synonym: leukocyte surface antigen CD47
Object_synonym: MER6
Object_synonym: protein MER6

subject: PR_000001399
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF04549
  Ontology_term: CD47 transmembrane region
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001399
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08204
  Ontology_term: CD47 immunoglobulin-like domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001401
type: Class
Object_term: membrane cofactor protein
Object_synonym: CD46
Object_synonym: MCP
Object_synonym: MIC10
Object_synonym: TLX
Object_synonym: trophoblast leukocyte common antigen

subject: PR_000001401
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00084
  Ontology_term: Sushi repeat (SCR repeat)
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001403
type: Class
Object_term: tetraspanin

subject: PR_000001403
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00335
  Ontology_term: Tetraspanin family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001404
type: Class
Object_term: tumor necrosis factor ligand superfamily member 8
Object_synonym: CD153
Object_synonym: CD30 ligand
Object_synonym: CD30-L
Object_synonym: CD30L
Object_synonym: CD30LG
Object_synonym: TNFSF8

subject: PR_000001404
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00229
  Ontology_term: TNF(Tumour Necrosis Factor) family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001405
type: Class
Object_term: tumor necrosis factor receptor superfamily member 16
Object_synonym: CD271
Object_synonym: gp80-LNGFR
Object_synonym: low affinity neurotrophin receptor p75NTR
Object_synonym: low-affinity nerve growth factor receptor
Object_synonym: NGF receptor
Object_synonym: NGFR
Object_synonym: p75 ICD
Object_synonym: TNFRSF16

subject: PR_000001405
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00020
  Ontology_term: TNFR/NGFR cysteine-rich region
Evidence_source: PIRSF:PIRSF001964
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001964
DB_ID: PIRSF:PIRSF001964
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001405
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00531
  Ontology_term: Death domain
Evidence_source: PIRSF:PIRSF001964
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001964
DB_ID: PIRSF:PIRSF001964
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001406
type: Class
Object_term: tumor necrosis factor receptor superfamily member 17
Object_synonym: B-cell maturation protein
Object_synonym: BCM
Object_synonym: BCMA
Object_synonym: CD269
Object_synonym: TNFRSF17

subject: PR_000001406
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF09257
  Ontology_term: BCMA, TALL-1 binding
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001407
type: Class
Object_term: tumor-associated calcium signal transducer
Object_synonym: carcinoma antigen GA733
Object_synonym: GA733

subject: PR_000001407
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00086
  Ontology_term: Thyroglobulin type-1 repeat
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001416
type: Class
Object_term: neurotensin receptor

subject: PR_000001416
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038642
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038642
DB_ID: PIRSF:PIRSF038642
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001420
type: Class
Object_term: GPR4-like G-protein coupled receptor

subject: PR_000001420
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF005853
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005853
DB_ID: PIRSF:PIRSF005853
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001421
type: Class
Object_term: GPR6-like G-protein coupled receptor

subject: PR_000001421
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038626
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038626
DB_ID: PIRSF:PIRSF038626
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001424
type: Class
Object_term: obsolete H3/H4 histamine receptor

subject: PR_000001424
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038646
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038646
DB_ID: PIRSF:PIRSF038646
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001427
type: Class
Object_term: LPAR1/S1PR1-like lysophospholipid receptor
Object_synonym: fam:[LPA_R/S1P_R]

subject: PR_000001427
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF005435
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005435
DB_ID: PIRSF:PIRSF005435
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001428
type: Class
Object_term: obsolete LPAR4-like receptor

subject: PR_000001428
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038616
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038616
DB_ID: PIRSF:PIRSF038616
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001429
type: Class
Object_term: MT1-like melatonin receptor

subject: PR_000001429
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038580
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038580
DB_ID: PIRSF:PIRSF038580
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001431
type: Class
Object_term: N-formyl peptide receptor
Object_synonym: formylpeptide receptor

subject: PR_000001431
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038561
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038561
DB_ID: PIRSF:PIRSF038561
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001433
type: Class
Object_term: obsolete P2RY10-like receptor

subject: PR_000001433
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038617
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038617
DB_ID: PIRSF:PIRSF038617
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001434
type: Class
Object_term: obsolete P2RY12-like receptor

subject: PR_000001434
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038637
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038637
DB_ID: PIRSF:PIRSF038637
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001435
type: Class
Object_term: obsolete P2Y purinoceptor 1/2/3/4/6

subject: PR_000001435
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF005445
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005445
DB_ID: PIRSF:PIRSF005445
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001439
type: Class
Object_term: adenosine receptor protein

subject: PR_000001439
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF005692
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005692
DB_ID: PIRSF:PIRSF005692
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001452
type: Class
Object_term: free fatty acid receptor
Object_synonym: fam:FFA_R

subject: PR_000001452
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF006358
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF006358
DB_ID: PIRSF:PIRSF006358
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001457
type: Class
Object_term: galanin receptor

subject: PR_000001457
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038570
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038570
DB_ID: PIRSF:PIRSF038570
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001463
type: Class
Object_term: glycoprotein hormone receptor

subject: PR_000001463
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF002408
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002408
DB_ID: PIRSF:PIRSF002408
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001463
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00560
  Ontology_term: Leucine Rich Repeat
Evidence_source: PIRSF:PIRSF002408
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002408
DB_ID: PIRSF:PIRSF002408
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001464
type: Class
Object_term: gonadotropin-releasing hormone receptor

subject: PR_000001464
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038576
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038576
DB_ID: PIRSF:PIRSF038576
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001477
type: Class
Object_term: leucine-rich repeat-containing G-protein coupled receptor 4/5/6

subject: PR_000001477
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038668
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038668
DB_ID: PIRSF:PIRSF038668
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001477
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00560
  Ontology_term: Leucine Rich Repeat
Evidence_source: PIRSF:PIRSF038668
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038668
DB_ID: PIRSF:PIRSF038668
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001477
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01462
  Ontology_term: Leucine rich repeat N-terminal domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001478
type: Class
Object_term: leukotriene B4 receptor

subject: PR_000001478
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038573
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038573
DB_ID: PIRSF:PIRSF038573
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001487
type: Class
Object_term: mas-related G-protein coupled receptor

subject: PR_000001487
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF001712
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001712
DB_ID: PIRSF:PIRSF001712
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001488
type: Class
Object_term: muscarinic acetylcholine receptor

subject: PR_000001488
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038548
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038548
DB_ID: PIRSF:PIRSF038548
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001489
type: Class
Object_term: neuromedin-U receptor
Object_synonym: fam:NMU_R
Object_synonym: neuromedin U receptor

subject: PR_000001489
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038640
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038640
DB_ID: PIRSF:PIRSF038640
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001490
type: Class
Object_term: neuropeptide FF/neuropeptide AF receptor
Object_synonym: fam:NPFF_R
Object_synonym: neuropeptide FF receptor

subject: PR_000001490
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038613
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038613
DB_ID: PIRSF:PIRSF038613
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001492
type: Class
Object_term: obsolete neuropeptide Y receptor 1/4/6

subject: PR_000001492
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038609
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038609
DB_ID: PIRSF:PIRSF038609
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001495
type: Class
Object_term: neuropeptides B/W receptor
Object_synonym: neuropeptide B receptor
Object_synonym: neuropeptide W receptor
Object_synonym: neuropeptide W/neuropeptide B receptor

subject: PR_000001495
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038569
DB_ID: PIRSF:PIRSF038569
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001496
type: Class
Object_term: hydroxycarboxylic acid receptor protein
Object_synonym: fam:HCA_R
Object_synonym: nicotinic acid receptor

subject: PR_000001496
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038604
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038604
DB_ID: PIRSF:PIRSF038604
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001497
type: Class
Object_term: opioid receptor protein

subject: PR_000001497
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038567
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038567
DB_ID: PIRSF:PIRSF038567
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001499
type: Class
Object_term: orexin receptor
Object_synonym: hypocretin receptor

subject: PR_000001499
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038624
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038624
DB_ID: PIRSF:PIRSF038624
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001499
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03827
  Ontology_term: Orexin receptor type 2
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001522
type: Class
Object_term: obsolete G-protein coupled receptor 21/52

subject: PR_000001522
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038583
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038583
DB_ID: PIRSF:PIRSF038583
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001525
type: Class
Object_term: obsolete G-protein coupled receptor 26/78

subject: PR_000001525
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038593
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038593
DB_ID: PIRSF:PIRSF038593
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001545
type: Class
Object_term: prokineticin receptor

subject: PR_000001545
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038582
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038582
DB_ID: PIRSF:PIRSF038582
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001549
type: Class
Object_term: prostanoid receptor

subject: PR_000001549
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF001962
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001962
DB_ID: PIRSF:PIRSF001962
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001550
type: Class
Object_term: proteinase-activated receptor
Object_synonym: fam:PAR

subject: PR_000001550
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF037996
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037996
DB_ID: PIRSF:PIRSF037996
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001551
type: Class
Object_term: relaxin family peptide receptor protein
Object_synonym: fam:RXFP
Object_synonym: relaxin receptor

subject: PR_000001551
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038662
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038662
DB_ID: PIRSF:PIRSF038662
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001551
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00057
  Ontology_term: Low-density lipoprotein receptor domain class A
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001551
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00560
  Ontology_term: Leucine Rich Repeat
Evidence_source: PIRSF:PIRSF038662
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038662
DB_ID: PIRSF:PIRSF038662
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001555
type: Class
Object_term: somatostatin receptor

subject: PR_000001555
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038568
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038568
DB_ID: PIRSF:PIRSF038568
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001558
type: Class
Object_term: trace amine receptor
Object_synonym: TAAR
Object_synonym: trace amine-associated receptor
Object_synonym: trace-amine-associated receptor

subject: PR_000001558
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF038555
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038555
DB_ID: PIRSF:PIRSF038555
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001562
type: Class
Object_term: vasopressin/oxytocin receptor
Object_synonym: name: vasopressin and oxytocin receptor

subject: PR_000001562
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF001841
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001841
DB_ID: PIRSF:PIRSF001841
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001597
type: Class
Object_term: obsolete lysophosphatidic acid receptor 1/2/3

subject: PR_000001597
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF501020
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501020
DB_ID: PIRSF:PIRSF501020
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001599
type: Class
Object_term: mas-related G-protein coupled receptor A
Object_synonym: fam:MRGPRA

subject: PR_000001599
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001600
type: Class
Object_term: mas-related G-protein coupled receptor B
Object_synonym: fam:MRGPRB

subject: PR_000001600
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001673
type: Class
Object_term: lysophospholipid (S1P) receptor
Object_synonym: sphingosine 1-phosphate receptor 1-5

subject: PR_000001673
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00001
  Ontology_term: 7 transmembrane receptor (rhodopsin family)
Evidence_source: PIRSF:PIRSF501018
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501018
DB_ID: PIRSF:PIRSF501018
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001719
type: Class
Object_term: transient receptor potential cation channel TRPM8
Object_synonym: long transient receptor potential channel 6
Object_synonym: LTrpC-6
Object_synonym: LTRPC6
Object_synonym: LTrpC6
Object_synonym: transient receptor potential p8
Object_synonym: Trp-p8
Object_synonym: TRPM8
Object_synonym: TRPP8

subject: PR_000001719
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Evidence_source: PIRSF:PIRSF005528
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005528
DB_ID: PIRSF:PIRSF005528
Date: 2008-10-15
Assigned_by: PRO:CNA

PR_000001740
type: Class
Object_term: myeloid differentiation primary response protein MyD88
Object_synonym: MYD88

subject: PR_000001740
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00531
  Ontology_term: Death domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001740
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01582
  Ontology_term: TIR domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001744
type: Class
Object_term: translocation-associated membrane protein
Object_synonym: TRAM

subject: PR_000001744
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03798
  Ontology_term: TLC domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001744
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08390
  Ontology_term: TRAM1-like protein
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001751
type: Class
Object_term: Toll/interleukin-1 receptor domain-containing adapter protein
Object_synonym: adaptor protein Wyatt
Object_synonym: MAL
Object_synonym: MyD88 adapter-like protein
Object_synonym: TIR domain-containing adapter protein
Object_synonym: TIRAP

subject: PR_000001751
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01582
  Ontology_term: TIR domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001753
type: Class
Object_term: transcription factor NF-kappa-B subunit
Object_synonym: transcription factor NF-kappa-B

subject: PR_000001753
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00023
  Ontology_term: Ankyrin repeat
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001753
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00531
  Ontology_term: Death domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001753
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00554
  Ontology_term: Rel homology DNA-binding domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001753
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01833
  Ontology_term: IPT/TIG domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001769
type: Class
Object_term: mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3
Object_synonym: fam:TAB2-TAB3

subject: PR_000001769
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00641
  Ontology_term: Zn-finger in Ran binding protein and others
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001769
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02845
  Ontology_term: CUE domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001770
type: Class
Object_term: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Object_synonym: MAP3K7IP1
Object_synonym: mitogen-activated protein kinase kinase kinase 7-interacting protein 1
Object_synonym: TAB1
Object_synonym: TAK1-binding protein 1
Object_synonym: TGF-beta-activated kinase 1-binding protein 1

subject: PR_000001770
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00481
  Ontology_term: Protein phosphatase 2C
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001774
type: Class
Object_term: inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits

subject: PR_000001774
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001777
type: Class
Object_term: IKK-related kinase

subject: PR_000001777
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001780
type: Class
Object_term: interleukin-1 receptor-associated kinase 4
Object_synonym: IRAK-4
Object_synonym: IRAK4
Object_synonym: renal carcinoma antigen NY-REN-64

subject: PR_000001780
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001780
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00531
  Ontology_term: Death domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001781
type: Class
Object_term: interleukin-1 receptor-associated kinase IRAK1/3

subject: PR_000001781
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001781
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00531
  Ontology_term: Death domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001800
type: Class
Object_term: 5'-nucleotidase
Object_synonym: 5'-NT
Object_synonym: CD73
Object_synonym: ecto-5'-nucleotidase
Object_synonym: NT5
Object_synonym: NT5E
Object_synonym: NTE

subject: PR_000001800
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00149
  Ontology_term: Calcineurin-like phosphoesterase
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001800
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02872
  Ontology_term: 5'-nucleotidase, C-terminal domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001808
type: Class
Object_term: C/C-C motif small inducible chemokine
Object_synonym: fam:C/C-C chemokine

subject: PR_000001808
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00048
  Ontology_term: Small cytokines (intecrine/chemokine), interleukin-8 like
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001809
type: Class
Object_term: CD59-like glycoprotein

subject: PR_000001809
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00021
  Ontology_term: u-PAR/Ly-6 domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001810
type: Class
Object_term: CSF-1/PDGF receptor-type tyrosine-protein kinase

subject: PR_000001810
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001810
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07679
  Ontology_term: Immunoglobulin I-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001810
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001810
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001812
type: Class
Object_term: EGF receptor type tyrosine-protein kinase

subject: PR_000001812
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00757
  Ontology_term: Furin-like cysteine rich region
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001812
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01030
  Ontology_term: Receptor L domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001812
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02757
  Ontology_term: YLP motif
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001812
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001813
type: Class
Object_term: adhesion G protein-coupled receptor E1
Object_synonym: ADGRE1
Object_synonym: cell surface glycoprotein F4/80
Object_synonym: EGF-like module receptor 1
Object_synonym: EGF-like module-containing mucin-like hormone receptor-like 1
Object_synonym: EMR1
Object_synonym: EMR1 hormone receptor
Object_synonym: Gpf480
Object_synonym: TM7LN3

subject: PR_000001813
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00002
  Ontology_term: 7 transmembrane receptor (Secretin family)
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001813
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01825
  Ontology_term: GPCR proteolysis site, GPS, motif
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001813
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07645
  Ontology_term: Calcium-binding EGF domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001814
type: Class
Object_term: G protein-activated inward rectifier potassium channel

subject: PR_000001814
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01007
  Ontology_term: Inward rectifier potassium channel transmembrane domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001814
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08466
  Ontology_term: Inward rectifier potassium channel N-terminal
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001815
type: Class
Object_term: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Object_synonym: ADP-ribosyltransferase C2 and C3 toxin-like 1
Object_synonym: ART1
Object_synonym: Art2
Object_synonym: ARTC1
Object_synonym: CD296
Object_synonym: mono(ADP-ribosyl)transferase 1
Object_synonym: YAC-1

subject: PR_000001815
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01129
  Ontology_term: NAD:arginine ADP-ribosyltransferase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001816
type: Class
Object_term: HGF/MSP receptor type tyrosine-protein kinase

subject: PR_000001816
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01403
  Ontology_term: Sema domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001816
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01437
  Ontology_term: Plexin repeat
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001816
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01833
  Ontology_term: IPT/TIG domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001816
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001817
type: Class
Object_term: LDL receptor-related protein

subject: PR_000001817
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00008
  Ontology_term: EGF-like domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001817
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00057
  Ontology_term: Low-density lipoprotein receptor domain class A
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001817
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00058
  Ontology_term: Low-density lipoprotein receptor repeat class B
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001817
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01436
  Ontology_term: NHL repeat
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001817
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07645
  Ontology_term: Calcium-binding EGF domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001817
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07974
  Ontology_term: EGF-like domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001818
type: Class
Object_term: MHC class I histocompatibility antigen alpha chain
Object_synonym: MHCcIalpha

subject: PR_000001818
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00129
  Ontology_term: Class I Histocompatibility antigen, domains alpha 1 and 2
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001818
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF06623
  Ontology_term: MHC_I C-terminus
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001818
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07654
  Ontology_term: Immunoglobulin C1-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001820
type: Class
Object_term: MHC class II histocompatibility antigen alpha chain
Object_synonym: MHCcIIalpha

subject: PR_000001820
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00993
  Ontology_term: Class II histocompatibility antigen, alpha domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001820
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07654
  Ontology_term: Immunoglobulin C1-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001821
type: Class
Object_term: MHC class II histocompatibility antigen beta chain
Object_synonym: MHCcIIbeta

subject: PR_000001821
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00969
  Ontology_term: Class II histocompatibility antigen, beta domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001821
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07654
  Ontology_term: Immunoglobulin C1-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001822
type: Class
Object_term: MHC class II histocompatibility antigen gamma chain
Object_synonym: CD74
Object_synonym: DHLAG
Object_synonym: HLA-DR antigens-associated invariant chain
Object_synonym: Ia antigen-associated invariant chain
Object_synonym: Ii
Object_synonym: MHC class II-associated invariant chain
Object_synonym: MHCcIIgamma
Object_synonym: p33

subject: PR_000001822
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00086
  Ontology_term: Thyroglobulin type-1 repeat
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001822
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08831
  Ontology_term: Class II MHC-associated invariant chain trimerisation domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001822
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF09307
  Ontology_term: CLIP, MHC2 interacting
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001829
type: Class
Object_term: OX-2 membrane glycoprotein
Object_synonym: CD200
Object_synonym: MOX1
Object_synonym: MOX2
Object_synonym: MRC OX-2 antigen
Object_synonym: My033

subject: PR_000001829
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001829
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001829
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08205
  Ontology_term: CD80-like C2-set immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001831
type: Class
Object_term: PR domain zinc finger protein 1
Object_synonym: beta-interferon gene positive regulatory domain I-binding factor
Object_synonym: BLIMP-1
Object_synonym: BLIMP1
Object_synonym: positive regulatory domain I-binding factor 1
Object_synonym: PR domain-containing protein 1
Object_synonym: PRDI-BF1
Object_synonym: PRDI-binding factor 1
Object_synonym: PRDM1

subject: PR_000001831
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00096
  Ontology_term: Zinc finger, C2H2 type
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001831
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00856
  Ontology_term: SET domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001832
type: Class
Object_term: SIRP/SHPS-1 family protein

subject: PR_000001832
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07654
  Ontology_term: Immunoglobulin C1-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001832
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001838
type: Class
Object_term: T-cell surface glycoprotein CD1
Object_synonym: CD1

subject: PR_000001838
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00129
  Ontology_term: Class I Histocompatibility antigen, domains alpha 1 and 2
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001838
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07654
  Ontology_term: Immunoglobulin C1-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001839
type: Class
Object_term: T-cell surface glycoprotein CD5
Object_synonym: CD5
Object_synonym: LEU1
Object_synonym: ly-1
Object_synonym: lymphocyte antigen 1
Object_synonym: lymphocyte antigen T1/Leu-1
Object_synonym: Lyt-1

subject: PR_000001839
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00530
  Ontology_term: Scavenger receptor cysteine-rich domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001840
type: Class
Object_term: T-cell surface protein tactile
Object_synonym: CD96
Object_synonym: cell surface antigen CD96
Object_synonym: T cell-activated increased late expression protein

subject: PR_000001840
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001840
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001840
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08205
  Ontology_term: CD80-like C2-set immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001844
type: Class
Object_term: arginase-1
Object_synonym: ARG1
Object_synonym: liver-type arginase
Object_synonym: type I arginase

subject: PR_000001844
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00491
  Ontology_term: Arginase family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001845
type: Class
Object_term: band 3-like protein

subject: PR_000001845
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00955
  Ontology_term: HCO3- transporter family
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001845
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07565
  Ontology_term: Band 3 cytoplasmic domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001848
type: Class
Object_term: butyrophilin
Object_synonym: fam:BTN

subject: PR_000001848
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00622
  Ontology_term: SPRY domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001848
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001848
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08205
  Ontology_term: CD80-like C2-set immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001849
type: Class
Object_term: calcium-activated potassium channel subunit alpha-1
Object_synonym: BK channel
Object_synonym: BKCA alpha
Object_synonym: calcium-activated potassium channel, subfamily M subunit alpha-1
Object_synonym: K(VCA)alpha
Object_synonym: KCa1.1
Object_synonym: KCNMA
Object_synonym: KCNMA1
Object_synonym: Maxi K channel
Object_synonym: MaxiK
Object_synonym: SLO
Object_synonym: Slo
Object_synonym: Slo homolog
Object_synonym: Slo-alpha
Object_synonym: slo1
Object_synonym: slowpoke homolog

subject: PR_000001849
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001849
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03493
  Ontology_term: Calcium-activated BK potassium channel alpha subunit
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001850
type: Class
Object_term: cathepsin K
Object_synonym: cathepsin O
Object_synonym: cathepsin O2
Object_synonym: cathepsin X
Object_synonym: CTSK
Object_synonym: CTSO
Object_synonym: CTSO2

subject: PR_000001850
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00112
  Ontology_term: Papain family cysteine protease
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001850
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00396
  Ontology_term: Granulin
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001850
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08127
  Ontology_term: Peptidase family C1 propeptide
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001850
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08246
  Ontology_term: Cathepsin propeptide inhibitor domain (I29)
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001850
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08773
  Ontology_term: Cathepsin C exclusion domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001851
type: Class
Object_term: 4F2 cell-surface antigen heavy chain
Object_synonym: 4F2 heavy chain antigen
Object_synonym: 4F2hc
Object_synonym: CD98
Object_synonym: cell surface antigen 4F2 heavy chain
Object_synonym: lymphocyte activation antigen 4F2 large subunit
Object_synonym: MDU1
Object_synonym: SLC3A2
Object_synonym: solute carrier family 3 member 2

subject: PR_000001851
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00128
  Ontology_term: Alpha amylase, catalytic domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001854
type: Class
Object_term: ectonucleoside triphosphate diphosphohydrolase 1
Object_synonym: CD39
Object_synonym: ecto-apyrase
Object_synonym: ecto-ATP diphosphohydrolase 1
Object_synonym: ecto-ATPase 1
Object_synonym: ecto-ATPDase 1
Object_synonym: ENTPD1
Object_synonym: lymphoid cell activation antigen
Object_synonym: NTPDase 1

subject: PR_000001854
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01150
  Ontology_term: GDA1/CD39 (nucleoside phosphatase) family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001857
type: Class
Object_term: immunoglobulin alpha Fc receptor
Object_synonym: CD89
Object_synonym: FCAR
Object_synonym: IgA Fc receptor

subject: PR_000001857
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001859
type: Class
Object_term: immunoglobulin lambda-like polypeptide 1
Object_synonym: CD179 antigen-like family member B
Object_synonym: CD179b
Object_synonym: Ig lambda-5
Object_synonym: Igl-5
Object_synonym: IGL1
Object_synonym: IGLL1
Object_synonym: immunoglobulin omega polypeptide
Object_synonym: immunoglobulin-related protein 14.1

subject: PR_000001859
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07654
  Ontology_term: Immunoglobulin C1-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001861
type: Class
Object_term: integrin beta

subject: PR_000001861
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00362
  Ontology_term: Integrin beta chain VWA domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001861
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07965
  Ontology_term: Integrin beta tail domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001861
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07974
  Ontology_term: EGF-like domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001861
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08725
  Ontology_term: Integrin beta cytoplasmic domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001862
type: Class
Object_term: interferon regulatory factor 1/2

subject: PR_000001862
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00605
  Ontology_term: Interferon regulatory factor transcription factor
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001863
type: Class
Object_term: interferon regulatory factor 3-9

subject: PR_000001863
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00605
  Ontology_term: Interferon regulatory factor transcription factor
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001863
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF10401
  Ontology_term: Interferon-regulatory factor 3
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001864
type: Class
Object_term: interferon-induced transmembrane protein
Object_synonym: fam:IFITM

subject: PR_000001864
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF04505
  Ontology_term: Interferon-induced transmembrane protein
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001866
type: Class
Object_term: interleukin-4 receptor subunit alpha
Object_synonym: 582J2.1
Object_synonym: CD124
Object_synonym: IL-4 receptor subunit alpha
Object_synonym: IL-4R subunit alpha
Object_synonym: IL-4R-alpha
Object_synonym: IL-4RA
Object_synonym: IL4R
Object_synonym: IL4RA

subject: PR_000001866
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001866
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF09238
  Ontology_term: Interleukin-4 receptor alpha chain, N-terminal
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001867
type: Class
Object_term: interleukin-5 receptor subunit alpha
Object_synonym: CD125
Object_synonym: CDw125
Object_synonym: IL-5 receptor subunit alpha
Object_synonym: IL-5R subunit alpha
Object_synonym: IL-5R-alpha
Object_synonym: IL-5RA
Object_synonym: IL5R
Object_synonym: IL5RA

subject: PR_000001867
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF09240
  Ontology_term: Interleukin-6 receptor alpha chain, binding
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001869
type: Class
Object_term: interleukin-7 receptor subunit alpha
Object_synonym: CD127
Object_synonym: CDw127
Object_synonym: IL-7 receptor subunit alpha
Object_synonym: IL-7R subunit alpha
Object_synonym: IL-7R-alpha
Object_synonym: IL-7RA
Object_synonym: IL7R

subject: PR_000001869
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001870
type: Class
Object_term: islet cell autoantigen 1
Object_synonym: 69 kDa islet cell autoantigen
Object_synonym: ICA1
Object_synonym: ICA69
Object_synonym: ICAp69
Object_synonym: islet cell autoantigen p69
Object_synonym: p69

subject: PR_000001870
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF04629
  Ontology_term: Islet cell autoantigen ICA69, C-terminal domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001870
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF06456
  Ontology_term: Arfaptin-like domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001875
type: Class
Object_term: leptin receptor
Object_synonym: B219
Object_synonym: CD295
Object_synonym: DB
Object_synonym: LEP-R
Object_synonym: LEPR
Object_synonym: OB receptor
Object_synonym: OB-R
Object_synonym: OBR

subject: PR_000001875
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001875
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF06328
  Ontology_term: Ig-like C2-type domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001880
type: Class
Object_term: low affinity immunoglobulin epsilon Fc receptor
Object_synonym: BLAST-2
Object_synonym: C-type lectin domain family 4 member J
Object_synonym: CD23
Object_synonym: CD23A
Object_synonym: CLEC4J
Object_synonym: Fc-epsilon-RII
Object_synonym: FCE2
Object_synonym: FCER2
Object_synonym: Fcer2a
Object_synonym: IGEBF
Object_synonym: immunoglobulin E-binding factor
Object_synonym: lymphocyte IgE receptor

subject: PR_000001880
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00059
  Ontology_term: Lectin C-type domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001881
type: Class
Object_term: lymphocyte activation gene 3 protein
Object_synonym: CD223
Object_synonym: FDC
Object_synonym: LAG-3
Object_synonym: LAG3
Object_synonym: protein FDC

subject: PR_000001881
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001881
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001883
type: Class
Object_term: lysosome-associated membrane protein

subject: PR_000001883
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01299
  Ontology_term: Lysosome-associated membrane glycoprotein (Lamp)
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001885
type: Class
Object_term: macrophage scavenger receptor types I and II
Object_synonym: CD204
Object_synonym: macrophage acetylated LDL receptor I and II
Object_synonym: MSR1
Object_synonym: SCARA1
Object_synonym: scavenger receptor class A member 1
Object_synonym: scavenger receptor type A
Object_synonym: Scvr
Object_synonym: SR-A

subject: PR_000001885
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00530
  Ontology_term: Scavenger receptor cysteine-rich domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001885
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01391
  Ontology_term: Collagen triple helix repeat (20 copies)
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001885
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03523
  Ontology_term: Macrophage scavenger receptor
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001886
type: Class
Object_term: major prion protein
Object_synonym: AltPrP
Object_synonym: ASCR
Object_synonym: CD230
Object_synonym: PRIP
Object_synonym: Prn-p
Object_synonym: PRNP
Object_synonym: PrP
Object_synonym: PrP27-30
Object_synonym: PrP33-35C

subject: PR_000001886
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00377
  Ontology_term: Prion/Doppel alpha-helical domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001886
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03991
  Ontology_term: Copper binding octapeptide repeat
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001887
type: Class
Object_term: melanotransferrin
Object_synonym: CD228
Object_synonym: MAP97
Object_synonym: melanoma-associated antigen p97
Object_synonym: MELTF
Object_synonym: membrane-bound transferrin-like protein p97
Object_synonym: MFI2
Object_synonym: MTf

subject: PR_000001887
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00405
  Ontology_term: Transferrin
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001888
type: Class
Object_term: membrane alanyl aminopeptidase-like metallopeptidase

subject: PR_000001888
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01433
  Ontology_term: Peptidase family M1 domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001889
type: Class
Object_term: CD14 molecule
Object_synonym: CD14
Object_synonym: monocyte differentiation antigen CD14
Object_synonym: myeloid cell-specific leucine-rich glycoprotein

subject: PR_000001889
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00560
  Ontology_term: Leucine Rich Repeat
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001891
type: Class
Object_term: ATP-dependent translocase ABCB1
Object_synonym: ABCB1
Object_synonym: Abcb4
Object_synonym: ATP-binding cassette sub-family B member 1
Object_synonym: CD243
Object_synonym: MDR1
Object_synonym: Mdr3
Object_synonym: multidrug resistance protein 1
Object_synonym: P-glycoprotein 1
Object_synonym: P-glycoprotein 3
Object_synonym: Pgy-3
Object_synonym: PGY1
Object_synonym: Pgy3

subject: PR_000001891
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00005
  Ontology_term: ABC transporter
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001891
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00664
  Ontology_term: ABC transporter transmembrane region
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001895
type: Class
Object_term: natural cytotoxicity triggering receptor 3
Object_synonym: 1C7
Object_synonym: activating natural killer receptor p30
Object_synonym: CD337
Object_synonym: LY117
Object_synonym: natural killer cell p30-related protein
Object_synonym: NCR3
Object_synonym: NK-p30
Object_synonym: NKp30

subject: PR_000001895
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001897
type: Class
Object_term: natural killer cell receptor NKG2

subject: PR_000001897
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00059
  Ontology_term: Lectin C-type domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001898
type: Class
Object_term: neprilysin
Object_synonym: atriopeptidase
Object_synonym: CALLA
Object_synonym: CD10
Object_synonym: common acute lymphocytic leukemia antigen
Object_synonym: enkephalinase
Object_synonym: EPN
Object_synonym: MME
Object_synonym: NEP
Object_synonym: neutral endopeptidase
Object_synonym: neutral endopeptidase 24.11
Object_synonym: SFE
Object_synonym: skin fibroblast elastase

subject: PR_000001898
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01431
  Ontology_term: Peptidase family M13
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001898
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF05649
  Ontology_term: Peptidase family M13
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001899
type: Class
Object_term: neural cell adhesion molecule-like protein

subject: PR_000001899
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001899
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001899
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07679
  Ontology_term: Immunoglobulin I-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001899
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001900
type: Class
Object_term: neuropilin-1
Object_synonym: A5 protein
Object_synonym: BDCA-4
Object_synonym: BDCA4
Object_synonym: blood dendritic cell antigen 4
Object_synonym: CD304
Object_synonym: NRP
Object_synonym: NRP1
Object_synonym: vascular endothelial cell growth factor 165 receptor
Object_synonym: VEGF165R

subject: PR_000001900
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00431
  Ontology_term: CUB domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001900
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00629
  Ontology_term: MAM domain, meprin/A5/mu
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001900
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00754
  Ontology_term: F5/8 type C domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001901
type: Class
Object_term: nitric oxide synthase, inducible
Object_synonym: HEP-NOS
Object_synonym: hepatocyte NOS
Object_synonym: inducible NO synthase
Object_synonym: inducible NOS
Object_synonym: iNOS
Object_synonym: Inosl
Object_synonym: MAC-NOS
Object_synonym: macrophage NOS
Object_synonym: NOS type II
Object_synonym: NOS2
Object_synonym: NOS2A
Object_synonym: peptidyl-cysteine S-nitrosylase NOS2

subject: PR_000001901
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00175
  Ontology_term: Oxidoreductase NAD-binding domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001901
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00258
  Ontology_term: Flavodoxin
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001901
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00667
  Ontology_term: FAD binding domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001901
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02898
  Ontology_term: Nitric oxide synthase, oxygenase domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001903
type: Class
Object_term: paired box protein PAX-5
Object_synonym: B-cell-specific transcription factor
Object_synonym: BSAP
Object_synonym: Pax-5
Object_synonym: PAX5

subject: PR_000001903
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00046
  Ontology_term: Homeodomain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001903
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00292
  Ontology_term: 'Paired box' domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001905
type: Class
Object_term: platelet glycoprotein 4
Object_synonym: CD36
Object_synonym: FAT
Object_synonym: fatty acid translocase
Object_synonym: glycoprotein IIIb
Object_synonym: GP3B
Object_synonym: GP4
Object_synonym: GPIIIB
Object_synonym: GPIV
Object_synonym: leukocyte differentiation antigen CD36
Object_synonym: PAS IV
Object_synonym: PAS-4
Object_synonym: platelet collagen receptor
Object_synonym: platelet glycoprotein IV
Object_synonym: thrombospondin receptor

subject: PR_000001905
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01130
  Ontology_term: CD36 family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001907
type: Class
Object_term: platelet glycoprotein Ib alpha chain
Object_synonym: antigen CD42b-alpha
Object_synonym: CD42b
Object_synonym: glycoprotein Ibalpha
Object_synonym: GP-Ib alpha
Object_synonym: GP1BA
Object_synonym: GPIb-alpha
Object_synonym: GPIbA

subject: PR_000001907
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00560
  Ontology_term: Leucine Rich Repeat
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001907
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01462
  Ontology_term: Leucine rich repeat N-terminal domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001908
type: Class
Object_term: platelet glycoprotein Ib beta chain
Object_synonym: antigen CD42b-beta
Object_synonym: CD42c
Object_synonym: GP-Ib beta
Object_synonym: GP1BB
Object_synonym: GPIb-beta
Object_synonym: GPIbB

subject: PR_000001908
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01462
  Ontology_term: Leucine rich repeat N-terminal domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001908
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01463
  Ontology_term: Leucine rich repeat C-terminal domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001911
type: Class
Object_term: poliovirus receptor-related protein

subject: PR_000001911
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001911
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001911
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08205
  Ontology_term: CD80-like C2-set immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001916
type: Class
Object_term: potassium channel subfamily T

subject: PR_000001916
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF03493
  Ontology_term: Calcium-activated BK potassium channel alpha subunit
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001916
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07885
  Ontology_term: Ion channel
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001917
type: Class
Object_term: potassium channel, TWIK-1-related

subject: PR_000001917
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07885
  Ontology_term: Ion channel
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001919
type: Class
Object_term: programmed cell death protein 1
Object_synonym: CD279
Object_synonym: PD-1
Object_synonym: PD1
Object_synonym: PDCD1
Object_synonym: protein PD-1

subject: PR_000001919
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001923
type: Class
Object_term: receptor-type tyrosine-protein kinase Tie

subject: PR_000001923
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001923
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001923
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00053
  Ontology_term: Laminin EGF domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001923
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001923
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07974
  Ontology_term: EGF-like domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001923
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF10430
  Ontology_term: Tie-2 Ig-like domain 1
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001924
type: Class
Object_term: receptor-type tyrosine-protein phosphatase eta
Object_synonym: Byp
Object_synonym: CD148
Object_synonym: density-enhanced phosphatase 1
Object_synonym: DEP-1
Object_synonym: DEP1
Object_synonym: HPTP beta-like tyrosine phosphatase
Object_synonym: HPTP eta
Object_synonym: protein-tyrosine phosphatase eta
Object_synonym: protein-tyrosine phosphatase receptor type J
Object_synonym: PTPRJ
Object_synonym: R-PTP-eta
Object_synonym: R-PTP-J
Object_synonym: Scc1
Object_synonym: susceptibility to colon cancer 1

subject: PR_000001924
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00041
  Ontology_term: Fibronectin type III domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001924
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00102
  Ontology_term: Protein-tyrosine phosphatase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001926
type: Class
Object_term: semaphorin

subject: PR_000001926
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001926
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01403
  Ontology_term: Sema domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001926
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01437
  Ontology_term: Plexin repeat
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001926
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07679
  Ontology_term: Immunoglobulin I-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001926
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001933
type: Class
Object_term: signal transducer and transcription activator STAT

subject: PR_000001933
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00017
  Ontology_term: SH2 domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001933
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01017
  Ontology_term: STAT protein, all-alpha domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001933
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02864
  Ontology_term: STAT protein, DNA binding domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001933
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02865
  Ontology_term: STAT protein, protein interaction domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001934
type: Class
Object_term: sodium/potassium-transporting ATPase subunit beta-3
Object_synonym: ATP1B3
Object_synonym: ATPB-3
Object_synonym: CD298
Object_synonym: sodium/potassium-dependent ATPase subunit beta-3

subject: PR_000001934
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00287
  Ontology_term: Sodium / potassium ATPase beta chain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001935
type: Class
Object_term: syndecan-1
Object_synonym: CD138
Object_synonym: SDC
Object_synonym: SDC1
Object_synonym: Synd-1
Object_synonym: SYND1

subject: PR_000001935
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01034
  Ontology_term: Syndecan domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001936
type: Class
Object_term: syndecan-3
Object_synonym: KIAA0468
Object_synonym: SDC3
Object_synonym: SYND3

subject: PR_000001936
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01034
  Ontology_term: Syndecan domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001937
type: Class
Object_term: tartrate-resistant acid phosphatase type 5
Object_synonym: ACP5
Object_synonym: T5ap
Object_synonym: tartrate-resistant acid ATPase
Object_synonym: TR-AP
Object_synonym: Trap
Object_synonym: TrATPase
Object_synonym: type 5 acid phosphatase

subject: PR_000001937
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00149
  Ontology_term: Calcineurin-like phosphoesterase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001938
type: Class
Object_term: thrombomodulin-like receptor

subject: PR_000001938
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00008
  Ontology_term: EGF-like domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001938
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00059
  Ontology_term: Lectin C-type domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001938
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07645
  Ontology_term: Calcium-binding EGF domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001938
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF09064
  Ontology_term: Thrombomodulin like fifth domain, EGF-like
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001940
type: Class
Object_term: tissue factor
Object_synonym: CD142
Object_synonym: Cf-3
Object_synonym: Cf3
Object_synonym: coagulation factor III
Object_synonym: F3
Object_synonym: TF
Object_synonym: thromboplastin

subject: PR_000001940
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01108
  Ontology_term: Tissue factor
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001941
type: Class
Object_term: trans-acting T-cell-specific transcription factor GATA-3
Object_synonym: Gata-3
Object_synonym: GATA-binding factor 3
Object_synonym: GATA3

subject: PR_000001941
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00320
  Ontology_term: GATA zinc finger
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001942
type: Class
Object_term: transcription factor COE1
Object_synonym: COE1
Object_synonym: early B-cell factor
Object_synonym: EBF
Object_synonym: EBF1
Object_synonym: O/E-1
Object_synonym: OE-1

subject: PR_000001942
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01833
  Ontology_term: IPT/TIG domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001943
type: Class
Object_term: transcription factor E2-alpha
Object_synonym: Alf2
Object_synonym: BHLHB21
Object_synonym: bHLHb21
Object_synonym: class B basic helix-loop-helix protein 21
Object_synonym: E2A
Object_synonym: immunoglobulin enhancer-binding factor E12/E47
Object_synonym: immunoglobulin transcription factor 1
Object_synonym: ITF1
Object_synonym: kappa-E2-binding factor
Object_synonym: Me2
Object_synonym: TCF-3
Object_synonym: TCF3
Object_synonym: Tcfe2a
Object_synonym: transcription factor 3
Object_synonym: transcription factor A1
Object_synonym: transcription factor ITF-1

subject: PR_000001943
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00010
  Ontology_term: Helix-loop-helix DNA-binding domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001944
type: Class
Object_term: transcription factor PU.1
Object_synonym: 31 kDa-transforming protein
Object_synonym: SFFV proviral integration 1 protein
Object_synonym: Sfpi-1
Object_synonym: Sfpi1
Object_synonym: SPI1

subject: PR_000001944
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00178
  Ontology_term: Ets-domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001945
type: Class
Object_term: transferrin receptor protein 1
Object_synonym: CD71
Object_synonym: p90
Object_synonym: T9
Object_synonym: TfR
Object_synonym: TfR1
Object_synonym: TFRC
Object_synonym: TR
Object_synonym: Trfr

subject: PR_000001945
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02225
  Ontology_term: PA domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001945
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF04253
  Ontology_term: Transferrin receptor-like dimerisation domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001946
type: Class
Object_term: tumor necrosis factor ligand superfamily member 10/11

subject: PR_000001946
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00229
  Ontology_term: TNF(Tumour Necrosis Factor) family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001948
type: Class
Object_term: tumor necrosis factor ligand superfamily member 13B
Object_synonym: B lymphocyte stimulator
Object_synonym: B-cell-activating factor
Object_synonym: BAFF
Object_synonym: BLYS
Object_synonym: BLyS
Object_synonym: CD257
Object_synonym: dendritic cell-derived TNF-like molecule
Object_synonym: TALL-1
Object_synonym: TALL1
Object_synonym: TNF- and APOL-related leukocyte expressed ligand 1
Object_synonym: TNFSF13B
Object_synonym: TNFSF20
Object_synonym: UNQ401/PRO738
Object_synonym: ZTNF4

subject: PR_000001948
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00229
  Ontology_term: TNF(Tumour Necrosis Factor) family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001949
type: Class
Object_term: tumor necrosis factor ligand superfamily member 4
Object_synonym: CD252
Object_synonym: glycoprotein Gp34
Object_synonym: OX40 ligand
Object_synonym: OX40L
Object_synonym: TAX transcriptionally-activated glycoprotein 1
Object_synonym: TNFSF4
Object_synonym: TXGP1
Object_synonym: Txgp1l

subject: PR_000001949
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00229
  Ontology_term: TNF(Tumour Necrosis Factor) family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001950
type: Class
Object_term: tumor necrosis factor ligand superfamily member 5
Object_synonym: CD154
Object_synonym: CD40-L
Object_synonym: CD40L
Object_synonym: CD40LG
Object_synonym: T-cell antigen Gp39
Object_synonym: TNF-related activation protein
Object_synonym: TNFSF5
Object_synonym: TRAP

subject: PR_000001950
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00229
  Ontology_term: TNF(Tumour Necrosis Factor) family
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001951
type: Class
Object_term: tumor necrosis factor receptor superfamily member 10A/B

subject: PR_000001951
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00020
  Ontology_term: TNFR/NGFR cysteine-rich region
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001951
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00531
  Ontology_term: Death domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001954
type: Class
Object_term: tumor necrosis factor receptor superfamily member 11A
Object_synonym: CD265
Object_synonym: ODFR
Object_synonym: osteoclast differentiation factor receptor
Object_synonym: RANK
Object_synonym: receptor activator of NF-KB
Object_synonym: TNFRSF11A

subject: PR_000001954
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00020
  Ontology_term: TNFR/NGFR cysteine-rich region
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001958
type: Class
Object_term: tumor necrosis factor receptor superfamily member 1A
Object_synonym: CD120a
Object_synonym: p55
Object_synonym: p60
Object_synonym: TNF-R1
Object_synonym: TNF-RI
Object_synonym: TNFAR
Object_synonym: Tnfr-1
Object_synonym: TNFR-I
Object_synonym: TNFR1
Object_synonym: TNFRSF1A
Object_synonym: tumor necrosis factor receptor 1
Object_synonym: tumor necrosis factor receptor type I

subject: PR_000001958
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00020
  Ontology_term: TNFR/NGFR cysteine-rich region
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001958
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00531
  Ontology_term: Death domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001959
type: Class
Object_term: tumor necrosis factor receptor superfamily member 1B
Object_synonym: CD120b
Object_synonym: etanercept
Object_synonym: p75
Object_synonym: p80 TNF-alpha receptor
Object_synonym: TNF-R2
Object_synonym: TNF-RII
Object_synonym: TNFBR
Object_synonym: Tnfr-2
Object_synonym: TNFR-II
Object_synonym: TNFR2
Object_synonym: TNFRSF1B
Object_synonym: tumor necrosis factor receptor 2
Object_synonym: tumor necrosis factor receptor type II

subject: PR_000001959
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00020
  Ontology_term: TNFR/NGFR cysteine-rich region
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001960
type: Class
Object_term: tumor necrosis factor receptor superfamily member 4
Object_synonym: ACT35 antigen
Object_synonym: CD134
Object_synonym: Ox40
Object_synonym: OX40 antigen
Object_synonym: OX40L receptor
Object_synonym: TAX transcriptionally-activated glycoprotein 1 receptor
Object_synonym: TNFRSF4
Object_synonym: Txgp1
Object_synonym: TXGP1L

subject: PR_000001960
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00020
  Ontology_term: TNFR/NGFR cysteine-rich region
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001963
type: Class
Object_term: CD27 molecule
Object_synonym: CD27
Object_synonym: CD27L receptor
Object_synonym: T-cell activation antigen CD27
Object_synonym: T14
Object_synonym: TNFRSF7
Object_synonym: tumor necrosis factor receptor superfamily member 7

subject: PR_000001963
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00020
  Ontology_term: TNFR/NGFR cysteine-rich region
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001967
type: Class
Object_term: TEC-type tyrosine-protein kinase
Object_synonym: Tec family kinase

subject: PR_000001967
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00017
  Ontology_term: SH2 domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001967
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00018
  Ontology_term: SH3 domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001967
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00169
  Ontology_term: PH domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001967
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00779
  Ontology_term: BTK motif
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001967
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001968
type: Class
Object_term: tyrosine-protein phosphatase non-receptor type substrate 1
Object_synonym: BIT
Object_synonym: Bit
Object_synonym: brain Ig-like molecule with tyrosine-based activation motifs
Object_synonym: CD172 antigen-like family member A
Object_synonym: CD172a
Object_synonym: inhibitory receptor SHPS-1
Object_synonym: macrophage fusion receptor
Object_synonym: MFR
Object_synonym: MyD-1 antigen
Object_synonym: MYD1
Object_synonym: p84
Object_synonym: PTPNS1
Object_synonym: SHP substrate 1
Object_synonym: SHPS-1
Object_synonym: SHPS1
Object_synonym: signal-regulatory protein alpha-1
Object_synonym: signal-regulatory protein alpha-2
Object_synonym: signal-regulatory protein alpha-3
Object_synonym: SIRP
Object_synonym: Sirp-alpha-1
Object_synonym: Sirp-alpha-2
Object_synonym: Sirp-alpha-3
Object_synonym: SIRPA

subject: PR_000001968
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07654
  Ontology_term: Immunoglobulin C1-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001968
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001969
type: Class
Object_term: urokinase plasminogen activator surface receptor
Object_synonym: CD87
Object_synonym: MO3
Object_synonym: monocyte activation antigen Mo3
Object_synonym: PLAUR
Object_synonym: U-PAR
Object_synonym: UPAR
Object_synonym: uPAR

subject: PR_000001969
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00021
  Ontology_term: u-PAR/Ly-6 domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001970
type: Class
Object_term: vascular cell adhesion protein 1
Object_synonym: CD106
Object_synonym: INCAM-100
Object_synonym: L1CAM
Object_synonym: V-CAM 1
Object_synonym: VCAM-1
Object_synonym: VCAM1

subject: PR_000001970
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001970
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF05790
  Ontology_term: Immunoglobulin C2-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001970
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07679
  Ontology_term: Immunoglobulin I-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001970
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001971
type: Class
Object_term: vascular endothelial growth factor receptor

subject: PR_000001971
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001971
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07679
  Ontology_term: Immunoglobulin I-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001971
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001971
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001974
type: Class
Object_term: voltage-gated calcium channel subunit alpha

subject: PR_000001974
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001974
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF08763
  Ontology_term: Voltage gated calcium channel IQ domain
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001975
type: Class
Object_term: voltage-gated sodium channel subunit alpha

subject: PR_000001975
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00520
  Ontology_term: Ion transport protein
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001975
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00612
  Ontology_term: IQ calmodulin-binding motif
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000001975
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF06512
  Ontology_term: Sodium ion transport-associated
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000001998
type: Class
Object_term: C-C motif chemokine 3/4

subject: PR_000001998
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00048
  Ontology_term: Small cytokines (intecrine/chemokine), interleukin-8 like
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002001
type: Class
Object_term: receptor-type tyrosine-protein kinase FLT3
Object_synonym: CD135
Object_synonym: fetal liver kinase 2
Object_synonym: FL cytokine receptor
Object_synonym: FLK-2
Object_synonym: FLK2
Object_synonym: FLT-3
Object_synonym: FLT3
Object_synonym: Fms-like tyrosine kinase 3
Object_synonym: stem cell tyrosine kinase 1
Object_synonym: STK-1
Object_synonym: STK1
Object_synonym: tyrosine-protein kinase FLT3
Object_synonym: tyrosine-protein kinase receptor flk-2
Object_synonym: tyrosine-protein kinase receptor FLT3

subject: PR_000002001
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002001
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002030
type: Class
Object_term: alpha-type platelet-derived growth factor receptor
Object_synonym: alpha platelet-derived growth factor receptor
Object_synonym: CD140 antigen-like family member A
Object_synonym: CD140a
Object_synonym: CD140a antigen
Object_synonym: PDGF-R-alpha
Object_synonym: PDGFR-alpha
Object_synonym: PDGFR2
Object_synonym: PDGFRA
Object_synonym: platelet-derived growth factor alpha receptor
Object_synonym: RHEPDGFRA

subject: PR_000002030
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002030
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07679
  Ontology_term: Immunoglobulin I-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002030
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002030
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002035
type: Class
Object_term: beta-type platelet-derived growth factor receptor
Object_synonym: beta platelet-derived growth factor receptor
Object_synonym: CD140 antigen-like family member B
Object_synonym: CD140b
Object_synonym: PDGF-R-beta
Object_synonym: Pdgfr
Object_synonym: PDGFR-1
Object_synonym: PDGFR-beta
Object_synonym: PDGFR1
Object_synonym: PDGFRB
Object_synonym: platelet-derived growth factor receptor 1

subject: PR_000002035
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002035
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07679
  Ontology_term: Immunoglobulin I-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002035
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002038
type: Class
Object_term: eotaxin-like cytokine

subject: PR_000002038
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00048
  Ontology_term: Small cytokines (intecrine/chemokine), interleukin-8 like
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002059
type: Class
Object_term: lymphotactin-like chemokine

subject: PR_000002059
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00048
  Ontology_term: Small cytokines (intecrine/chemokine), interleukin-8 like
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002062
type: Class
Object_term: macrophage colony-stimulating factor 1 receptor
Object_synonym: CD115
Object_synonym: CSF-1 receptor
Object_synonym: CSF-1-R
Object_synonym: CSF-1R
Object_synonym: CSF1R
Object_synonym: Csfmr
Object_synonym: FMS
Object_synonym: M-CSF-R
Object_synonym: proto-oncogene c-Fms

subject: PR_000002062
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002062
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07679
  Ontology_term: Immunoglobulin I-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002062
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002062
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002065
type: Class
Object_term: mast/stem cell growth factor receptor
Object_synonym: CD117
Object_synonym: KIT
Object_synonym: proto-oncogene c-Kit
Object_synonym: SCFR
Object_synonym: Sl
Object_synonym: tyrosine-protein kinase Kit

subject: PR_000002065
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00047
  Ontology_term: Immunoglobulin domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002065
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07679
  Ontology_term: Immunoglobulin I-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002065
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07686
  Ontology_term: Immunoglobulin V-set domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002065
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002094
type: Class
Object_term: C-C motif chemokine 5
Object_synonym: CCL5
Object_synonym: D17S136E
Object_synonym: EoCP
Object_synonym: eosinophil chemotactic cytokine
Object_synonym: RANTES
Object_synonym: SCYA5
Object_synonym: SIS-delta
Object_synonym: small inducible cytokine A5
Object_synonym: small-inducible cytokine A5
Object_synonym: T cell-specific protein P228
Object_synonym: T-cell-specific protein RANTES
Object_synonym: TCP228

subject: PR_000002094
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00048
  Ontology_term: Small cytokines (intecrine/chemokine), interleukin-8 like
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002110
type: Class
Object_term: tyrosine-protein kinase BTK
Object_synonym: agammaglobulinaemia tyrosine kinase
Object_synonym: agammaglobulinemia tyrosine kinase
Object_synonym: AGMX1
Object_synonym: ATK
Object_synonym: B-cell progenitor kinase
Object_synonym: BPK
Object_synonym: bruton tyrosine kinase
Object_synonym: BTK
Object_synonym: kinase EMB

subject: PR_000002110
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00017
  Ontology_term: SH2 domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002110
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00018
  Ontology_term: SH3 domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002110
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00169
  Ontology_term: PH domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002110
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00779
  Ontology_term: BTK motif
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002110
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002111
type: Class
Object_term: tyrosine-protein kinase ITK/TSK
Object_synonym: EMT
Object_synonym: IL-2-inducible T-cell kinase
Object_synonym: ITK
Object_synonym: kinase EMT
Object_synonym: kinase TLK
Object_synonym: LYK
Object_synonym: T-cell-specific kinase
Object_synonym: Tlk
Object_synonym: Tsk
Object_synonym: tyrosine-protein kinase Lyk

subject: PR_000002111
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00017
  Ontology_term: SH2 domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002111
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00018
  Ontology_term: SH3 domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002111
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00169
  Ontology_term: PH domain
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002111
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00779
  Ontology_term: BTK motif
Date: 2009-03-26
Assigned_by: PRO:CNA

subject: PR_000002111
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF07714
  Ontology_term: Protein tyrosine kinase
Date: 2009-03-26
Assigned_by: PRO:CNA

PR_000002131
type: Class
Object_term: angiopoietin-1 receptor sequence variant R849W (human)
Object_synonym: angiopoietin-1 receptor sequence variant 1 (human)
Object_synonym: hTEK/var:R849W
Object_synonym: UniProtKB:Q02763-1, Arg-849, CHEBI:29954

subject: PR_000002131
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050792
  Ontology_term: multiple cutaneous and mucosal venous malformations
Evidence_source: PMID:10369874
Evidence_source: PMID:8980225
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006352
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000002131
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P27986-1
Evidence_source: PMID:10369874
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006352
Date: 2009-03-09
Assigned_by: PRO:CNA
Comments: Note=Binding to SH2 domain (PF00017) of p85

PR_000002132
type: Class
Object_term: angiopoietin-1 receptor sequence variant Y897S (human)
Object_synonym: angiopoietin-1 receptor sequence variant 2 (human)
Object_synonym: hTEK/var:Y897S
Object_synonym: UniProtKB:Q02763-1, Tyr-897, CHEBI:29999

subject: PR_000002132
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050792
  Ontology_term: multiple cutaneous and mucosal venous malformations
Evidence_source: PMID:10369874
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008716
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000002132
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P27986-1
Evidence_source: PMID:10369874
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008716
Date: 2009-03-09
Assigned_by: PRO:CNA
Comments: Note=Binding to SH2 domain (PF00017) of p85

PR_000002173
type: Class
Object_term: zinc finger protein Helios isoform 1
Object_synonym: IKZF2/iso:1
Object_synonym: zinc finger protein Helios isoform B

subject: PR_000002173
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0046982
  Ontology_term: protein heterodimerization activity
Interaction_with: PR O08900
Interaction_with: PR Q03267-1
Evidence_source: MGI:1203354
Evidence_source: PMID:9560339
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:1342541
Date: 2009-05-13
Assigned_by: MGI:MGI

PR_000002174
type: Class
Object_term: zinc finger protein Helios isoform 2
Object_synonym: IKZF2/iso:2
Object_synonym: zinc finger protein Helios isoform A

subject: PR_000002174
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0046982
  Ontology_term: protein heterodimerization activity
Interaction_with: PR P81183-1
Interaction_with: PR P81183-2
Evidence_source: MGI:1203354
Evidence_source: PMID:9560339
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:1342541
Date: 2011-12-16
Assigned_by: MGI:MGI

PR_000002186
type: Class
Object_term: Bcl-2-like apoptosis inhibitor

subject: PR_000002186
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02180
  Ontology_term: Bcl-2 homology region 4
Date: 2009-05-12
Assigned_by: PRO:CNA

PR_000002190
type: Class
Object_term: RAC-alpha serine/threonine-protein kinase
Object_synonym: Akt
Object_synonym: AKT1
Object_synonym: AKT1 kinase
Object_synonym: PKB
Object_synonym: PKB alpha
Object_synonym: protein kinase B
Object_synonym: protein kinase B alpha
Object_synonym: proto-oncogene c-Akt
Object_synonym: RAC
Object_synonym: RAC-PK-alpha
Object_synonym: thymoma viral proto-oncogene

subject: PR_000002190
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002190
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00169
  Ontology_term: PH domain
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002190
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00433
  Ontology_term: Protein kinase C terminal domain
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002190
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00787
  Ontology_term: PX domain
Date: 2009-05-12
Assigned_by: PRO:CNA

PR_000002191
type: Class
Object_term: TNF receptor-associated factor
Object_synonym: TRAF

subject: PR_000002191
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00097
  Ontology_term: Zinc finger, C3HC4 type (RING finger)
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002191
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00917
  Ontology_term: MATH domain
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002191
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02176
  Ontology_term: TRAF-type zinc finger
Date: 2009-05-12
Assigned_by: PRO:CNA

PR_000002195
type: Class
Object_term: caspase-1-like protease

subject: PR_000002195
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00619
  Ontology_term: Caspase recruitment domain
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002195
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00656
  Ontology_term: Caspase domain
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002195
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF02758
  Ontology_term: PAAD/DAPIN/Pyrin domain
Date: 2009-05-12
Assigned_by: PRO:CNA

PR_000002196
type: Class
Object_term: caspase-3-like protease

subject: PR_000002196
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00656
  Ontology_term: Caspase domain
Date: 2009-05-12
Assigned_by: PRO:CNA

PR_000002197
type: Class
Object_term: caspase-8-like protease

subject: PR_000002197
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00656
  Ontology_term: Caspase domain
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002197
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01335
  Ontology_term: Death effector domain
Date: 2009-05-12
Assigned_by: PRO:CNA

PR_000002199
type: Class
Object_term: cytochrome c protein

subject: PR_000002199
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00034
  Ontology_term: Cytochrome c
Date: 2009-05-12
Assigned_by: PRO:CNA

PR_000002201
type: Class
Object_term: dynein light chain

subject: PR_000002201
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF01221
  Ontology_term: Dynein light chain type 1
Date: 2009-05-12
Assigned_by: PRO:CNA

PR_000002210
type: Class
Object_term: protein kinase C, delta-like
Object_synonym: Ca(2+)-independent PKC
Object_synonym: Calcium independent PKC
Object_synonym: nPKC

subject: PR_000002210
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002210
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00130
  Ontology_term: Phorbol esters/diacylglycerol binding domain (C1 domain)
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002210
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00168
  Ontology_term: C2 domain
Date: 2009-05-12
Assigned_by: PRO:CNA

subject: PR_000002210
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00433
  Ontology_term: Protein kinase C terminal domain
Date: 2009-05-12
Assigned_by: PRO:CNA

PR_000002212
type: Class
Object_term: serine/threonine-protein kinase, MST4-like

subject: PR_000002212
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00069
  Ontology_term: Protein kinase domain
Date: 2009-05-12
Assigned_by: PRO:CNA

PR_000002684
type: Class
Object_term: voltage-gated potassium channel subunit KCNA5 isoform 2 unmodified form
Object_synonym: KCNA5/iso:2/UnMod

subject: PR_000002684
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005887
  Ontology_term: integral component of plasma membrane
Evidence_source: MGI:63618
Evidence_source: PMID:8226976
Evidence_code: IC
Taxon: NCBITaxon:10090
Inferred_from: GO:0005249
DB_ID: MGI:96662
Date: 2014-04-25
Assigned_by: MGI:MGI

PR_000002988
type: Class
Object_term: zinc finger protein Eos isoform 1
Object_synonym: IKZF4/iso:1

subject: PR_000002988
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0046982
  Ontology_term: protein heterodimerization activity
Interaction_with: PR Q03267-1
Evidence_source: MGI:1333610
Evidence_source: PMID:10218586
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:1343139
Date: 2009-05-15
Assigned_by: MGI:MGI

PR_000002989
type: Class
Object_term: zinc finger protein Eos isoform 2
Object_synonym: IKZF4/iso:2

subject: PR_000002989
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Interaction_with: PR Q8C208-1
Evidence_source: MGI:1333610
Evidence_source: PMID:10218586
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:1343139
Date: 2009-05-15
Assigned_by: MGI:MGI

PR_000010211
type: Class
Object_term: protein max
Object_synonym: bHLH clade B
Object_synonym: BHLHD4
Object_synonym: bHLHd4
Object_synonym: class D basic helix-loop-helix protein 4
Object_synonym: MAX
Object_synonym: Myc-associated factor X
Object_synonym: Myc-binding novel HLH/LZ protein
Object_synonym: Myn
Object_synonym: protein myn

subject: PR_000010211
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00010
  Ontology_term: Helix-loop-helix DNA-binding domain
Evidence_source: PIRSF:PIRSF038026
Evidence_code: ISS
Date: 2010-09-25
Assigned_by: PRO:CNA

PR_000022012
type: Class
Object_term: nucleolar transcription factor 1 isoform UBF2
Object_synonym: nucleolar transcription factor 1 isoform 2
Object_synonym: nucleolar transcription factor 1 isoform short
Object_synonym: UBTF/iso:UBF2

subject: PR_000022012
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005730
  Ontology_term: nucleolus
Evidence_source: MGI:3836497
Evidence_source: PMID:19103806
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:98512
Date: 2009-12-15
Assigned_by: MGI:MGI

subject: PR_000022012
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0000183
  Ontology_term: chromatin silencing at rDNA
Evidence_source: MGI:3836497
Evidence_source: PMID:19103806
Evidence_code: IMP
Taxon: NCBITaxon:10090
DB_ID: MGI:98512
Date: 2009-12-15
Assigned_by: MGI:MGI

PR_000022016
type: Class
Object_term: sphingolipid Delta(4)-desaturase/C4-monooxygenase DES2 isoform 1
Object_synonym: DEGS2/iso:1

subject: PR_000022016
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0000170
  Ontology_term: sphingosine hydroxylase activity
Evidence_source: MGI:3056825
Evidence_source: PMID:15474011
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1917309
Date: 2010-02-02
Assigned_by: MGI:MGI

subject: PR_000022016
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0000170
  Ontology_term: sphingosine hydroxylase activity
Evidence_source: MGI:3694278
Evidence_source: PMID:16571104
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1917309
Date: 2010-02-02
Assigned_by: MGI:MGI

subject: PR_000022016
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006667
  Ontology_term: sphinganine metabolic process
Evidence_source: MGI:3694278
Evidence_source: PMID:16571104
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1917309
Date: 2010-02-02
Assigned_by: MGI:MGI

subject: PR_000022016
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0046513
  Ontology_term: ceramide biosynthetic process
Evidence_source: MGI:3694278
Evidence_source: PMID:16571104
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1917309
Date: 2010-02-02
Assigned_by: MGI:MGI

PR_000024937
type: Class
Object_term: FUN30 homodimer (yeast)
Object_synonym: y(FUN30)*2

subject: PR_000024937
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Evidence_source: PMID:23779104
Evidence_code: IDA
Taxon: NCBITaxon:559292
Date: 2014-12-14
Assigned_by: PRO:CNA

subject: PR_000024937
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003682
  Ontology_term: chromatin binding
Evidence_source: PMID:23779104
Evidence_code: IDA
Taxon: NCBITaxon:559292
Date: 2014-01-14
Assigned_by: PRO:CNA

subject: PR_000024937
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004386
  Ontology_term: helicase activity
Evidence_source: PMID:23779104
Evidence_code: IDA
Taxon: NCBITaxon:559292
Date: 2014-01-14
Assigned_by: PRO:CNA

subject: PR_000024937
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008094
  Ontology_term: DNA-dependent ATPase activity
Evidence_source: PMID:23779104
Evidence_code: IDA
Taxon: NCBITaxon:559292
Date: 2014-01-14
Assigned_by: PRO:CNA

subject: PR_000024937
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0042766
  Ontology_term: nucleosome mobilization
Evidence_source: PMID:23779104
Evidence_code: IDA
Taxon: NCBITaxon:559292
Date: 2014-01-14
Assigned_by: PRO:CNA

PR_000025509
type: Class
Object_term: synapsin-1 isoform 1b
Object_synonym: SYN1 isoform 2
Object_synonym: SYN1/iso:1b
Object_synonym: synapsin-1 isoform 2
Object_synonym: synapsin-1 isoform Ib

subject: PR_000025509
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P04925
Evidence_source: MGI:2153789
Evidence_source: PMID:11571277
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:98460
Date: 2010-04-15
Assigned_by: MGI:MGI

PR_000025560
type: Class
Object_term: amyloid-beta precursor protein sequence variant D678N (human)
Object_synonym: hAPP/var:D678N
Object_synonym: Tottori APP

subject: PR_000025560
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:15201367
Evidence_source: UniProtKB_VAR:VAR_044424
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_044424
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025561
type: Class
Object_term: amyloid-beta precursor protein sequence variant A692G (human)
Object_synonym: Flemish APP
Object_synonym: hAPP/var:A692G

subject: PR_000025561
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:11311152
Evidence_source: PMID:1303239
Evidence_source: PMID:9754958
Evidence_source: UniProtKB_VAR:VAR_000016
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000016
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025562
type: Class
Object_term: amyloid-beta precursor protein sequence variant E693G (human)
Object_synonym: Arctic APP
Object_synonym: hAPP/var:E693G

subject: PR_000025562
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:11528419
Evidence_source: PMID:1415269
Evidence_source: UniProtKB_VAR:VAR_014215
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_014215
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025563
type: Class
Object_term: amyloid-beta precursor protein sequence variant E693K (human)
Object_synonym: hAPP/var:E693K
Object_synonym: Italian APP

subject: PR_000025563
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9246
  Ontology_term: cerebral amyloid angiopathy
Evidence_source: UniProtKB_VAR:VAR_014216
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_014216
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025564
type: Class
Object_term: amyloid-beta precursor protein sequence variant E693Q (human)
Object_synonym: Dutch APP
Object_synonym: hAPP/var:E693Q

subject: PR_000025564
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9246
  Ontology_term: cerebral amyloid angiopathy
Evidence_source: PMID:2111584
Evidence_source: UniProtKB_VAR:VAR_000017
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000017
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025565
type: Class
Object_term: amyloid-beta precursor protein sequence variant D694N (human)
Object_synonym: hAPP/var:D694N
Object_synonym: Iowa APP

subject: PR_000025565
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-d694n-iowa
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-d694n-iowa
Date: 2018-05-10
Assigned_by: PRO:DAN

subject: PR_000025565
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9246
  Ontology_term: cerebral amyloid angiopathy
Evidence_source: PMID:11409420
Evidence_source: PMID:12654973
Evidence_source: UniProtKB_VAR:VAR_014217
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_014217
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025566
type: Class
Object_term: amyloid-beta precursor protein sequence variant L705V (human)
Object_synonym: hAPP/var:L705V

subject: PR_000025566
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9246
  Ontology_term: cerebral amyloid angiopathy
Evidence_source: PMID:16178030
Evidence_source: UniProtKB_VAR:VAR_032276
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_032276
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025567
type: Class
Object_term: amyloid-beta precursor protein sequence variant A713T (human)
Object_synonym: hAPP/var:A713T

subject: PR_000025567
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:1303275
Evidence_source: PMID:15365148
Evidence_source: UniProtKB_VAR:VAR_000019
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000019
Date: 2012-04-12
Assigned_by: PRO:DAN

subject: PR_000025567
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9246
  Ontology_term: cerebral amyloid angiopathy
Evidence_source: Alzforum:app-a713t
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-a713t
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025568
type: Class
Object_term: amyloid-beta precursor protein sequence variant T714A (human)
Object_synonym: hAPP/var:T714A
Object_synonym: Iranian APP

subject: PR_000025568
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:12034808
Evidence_source: UniProtKB_VAR:VAR_032277
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_032277
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025569
type: Class
Object_term: amyloid-beta precursor protein sequence variant T714I (human)
Object_synonym: Austrian APP
Object_synonym: hAPP/var:T714I

subject: PR_000025569
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:11063718
Evidence_source: PMID:15668448
Evidence_source: UniProtKB_VAR:VAR_014218
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_014218
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025570
type: Class
Object_term: amyloid-beta precursor protein sequence variant V715M (human)
Object_synonym: French APP
Object_synonym: hAPP/var:V715M

subject: PR_000025570
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:10097173
Evidence_source: UniProtKB_VAR:VAR_010108
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010108
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025571
type: Class
Object_term: amyloid-beta precursor protein sequence variant I716V (human)
Object_synonym: Florida APP
Object_synonym: hAPP/var:I716V

subject: PR_000025571
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:9328472
Evidence_source: UniProtKB_VAR:VAR_000020
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000020
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025572
type: Class
Object_term: amyloid-beta precursor protein sequence variant V717F (human)
Object_synonym: hAPP/var:V717F
Object_synonym: Indiana APP

subject: PR_000025572
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:1925564
Evidence_source: PMID:8267572
Evidence_source: PMID:8290042
Evidence_source: PMID:8476439
Evidence_source: UniProtKB_VAR:VAR_000023
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000023
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025573
type: Class
Object_term: amyloid-beta precursor protein sequence variant V717G (human)
Object_synonym: hAPP/var:V717G

subject: PR_000025573
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:1944558
Evidence_source: PMID:8476439
Evidence_source: UniProtKB_VAR:VAR_000022
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000022
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025574
type: Class
Object_term: amyloid-beta precursor protein sequence variant V717I (human)
Object_synonym: hAPP/var:V717I
Object_synonym: London APP

subject: PR_000025574
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:10631141
Evidence_source: PMID:1671712
Evidence_source: PMID:1678058
Evidence_source: PMID:1908231
Evidence_source: PMID:8267572
Evidence_source: PMID:8476439
Evidence_source: PMID:8577393
Evidence_source: UniProtKB_VAR:VAR_000021
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000021
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025575
type: Class
Object_term: amyloid-beta precursor protein sequence variant V717L (human)
Object_synonym: hAPP/var:V717L

subject: PR_000025575
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:10867787
Evidence_source: UniProtKB_VAR:VAR_014219
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_014219
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025576
type: Class
Object_term: amyloid-beta precursor protein sequence variant L723P (human)
Object_synonym: Australian APP
Object_synonym: hAPP/var:L723P

subject: PR_000025576
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:10665499
Evidence_source: UniProtKB_VAR:VAR_010109
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010109
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025591
type: Class
Object_term: amyloid-beta precursor protein sequence variant A673T (human)
Object_synonym: hAPP/var:A673T
Object_synonym: Icelandic APP

subject: PR_000025591
predicate:
  Relation: associated_with_disease_suppression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-a673t-icelandic
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-a673t-icelandic
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025594
type: Class
Object_term: amyloid-beta precursor protein sequence variant V715A (human)
Object_synonym: German APP
Object_synonym: hAPP/var:V715A

subject: PR_000025594
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-v715a-german
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-v715a-german
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025595
type: Class
Object_term: amyloid-beta precursor protein sequence variant I716F (human)
Object_synonym: hAPP/var:I716F
Object_synonym: Iberian APP

subject: PR_000025595
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-i716f-iberian
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-i716f-iberian
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025596
type: Class
Object_term: amyloid-beta precursor protein sequence variant I716T (human)
Object_synonym: hAPP/var:I716T

subject: PR_000025596
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-i716t
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-i716t
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025597
type: Class
Object_term: amyloid-beta precursor protein sequence variant T719P (human)
Object_synonym: hAPP/var:T719P

subject: PR_000025597
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-t719p
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-t719p
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025598
type: Class
Object_term: amyloid-beta precursor protein sequence variant K724N (human)
Object_synonym: Belgian APP
Object_synonym: hAPP/var:K724N

subject: PR_000025598
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-k724n-belgian
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-k724n-belgian
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025599
type: Class
Object_term: amyloid-beta precursor protein sequence variant E682K (human)
Object_synonym: hAPP/var:E682K
Object_synonym: Leuven APP

subject: PR_000025599
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-e682k-leuven
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-e682k-leuven
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025601
type: Class
Object_term: amyloid-beta precursor protein sequence variant KM670/671NL (human)
Object_synonym: hAPP/var:KM670/671NL
Object_synonym: Swedish APP

subject: PR_000025601
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: UniProtKB_VAR:VAR_000015
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000015
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025602
type: Class
Object_term: amyloid-beta precursor protein sequence variant E693del (human)
Object_synonym: APP deltaGlu693
Object_synonym: APP E693delta
Object_synonym: hAPP/var:E693del
Object_synonym: Osaka APP

subject: PR_000025602
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-e693del-osaka
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-e693del-osaka
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025633
type: Class
Object_term: mediator of RNA polymerase II transcription subunit 28 isoform 1 phosphorylated 1 (human)
Object_synonym: hMED28/iso:1/Phos:1
Object_synonym: UniProtKB:Q9H204-1, Tyr-64, MOD:00048

subject: PR_000025633
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P62993
Evidence_source: PMID:16899217
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9H204-1
Date: 2010-05-10
Assigned_by: PRO:JAN

PR_000025637
type: Class
Object_term: G1/S-specific cyclin-E1 isoform 3 phosphorylated 1 (human)
Object_synonym: hCCNE1/iso:3/Phos:1
Object_synonym: UniProtKB:P24864-3, Ser-384, MOD:00046

subject: PR_000025637
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q13526
Evidence_source: PMID:16223725
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P24864-3
Date: 2010-05-10
Assigned_by: PRO:JAN

PR_000025639
type: Class
Object_term: platelet endothelial aggregation receptor 1 isoform 1 phosphorylated 1 (human)
Object_synonym: hPEAR1/iso:1/Phos:1
Object_synonym: UniProtKB:Q5VY43-1, Tyr-925, MOD:00048
Object_synonym: Ser-953/Ser-1029, MOD:00046

subject: PR_000025639
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P29353
Evidence_source: PMID:15851471
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q5VY43-1
Date: 2010-05-15
Assigned_by: PRO:CNA

subject: PR_000025639
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P98077
Evidence_source: PMID:15851471
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q5VY43-1
Date: 2010-05-15
Assigned_by: PRO:CNA

subject: PR_000025639
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:15851471
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q5VY43-1
Date: 2010-05-15
Assigned_by: PRO:CNA

PR_000025641
type: Class
Object_term: E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human)
Object_synonym: hSIAH1/iso:1/Phos:1
Object_synonym: UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048

subject: PR_000025641
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0043525
  Ontology_term: positive regulation of neuron apoptotic process
Evidence_source: PMID:16230351
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8IUQ4-1
Date: 2010-05-15
Assigned_by: PRO:CNA

subject: PR_000025641
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0070304
  Ontology_term: positive regulation of stress-activated protein kinase signaling cascade
Evidence_source: PMID:16230351
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8IUQ4-1
Date: 2010-05-15
Assigned_by: PRO:CNA

subject: PR_000025641
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000045369
Interaction_with: PR Q69ZI1-1
Evidence_source: PMID:16230351
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8IUQ4-1
Date: 2015-11-05
Assigned_by: PRO:CNA

PR_000025712
type: Class
Object_term: alpha-actinin-1 isoform 1 phosphorylated 1 (human)
Object_synonym: hACTN1/iso:1/Phos:1
Object_synonym: UniProtKB:P12814-1, Tyr-12, MOD:00048

subject: PR_000025712
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P12931
Evidence_source: PMID:16291744
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12814-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025712
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0019903
  Ontology_term: protein phosphatase binding
Interaction_with: PR P18031
Evidence_source: PMID:16291744
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12814-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025712
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0016477
  Ontology_term: cell migration
Evidence_source: PMID:16291744
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12814-1
Date: 2010-05-20
Assigned_by: PRO:JAN

PR_000025714
type: Class
Object_term: B-cell lymphoma/leukemia 10 isoform 1 phosphorylated 1 (human)
Object_synonym: hBCL10/iso:1/Phos:1
Object_synonym: UniProtKB:O95999-1, Ser-218/Ser-231, MOD:00046

subject: PR_000025714
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P20749
Evidence_source: PMID:16280327
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O95999-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025714
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:16280327
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O95999-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025714
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0032996
  Ontology_term: Bcl3-Bcl10 complex
Evidence_source: PMID:16280327
Evidence_code: EXP
Taxon: NCBITaxon:9606
Inferred_from: UniProtKB:P20749
DB_ID: UniProtKB:O95999-1
Date: 2010-05-20
Assigned_by: PRO:JAN

PR_000025723
type: Class
Object_term: heat shock factor protein 1 isoform Long phosphorylated 1 (human)
Object_synonym: hHSF1/iso:Long/Phos:1
Object_synonym: UniProtKB:Q00613-1, Ser-121, MOD:00046

subject: PR_000025723
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P07900
Evidence_source: PMID:16278218
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q00613-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025723
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P08238
Evidence_source: PMID:16278218
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q00613-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025723
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0044212
  Ontology_term: transcription regulatory region DNA binding
Modifier: NOT
Evidence_source: PMID:16278218
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q00613-1
Date: 2015-08-20
Assigned_by: PRO:JAN

PR_000025725
type: Class
Object_term: heat shock factor protein 1 isoform Long phosphorylated 2 (human)
Object_synonym: hHSF1/iso:Long/Phos:2
Object_synonym: UniProtKB:Q00613-1, Ser-303/Ser-307, MOD:00046

subject: PR_000025725
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P62258
Evidence_source: PMID:12917326
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q00613-1
Date: 2015-05-04
Assigned_by: PRO:CNA

subject: PR_000025725
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:12917326
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q00613-1
Date: 2015-05-04
Assigned_by: PRO:CNA

PR_000025727
type: Class
Object_term: Bcl-2-like protein 11 isoform 1 phosphorylated 1 (human)
Object_synonym: hBCL2L11/iso:1/Phos:1
Object_synonym: UniProtKB:O43521-1, Ser-87, MOD:00046

subject: PR_000025727
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P31946
Evidence_source: PMID:16282323
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43521-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025727
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:16282323
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43521-1
Date: 2010-05-20
Assigned_by: PRO:JAN

PR_000025750
type: Class
Object_term: cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 (human)
Object_synonym: hCDKN1B/iso:1/Phos:2
Object_synonym: UniProtKB:P46527-1, Tyr-88, MOD:00048

subject: PR_000025750
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P20248
Evidence_source: PMID:17254966
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

subject: PR_000025750
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P24385
Evidence_source: PMID:17254966
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

subject: PR_000025750
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P24864
Evidence_source: PMID:17254966
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

subject: PR_000025750
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0044877
  Ontology_term: protein-containing complex binding
Interaction_with: PR_000026741
Evidence_source: PMID:17254966
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

subject: PR_000025750
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0051318
  Ontology_term: G1 phase
Evidence_source: PMID:17254966
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

subject: PR_000025750
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004861
  Ontology_term: cyclin-dependent protein serine/threonine kinase inhibitor activity
Modifier: decreased
Relative_to: PR_000045370
Evidence_source: PMID:17254966
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

PR_000025763
type: Class
Object_term: interferon regulatory factor 3 isoform 1 phosphorylated 1 (human)
Object_synonym: hIRF3/iso:1/Phos:1
Object_synonym: IRF3-P (human)
Object_synonym: UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046

subject: PR_000025763
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR O14980
Evidence_source: PMID:10805757
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7149
Date: 2011-05-13
Assigned_by: PRO:CNA
Comments: Evidence=Fig4f

subject: PR_000025763
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: Reactome:REACT_7149
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q14653-1
Date: 2010-07-18
Assigned_by: PRO:CNA

PR_000025765
type: Class
Object_term: IRF3-P:IRF3-P complex (human)

subject: PR_000025765
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:10805757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7444
Date: 2011-05-13
Assigned_by: PRO:CNA

subject: PR_000025765
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005654
  Ontology_term: nucleoplasm
Evidence_source: Reactome:REACT_7444
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7444
Date: 2010-07-18
Assigned_by: PRO:CNA

subject: PR_000025765
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: Reactome:REACT_7146
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7146
Date: 2010-07-18
Assigned_by: PRO:CNA

subject: PR_000025765
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

subject: PR_000025765
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: Reactome:REACT_6894

subject: PR_000025765
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0034340
  Ontology_term: response to type I interferon
Evidence_source: PMID:10805757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7444
Date: 2011-05-13
Assigned_by: PRO:CNA

subject: PR_000025765
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0039528
  Ontology_term: cytoplasmic pattern recognition receptor signaling pathway in response to virus
Evidence_source: Reactome:REACT_7146
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

PR_000025773
type: Class
Object_term: lipopolysaccharide receptor complex 3 (human)
Object_synonym: h(LPSR:3)
Object_synonym: TLR4:MD2:LPS:CD14 (human)

subject: PR_000025773
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2015-05-13
Assigned_by: PRO:CNA

PR_000025780
type: Class
Object_term: CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)
Object_synonym: CD3 gamma with phosphorylated ITAM (human)
Object_synonym: hCD3G/iso:1/SigPep-/Phos:1
Object_synonym: PRO_0000014615, Tyr-160/Tyr-171, MOD:00048
Object_synonym: UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048

subject: PR_000025780
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_13072
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P09693-1
Date: 2010-07-18
Assigned_by: PRO:CNA

PR_000025782
type: Class
Object_term: CD3 epsilon:CD3 gamma with phosphorylated ITAM (human)
Object_synonym: h(CD3E:CD3G)

subject: PR_000025782
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_13214
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_13214
Date: 2010-07-18
Assigned_by: PRO:CNA

PR_000025786
type: Class
Object_term: lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
Object_synonym: hLY96/iso:1/SigPep-/NGlyco:1
Object_synonym: MD-2 glycosylated
Object_synonym: PRO_0000018619, Asn-26/Asn-114, MOD:00160
Object_synonym: UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160

subject: PR_000025786
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0001530
  Ontology_term: lipopolysaccharide binding
Evidence_source: PMID:17569869
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Y9-1
Date: 2014-05-14
Assigned_by: PRO:CNA
Comments: Occurs_in=PR:000025773.

subject: PR_000025786
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:1990458
  Ontology_term: lipooligosaccharide binding
Evidence_source: PMID:19783674
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Y9-1
Date: 2014-08-14
Assigned_by: PRO:CNA
Comments: Target=lipooligosaccharide (CHEBI:35371).

subject: PR_000025786
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11593030
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Y9-1
Date: 2010-07-18
Assigned_by: PRO:CNA

subject: PR_000025786
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:19783674
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Y9-1
Date: 2014-08-14
Assigned_by: PRO:CNA

subject: PR_000025786
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_7660
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Y9-1
Date: 2013-05-20
Assigned_by: PRO:CNA

PR_000025790
type: Class
Object_term: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
Object_synonym: hCD28/iso:1/SigPep-/Phos:1
Object_synonym: PRO_0000014652, Tyr-191, MOD:00048
Object_synonym: UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048

subject: PR_000025790
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_20178
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P10747-1
Date: 2010-07-18
Assigned_by: PRO:CNA

PR_000025792
type: Class
Object_term: phospho CD28 homodimer (human)
Object_synonym: h(CD28/iso:1/SigPep-/Phos:1)*2

subject: PR_000025792
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_20268
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_20268
Date: 2010-07-18
Assigned_by: PRO:CNA

PR_000025800
type: Class
Object_term: eukaryotic translation initiation factor 3 subunit F isoform 1 CDK11-phosphorylated 1 (human)
Object_synonym: hEIF3F/iso:1/Phos:1
Object_synonym: UniProtKB:O00303-1, Ser-46, MOD:00046
Object_synonym: Thr-119, MOD:00047

subject: PR_000025800
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0005852
  Ontology_term: eukaryotic translation initiation factor 3 complex
Evidence_source: PMID:19245811
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O00303-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025800
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0017148
  Ontology_term: negative regulation of translation
Evidence_source: PMID:19245811
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O00303-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025800
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0043065
  Ontology_term: positive regulation of apoptotic process
Evidence_source: PMID:19245811
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O00303-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025800
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0031369
  Ontology_term: translation initiation factor binding
Modifier: increased
Relative_to: PR_000025839
Interaction_with: PR P55884
Evidence_source: PMID:19245811
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O00303-1
Date: 2010-08-04
Assigned_by: PRO:JAN

PR_000025834
type: Class
Object_term: tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)
Object_synonym: mSYK/iso:1/Phos:1
Object_synonym: UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048

subject: PR_000025834
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0019901
  Ontology_term: protein kinase binding
Interaction_with: PR P09769
Evidence_source: PMID:15536084
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P48025-1
Date: 2010-08-04
Assigned_by: PRO:JAN
Comments: Note=SH2 domain (PF00017) of p85is involved in binding

subject: PR_000025834
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0031625
  Ontology_term: ubiquitin protein ligase binding
Interaction_with: PR P09769
Evidence_source: PMID:15536084
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P48025-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025834
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0043548
  Ontology_term: phosphatidylinositol 3-kinase binding
Interaction_with: PR P27986
Evidence_source: PMID:15536084
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P48025-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025834
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0002433
  Ontology_term: immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Evidence_source: PMID:15536084
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P48025-1
Date: 2010-08-04
Assigned_by: PRO:JAN

PR_000025837
type: Class
Object_term: protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 (human)
Object_synonym: hMDM4/iso:1/PhosUbiq:1
Object_synonym: UniProtKB:O15151-1, Ser-367, MOD:00046
Object_synonym: MOD:01148

subject: PR_000025837
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P27348
Evidence_source: PMID:16511560
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O15151-1
Date: 2015-05-04
Assigned_by: PRO:JAN

subject: PR_000025837
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P61981
Evidence_source: PMID:16511572
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O15151-1
Date: 2015-05-04
Assigned_by: PRO:CNA

subject: PR_000025837
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:16511560
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O15151-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025837
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0043516
  Ontology_term: regulation of DNA damage response, signal transduction by p53 class mediator
Evidence_source: PMID:16511560
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O15151-1
Date: 2010-08-04
Assigned_by: PRO:JAN

PR_000025865
type: Class
Object_term: bacterial glutaminase

subject: PR_000025865
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF04960
  Ontology_term: Glutaminase
Evidence_source: PIRSF:PIRSF005073
Evidence_code: ISS
Date: 2010-09-21
Assigned_by: PRO:CNA

PR_000025873
type: Class
Object_term: glutaminase 1 tetramer (Escherichia coli K-12)

subject: PR_000025873
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004359
  Ontology_term: glutaminase activity
Evidence_source: PMID:18459799
Evidence_code: EXP
Taxon: NCBITaxon:83333
Date: 2010-09-21
Assigned_by: PRO:CNA

PR_000025874
type: Class
Object_term: glutaminase 1 tetramer (Bacillus subtilis subsp. subtilis str. 168)

subject: PR_000025874
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004359
  Ontology_term: glutaminase activity
Evidence_source: PMID:18459799
Evidence_code: EXP
Taxon: NCBITaxon:1423
Date: 2010-09-21
Assigned_by: PRO:CNA

PR_000025875
type: Class
Object_term: serpin

subject: PR_000025875
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00079
  Ontology_term: Serpin (serine protease inhibitor)
Evidence_source: PIRSF:PIRSF001630
Evidence_code: ISS
Date: 2010-09-21
Assigned_by: PRO:CNA

PR_000025879
type: Class
Object_term: siroheme synthase

subject: PR_000025879
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF00590
  Ontology_term: Tetrapyrrole (Corrin/Porphyrin) Methylases
Evidence_source: PIRSF:PIRSF036426
Evidence_code: ISS
Date: 2010-09-21
Assigned_by: PRO:CNA

subject: PR_000025879
predicate:
  Relation: has_part
object:
  Ontology_ID: Pfam:PF10414
  Ontology_term: Sirohaem synthase dimerisation region
Evidence_source: PIRSF:PIRSF036426
Evidence_code: ISS
Date: 2010-09-21
Assigned_by: PRO:CNA

PR_000025882
type: Class
Object_term: siroheme synthase cysG isoform 1 phosphorylated 1 (Salmonella typhimurium)
Object_synonym: cysG/iso:1/Phos:1 (SALTM)
Object_synonym: UniProtKB:P25924-1, Ser-128, MOD:00046

subject: PR_000025882
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0043115
  Ontology_term: precorrin-2 dehydrogenase activity
Modifier: decreased
Relative_to: PR_000025884
Evidence_source: PDB:1PJQ
Evidence_source: PMID:14595395
Evidence_code: EXP
Taxon: NCBITaxon:99287
DB_ID: UniProtKB:P25924-1
Date: 2010-09-21
Assigned_by: PRO:CNA
Comments: Note=Strain information inferred from PDB sequence [PRO:DAN]

PR_000025884
type: Class
Object_term: siroheme synthase cysG isoform 1 unmodified form (Salmonella typhimurium)
Object_synonym: cysG/iso:1/UnMod (SALTM)

subject: PR_000025884
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0043115
  Ontology_term: precorrin-2 dehydrogenase activity
Evidence_source: PDB:1PJQ
Evidence_source: PMID:14595395
Evidence_code: EXP
Taxon: NCBITaxon:99287
DB_ID: UniProtKB:P25924-1
Date: 2015-11-04
Assigned_by: PRO:CNA
Comments: Note=Strain information inferred from PDB sequence [PRO:DAN]

PR_000025892
type: Class
Object_term: transcription factor AP-1 isoform 1 phosphorylated 1 (mouse)
Object_synonym: mJUN/iso:1/Phos:1
Object_synonym: UniProtKB:P05627-1, Ser-63/Ser-73, MOD:00046
Object_synonym: MOD:00696

subject: PR_000025892
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q60739-1
Evidence_source: PMID:20516211
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P05627-1
Date: 2010-08-25
Assigned_by: PRO:HJD

PR_000025906
type: Class
Object_term: phosphocarrier protein HPr isoform 1 phosphorylated 1 (Escherichia coli K-12)
Object_synonym: Ec-ptsH/iso:1/Phos:1
Object_synonym: phosphocarrier protein HPr isoform 1 P-Ser-HPr (Escherichia coli K-12)
Object_synonym: UniProtKB:P0AA04-1, His-15, MOD:00890

subject: PR_000025906
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P0AC86
Evidence_source: PMID:9334229
Evidence_code: IPI
Taxon: NCBITaxon:83333
DB_ID: UniProtKB:P0AA04-1
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025906
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0009927
  Ontology_term: histidine phosphotransfer kinase activity
Evidence_source: PMID:12963714
Evidence_code: EXP
Taxon: NCBITaxon:83333
DB_ID: UniProtKB:P0AA04-1
Date: 2010-09-25
Assigned_by: PRO:CNA

subject: PR_000025906
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0009401
  Ontology_term: phosphoenolpyruvate-dependent sugar phosphotransferase system
Evidence_source: PMID:12963714
Evidence_code: EXP
Taxon: NCBITaxon:83333
DB_ID: UniProtKB:P0AA04-1
Date: 2010-09-25
Assigned_by: PRO:CNA

subject: PR_000025906
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0010675
  Ontology_term: regulation of cellular carbohydrate metabolic process
Evidence_source: PMID:9334229
Evidence_code: EXP
Taxon: NCBITaxon:83333
DB_ID: UniProtKB:P0AA04-1
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025907
type: Class
Object_term: phosphocarrier protein HPr isoform 1 phosphorylated 1 (Bacillus subtilis subsp. subtilis str. 168)
Object_synonym: Bsub-ptsH/iso:1/Phos:1
Object_synonym: UniProtKB:P08877-1, His-15, MOD:00890

subject: PR_000025907
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0009927
  Ontology_term: histidine phosphotransfer kinase activity
Evidence_source: PMID:14527945
Evidence_code: EXP
Taxon: NCBITaxon:1423
DB_ID: UniProtKB:P08877-1
Date: 2010-09-25
Assigned_by: PRO:CNA

subject: PR_000025907
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0009401
  Ontology_term: phosphoenolpyruvate-dependent sugar phosphotransferase system
Evidence_source: PMID:14527945
Evidence_code: EXP
Taxon: NCBITaxon:1423
DB_ID: UniProtKB:P08877-1
Date: 2010-09-25
Assigned_by: PRO:CNA

PR_000025921
type: Class
Object_term: protein max isoform short acetylated 1 (human)
Object_synonym: hMAX/iso:short/Ac:1
Object_synonym: UniProtKB:P61244-2, Lys-57/Lys-144/Lys-145, MOD:00064

subject: PR_000025921
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:17217336
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P61244-2
Date: 2010-09-25
Assigned_by: PRO:CNA

PR_000025924
type: Class
Object_term: Max homodimer acetylated 1 (human)
Object_synonym: h(MAX/iso:short/AcRes+)*2

subject: PR_000025924
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:17217336
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025924
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008134
  Ontology_term: transcription factor binding
Modifier: NOT
Interaction_with: PR Q13105
Evidence_source: PMID:16126174
Evidence_code: IPI
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025927
type: Class
Object_term: TGF-beta 1 isoform 1 mature form (human)
Object_synonym: hTGFB1/iso:1/mature
Object_synonym: PRO_0000033763
Object_synonym: UniProtKB:P01137-1, 279-390

subject: PR_000025927
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:3162913
Evidence_source: PMID:8471846
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025927
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: PMID:8294500
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025927
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:8471846
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025927
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:9918798
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025928
type: Class
Object_term: TGF-beta 1 isoform 1 mature form (mouse)
Object_synonym: mTGFB1/iso:1/mature
Object_synonym: PRO_0000033767
Object_synonym: UniProtKB:P04202-1, 279-390

subject: PR_000025928
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005160
  Ontology_term: transforming growth factor beta receptor binding
Evidence_source: PMID:14764882
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P04202-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025928
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: PMID:9008713
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P04202-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025928
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030879
  Ontology_term: mammary gland development
Evidence_source: PMID:1821856
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P04202-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025929
type: Class
Object_term: TGF-beta 1 isoform 1 mature form (rat)
Object_synonym: PRO_0000033771
Object_synonym: rTGFB1/iso:1/mature
Object_synonym: UniProtKB:P17246-1, 279-390

subject: PR_000025929
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: PMID:11907708
Evidence_code: IDA
Taxon: NCBITaxon:10116
DB_ID: UniProtKB:P17246-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025930
type: Class
Object_term: TGF-beta 1 isoform 1 mature form (green monkey)
Object_synonym: GrMonkey-TGFB1/iso:1/mature
Object_synonym: PRO_0000033761
Object_synonym: UniProtKB:P09533-1, 279-390

subject: PR_000025930
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:3185545
Evidence_code: IDA
Taxon: NCBITaxon:9534
DB_ID: UniProtKB:P09533-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025930
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: PMID:3185545
Evidence_code: IDA
Taxon: NCBITaxon:9534
DB_ID: UniProtKB:P09533-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025930
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:3185545
Evidence_code: IDA
Taxon: NCBITaxon:9534
DB_ID: UniProtKB:P09533-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025933
type: Class
Object_term: smad2-smad4 protein complex 1 (human)
Object_synonym: h(pSMAD2:SMAD4):1

subject: PR_000025933
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005654
  Ontology_term: nucleoplasm
Evidence_source: Reactome:REACT_7382
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025933
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: Reactome:REACT_7344
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025933
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:8752209
Evidence_source: PMID:8980228
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025934
type: Class
Object_term: smad2 isoform Long phosphorylated 1 (human)
Object_synonym: hSMAD2/iso:Long/Phos:1
Object_synonym: UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046

subject: PR_000025934
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Evidence_source: PMID:9689110
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0030618
  Ontology_term: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Evidence_source: PMID:8980228
Evidence_source: PMID:9346966
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Interaction_with: PR Q13485
Evidence_source: PMID:9311995
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:9006934
Evidence_source: PMID:9346966
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of transcription, DNA-templated
Evidence_source: PMID:15690394
Evidence_source: PMID:9689110
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:8752209
Evidence_source: PMID:8980228
Evidence_source: PMID:9346966
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:8752209
Evidence_source: PMID:8980228
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007183
  Ontology_term: SMAD protein complex assembly
Evidence_source: PMID:9346966
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025935
type: Class
Object_term: smad2 isoform Long phosphorylated 2 (human)
Object_synonym: hSMAD2/iso:Long/Phos:2
Object_synonym: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047
Object_synonym: Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046

subject: PR_000025935
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0030618
  Ontology_term: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Evidence_source: PMID:12193595
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Interaction_with: PR Q13485
Evidence_source: PMID:12193595
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:12193595
Evidence_source: PMID:17074053
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of transcription, DNA-templated
Evidence_source: PMID:12193595
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:12193595
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007183
  Ontology_term: SMAD protein complex assembly
Evidence_source: PMID:12193595
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

PR_000025936
type: Class
Object_term: smad2 isoform Long phosphorylated 3 (human)
Object_synonym: hSMAD2/iso:Long/Phos:3
Object_synonym: UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046

subject: PR_000025936
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Interaction_with: PR Q13485
Evidence_source: PMID:11027280
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025936
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:11027280
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025936
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:11027280
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025936
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007183
  Ontology_term: SMAD protein complex assembly
Evidence_source: PMID:11027280
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025936
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:11027280
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025937
type: Class
Object_term: smad2 isoform Long phosphorylated 4 (human)
Object_synonym: hSMAD2/iso:Long/Phos:4
Object_synonym: UniProtKB:Q15796-1, Thr-220, MOD:00047
Object_synonym: Ser-245/Ser-250/Ser-255, MOD:00046

subject: PR_000025937
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:10197981
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025937
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:10197981
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025938
type: Class
Object_term: smad2 isoform Short phosphorylated 1 (human)
Object_synonym: hSMAD2/iso:Short/Phos:1
Object_synonym: UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046

subject: PR_000025938
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Evidence_source: PMID:14701940
Evidence_source: PMID:9873005
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025938
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PMID:9873005
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025938
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0030618
  Ontology_term: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Evidence_source: PMID:14701940
Evidence_source: PMID:9873005
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025938
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:9873005
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025942
type: Class
Object_term: smad2 isoform Long phosphorylated 1 (mouse)
Object_synonym: mSMAD2/iso:Long/Phos:1
Object_synonym: UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046

subject: PR_000025942
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Evidence_source: PMID:15282343
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025942
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Interaction_with: PR P97471
Evidence_source: PMID:11043574
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025942
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:11557747
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025942
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:11262418
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025942
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11262418
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025943
type: Class
Object_term: smad2 isoform Short phosphorylated 1 (mouse)
Object_synonym: mSMAD2/iso:Short/Phos:1
Object_synonym: UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046

subject: PR_000025943
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PMID:15630024
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025943
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:15630024
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025944
type: Class
Object_term: smad2-smad4 protein complex 1 (mouse)
Object_synonym: m(SMAD2:SMAD4):1

subject: PR_000025944
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:12672795
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025944
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12672795
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025946
type: Class
Object_term: smad2-smad4 protein complex 3 (human)
Object_synonym: h(SMAD2:SMAD4):3

subject: PR_000025946
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:12193595
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025946
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030511
  Ontology_term: positive regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12193595
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025947
type: Class
Object_term: smad2-smad4 protein complex 4 (human)
Object_synonym: h(SMAD2:SMAD4):4

subject: PR_000025947
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:11027280
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025947
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11027280
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025950
type: Class
Object_term: smad2-smad4-ski protein complex

subject: PR_000025950
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:10705283
Evidence_source: PMID:15107821
Evidence_code: EXP
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025951
type: Class
Object_term: smad2-smad4-ski protein complex 1 (human)

subject: PR_000025951
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:10485843
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Note=Conflicting information with data for complex 2

subject: PR_000025951
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:10485843
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Note=Conflicting information with data for complex 2

PR_000025952
type: Class
Object_term: smad2-smad4-ski protein complex 2 (human)

subject: PR_000025952
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:12732634
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Note=Conflicting information with data for complex 1

subject: PR_000025952
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12732634
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Note=Conflicting information with data for complex 1

PR_000025958
type: Class
Object_term: mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human)
Object_synonym: hSMAD4/iso:1/MonoUbiq:2
Object_synonym: UniProtKB:Q13485-1, Lys-519, MOD:01148

subject: PR_000025958
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:19135894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13485-1
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025958
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Modifier: NOT
Evidence_source: PMID:19135894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13485-1
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025959
type: Class
Object_term: TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
Object_synonym: hTGFBR1/iso:1/SigPep-/Phos:1
Object_synonym: PRO_0000024423, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046
Object_synonym: Thr-185/Thr-186, MOD:00047
Object_synonym: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046

subject: PR_000025959
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0005025
  Ontology_term: transforming growth factor beta receptor activity, type I
Evidence_source: PMID:7774578
Evidence_source: PMID:8947046
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36897-1
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000025959
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005887
  Ontology_term: integral component of plasma membrane
Evidence_source: PMID:8947046
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36897-1
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000025959
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PMID:7774578
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36897-1
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000025959
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:8242743
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36897-1
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000025959
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0007181
  Ontology_term: transforming growth factor beta receptor complex assembly
Evidence_source: PMID:8947046
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36897-1
Date: 2009-03-09
Assigned_by: PRO:CNA

PR_000025981
type: Class
Object_term: ccap-HPr-Ser46-P-cre operator complex (Bacillus megaterium)

subject: PR_000025981
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0045013
  Ontology_term: carbon catabolite repression of transcription
Evidence_source: PMID:15369672
Evidence_code: EXP
Taxon: NCBITaxon:1404
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025982
type: Class
Object_term: ccap-HPr-Ser46-P-cre operator complex (Bacillus subtilis subsp. subtilis str. 168)

subject: PR_000025982
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0045013
  Ontology_term: carbon catabolite repression of transcription
Evidence_source: PMID:15885105
Evidence_code: EXP
Taxon: NCBITaxon:1423
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026021
type: Class
Object_term: Max-binding protein MNT isoform 1 phosphorylated 1 (human)
Object_synonym: hMNT/iso:1/Phos:1

subject: PR_000026021
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0051726
  Ontology_term: regulation of cell cycle
Evidence_source: PMID:16103876
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q99583-1
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026022
type: Class
Object_term: Max-binding protein MNT isoform 1 phosphorylated 1 (mouse)
Object_synonym: mMNT/iso:1/Phos:1

subject: PR_000026022
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0051726
  Ontology_term: regulation of cell cycle
Evidence_source: PMID:16103876
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:O08789-1
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000026022
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0070491
  Ontology_term: repressing transcription factor binding
Modifier: NOT
Interaction_with: PR Q62141
Evidence_source: PMID:16103876
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:O08789-1
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026023
type: Class
Object_term: mnt-msin3-hdac1 complex

subject: PR_000026023
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004407
  Ontology_term: histone deacetylase activity
Evidence_source: PMID:16103876
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000026023
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of transcription, DNA-templated
Evidence_source: PMID:16103876
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2015-08-20
Assigned_by: PRO:CNA

subject: PR_000026023
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Evidence_source: PMID:16103876
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026030
type: Class
Object_term: mnt-max complex (human)

subject: PR_000026030
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Evidence_source: PMID:9184233
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026033
type: Class
Object_term: c-myc protein isoform 1 acetylated 1 (human)
Object_synonym: hMYC/iso:1/Ac:1
Object_synonym: UniProtKB:P01106-1, Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394

subject: PR_000026033
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PMID:16126174
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026033
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:16126174
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026033
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0005667
  Ontology_term: transcription factor complex
Evidence_source: PMID:16126174
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026035
type: Class
Object_term: Myc-max acetylated complex (human)

subject: PR_000026035
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0008134
  Ontology_term: transcription factor binding
Interaction_with: PR Q13105
Evidence_source: PMID:16126174
Evidence_code: IPI
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Evidence=Fig6. Evidence for max short isoform comes from cited sources PMID:15003254, PMID:9162900.

subject: PR_000026035
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Evidence_source: PMID:16126174
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Evidence=Fig6. Evidence for max short isoform comes from cited source PMID:9162900.

PR_000026039
type: Class
Object_term: Myc-max complex 1 (human)

subject: PR_000026039
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Evidence_source: PMID:15003254
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Evidence for max short isoform comes from cited source PMID:9162900.

PR_000026046
type: Class
Object_term: mga-max complex (mouse)

subject: PR_000026046
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0043565
  Ontology_term: sequence-specific DNA binding
Evidence_source: PMID:10601024
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Note=T-box DNA binding

subject: PR_000026046
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Evidence_source: PMID:10601024
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026051
type: Class
Object_term: c-myc protein isoform 1 O-glycosylated 1 (human)
Object_synonym: hMYC/iso:1/OGlyco:1
Object_synonym: UniProtKB:P01106-1, Thr-58, MOD:00806

subject: PR_000026051
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PMID:11904304
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026051
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006357
  Ontology_term: regulation of transcription by RNA polymerase II
Evidence_source: PMID:11904304
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026052
type: Class
Object_term: c-myc protein isoform 1 phosphorylated 1 (mouse)
Object_synonym: mMYC/iso:1/Phos:1
Object_synonym: UniProtKB:P01108-1, Ser-62, MOD:00046

subject: PR_000026052
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026052
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026052
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0005667
  Ontology_term: transcription factor complex
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026052
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0006357
  Ontology_term: regulation of transcription by RNA polymerase II
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026052
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0008283
  Ontology_term: cell proliferation
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026052
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0055072
  Ontology_term: iron ion homeostasis
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026053
type: Class
Object_term: c-myc protein isoform 1 phosphorylated 2 (mouse)
Object_synonym: mMYC/iso:1/Phos:2
Object_synonym: UniProtKB:P01108-1, Thr-58, MOD:00047
Object_synonym: Ser-62, MOD:00046

subject: PR_000026053
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:14563837
Evidence_source: PMID:15503302
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026054
type: Class
Object_term: c-myc protein isoform 1 phosphorylated 2 (human)
Object_synonym: hMYC/iso:1/Phos:2
Object_synonym: UniProtKB:P01106-1, Thr-58, MOD:00047
Object_synonym: Ser-62, MOD:00046

subject: PR_000026054
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Modifier: NOT
Evidence_source: PMID:7623799
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026055
type: Class
Object_term: c-myc protein isoform 1 phosphorylated 3 (human)
Object_synonym: hMYC/iso:1/Phos:3
Object_synonym: UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046

subject: PR_000026055
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:12676581
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026055
predicate:
  Relation: participates_in
object:
  Ontology_ID: GO:0045766
  Ontology_term: positive regulation of angiogenesis
Evidence_source: PMID:12676581
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026111
type: Class
Object_term: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA D532H (human)
Object_synonym: hMCCC1/var:MCCA D532H

subject: PR_000026111
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-Methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe form of disease.

subject: PR_000026111
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001630
  Ontology_term: splice_region_variant
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026112
type: Class
Object_term: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA L437P (human)
Object_synonym: hMCCC1/var:MCCA L437P
Object_synonym: UniProtKB:Q96RQ3, Leu-437, CHEBI:50342

subject: PR_000026112
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-Methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012788
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe form of disease.

subject: PR_000026112
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012788
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026113
type: Class
Object_term: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA R385S (human)
Object_synonym: hMCCC1/var:MCCA R385S
Object_synonym: UniProtKB:Q96RQ3, Arg-385, CHEBI:29999

subject: PR_000026113
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-Methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012787
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe form of disease.

subject: PR_000026113
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012787
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026114
type: Class
Object_term: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA A289V (human)
Object_synonym: hMCCC1/var:MCCA A289V
Object_synonym: UniProtKB:Q96RQ3, Ala-289, CHEBI:30015

subject: PR_000026114
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-Methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012785
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Mild form of disease

subject: PR_000026114
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012785
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026118
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB S173L (human)
Object_synonym: hMCCC2/var:MCCB S173L

subject: PR_000026118
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-Methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012795
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe form of disease.

PR_000026119
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB E99Q (human)
Object_synonym: hMCCC2/var:MCCB E99Q

subject: PR_000026119
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-Methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012792
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe and mild forms of disease

PR_000026120
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB V339M (human)
Object_synonym: hMCCC2/var:MCCB V339M

subject: PR_000026120
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-Methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012800
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe form of disease

PR_000026121
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB I437V (human)
Object_synonym: hMCCC2/var:MCCB I437V

subject: PR_000026121
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-Methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Mild form of disease

subject: PR_000026121
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001569
  Ontology_term: cryptic_splice_site_variant
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026122
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB D172fs (human)
Object_synonym: hMCCC2/var:MCCB D172fs

subject: PR_000026122
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-Methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11170888
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026123
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB IVS3+5G->T (human)
Object_synonym: hMCCC2/var:MCCB IVS3+5G->T

subject: PR_000026123
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-Methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11170888
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026130
type: Class
Object_term: bacterial-type serine palmitoyltransferase complex (Sphingomonas paucimobilis)
Object_synonym: SPT complex (SPHPI)

subject: PR_000026130
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004758
  Ontology_term: serine C-palmitoyltransferase activity
Evidence_source: PMID:17559874
Evidence_code: EXP
Taxon: NCBITaxon:13689
Date: 2010-12-06
Assigned_by: PRO:CNA

subject: PR_000026130
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:11279212
Evidence_source: PMID:17559874
Evidence_code: EXP
Taxon: NCBITaxon:13689
Date: 2015-08-20
Assigned_by: PRO:CNA

PR_000026132
type: Class
Object_term: bacterial-type serine palmitoyltransferase complex (Sphingomonas wittichii RW1)
Object_synonym: SPT complex (SPHWW)

subject: PR_000026132
predicate:
  Relation: capable_of
object:
  Ontology_ID: GO:0004758
  Ontology_term: serine C-palmitoyltransferase activity
Evidence_source: PMID:17559874
Evidence_code: EXP
Taxon: NCBITaxon:392499
Date: 2010-12-06
Assigned_by: PRO:CNA

subject: PR_000026132
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:17559874
Evidence_code: IC
Taxon: NCBITaxon:392499
Date: 2015-08-20
Assigned_by: PRO:CNA