PRO_ID
type: ObjectProperty
comment: PRO identifier, mandatory.

Object_term
type: ObjectProperty
comment: Name of the PRO term, Mandatory, cardinality 1.

Object_synonym
type: ObjectProperty
comment: Other names by which the described object is known, Optional field. Cardinality 0, 1 or >1. Separated by | (e.g. smad5beta|smad5b).

Modifier
type: ObjectProperty
comment: Modifiers are used within an annotation to modify a relation between a PRO term (protein) and another term (which can be internal or external to PRO). It includes the qualifiers used by GO: NOT, and contributes_to. And also includes decreased, increased and altered (see table 2 below for more information). This field is not mandatory; cardinality 0, 1, >1; for cardinality >1 use a pipe to separate entries (e.g. NOT|contributes_to).

Relation
type: ObjectProperty
comment: Relation to the corresponding annotation. For the list of relations used in PRO see table 3 below. Mandatory, cardinality 1.

Ontology_ID
type: ObjectProperty
comment: ID for the corresponding annotation. Mandatory, cardinality 1.

Ontology_term
type: ObjectProperty
comment: Term name for the corresponding ontology ID. Mandatory, cardinality 1.

Relative_to
type: ObjectProperty
comment: Contains a PRO identifier. Modifiers increased, decreased and altered require an entry in this column to indicate what the change is relative to.

Interaction_with
type: ObjectProperty
comment: To indicate binding partner. For GO component complex and GO function protein binding. If possible indicate the most exact protein object by using PRO ID. If part of a complex please add the GO ID for the corresponding one. Not mandatory, cardinality 0 or 1.

Evidence_source
type: ObjectProperty
comment: Pubmed ID or database source for the evidence. Mandatory, cardinality 1. (or >1?)

Evidence_code
type: ObjectProperty
comment: At the ProEvo level, the evidence code is ISS (inferred by sequence and/or structural similarity) At the protein form level only experimental evidence codes are allowed. If no expertise in evidence code assignation please use EXP (experimental evidence) as a general code. For GO term protein binding, the evidence code should be IPI. From GOA source: see the GO evidence code guide for the list of valid evidence codes for GO annotations. This field is mandatory for GO terms, cardinality 1.

Taxon
type: ObjectProperty
comment: Taxon identifier for the species that the annotation is extracted from. Related to column 9. Not mandatory, cardinality 0 or 1.

Inferred_from
type: ObjectProperty
comment: This field is used only for certain types of evidence code: IPI and ISS for PRO. Cardinality 0, 1, >1; for cardinality >1 use a pipe to separate entries (e.g. PANTHER:PTHR13703:SF17|PIRSF:PIRSF500500).

DB_ID
type: ObjectProperty
comment: GOA Source:one or more unique identifiers for a single source cited as an authority for the attribution of the ontology ID to the DB_Object_ID. This may be a literature reference or a database record. The syntax is DB:accession_number.

Date
type: ObjectProperty
comment: From GOA source: Date on which the annotation was made; format is YYYY-MM-DD this field is mandatory, cardinality 1.

Assigned_by
type: ObjectProperty
comment: The database which made the annotation. This field is mandatory, cardinality 1. Format: Source DB:curator initials.

Comments
type: ObjectProperty
comment: Curator comment for some annotations.

PR_000000002
type: Class
Object_term: E3 ubiquitin ligase SFC complex Skp1 subunit

subject: PR_000000002
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0019005
  Ontology_term: SCF ubiquitin ligase complex
Evidence_source: PIRSF:PIRSF028729
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF028729
DB_ID: PIRSF:PIRSF028729
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000002
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006511
  Ontology_term: ubiquitin-dependent protein catabolic process
Evidence_source: PIRSF:PIRSF028729
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF028729
DB_ID: PIRSF:PIRSF028729
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000003
type: Class
Object_term: HLH DNA-binding protein inhibitor
Object_synonym: bHLH clade D
Object_synonym: bHLH class V
Object_synonym: DNA-binding protein inhibitor ID
Object_synonym: ID protein

subject: PR_000000003
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PIRSF:PIRSF005808
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005808
DB_ID: PIRSF:PIRSF005808
Date: 2015-08-20
Assigned_by: PRO:CNA

subject: PR_000000003
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of DNA-templated transcription
Evidence_source: PIRSF:PIRSF005808
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF005808
DB_ID: PIRSF:PIRSF005808
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000004
type: Class
Object_term: RING-box protein

subject: PR_000000004
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004842
  Ontology_term: ubiquitin-protein transferase activity
Evidence_source: PIRSF:PIRSF016237
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF016237
DB_ID: PIRSF:PIRSF016237
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000004
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF016237
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF016237
DB_ID: PIRSF:PIRSF016237
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000004
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0016567
  Ontology_term: protein ubiquitination
Evidence_source: PIRSF:PIRSF016237
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF016237
DB_ID: PIRSF:PIRSF016237
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000005
type: Class
Object_term: TGF-beta receptor type-2
Object_synonym: TbetaR-II
Object_synonym: TGF-beta receptor type II
Object_synonym: TGF-beta type II receptor
Object_synonym: TGFBR2
Object_synonym: TGFR-2
Object_synonym: transforming growth factor-beta receptor type II

subject: PR_000000005
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000005
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000005
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000005
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000005
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0042127
  Ontology_term: regulation of cell population proliferation
Evidence_source: PIRSF:PIRSF037393
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037393
DB_ID: PIRSF:PIRSF037393
DB_ID: UniProtKB:P37173
DB_ID: UniProtKB:Q62312
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000006
type: Class
Object_term: TGF-beta superfamily receptor type-1
Object_synonym: TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I (PTHR23255:SF15)

subject: PR_000000006
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005025
  Ontology_term: transforming growth factor beta receptor activity, type I
Evidence_source: PIRSF:PIRSF037391
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037391
DB_ID: PIRSF:PIRSF037391
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000006
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0019838
  Ontology_term: growth factor binding
Interaction_with: PR_000000046
Evidence_source: PANTHER:PTHR23255:SF14
Evidence_source: PIRSF:PIRSF037391
Evidence_code: ISS
Inferred_from: PANTHER:PTHR23255:SF14
Inferred_from: PIRSF:PIRSF037391
DB_ID: PANTHER:PTHR23255:SF14
DB_ID: PIRSF:PIRSF037391
Date: 2008-09-22
Assigned_by: PRO:CNA

subject: PR_000000006
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007178
  Ontology_term: cell surface receptor protein serine/threonine kinase signaling pathway
Evidence_source: PIRSF:PIRSF037391
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037391
DB_ID: PIRSF:PIRSF037391
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000007
type: Class
Object_term: TGF-beta superfamily receptor type-2 with activin receptor domain

subject: PR_000000007
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Evidence_source: PIRSF:PIRSF000627
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000627
DB_ID: PIRSF:PIRSF000627
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000007
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF000627
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000627
DB_ID: PIRSF:PIRSF000627
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000007
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PIRSF:PIRSF000627
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000627
DB_ID: PIRSF:PIRSF000627
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000007
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007178
  Ontology_term: cell surface receptor protein serine/threonine kinase signaling pathway
Evidence_source: PIRSF:PIRSF000627
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000627
DB_ID: PIRSF:PIRSF000627
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000009
type: Class
Object_term: anti-Muellerian hormone type-2 receptor
Object_synonym: AMH type II receptor
Object_synonym: AMHR
Object_synonym: AMHR2
Object_synonym: anti-Muellerian hormone type II receptor
Object_synonym: MIS type II receptor
Object_synonym: MISR2
Object_synonym: MISRII
Object_synonym: MRII

subject: PR_000000009
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007178
  Ontology_term: cell surface receptor protein serine/threonine kinase signaling pathway
Evidence_source: PIRSF:PIRSF037392
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037392
DB_ID: PIRSF:PIRSF037392
DB_ID: UniProtKB:Q16671
DB_ID: UniProtKB:Q8K592
Date: 2015-08-20
Assigned_by: PRO:CNA

subject: PR_000000009
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007548
  Ontology_term: sex differentiation
Evidence_source: PIRSF:PIRSF037392
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037392
DB_ID: PIRSF:PIRSF037392
DB_ID: UniProtKB:Q16671
DB_ID: UniProtKB:Q8K592
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000010
type: Class
Object_term: chordin
Object_synonym: CHRD
Object_synonym: UNQ217/PRO243

subject: PR_000000010
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF002496
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002496
DB_ID: PIRSF:PIRSF002496
DB_ID: UniProtKB:Q9H2X0
DB_ID: UniProtKB:Q9Z0E2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000010
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008201
  Ontology_term: heparin binding
Evidence_source: PIRSF:PIRSF002496
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002496
DB_ID: PIRSF:PIRSF002496
DB_ID: UniProtKB:Q9H2X0
DB_ID: UniProtKB:Q9Z0E2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000010
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0045545
  Ontology_term: syndecan binding
Evidence_source: PIRSF:PIRSF002496
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002496
DB_ID: PIRSF:PIRSF002496
DB_ID: UniProtKB:Q9H2X0
DB_ID: UniProtKB:Q9Z0E2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000010
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030510
  Ontology_term: regulation of BMP signaling pathway
Evidence_source: PIRSF:PIRSF002496
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002496
DB_ID: PIRSF:PIRSF002496
DB_ID: UniProtKB:Q9H2X0
DB_ID: UniProtKB:Q9Z0E2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000011
type: Class
Object_term: class 1 small leucine-rich proteoglycan

subject: PR_000000011
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005201
  Ontology_term: extracellular matrix structural constituent
Evidence_source: PIRSF:PIRSF002490
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002490
DB_ID: PIRSF:PIRSF002490
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000013
type: Class
Object_term: cullin

subject: PR_000000013
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0031461
  Ontology_term: cullin-RING ubiquitin ligase complex
Evidence_source: PIRSF:PIRSF017874
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF017874
DB_ID: PIRSF:PIRSF017874
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000014
type: Class
Object_term: cyclin-dependent kinase inhibitor

subject: PR_000000014
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004861
  Ontology_term: cyclin-dependent protein serine/threonine kinase inhibitor activity
Evidence_source: PIRSF:PIRSF036346
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036346
DB_ID: PIRSF:PIRSF036346
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000014
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0000079
  Ontology_term: regulation of cyclin-dependent protein serine/threonine kinase activity
Evidence_source: PIRSF:PIRSF036346
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036346
DB_ID: PIRSF:PIRSF036346
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000014
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051726
  Ontology_term: regulation of cell cycle
Evidence_source: PIRSF:PIRSF036346
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036346
DB_ID: PIRSF:PIRSF036346
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000014
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008285
  Ontology_term: negative regulation of cell population proliferation
Evidence_source: PIRSF:PIRSF036346
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF036346
DB_ID: PIRSF:PIRSF036346
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000015
type: Class
Object_term: follistatin
Object_synonym: activin-binding protein
Object_synonym: FS
Object_synonym: FST

subject: PR_000000015
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0032926
  Ontology_term: negative regulation of activin receptor signaling pathway
Evidence_source: PIRSF:PIRSF002278
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002278
DB_ID: PIRSF:PIRSF002278
DB_ID: UniProtKB:P19883
DB_ID: UniProtKB:P47931
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000016
type: Class
Object_term: HECT domain-containing E3 ubiquitin-protein ligase with WW domains

subject: PR_000000016
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004842
  Ontology_term: ubiquitin-protein transferase activity
Evidence_source: PIRSF:PIRSF001569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001569
DB_ID: PIRSF:PIRSF001569
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000017
type: Class
Object_term: interferon gamma
Object_synonym: IFN-gamma
Object_synonym: IFNG
Object_synonym: immune interferon

subject: PR_000000017
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006955
  Ontology_term: immune response
Evidence_source: PIRSF:PIRSF001936
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001936
DB_ID: PIRSF:PIRSF001936
DB_ID: UniProtKB:P01579
DB_ID: UniProtKB:P01580
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000017
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0032722
  Ontology_term: positive regulation of chemokine production
Evidence_source: PIRSF:PIRSF001936
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001936
DB_ID: PIRSF:PIRSF001936
DB_ID: UniProtKB:P01579
DB_ID: UniProtKB:P01580
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000018
type: Class
Object_term: latent TGF-beta-binding protein

subject: PR_000000018
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0019838
  Ontology_term: growth factor binding
Interaction_with: PR_000000046
Evidence_source: PIRSF:PIRSF037569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037569
DB_ID: PIRSF:PIRSF037569
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000018
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PIRSF:PIRSF037569
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037569
DB_ID: PIRSF:PIRSF037569
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000019
type: Class
Object_term: mitogen-activated protein kinase
Object_synonym: kinase-related transforming protein
Object_synonym: MAPK

subject: PR_000000019
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PIRSF:PIRSF501110
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501110
DB_ID: PIRSF:PIRSF501110
Date: 2009-06-01
Assigned_by: PRO:CNA

subject: PR_000000019
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PIRSF:PIRSF501110
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF501110
DB_ID: PIRSF:PIRSF501110
Date: 2009-06-01
Assigned_by: PRO:CNA

PR_000000020
type: Class
Object_term: Myc protein
Object_synonym: bHLH clade B
Object_synonym: bHLH class III

subject: PR_000000020
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Evidence_source: PIRSF:PIRSF001705
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001705
DB_ID: PIRSF:PIRSF001705
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000020
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF001705
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001705
DB_ID: PIRSF:PIRSF001705
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000020
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0042127
  Ontology_term: regulation of cell population proliferation
Evidence_source: PIRSF:PIRSF001705
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001705
DB_ID: PIRSF:PIRSF001705
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000021
type: Class
Object_term: noggin
Object_synonym: NOG

subject: PR_000000021
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007275
  Ontology_term: multicellular organism development
Evidence_source: PANTHER:PTHR10494:SF2
Evidence_source: PIRSF:PIRSF008129
Evidence_source: UniProtKB:P97466
Evidence_source: UniProtKB:Q13253
Evidence_code: ISS
Inferred_from: PANTHER:PTHR10494:SF2
Inferred_from: PIRSF:PIRSF008129
Inferred_from: UniProtKB:P97466
Inferred_from: UniProtKB:Q13253
DB_ID: PANTHER:PTHR10494:SF2
DB_ID: PIRSF:PIRSF008129
DB_ID: UniProtKB:P97466
DB_ID: UniProtKB:Q13253
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000021
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030509
  Ontology_term: BMP signaling pathway
Evidence_source: PANTHER:PTHR10494:SF2
Evidence_source: PIRSF:PIRSF008129
Evidence_source: UniProtKB:P97466
Evidence_source: UniProtKB:Q13253
Evidence_code: ISS
Inferred_from: PANTHER:PTHR10494:SF2
Inferred_from: PIRSF:PIRSF008129
Inferred_from: UniProtKB:P97466
Inferred_from: UniProtKB:Q13253
DB_ID: PANTHER:PTHR10494:SF2
DB_ID: PIRSF:PIRSF008129
DB_ID: UniProtKB:P97466
DB_ID: UniProtKB:Q13253
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000021
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030514
  Ontology_term: negative regulation of BMP signaling pathway
Evidence_source: PANTHER:PTHR10494:SF2
Evidence_source: PIRSF:PIRSF008129
Evidence_source: UniProtKB:P97466
Evidence_source: UniProtKB:Q13253
Evidence_code: ISS
Inferred_from: PANTHER:PTHR10494:SF2
Inferred_from: PIRSF:PIRSF008129
Inferred_from: UniProtKB:P97466
Inferred_from: UniProtKB:Q13253
DB_ID: PANTHER:PTHR10494:SF2
DB_ID: PIRSF:PIRSF008129
DB_ID: UniProtKB:P97466
DB_ID: UniProtKB:Q13253
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000022
type: Class
Object_term: ptx homeobox protein

subject: PR_000000022
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PIRSF:PIRSF000563
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000563
DB_ID: PIRSF:PIRSF000563
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000022
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of DNA-templated transcription
Evidence_source: PIRSF:PIRSF000563
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000563
DB_ID: PIRSF:PIRSF000563
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000022
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007275
  Ontology_term: multicellular organism development
Evidence_source: PIRSF:PIRSF000563
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000563
DB_ID: PIRSF:PIRSF000563
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000023
type: Class
Object_term: retinoblastoma-like protein

subject: PR_000000023
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF037408
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037408
DB_ID: PIRSF:PIRSF037408
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000023
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051726
  Ontology_term: regulation of cell cycle
Evidence_source: PIRSF:PIRSF037408
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037408
DB_ID: PIRSF:PIRSF037408
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000024
type: Class
Object_term: Rho-associated protein kinase
Object_synonym: RHO-ASSOCIATED, COILED-COIL CONTAINING PROTEIN KINASE (PTHR22988:SF3)

subject: PR_000000024
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000024
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007266
  Ontology_term: Rho protein signal transduction
Evidence_source: PANTHER:PTHR22988:SF3
Evidence_source: PIRSF:PIRSF037568
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22988:SF3
Inferred_from: PIRSF:PIRSF037568
DB_ID: PANTHER:PTHR22988:SF3
DB_ID: PIRSF:PIRSF037568
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000025
type: Class
Object_term: ribosomal protein S6 kinase beta

subject: PR_000000025
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PANTHER:PTHR24351:SF83
Evidence_source: PIRSF:PIRSF000605
Evidence_code: ISS
Inferred_from: PANTHER:PTHR24351:SF83
Inferred_from: PIRSF:PIRSF000605
DB_ID: PANTHER:PTHR24351:SF83
DB_ID: PIRSF:PIRSF000605
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000025
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004711
  Ontology_term: ribosomal protein S6 kinase activity
Evidence_source: PANTHER:PTHR24351:SF83
Evidence_source: PIRSF:PIRSF000605
Evidence_code: ISS
Inferred_from: PANTHER:PTHR24351:SF83
Inferred_from: PIRSF:PIRSF000605
DB_ID: PANTHER:PTHR24351:SF83
DB_ID: PIRSF:PIRSF000605
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000025
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PANTHER:PTHR24351:SF83
Evidence_source: PIRSF:PIRSF000605
Evidence_code: ISS
Inferred_from: PANTHER:PTHR24351:SF83
Inferred_from: PIRSF:PIRSF000605
DB_ID: PANTHER:PTHR24351:SF83
DB_ID: PIRSF:PIRSF000605
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000026
type: Class
Object_term: sara-type zinc finger FYVE domain-containing protein

subject: PR_000000026
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008104
  Ontology_term: protein localization
Evidence_source: PIRSF:PIRSF037289
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037289
DB_ID: PIRSF:PIRSF037289
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000027
type: Class
Object_term: smad protein

subject: PR_000000027
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF037286
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037286
DB_ID: PIRSF:PIRSF037286
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000027
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of DNA-templated transcription
Evidence_source: PIRSF:PIRSF037286
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037286
DB_ID: PIRSF:PIRSF037286
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000027
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PIRSF:PIRSF037286
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037286
DB_ID: PIRSF:PIRSF037286
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000029
type: Class
Object_term: thrombospondin subgroup A

subject: PR_000000029
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004866
  Ontology_term: endopeptidase inhibitor activity
Evidence_source: PIRSF:PIRSF002478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002478
DB_ID: PIRSF:PIRSF002478
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000029
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008201
  Ontology_term: heparin binding
Evidence_source: PIRSF:PIRSF002478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002478
DB_ID: PIRSF:PIRSF002478
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000029
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0016525
  Ontology_term: negative regulation of angiogenesis
Evidence_source: PIRSF:PIRSF002478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002478
DB_ID: PIRSF:PIRSF002478
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000030
type: Class
Object_term: thrombospondin subgroup B

subject: PR_000000030
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008201
  Ontology_term: heparin binding
Evidence_source: PIRSF:PIRSF002479
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002479
DB_ID: PIRSF:PIRSF002479
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000031
type: Class
Object_term: transcription adapter with TAZ, KIX and bromo-domains
Object_synonym: fam:CBP-p300

subject: PR_000000031
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004402
  Ontology_term: histone acetyltransferase activity
Evidence_source: PANTHER:PTHR13808
Evidence_source: PIRSF:PIRSF036333
Evidence_code: ISS
Inferred_from: PANTHER:PTHR13808
Inferred_from: PIRSF:PIRSF036333
DB_ID: PANTHER:PTHR13808
DB_ID: PIRSF:PIRSF036333
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000032
type: Class
Object_term: transcription factor Sp

subject: PR_000000032
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Evidence_source: PIRSF:PIRSF037570
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037570
DB_ID: PIRSF:PIRSF037570
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000032
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PIRSF:PIRSF037570
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037570
DB_ID: PIRSF:PIRSF037570
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000032
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of DNA-templated transcription
Evidence_source: PIRSF:PIRSF037570
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037570
DB_ID: PIRSF:PIRSF037570
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000033
type: Class
Object_term: tumor necrosis factor, TNF-like

subject: PR_000000033
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005125
  Ontology_term: cytokine activity
Evidence_source: PIRSF:PIRSF001873
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001873
DB_ID: PIRSF:PIRSF001873
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000033
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006915
  Ontology_term: apoptotic process
Evidence_source: PIRSF:PIRSF001873
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001873
DB_ID: PIRSF:PIRSF001873
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000033
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PIRSF:PIRSF001873
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001873
DB_ID: PIRSF:PIRSF001873
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000034
type: Class
Object_term: bone morphogenetic protein

subject: PR_000000034
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005102
  Ontology_term: signaling receptor binding
Evidence_source: PIRSF:PIRSF037272
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037272
DB_ID: PIRSF:PIRSF037272
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000034
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005125
  Ontology_term: cytokine activity
Evidence_source: PIRSF:PIRSF037272
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037272
DB_ID: PIRSF:PIRSF037272
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000034
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Evidence_source: PIRSF:PIRSF037272
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037272
DB_ID: PIRSF:PIRSF037272
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000034
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PIRSF:PIRSF037272
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037272
DB_ID: PIRSF:PIRSF037272
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000037
type: Class
Object_term: BMP receptor type-2
Object_synonym: BMP type II receptor
Object_synonym: BMP type-2 receptor
Object_synonym: BMPR-2
Object_synonym: BMPR-II
Object_synonym: BMPR2
Object_synonym: bone morphogenetic protein receptor type II
Object_synonym: BRK-3
Object_synonym: PPH1

subject: PR_000000037
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030509
  Ontology_term: BMP signaling pathway
Evidence_source: PIRSF:PIRSF500434
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500434
DB_ID: PIRSF:PIRSF500434
DB_ID: UniProtKB:O35607
DB_ID: UniProtKB:Q13873
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000038
type: Class
Object_term: BMP receptor-regulated smad protein
Object_synonym: R-SMAD(BMP)

subject: PR_000000038
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030509
  Ontology_term: BMP signaling pathway
Evidence_source: PANTHER:PTHR13703:SF19
Evidence_source: PIRSF:PIRSF500500
Evidence_code: ISS
Inferred_from: PANTHER:PTHR13703:SF19
Inferred_from: PIRSF:PIRSF500500
DB_ID: PANTHER:PTHR13703:SF19
DB_ID: PIRSF:PIRSF500500
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000039
type: Class
Object_term: DNA-binding protein inhibitor ID-1
Object_synonym: BHLHB24
Object_synonym: bHLHb24
Object_synonym: class B basic helix-loop-helix protein 24
Object_synonym: ID
Object_synonym: Id-1
Object_synonym: ID1
Object_synonym: Idb1
Object_synonym: inhibitor of differentiation 1
Object_synonym: inhibitor of DNA binding 1

subject: PR_000000039
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046983
  Ontology_term: protein dimerization activity
Evidence_source: PANTHER:PTHR11723:SF4
Evidence_source: PIRSF:PIRSF500477
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11723:SF4
Inferred_from: PIRSF:PIRSF500477
DB_ID: PANTHER:PTHR11723:SF4
DB_ID: PIRSF:PIRSF500477
DB_ID: UniProtKB:P20067
DB_ID: UniProtKB:P41134
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000040
type: Class
Object_term: DNA-binding protein inhibitor ID-2
Object_synonym: BHLHB26
Object_synonym: bHLHb26
Object_synonym: class B basic helix-loop-helix protein 26
Object_synonym: Id-2
Object_synonym: ID2
Object_synonym: Idb2
Object_synonym: inhibitor of differentiation 2
Object_synonym: inhibitor of DNA binding 2

subject: PR_000000040
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of DNA-templated transcription
Evidence_source: PIRSF:PIRSF500478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500478
Inferred_from: UniProtKB:P41136
Inferred_from: UniProtKB:Q02363
Inferred_from: UniProtKB:Q545T4
DB_ID: PIRSF:PIRSF500478
DB_ID: UniProtKB:P41136
DB_ID: UniProtKB:Q02363
DB_ID: UniProtKB:Q545T4
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000041
type: Class
Object_term: DNA-binding protein inhibitor ID-3
Object_synonym: 1R21
Object_synonym: BHLHB25
Object_synonym: bHLHb25
Object_synonym: class B basic helix-loop-helix protein 25
Object_synonym: HEIR1
Object_synonym: helix-loop-helix protein HEIR-1
Object_synonym: Hlh462
Object_synonym: Id-3
Object_synonym: ID-like protein inhibitor HLH 1R21
Object_synonym: ID-like protein inhibitor HLH 462
Object_synonym: ID3
Object_synonym: Idb3
Object_synonym: inhibitor of differentiation 3
Object_synonym: inhibitor of DNA binding 3

subject: PR_000000041
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of DNA-templated transcription
Evidence_source: PIRSF:PIRSF500479
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500479
Inferred_from: UniProtKB:P41133
Inferred_from: UniProtKB:Q02535
Inferred_from: UniProtKB:Q545W1
DB_ID: PIRSF:PIRSF500479
DB_ID: UniProtKB:P41133
DB_ID: UniProtKB:Q02535
DB_ID: UniProtKB:Q545W1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000042
type: Class
Object_term: DNA-binding protein inhibitor ID-4
Object_synonym: BHLHB27
Object_synonym: bHLHb27
Object_synonym: class B basic helix-loop-helix protein 27
Object_synonym: Id-4
Object_synonym: ID4
Object_synonym: Idb4
Object_synonym: inhibitor of differentiation 4
Object_synonym: inhibitor of DNA binding 4

subject: PR_000000042
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of DNA-templated transcription
Evidence_source: PIRSF:PIRSF500478
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500478
Inferred_from: UniProtKB:P41139
Inferred_from: UniProtKB:P47928
Inferred_from: UniProtKB:Q544D2
DB_ID: PIRSF:PIRSF500478
DB_ID: UniProtKB:P41139
DB_ID: UniProtKB:P47928
DB_ID: UniProtKB:Q544D2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000043
type: Class
Object_term: E3 ubiquitin-protein ligase RBX1
Object_synonym: E3 ubiquitin-protein transferase RBX1
Object_synonym: protein ZYP
Object_synonym: RBX1
Object_synonym: rbx1
Object_synonym: regulator of cullins 1
Object_synonym: RING finger protein 75
Object_synonym: RING-box protein 1
Object_synonym: RNF75
Object_synonym: ROC1

subject: PR_000000043
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0019005
  Ontology_term: SCF ubiquitin ligase complex
Evidence_source: PIRSF:PIRSF500724
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500724
Inferred_from: UniProtKB:P62877
Inferred_from: UniProtKB:P62878
DB_ID: PIRSF:PIRSF500724
DB_ID: UniProtKB:P62877
DB_ID: UniProtKB:P62878
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000043
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031146
  Ontology_term: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Evidence_source: PIRSF:PIRSF500724
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500724
Inferred_from: UniProtKB:P62877
Inferred_from: UniProtKB:P62878
DB_ID: PIRSF:PIRSF500724
DB_ID: UniProtKB:P62877
DB_ID: UniProtKB:P62878
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000044
type: Class
Object_term: RING-box protein 2
Object_synonym: CKBBP1
Object_synonym: CKII beta-binding protein 1
Object_synonym: RBX2
Object_synonym: rbx2
Object_synonym: regulator of cullins 2
Object_synonym: RING finger protein 7
Object_synonym: RNF7
Object_synonym: ROC2
Object_synonym: SAG
Object_synonym: sensitive to apoptosis gene protein

subject: PR_000000044
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0019005
  Ontology_term: SCF ubiquitin ligase complex
Evidence_source: PIRSF:PIRSF500725
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500725
Inferred_from: UniProtKB:Q9UBF6
Inferred_from: UniProtKB:Q9WTZ1
DB_ID: PIRSF:PIRSF500725
DB_ID: UniProtKB:Q9UBF6
DB_ID: UniProtKB:Q9WTZ1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000044
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031146
  Ontology_term: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Evidence_source: PIRSF:PIRSF500725
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500725
Inferred_from: UniProtKB:Q9UBF6
Inferred_from: UniProtKB:Q9WTZ1
DB_ID: PIRSF:PIRSF500725
DB_ID: UniProtKB:Q9UBF6
DB_ID: UniProtKB:Q9WTZ1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000046
type: Class
Object_term: TGF-beta
Object_synonym: transforming growth factor beta

subject: PR_000000046
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005160
  Ontology_term: transforming growth factor beta receptor binding
Evidence_source: PIRSF:PIRSF001787
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001787
DB_ID: PIRSF:PIRSF001787
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000046
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Evidence_source: PIRSF:PIRSF001787
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001787
DB_ID: PIRSF:PIRSF001787
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000046
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PIRSF:PIRSF001787
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001787
DB_ID: PIRSF:PIRSF001787
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000046
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PIRSF:PIRSF001787
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001787
DB_ID: PIRSF:PIRSF001787
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000046
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0042127
  Ontology_term: regulation of cell population proliferation
Evidence_source: PIRSF:PIRSF001787
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF001787
DB_ID: PIRSF:PIRSF001787
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000050
type: Class
Object_term: TGF-beta receptor type-2 sequence variant L308P (human)
Object_synonym: hTGFBR2/var:L308P
Object_synonym: TGF-beta receptor type-2 sequence variant 1 (human)
Object_synonym: UniProtKB:P37173-1, Leu-308, CHEBI:50342

subject: PR_000000050
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022351
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000050
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: NOT
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022351
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000051
type: Class
Object_term: TGF-beta receptor type-2 sequence variant R460H (human)
Object_synonym: hTGFBR2/var:R460H
Object_synonym: TGF-beta receptor type-2 sequence variant 10 (human)
Object_synonym: UniProtKB:P37173-1, Arg-460, CHEBI:29979

subject: PR_000000051
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029761
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000052
type: Class
Object_term: TGF-beta receptor type-2 sequence variant R460C (human)
Object_synonym: hTGFBR2/var:R460C
Object_synonym: TGF-beta receptor type-2 sequence variant 11 (human)
Object_synonym: UniProtKB:P37173-1, Arg-460, CHEBI:29950

subject: PR_000000052
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029760
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000053
type: Class
Object_term: TGF-beta receptor type-2 sequence variant E526Q (human)
Object_synonym: hTGFBR2/var:E526Q
Object_synonym: TGF-beta receptor type-2 sequence variant 12 (human)
Object_synonym: UniProtKB:P37173-1, Glu-526, CHEBI:30011

subject: PR_000000053
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:3748
  Ontology_term: esophagus squamous cell carcinoma
Evidence_source: PMID:10789724
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015816
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000053
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: NOT
Evidence_source: PMID:10789724
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015816
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000054
type: Class
Object_term: TGF-beta receptor type-2 sequence variant R528C (human)
Object_synonym: hTGFBR2/var:R528C
Object_synonym: TGF-beta receptor type-2 sequence variant 13 (human)
Object_synonym: UniProtKB:P37173-1, Arg-528, CHEBI:29950

subject: PR_000000054
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022360
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000055
type: Class
Object_term: TGF-beta receptor type-2 sequence variant R528H (human)
Object_synonym: hTGFBR2/var:R528H
Object_synonym: TGF-beta receptor type-2 sequence variant 14 (human)
Object_synonym: UniProtKB:P37173-1, Arg-528, CHEBI:29979

subject: PR_000000055
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022361
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000056
type: Class
Object_term: TGF-beta receptor type-2 sequence variant R537C (human)
Object_synonym: hTGFBR2/var:R537C
Object_synonym: TGF-beta receptor type-2 sequence variant 15 (human)
Object_synonym: UniProtKB:P37173-1, Arg-537, CHEBI:29950

subject: PR_000000056
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022362
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000056
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: NOT
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022362
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000057
type: Class
Object_term: TGF-beta receptor type-2 sequence variant G357W (human)
Object_synonym: hTGFBR2/var:G357W
Object_synonym: TGF-beta receptor type-2 sequence variant 16 (human)
Object_synonym: UniProtKB:P37173-1, Gly-357, CHEBI:29954

subject: PR_000000057
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022354
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000058
type: Class
Object_term: TGF-beta receptor type-2 sequence variant T315M (human)
Object_synonym: hTGFBR2/var:T315M
Object_synonym: TGF-beta receptor type-2 sequence variant 2 (human)
Object_synonym: UniProtKB:P37173-1, Thr-315, CHEBI:16044

subject: PR_000000058
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:3883
  Ontology_term: Lynch syndrome
Evidence_source: PMID:9590282
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008156
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000058
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008284
  Ontology_term: positive regulation of cell population proliferation
Evidence_source: PMID:9590282
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008156
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000059
type: Class
Object_term: TGF-beta receptor type-2 sequence variant Y336N (human)
Object_synonym: hTGFBR2/var:Y336N
Object_synonym: TGF-beta receptor type-2 sequence variant 3 (human)
Object_synonym: UniProtKB:P37173-1, Tyr-336, CHEBI:50347

subject: PR_000000059
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022352
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000060
type: Class
Object_term: TGF-beta receptor type-2 sequence variant A355P (human)
Object_synonym: hTGFBR2/var:A355P
Object_synonym: TGF-beta receptor type-2 sequence variant 4 (human)
Object_synonym: UniProtKB:P37173-1, Ala-355, CHEBI:50342

subject: PR_000000060
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022353
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000060
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0016020
  Ontology_term: membrane
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022353
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000060
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022353
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000061
type: Class
Object_term: TGF-beta receptor type-2 sequence variant V387M (human)
Object_synonym: hTGFBR2/var:V387M
Object_synonym: TGF-beta receptor type-2 sequence variant 5 (human)
Object_synonym: UniProtKB:P37173-1, Val-387, CHEBI:16044

subject: PR_000000061
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0016020
  Ontology_term: membrane
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022355
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000061
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022355
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000061
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: decreased
Relative_to: PR_000000409
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022355
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000062
type: Class
Object_term: TGF-beta receptor type-2 sequence variant N435S (human)
Object_synonym: hTGFBR2/var:N435S
Object_synonym: TGF-beta receptor type-2 sequence variant 6 (human)
Object_synonym: UniProtKB:P37173-1, Asn-435, CHEBI:29999

subject: PR_000000062
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022356
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000062
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: decreased
Relative_to: PR_000000409
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022356
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000063
type: Class
Object_term: TGF-beta receptor type-2 sequence variant V447A (human)
Object_synonym: hTGFBR2/var:V447A
Object_synonym: TGF-beta receptor type-2 sequence variant 7 (human)
Object_synonym: UniProtKB:P37173-1, Val-447, CHEBI:46217

subject: PR_000000063
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0016020
  Ontology_term: membrane
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022357
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000063
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022357
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000063
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: decreased
Relative_to: PR_000000409
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022357
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000064
type: Class
Object_term: TGF-beta receptor type-2 sequence variant S449F (human)
Object_synonym: hTGFBR2/var:S449F
Object_synonym: TGF-beta receptor type-2 sequence variant 8 (human)
Object_synonym: UniProtKB:P37173-1, Ser-449, CHEBI:29997

subject: PR_000000064
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022358
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000064
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: NOT
Evidence_source: PMID:15235604
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022358
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000065
type: Class
Object_term: TGF-beta receptor type-2 sequence variant L452M (human)
Object_synonym: hTGFBR2/var:L452M
Object_synonym: TGF-beta receptor type-2 sequence variant 9 (human)
Object_synonym: UniProtKB:P37173-1, Leu-452, CHEBI:16044

subject: PR_000000065
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022359
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000065
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Modifier: decreased
Relative_to: PR_000000409
Evidence_source: PMID:11212236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022359
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000066
type: Class
Object_term: TGF-beta receptor-regulated smad protein
Object_synonym: R-SMAD(TGFB)

subject: PR_000000066
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PIRSF:PIRSF500455
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500455
DB_ID: PIRSF:PIRSF500455
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000066
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0060395
  Ontology_term: SMAD protein signal transduction
Evidence_source: PIRSF:PIRSF500455
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500455
DB_ID: PIRSF:PIRSF500455
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000070
type: Class
Object_term: activin receptor type-2A
Object_synonym: activin receptor type IIA
Object_synonym: ACTR-IIA
Object_synonym: ACTRIIA
Object_synonym: ACVR2
Object_synonym: ACVR2A

subject: PR_000000070
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0048185
  Ontology_term: activin binding
Evidence_source: PIRSF:PIRSF500457
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500457
Inferred_from: UniProtKB:P27037
Inferred_from: UniProtKB:P27038
Inferred_from: UniProtKB:Q8BRV4
DB_ID: PIRSF:PIRSF500457
DB_ID: UniProtKB:P27037
DB_ID: UniProtKB:P27038
DB_ID: UniProtKB:Q8BRV4
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000070
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0032924
  Ontology_term: activin receptor signaling pathway
Evidence_source: PIRSF:PIRSF500457
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500457
Inferred_from: UniProtKB:P27037
Inferred_from: UniProtKB:P27038
Inferred_from: UniProtKB:Q8BRV4
DB_ID: PIRSF:PIRSF500457
DB_ID: UniProtKB:P27037
DB_ID: UniProtKB:P27038
DB_ID: UniProtKB:Q8BRV4
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000071
type: Class
Object_term: activin receptor type-2B
Object_synonym: activin receptor type IIB
Object_synonym: ACTR-IIB
Object_synonym: ACVR2B

subject: PR_000000071
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0048185
  Ontology_term: activin binding
Evidence_source: PIRSF:PIRSF500456
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500456
Inferred_from: UniProtKB:P27040
Inferred_from: UniProtKB:Q13705
Inferred_from: UniProtKB:Q3KQI1
DB_ID: PIRSF:PIRSF500456
DB_ID: UniProtKB:P27040
DB_ID: UniProtKB:Q13705
DB_ID: UniProtKB:Q3KQI1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000071
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0032924
  Ontology_term: activin receptor signaling pathway
Evidence_source: PIRSF:PIRSF500456
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500456
Inferred_from: UniProtKB:P27040
Inferred_from: UniProtKB:Q13705
Inferred_from: UniProtKB:Q3KQI1
DB_ID: PIRSF:PIRSF500456
DB_ID: UniProtKB:P27040
DB_ID: UniProtKB:Q13705
DB_ID: UniProtKB:Q3KQI1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000072
type: Class
Object_term: activin/inhibin beta subunit

subject: PR_000000072
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005102
  Ontology_term: signaling receptor binding
Evidence_source: PIRSF:PIRSF037268
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037268
DB_ID: PIRSF:PIRSF037268
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000073
type: Class
Object_term: Muellerian-inhibiting factor
Object_synonym: AMH
Object_synonym: anti-Muellerian hormone
Object_synonym: MIF
Object_synonym: MIS
Object_synonym: Muellerian-inhibiting substance

subject: PR_000000073
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005102
  Ontology_term: signaling receptor binding
Evidence_source: PIRSF:PIRSF037270
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037270
DB_ID: PIRSF:PIRSF037270
DB_ID: UniProtKB:P03971
DB_ID: UniProtKB:P27106
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000073
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005179
  Ontology_term: hormone activity
Evidence_source: PIRSF:PIRSF037270
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037270
DB_ID: PIRSF:PIRSF037270
DB_ID: UniProtKB:P03971
DB_ID: UniProtKB:P27106
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000073
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007548
  Ontology_term: sex differentiation
Evidence_source: PIRSF:PIRSF037270
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037270
DB_ID: PIRSF:PIRSF037270
DB_ID: UniProtKB:P03971
DB_ID: UniProtKB:P27106
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000073
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008406
  Ontology_term: gonad development
Evidence_source: PIRSF:PIRSF037270
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037270
DB_ID: PIRSF:PIRSF037270
DB_ID: UniProtKB:P03971
DB_ID: UniProtKB:P27106
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000075
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant R54C (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 1 (human)
Object_synonym: hAMHR2/var:R54C
Object_synonym: UniProtKB:Q16671-1, Arg-54, CHEBI:29950

subject: PR_000000075
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015525
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000076
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant G142V (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 2 (human)
Object_synonym: hAMHR2/var:G142V
Object_synonym: UniProtKB:Q16671-1, Gly-142, CHEBI:30015

subject: PR_000000076
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015526
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000077
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant H282Q (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 3 (human)
Object_synonym: hAMHR2/var:H282Q
Object_synonym: UniProtKB:Q16671-1, His-282, CHEBI:30011

subject: PR_000000077
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015527
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000078
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant R406Q (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 4 (human)
Object_synonym: hAMHR2/var:R406Q
Object_synonym: UniProtKB:Q16671-1, Arg-406, CHEBI:30011

subject: PR_000000078
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:11549681
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015528
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000079
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant D426G (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 5 (human)
Object_synonym: hAMHR2/var:D426G
Object_synonym: UniProtKB:Q16671-1, Asp-426, CHEBI:29947

subject: PR_000000079
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015529
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000080
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant V458A (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 6 (human)
Object_synonym: hAMHR2/var:V458A
Object_synonym: UniProtKB:Q16671-1, Val-458, CHEBI:46217

subject: PR_000000080
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015530
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000081
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant D491H (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 7 (human)
Object_synonym: hAMHR2/var:D491H
Object_synonym: UniProtKB:Q16671-1, Asp-491, CHEBI:29979

subject: PR_000000081
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015531
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000082
type: Class
Object_term: anti-Muellerian hormone type-2 receptor sequence variant R504C (human)
Object_synonym: anti-Muellerian hormone type-2 receptor sequence variant 8 (human)
Object_synonym: hAMHR2/var:R504C
Object_synonym: UniProtKB:Q16671-1, Arg-504, CHEBI:29950

subject: PR_000000082
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8872466
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015532
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000092
type: Class
Object_term: fungal/metazoan cullin-1
Object_synonym: CUL-1
Object_synonym: CUL1

subject: PR_000000092
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0019005
  Ontology_term: SCF ubiquitin ligase complex
Evidence_source: PANTHER:PTHR11932:SF19
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11932:SF19
DB_ID: PANTHER:PTHR11932:SF19
DB_ID: UniProtKB:Q13616
DB_ID: UniProtKB:Q9WTX6
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000092
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031146
  Ontology_term: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Evidence_source: PANTHER:PTHR11932:SF19
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11932:SF19
DB_ID: PANTHER:PTHR11932:SF19
DB_ID: UniProtKB:Q13616
DB_ID: UniProtKB:Q9WTX6
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000093
type: Class
Object_term: cyclin-dependent kinase 4 inhibitor B
Object_synonym: CDKN2B
Object_synonym: MTS-2
Object_synonym: MTS2
Object_synonym: multiple tumor suppressor 2
Object_synonym: p14-INK4b
Object_synonym: p15-INK4b
Object_synonym: p15INK4B

subject: PR_000000093
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051726
  Ontology_term: regulation of cell cycle
Evidence_source: PANTHER:PTHR24144:SF138
Evidence_code: ISS
Inferred_from: PANTHER:PTHR24144:SF138
DB_ID: PANTHER:PTHR24144:SF138
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000095
type: Class
Object_term: tumor necrosis factor ligand superfamily member 6
Object_synonym: apoptosis antigen ligand
Object_synonym: APT1LG1
Object_synonym: APTL
Object_synonym: CD178
Object_synonym: CD95 ligand
Object_synonym: CD95-L
Object_synonym: CD95L
Object_synonym: fas antigen ligand
Object_synonym: fas ligand
Object_synonym: fas ligand, TNF-like
Object_synonym: FASL
Object_synonym: FASLG
Object_synonym: gld
Object_synonym: TNFSF6

subject: PR_000000095
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007267
  Ontology_term: cell-cell signaling
Evidence_source: PANTHER:PTHR11471:SF7
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11471:SF7
DB_ID: PANTHER:PTHR11471:SF7
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000099
type: Class
Object_term: inhibitory smad protein

subject: PR_000000099
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009968
  Ontology_term: negative regulation of signal transduction
Evidence_source: PIRSF:PIRSF500412
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500412
DB_ID: PIRSF:PIRSF500412
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000099
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PIRSF:PIRSF500412
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500412
DB_ID: PIRSF:PIRSF500412
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000099
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030514
  Ontology_term: negative regulation of BMP signaling pathway
Evidence_source: PIRSF:PIRSF500412
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500412
DB_ID: PIRSF:PIRSF500412
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000102
type: Class
Object_term: lefty protein

subject: PR_000000102
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007275
  Ontology_term: multicellular organism development
Evidence_source: PIRSF:PIRSF037402
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037402
DB_ID: PIRSF:PIRSF037402
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000105
type: Class
Object_term: nodal protein
Object_synonym: NODAL

subject: PR_000000105
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0016015
  Ontology_term: morphogen activity
Evidence_source: PIRSF:PIRSF037400
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037400
DB_ID: PIRSF:PIRSF037400
DB_ID: UniProtKB:P43021
DB_ID: UniProtKB:Q96S42
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000105
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007368
  Ontology_term: determination of left/right symmetry
Evidence_source: PIRSF:PIRSF037400
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037400
DB_ID: PIRSF:PIRSF037400
DB_ID: UniProtKB:P43021
DB_ID: UniProtKB:Q96S42
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000107
type: Class
Object_term: noggin sequence variant P35S (human)
Object_synonym: hNOG/var:P35S
Object_synonym: noggin sequence variant 1 (human)
Object_synonym: UniProtKB:Q13253, Pro-35, CHEBI:29999

subject: PR_000000107
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:11857750
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_018324
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000108
type: Class
Object_term: noggin sequence variant P223L (human)
Object_synonym: hNOG/var:P223L
Object_synonym: noggin sequence variant 10 (human)
Object_synonym: UniProtKB:Q13253, Pro-223, CHEBI:30006

subject: PR_000000108
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:10080184
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011367
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000109
type: Class
Object_term: noggin sequence variant P35R (human)
Object_synonym: hNOG/var:P35R
Object_synonym: noggin sequence variant 2 (human)
Object_synonym: UniProtKB:Q13253, Pro-35, CHEBI:29952

subject: PR_000000109
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:11545688
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011361
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000109
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050789
  Ontology_term: tarsal-carpal coalition syndrome
Evidence_source: PMID:11545688
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011361
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000110
type: Class
Object_term: noggin sequence variant C184Y (human)
Object_synonym: hNOG/var:C184Y
Object_synonym: noggin sequence variant 3 (human)
Object_synonym: UniProtKB:Q13253, Cys-184, CHEBI:46858

subject: PR_000000110
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:11846737
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_018325
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000111
type: Class
Object_term: noggin sequence variant G189C (human)
Object_synonym: hNOG/var:G189C
Object_synonym: noggin sequence variant 4 (human)
Object_synonym: UniProtKB:Q13253, Gly-189, CHEBI:29950

subject: PR_000000111
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:99178269
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011362
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000112
type: Class
Object_term: noggin sequence variant R204L (human)
Object_synonym: hNOG/var:R204L
Object_synonym: noggin sequence variant 5 (human)
Object_synonym: UniProtKB:Q13253, Arg-204, CHEBI:30006

subject: PR_000000112
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050789
  Ontology_term: tarsal-carpal coalition syndrome
Evidence_source: PMID:11545688
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011326
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000113
type: Class
Object_term: noggin sequence variant W217G (human)
Object_synonym: hNOG/var:W217G
Object_synonym: noggin sequence variant 6 (human)
Object_synonym: UniProtKB:Q13253, Trp-217, CHEBI:29947

subject: PR_000000113
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:10080184
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011363
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000114
type: Class
Object_term: noggin sequence variant I220N (human)
Object_synonym: hNOG/var:I220N
Object_synonym: noggin sequence variant 7 (human)
Object_synonym: UniProtKB:Q13253, Ile-220, CHEBI:50347

subject: PR_000000114
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:10080184
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011364
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000115
type: Class
Object_term: noggin sequence variant Y222C (human)
Object_synonym: hNOG/var:Y222C
Object_synonym: noggin sequence variant 8 (human)
Object_synonym: UniProtKB:Q13253, Tyr-222, CHEBI:29950

subject: PR_000000115
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:11545688
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011365
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000115
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050789
  Ontology_term: tarsal-carpal coalition syndrome
Evidence_source: PMID:10080184
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011365
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000116
type: Class
Object_term: noggin sequence variant Y222D (human)
Object_synonym: hNOG/var:Y222D
Object_synonym: noggin sequence variant 9 (human)
Object_synonym: UniProtKB:Q13253, Tyr-222, CHEBI:29958

subject: PR_000000116
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050788
  Ontology_term: proximal symphalangism
Evidence_source: PMID:10080184
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011366
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000122
type: Class
Object_term: Rho-related small GTPase
Object_synonym: fam:RHO

subject: PR_000000122
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003924
  Ontology_term: GTPase activity
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000122
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000122
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005525
  Ontology_term: GTP binding
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000122
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0000902
  Ontology_term: cell morphogenesis
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000122
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007264
  Ontology_term: small GTPase-mediated signal transduction
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000122
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007266
  Ontology_term: Rho protein signal transduction
Evidence_source: PIRSF:PIRSF037169
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF037169
DB_ID: PIRSF:PIRSF037169
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000125
type: Class
Object_term: zinc finger FYVE domain-containing protein 9
Object_synonym: Madh-interacting protein
Object_synonym: MADHIP
Object_synonym: mothers against decapentaplegic homolog-interacting protein
Object_synonym: novel serine protease
Object_synonym: NSP
Object_synonym: receptor activation anchor
Object_synonym: SARA
Object_synonym: smad anchor for receptor activation
Object_synonym: SMADIP
Object_synonym: ZFYVE9

subject: PR_000000125
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007178
  Ontology_term: cell surface receptor protein serine/threonine kinase signaling pathway
Evidence_source: PANTHER:PTHR22835:SF7
Evidence_code: ISS
Inferred_from: PANTHER:PTHR22835:SF7
DB_ID: PANTHER:PTHR22835:SF7
DB_ID: UniProtKB:A2A8R0
DB_ID: UniProtKB:O95405
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000127
type: Class
Object_term: smad ubiquitination regulatory factor
Object_synonym: smurf

subject: PR_000000127
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006511
  Ontology_term: ubiquitin-dependent protein catabolic process
Evidence_source: PIRSF:PIRSF500454
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500454
DB_ID: PIRSF:PIRSF500454
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000127
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007398
  Ontology_term: ectoderm development
Evidence_source: PIRSF:PIRSF500454
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500454
DB_ID: PIRSF:PIRSF500454
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000127
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009968
  Ontology_term: negative regulation of signal transduction
Evidence_source: PIRSF:PIRSF500454
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500454
DB_ID: PIRSF:PIRSF500454
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000129
type: Class
Object_term: thrombospondin-1
Object_synonym: glycoprotein G
Object_synonym: THBS1
Object_synonym: TSP
Object_synonym: TSP1

subject: PR_000000129
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007596
  Ontology_term: blood coagulation
Evidence_source: PANTHER:PTHR10199:SF37
Evidence_code: ISS
Inferred_from: PANTHER:PTHR10199:SF37
Inferred_from: UniProtKB:P07996
Inferred_from: UniProtKB:P35441
Inferred_from: UniProtKB:Q80YQ1
Inferred_from: UniProtKB:Q8CGB2
DB_ID: PANTHER:PTHR10199:SF37
DB_ID: UniProtKB:P07996
DB_ID: UniProtKB:P35441
DB_ID: UniProtKB:Q80YQ1
DB_ID: UniProtKB:Q8CGB2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000137
type: Class
Object_term: BMP receptor type-1A sequence variant Y62D (human)
Object_synonym: BMP receptor type-1A sequence variant 1 (human)
Object_synonym: hBMPR1A/var:Y62D
Object_synonym: UniProtKB:P36894, Tyr-62, CHEBI:29958

subject: PR_000000137
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12417513
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022828
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000138
type: Class
Object_term: BMP receptor type-1A sequence variant C82Y (human)
Object_synonym: BMP receptor type-1A sequence variant 2 (human)
Object_synonym: hBMPR1A/var:C82Y
Object_synonym: UniProtKB:P36894, Cys-82, CHEBI:46858

subject: PR_000000138
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12417513
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022829
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000139
type: Class
Object_term: BMP receptor type-1A sequence variant C124R (human)
Object_synonym: BMP receptor type-1A sequence variant 3 (human)
Object_synonym: hBMPR1A/var:C124R
Object_synonym: UniProtKB:P36894, Cys-124, CHEBI:29952

subject: PR_000000139
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:11536076
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015533
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000140
type: Class
Object_term: BMP receptor type-1A sequence variant C130R (human)
Object_synonym: BMP receptor type-1A sequence variant 4 (human)
Object_synonym: hBMPR1A/var:C130R
Object_synonym: UniProtKB:P36894, Cys-130, CHEBI:29952

subject: PR_000000140
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12136244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022830
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000141
type: Class
Object_term: BMP receptor type-1A sequence variant A338D (human)
Object_synonym: BMP receptor type-1A sequence variant 5 (human)
Object_synonym: hBMPR1A/var:A338D
Object_synonym: UniProtKB:P36894, Ala-338, CHEBI:29958

subject: PR_000000141
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:6457
  Ontology_term: Cowden syndrome
Evidence_source: PMID:11536076
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015534
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000142
type: Class
Object_term: BMP receptor type-1A sequence variant C376Y (human)
Object_synonym: BMP receptor type-1A sequence variant 6 (human)
Object_synonym: hBMPR1A/var:C376Y
Object_synonym: UniProtKB:P36894, Cys-376, CHEBI:46858

subject: PR_000000142
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:11536076
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015535
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000143
type: Class
Object_term: BMP receptor type-1A sequence variant R443C (human)
Object_synonym: BMP receptor type-1A sequence variant 7 (human)
Object_synonym: hBMPR1A/var:R443C
Object_synonym: UniProtKB:P36894, Arg-443, CHEBI:29950

subject: PR_000000143
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12417513
Evidence_source: PMID:17344846
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022831
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000144
type: Class
Object_term: BMP receptor type-1A sequence variant M470T (human)
Object_synonym: BMP receptor type-1A sequence variant 8 (human)
Object_synonym: hBMPR1A/var:M470T
Object_synonym: UniProtKB:P36894, Met-470, CHEBI:30013

subject: PR_000000144
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12630959
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022832
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000146
type: Class
Object_term: BMP receptor type-1B sequence variant I200K (human)
Object_synonym: BMP receptor type-1B sequence variant 1 (human)
Object_synonym: hBMPR1B/var:I200K
Object_synonym: UniProtKB:O00238-1, Ile-200, CHEBI:29967

subject: PR_000000146
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050581
  Ontology_term: brachydactyly
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023819
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000146
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023819
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000146
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023819
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000147
type: Class
Object_term: BMP receptor type-1B sequence variant R486W (human)
Object_synonym: BMP receptor type-1B sequence variant 2 (human)
Object_synonym: hBMPR1B/var:R486W
Object_synonym: UniProtKB:O00238-1, Arg-486, CHEBI:29954

subject: PR_000000147
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050581
  Ontology_term: brachydactyly
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023820
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000147
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023820
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000147
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:14523231
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023820
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000149
type: Class
Object_term: BMP receptor type-2 sequence variant C60Y (human)
Object_synonym: BMP receptor type-2 sequence variant 1 (human)
Object_synonym: hBMPR2/var:C60Y
Object_synonym: UniProtKB:Q13873-1, Cys-60, CHEBI:46858

subject: PR_000000149
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11015450
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013670
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000150
type: Class
Object_term: BMP receptor type-2 sequence variant D485G (human)
Object_synonym: BMP receptor type-2 sequence variant 10 (human)
Object_synonym: hBMPR2/var:D485G
Object_synonym: UniProtKB:Q13873-1, Asp-485, CHEBI:29947

subject: PR_000000150
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:10973254
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013679
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000151
type: Class
Object_term: BMP receptor type-2 sequence variant R491Q (human)
Object_synonym: BMP receptor type-2 sequence variant 11 (human)
Object_synonym: hBMPR2/var:R491Q
Object_synonym: UniProtKB:Q13873-1, Arg-491, CHEBI:30011

subject: PR_000000151
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:10903931
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013680
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000152
type: Class
Object_term: BMP receptor type-2 sequence variant R491W (human)
Object_synonym: BMP receptor type-2 sequence variant 12 (human)
Object_synonym: hBMPR2/var:R491W
Object_synonym: UniProtKB:Q13873-1, Arg-491, CHEBI:29954

subject: PR_000000152
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:10903931
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013681
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000153
type: Class
Object_term: BMP receptor type-2 sequence variant K512T (human)
Object_synonym: BMP receptor type-2 sequence variant 13 (human)
Object_synonym: hBMPR2/var:K512T
Object_synonym: UniProtKB:Q13873-1, Lys-512, CHEBI:30013

subject: PR_000000153
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11115378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013682
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000154
type: Class
Object_term: BMP receptor type-2 sequence variant N519K (human)
Object_synonym: BMP receptor type-2 sequence variant 14 (human)
Object_synonym: hBMPR2/var:N519K
Object_synonym: UniProtKB:Q13873-1, Asn-519, CHEBI:29967

subject: PR_000000154
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: UniProtKB_VAR:VAR_013683
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013683
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000155
type: Class
Object_term: BMP receptor type-2 sequence variant C117Y (human)
Object_synonym: BMP receptor type-2 sequence variant 2 (human)
Object_synonym: hBMPR2/var:C117Y
Object_synonym: UniProtKB:Q13873-1, Cys-117, CHEBI:46858

subject: PR_000000155
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11015450
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013671
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000156
type: Class
Object_term: BMP receptor type-2 sequence variant C118W (human)
Object_synonym: BMP receptor type-2 sequence variant 3 (human)
Object_synonym: hBMPR2/var:C118W
Object_synonym: UniProtKB:Q13873-1, Cys-118, CHEBI:29954

subject: PR_000000156
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:10973254
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013672
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000157
type: Class
Object_term: BMP receptor type-2 sequence variant C123R (human)
Object_synonym: BMP receptor type-2 sequence variant 4 (human)
Object_synonym: hBMPR2/var:C123R
Object_synonym: UniProtKB:Q13873-1, Cys-123, CHEBI:29952

subject: PR_000000157
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11115378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013673
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000158
type: Class
Object_term: BMP receptor type-2 sequence variant C123S (human)
Object_synonym: BMP receptor type-2 sequence variant 5 (human)
Object_synonym: hBMPR2/var:C123S
Object_synonym: UniProtKB:Q13873-1, Cys-123, CHEBI:29999

subject: PR_000000158
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11115378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013674
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000159
type: Class
Object_term: BMP receptor type-2 sequence variant E224D (human)
Object_synonym: BMP receptor type-2 sequence variant 6 (human)
Object_synonym: hBMPR2/var:E224D
Object_synonym: UniProtKB:Q13873-1, Glu-224, CHEBI:29958

subject: PR_000000159
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11115378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013675
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000160
type: Class
Object_term: BMP receptor type-2 sequence variant C347Y (human)
Object_synonym: BMP receptor type-2 sequence variant 7 (human)
Object_synonym: hBMPR2/var:C347Y
Object_synonym: UniProtKB:Q13873-1, Cys-347, CHEBI:46858

subject: PR_000000160
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:10973254
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013676
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000161
type: Class
Object_term: BMP receptor type-2 sequence variant C420R (human)
Object_synonym: BMP receptor type-2 sequence variant 8 (human)
Object_synonym: hBMPR2/var:C420R
Object_synonym: UniProtKB:Q13873-1, Cys-420, CHEBI:29952

subject: PR_000000161
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11115378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013677
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000162
type: Class
Object_term: BMP receptor type-2 sequence variant C483R (human)
Object_synonym: BMP receptor type-2 sequence variant 9 (human)
Object_synonym: hBMPR2/var:C483R
Object_synonym: UniProtKB:Q13873-1, Cys-483, CHEBI:29952

subject: PR_000000162
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14557
  Ontology_term: primary pulmonary hypertension
Evidence_source: PMID:11015450
Evidence_source: PMID:12358323
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013678
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000164
type: Class
Object_term: bone morphogenetic protein 2
Object_synonym: BMP-2
Object_synonym: BMP-2A
Object_synonym: BMP2
Object_synonym: BMP2A
Object_synonym: bone morphogenetic protein 2A

subject: PR_000000164
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0001501
  Ontology_term: skeletal system development
Evidence_source: PANTHER:PTHR11848:SF50
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF50
DB_ID: PANTHER:PTHR11848:SF50
DB_ID: UniProtKB:P12643
DB_ID: UniProtKB:P21274
DB_ID: UniProtKB:Q3V1I4
DB_ID: UniProtKB:Q497W8
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000164
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007267
  Ontology_term: cell-cell signaling
Evidence_source: PANTHER:PTHR11848:SF50
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF50
DB_ID: PANTHER:PTHR11848:SF50
DB_ID: UniProtKB:P12643
DB_ID: UniProtKB:P21274
DB_ID: UniProtKB:Q3V1I4
DB_ID: UniProtKB:Q497W8
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000164
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030509
  Ontology_term: BMP signaling pathway
Evidence_source: PANTHER:PTHR11848:SF50
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF50
DB_ID: PANTHER:PTHR11848:SF50
DB_ID: UniProtKB:P12643
DB_ID: UniProtKB:P21274
DB_ID: UniProtKB:Q3V1I4
DB_ID: UniProtKB:Q497W8
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000165
type: Class
Object_term: bone morphogenetic protein 4
Object_synonym: BMP-2B
Object_synonym: BMP-4
Object_synonym: BMP2B
Object_synonym: BMP4
Object_synonym: bone morphogenetic protein 2B
Object_synonym: Dvr-4
Object_synonym: DVR4

subject: PR_000000165
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0001501
  Ontology_term: skeletal system development
Evidence_source: PANTHER:PTHR11848:SF49
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF49
DB_ID: PANTHER:PTHR11848:SF49
DB_ID: UniProtKB:P12644
DB_ID: UniProtKB:P21275
DB_ID: UniProtKB:Q3ULR1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000182
type: Class
Object_term: TGF-beta 1
Object_synonym: TGF-beta-1
Object_synonym: TGFB
Object_synonym: TGFB1

subject: PR_000000182
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008283
  Ontology_term: cell population proliferation
Evidence_source: PANTHER:PTHR11848:SF32
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF32
DB_ID: PANTHER:PTHR11848:SF32
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000182
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030154
  Ontology_term: cell differentiation
Evidence_source: PANTHER:PTHR11848:SF32
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF32
DB_ID: PANTHER:PTHR11848:SF32
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000183
type: Class
Object_term: TGF-beta 2
Object_synonym: BSC-1 cell growth inhibitor
Object_synonym: cetermin
Object_synonym: G-TSF
Object_synonym: glioblastoma-derived T-cell suppressor factor
Object_synonym: polyergin
Object_synonym: TGF-beta-2
Object_synonym: TGFB2

subject: PR_000000183
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008283
  Ontology_term: cell population proliferation
Evidence_source: PANTHER:PTHR11848:SF33
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF33
DB_ID: PANTHER:PTHR11848:SF33
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000186
type: Class
Object_term: TGF-beta receptor type-1 sequence variant T200I (human)
Object_synonym: hTGFBR1/var:T200I
Object_synonym: TGF-beta receptor type-1 sequence variant 1 (human)
Object_synonym: UniProtKB:P36897, Thr-200, CHEBI:30009
Object_synonym: UniProtKB:P36897-1, Thr-200, CHEBI:30009

subject: PR_000000186
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022344
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000187
type: Class
Object_term: TGF-beta receptor type-1 sequence variant 10 (human)
Object_synonym: hTGFBR1/var:10
Object_synonym: TGFBR1*10A

subject: PR_000000187
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001605
  Ontology_term: amino_acid_insertion
Evidence_source: PMID:9661882
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022343
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000188
type: Class
Object_term: TGF-beta receptor type-1 sequence variant 11 (human)
Object_synonym: hTGFBR1/var:11
Object_synonym: TGFBR1*6A (human)
Object_synonym: UniProtKB:P36897, 1-23, 27-503
Object_synonym: UniProtKB:P36897-1, 1-23, 27-503

subject: PR_000000188
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:9661882
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022342
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000188
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:9661882
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022342
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000189
type: Class
Object_term: TGF-beta receptor type-1 sequence variant K232E (human)
Object_synonym: hTGFBR1/var:K232E
Object_synonym: TGF-beta receptor type-1 sequence variant 2 (human)
Object_synonym: UniProtKB:P36897-1, Lys-232, CHEBI:29972

subject: PR_000000189
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:16928994
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029481
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000190
type: Class
Object_term: TGF-beta receptor type-1 sequence variant S241L (human)
Object_synonym: hTGFBR1/var:S241L
Object_synonym: TGF-beta receptor type-1 sequence variant 3 (human)
Object_synonym: UniProtKB:P36897-1, Ser-241, CHEBI:30006

subject: PR_000000190
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:16596670
Evidence_source: PMID:16791849
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029482
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000191
type: Class
Object_term: TGF-beta receptor type-1 sequence variant N267H (human)
Object_synonym: hTGFBR1/var:N267H
Object_synonym: TGF-beta receptor type-1 sequence variant 4 (human)
Object_synonym: UniProtKB:P36897-1, Asn-267, CHEBI:29979

subject: PR_000000191
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:16791849
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029483
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000192
type: Class
Object_term: TGF-beta receptor type-1 sequence variant M318R (human)
Object_synonym: hTGFBR1/var:M318R
Object_synonym: TGF-beta receptor type-1 sequence variant 5 (human)
Object_synonym: UniProtKB:P36897-1, Met-318, CHEBI:29952

subject: PR_000000192
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022345
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000193
type: Class
Object_term: TGF-beta receptor type-1 sequence variant D400G (human)
Object_synonym: hTGFBR1/var:D400G
Object_synonym: TGF-beta receptor type-1 sequence variant 6 (human)
Object_synonym: UniProtKB:P36897-1, Asp-400, CHEBI:29947

subject: PR_000000193
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:15731757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022346
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000194
type: Class
Object_term: TGF-beta receptor type-1 sequence variant R487P (human)
Object_synonym: hTGFBR1/var:R487P
Object_synonym: TGF-beta receptor type-1 sequence variant 7 (human)
Object_synonym: UniProtKB:P36897-1, Arg-487, CHEBI:50342

subject: PR_000000194
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14756
  Ontology_term: vascular type Ehlers-Danlos syndrome
Evidence_source: PMID:15731757
Evidence_source: PMID:16928994
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022347
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000195
type: Class
Object_term: TGF-beta receptor type-1 sequence variant R487E (human)
Object_synonym: hTGFBR1/var:R487E
Object_synonym: TGF-beta receptor type-1 sequence variant 8 (human)
Object_synonym: UniProtKB:P36897-1, Arg-487, CHEBI:29972

subject: PR_000000195
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050466
  Ontology_term: Loeys-Dietz syndrome
Evidence_source: PMID:16791849
Evidence_source: PMID:16928994
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029484
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000196
type: Class
Object_term: TGF-beta receptor type-1 sequence variant R487W (human)
Object_synonym: hTGFBR1/var:R487W
Object_synonym: TGF-beta receptor type-1 sequence variant 9 (human)
Object_synonym: UniProtKB:P36897-1, Arg-487, CHEBI:29954

subject: PR_000000196
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14756
  Ontology_term: vascular type Ehlers-Danlos syndrome
Evidence_source: PMID:16928994
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_029485
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000200
type: Class
Object_term: activin receptor type-1 sequence variant R206H (human)
Object_synonym: activin receptor type-1 sequence variant 1 (human)
Object_synonym: hACVR1/var:R206H
Object_synonym: UniProtKB:Q04771, Arg-206, CHEBI:29979

subject: PR_000000200
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13374
  Ontology_term: fibrodysplasia ossificans progressiva
Evidence_source: PMID:8397373
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_028244
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000200
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: PMID:8397373
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_028444
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000214
type: Class
Object_term: activin receptor type-2B sequence variant R40H (human)
Object_synonym: activin receptor type-2B sequence variant 1 (human)
Object_synonym: hACVR2B/var:R40H
Object_synonym: UniProtKB:Q13705-1, Arg-40, CHEBI:29979

subject: PR_000000214
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050545
  Ontology_term: visceral heterotaxy
Evidence_source: PMID:9916847
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013281
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000215
type: Class
Object_term: activin receptor type-2B sequence variant V494I (human)
Object_synonym: activin receptor type-2B sequence variant 2 (human)
Object_synonym: hACVR2B/var:V494I
Object_synonym: UniProtKB:Q13705-1, Val-494, CHEBI:30009

subject: PR_000000215
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050545
  Ontology_term: visceral heterotaxy
Evidence_source: PMID:9916847
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_013282
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000221
type: Class
Object_term: Muellerian-inhibiting factor sequence variant V12G (human)
Object_synonym: anti-Muellerian hormone sequence variant 1 (human)
Object_synonym: hAMH/var:V12G
Object_synonym: UniProtKB:P03971, Val-12, CHEBI:29947

subject: PR_000000221
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007483
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000222
type: Class
Object_term: Muellerian-inhibiting factor sequence variant L70P (human)
Object_synonym: anti-Muellerian hormone sequence variant 2 (human)
Object_synonym: hAMH/var:L70P
Object_synonym: UniProtKB:P03971, Leu-70, CHEBI:50342

subject: PR_000000222
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007485
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000223
type: Class
Object_term: Muellerian-inhibiting factor sequence variant G101V (human)
Object_synonym: anti-Muellerian hormone sequence variant 3 (human)
Object_synonym: hAMH/var:G101V
Object_synonym: UniProtKB:P03971, Gly-101, CHEBI:30015

subject: PR_000000223
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007486
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000224
type: Class
Object_term: Muellerian-inhibiting factor sequence variant R123W (human)
Object_synonym: anti-Muellerian hormone sequence variant 4 (human)
Object_synonym: hAMH/var:R123W
Object_synonym: UniProtKB:P03971, Arg-123, CHEBI:29954

subject: PR_000000224
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007487
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000225
type: Class
Object_term: Muellerian-inhibiting factor sequence variant Y167C (human)
Object_synonym: anti-Muellerian hormone sequence variant 5 (human)
Object_synonym: hAMH/var:Y167C
Object_synonym: UniProtKB:P03971, Tyr-167, CHEBI:29950

subject: PR_000000225
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007488
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000226
type: Class
Object_term: Muellerian-inhibiting factor sequence variant R194C (human)
Object_synonym: anti-Muellerian hormone sequence variant 6 (human)
Object_synonym: hAMH/var:R194C
Object_synonym: UniProtKB:P03971, Arg-194, CHEBI:29950

subject: PR_000000226
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050791
  Ontology_term: persistent Mullerian duct syndrome
Evidence_source: PMID:14673134
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007490
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000226
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001555
  Ontology_term: decreased_translational_product_level
Evidence_source: PMID:14673134
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007490
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000226
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001558
  Ontology_term: polypeptide_localization_variant
Evidence_source: PMID:14673134
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007490
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000227
type: Class
Object_term: Muellerian-inhibiting factor sequence variant V477A (human)
Object_synonym: anti-Muellerian hormone sequence variant 7 (human)
Object_synonym: hAMH/var:V477A
Object_synonym: UniProtKB:P03971, Val-477, CHEBI:46217

subject: PR_000000227
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001558
  Ontology_term: polypeptide_localization_variant
Evidence_source: PMID:8162013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007492
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000231
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant P276R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 1 (human)
Object_synonym: hCOMP/var:P276R
Object_synonym: UniProtKB:P49747-1, Pro-276, CHEBI:29952

subject: PR_000000231
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:11565064
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026239
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000232
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant C387G (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 10 (human)
Object_synonym: hCOMP/var:C387G
Object_synonym: UniProtKB:P49747-1, Cys-387, CHEBI:29947

subject: PR_000000232
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007625
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007625
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000233
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D408Y (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 11 (human)
Object_synonym: hCOMP/var:D408Y
Object_synonym: UniProtKB:P49747-1, Asp-408, CHEBI:46858

subject: PR_000000233
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007627
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000234
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D420A (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 12 (human)
Object_synonym: hCOMP/var:D420A
Object_synonym: UniProtKB:P49747-1, Asp-420, CHEBI:46217

subject: PR_000000234
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:11565064
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026240
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000235
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant G440E (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 13 (human)
Object_synonym: hCOMP/var:G440E
Object_synonym: UniProtKB:P49747-1, Gly-440, CHEBI:29972

subject: PR_000000235
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007628
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007628
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000236
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant G440R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 14 (human)
Object_synonym: hCOMP/var:G440R
Object_synonym: UniProtKB:P49747-1, Gly-440, CHEBI:29952

subject: PR_000000236
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007629
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000237
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant N453S (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 15 (human)
Object_synonym: hCOMP/var:N453S
Object_synonym: UniProtKB:P49747-1, Asn-453, CHEBI:29999

subject: PR_000000237
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: UniProtKB_VAR:VAR_007630
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007630
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000238
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D439V (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 16 (human)
Object_synonym: hCOMP/var:D439V
Object_synonym: UniProtKB:P49747-1, Asp-439, CHEBI:30015

subject: PR_000000238
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007618
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007618
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000239
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant C468Y (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 17 (human)
Object_synonym: hCOMP/var:C468Y
Object_synonym: UniProtKB:P49747-1, Cys-468, CHEBI:46858

subject: PR_000000239
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:7670471
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007632
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000240
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D472Y (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 18 (human)
Object_synonym: hCOMP/var:D472Y
Object_synonym: UniProtKB:P49747-1, Asp-472, CHEBI:46858

subject: PR_000000240
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:7670471
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007634
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000241
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D473G (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 19 (human)
Object_synonym: hCOMP/var:D473G
Object_synonym: UniProtKB:P49747-1, Asp-473, CHEBI:29947

subject: PR_000000241
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007635
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007635
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000242
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D290N (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 2 (human)
Object_synonym: hCOMP/var:D290N
Object_synonym: UniProtKB:P49747-1, Asp-290, CHEBI:50347

subject: PR_000000242
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007614
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007614
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000243
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D482G (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 20 (human)
Object_synonym: hCOMP/var:D482G
Object_synonym: UniProtKB:P49747-1, Asp-482, CHEBI:29947

subject: PR_000000243
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:9452063
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007637
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000244
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D518N (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 21 (human)
Object_synonym: hCOMP/var:D518N
Object_synonym: UniProtKB:P49747-1, Asp-518, CHEBI:50347

subject: PR_000000244
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007639
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007639
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000245
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant G719D (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 22 (human)
Object_synonym: hCOMP/var:G719D
Object_synonym: UniProtKB:P49747-1, Gly-719, CHEBI:29958

subject: PR_000000245
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:11746044
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017103
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000246
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant N523K (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 23 (human)
Object_synonym: hCOMP/var:N523K
Object_synonym: UniProtKB:P49747-1, Asn-523, CHEBI:29967

subject: PR_000000246
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:9021009
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007640
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000247
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant T585M (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 24 (human)
Object_synonym: hCOMP/var:T585M
Object_synonym: UniProtKB:P49747-1, Thr-585, CHEBI:16044

subject: PR_000000247
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:11565064
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007641
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000247
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:11565064
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007641
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000248
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant T585R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 25 (human)
Object_synonym: hCOMP/var:T585R
Object_synonym: UniProtKB:P49747-1, Thr-585, CHEBI:29952

subject: PR_000000248
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: UniProtKB_VAR:VAR_007642
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007642
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000249
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant 26 (human)
Object_synonym: hCOMP/var:26

subject: PR_000000249
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007626
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007626
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000250
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D372del (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 27 (human)
Object_synonym: hCOMP/var:D372del
Object_synonym: UniProtKB:P49747-1, 21-371, 373-757

subject: PR_000000250
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007623
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007623
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000251
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D374del (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 28 (human)
Object_synonym: hCOMP/var:D374del
Object_synonym: UniProtKB:P49747-1, 21-373, 375-757

subject: PR_000000251
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007624
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007624
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000252
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant S459del (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 29 (human)
Object_synonym: hCOMP/var:S459del
Object_synonym: UniProtKB:P49747-1, 21-458, 460-757

subject: PR_000000252
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007631
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007631
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000253
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant G299R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 3 (human)
Object_synonym: hCOMP/var:G299R
Object_synonym: UniProtKB:P49747-1, Gly-299, CHEBI:29952

subject: PR_000000253
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007615
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007615
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000254
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D469del (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 30 (human)
Object_synonym: hCOMP/var:D469del
Object_synonym: UniProtKB:P49747-1, 21-468, 470-757

subject: PR_000000254
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007633
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007633
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000255
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D473del (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 31 (human)
Object_synonym: hCOMP/var:D473del
Object_synonym: UniProtKB:P49747-1, 21-472, 474-757

subject: PR_000000255
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007636
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007636
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000256
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant 32 (human)
Object_synonym: hCOMP/var:32
Object_synonym: UniProtKB:P49747-1, 21-366, 369-757

subject: PR_000000256
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: UniProtKB_VAR:VAR_007621
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007621
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000257
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant 33 (human)
Object_synonym: hCOMP/var:33
Object_synonym: UniProtKB:P49747-1, 21-512, 517-757

subject: PR_000000257
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007638
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007638
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000258
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant C328R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 4 (human)
Object_synonym: hCOMP/var:C328R
Object_synonym: UniProtKB:P49747-1, Cys-328, CHEBI:29952

subject: PR_000000258
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: UniProtKB_VAR:VAR_007616
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007616
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000259
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D342Y (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 5 (human)
Object_synonym: hCOMP/var:D342Y
Object_synonym: UniProtKB:P49747-1, Asp-342, CHEBI:46858

subject: PR_000000259
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:7670472
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007617
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000260
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant C348R (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 6 (human)
Object_synonym: hCOMP/var:C348R
Object_synonym: UniProtKB:P49747-1, Cys-348, CHEBI:29952

subject: PR_000000260
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080047
  Ontology_term: pseudoachondroplasia
Evidence_source: PMID:11746045
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017102
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000261
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D361V (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 7 (human)
Object_synonym: hCOMP/var:D361V
Object_synonym: UniProtKB:P49747-1, Asp-361, CHEBI:30015

subject: PR_000000261
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: UniProtKB_VAR:VAR_007619
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007619
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000262
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant D361Y (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 8 (human)
Object_synonym: hCOMP/var:D361Y
Object_synonym: UniProtKB:P49747-1, Asp-361, CHEBI:46858

subject: PR_000000262
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:9452026
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007620
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000263
type: Class
Object_term: cartilage oligomeric matrix protein sequence variant C371S (human)
Object_synonym: cartilage oligomeric matrix protein sequence variant 9 (human)
Object_synonym: hCOMP/var:C371S
Object_synonym: UniProtKB:P49747-1, Cys-371, CHEBI:29999

subject: PR_000000263
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:12721
  Ontology_term: multiple epiphyseal dysplasia
Evidence_source: PMID:9184241
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_007622
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000266
type: Class
Object_term: CREB-binding protein sequence variant R1378P (human)
Object_synonym: CREB-binding protein sequence variant 1 (human)
Object_synonym: hCREBBP/var:R1378P
Object_synonym: UniProtKB:Q92793-1, Arg-1378, CHEBI:50342

subject: PR_000000266
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1933
  Ontology_term: Rubinstein-Taybi syndrome
Evidence_source: PMID:11331617
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015578
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000266
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:11331617
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015578
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000266
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004402
  Ontology_term: histone acetyltransferase activity
Modifier: NOT
Evidence_source: PMID:11331617
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015578
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000281
type: Class
Object_term: growth/differentiation factor 5
Object_synonym: BMP-14
Object_synonym: BMP14
Object_synonym: bone morphogenetic protein 14
Object_synonym: Bp
Object_synonym: cartilage-derived morphogenetic protein 1
Object_synonym: CDMP-1
Object_synonym: CDMP1
Object_synonym: GDF-5
Object_synonym: GDF5
Object_synonym: radotermin

subject: PR_000000281
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030326
  Ontology_term: embryonic limb morphogenesis
Evidence_source: PANTHER:PTHR11848:SF44
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF44
DB_ID: PANTHER:PTHR11848:SF44
DB_ID: UniProtKB:P43026
DB_ID: UniProtKB:P43027
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000282
type: Class
Object_term: growth/differentiation factor 7
Object_synonym: GDF-7
Object_synonym: GDF7

subject: PR_000000282
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007154
  Ontology_term: cell communication
Evidence_source: PANTHER:PTHR11848:SF42
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11848:SF42
DB_ID: PANTHER:PTHR11848:SF42
DB_ID: UniProtKB:P43029
DB_ID: UniProtKB:Q7Z4P5
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000292
type: Class
Object_term: nodal protein sequence variant R183Q (human)
Object_synonym: hNODAL/var:R183Q
Object_synonym: nodal protein sequence variant 1 (human)
Object_synonym: UniProtKB:Q96S42, Arg-183, CHEBI:30011

subject: PR_000000292
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050545
  Ontology_term: visceral heterotaxy
Evidence_source: PMID:9354794
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015111
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000298
type: Class
Object_term: pituitary homeobox 2 sequence variant R89W (human)
Object_synonym: hPITX2/var:R89W
Object_synonym: pituitary homeobox 2 sequence variant 1 (human)
Object_synonym: UniProtKB:Q99697-1, Arg-89, CHEBI:29954

subject: PR_000000298
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050786
  Ontology_term: iridogoniodysgenesis syndrome
Evidence_source: PMID:9437321
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_003762
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000299
type: Class
Object_term: pituitary homeobox 2 sequence variant L100Q (human)
Object_synonym: hPITX2/var:L100Q
Object_synonym: pituitary homeobox 2 sequence variant 2 (human)
Object_synonym: UniProtKB:Q99697-1, Leu-100, CHEBI:30011

subject: PR_000000299
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14686
  Ontology_term: Axenfeld-Rieger syndrome
Evidence_source: PMID:8944018
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_003763
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000300
type: Class
Object_term: pituitary homeobox 2 sequence variant T114P (human)
Object_synonym: hPITX2/var:T114P
Object_synonym: pituitary homeobox 2 sequence variant 3 (human)
Object_synonym: UniProtKB:Q99697-1, Thr-114, CHEBI:50342

subject: PR_000000300
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14686
  Ontology_term: Axenfeld-Rieger syndrome
Evidence_source: PMID:8944018
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_003764
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000301
type: Class
Object_term: pituitary homeobox 2 sequence variant R115H (human)
Object_synonym: hPITX2/var:R115H
Object_synonym: pituitary homeobox 2 sequence variant 4 (human)
Object_synonym: UniProtKB:Q99697-1, Arg-115, CHEBI:29979

subject: PR_000000301
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050786
  Ontology_term: iridogoniodysgenesis syndrome
Evidence_source: PMID:9618168
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_003765
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000302
type: Class
Object_term: pituitary homeobox 2 sequence variant R137P (human)
Object_synonym: hPITX2/var:R137P
Object_synonym: pituitary homeobox 2 sequence variant 5 (human)
Object_synonym: UniProtKB:Q99697-1, Arg-137, CHEBI:50342

subject: PR_000000302
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14686
  Ontology_term: Axenfeld-Rieger syndrome
Evidence_source: PMID:8944018
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_003766
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000317
type: Class
Object_term: activin receptor type-1-like sequence variant G48R (human)
Object_synonym: hACVRL1/var:G48R
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 1 (human)
Object_synonym: UniProtKB:P37023, Gly-48, CHEBI:29952

subject: PR_000000317
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026785
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000318
type: Class
Object_term: activin receptor type-1-like sequence variant E215K (human)
Object_synonym: hACVRL1/var:E215K
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 10 (human)
Object_synonym: UniProtKB:P37023, Glu-215, CHEBI:29967

subject: PR_000000318
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026789
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000319
type: Class
Object_term: activin receptor type-1-like sequence variant H222del (human)
Object_synonym: hACVRL1/var:H222del
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 11 (human)
Object_synonym: UniProtKB:P37023, 22-221, 223-503

subject: PR_000000319
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: UniProtKB_VAR:VAR_006209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006209
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000319
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006209
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000320
type: Class
Object_term: activin receptor type-1-like sequence variant S233del (human)
Object_synonym: hACVRL1/var:S233del
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 12 (human)
Object_synonym: UniProtKB:P37023, 22-232, 234-503

subject: PR_000000320
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: UniProtKB_VAR:VAR_026792
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026792
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000321
type: Class
Object_term: activin receptor type-1-like sequence variant G223R (human)
Object_synonym: hACVRL1/var:G223R
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 13 (human)
Object_synonym: UniProtKB:P37023, Gly-223, CHEBI:29952

subject: PR_000000321
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026790
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000322
type: Class
Object_term: activin receptor type-1-like sequence variant K229R (human)
Object_synonym: hACVRL1/var:K229R
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 14 (human)
Object_synonym: UniProtKB:P37023, Lys-229, CHEBI:29952

subject: PR_000000322
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026791
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000323
type: Class
Object_term: activin receptor type-1-like sequence variant D254del (human)
Object_synonym: hACVRL1/var:D254del
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 15 (human)
Object_synonym: UniProtKB:P37023, 22-253, 255-503

subject: PR_000000323
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: UniProtKB_VAR:VAR_026793
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026793
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000323
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026793
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000323
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026793
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000324
type: Class
Object_term: activin receptor type-1-like sequence variant M376V (human)
Object_synonym: hACVRL1/var:M376V
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 16 (human)
Object_synonym: UniProtKB:P37023, Met-376, CHEBI:30015

subject: PR_000000324
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026801
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000325
type: Class
Object_term: activin receptor type-1-like sequence variant L285F (human)
Object_synonym: hACVRL1/var:L285F
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 17 (human)
Object_synonym: UniProtKB:P37023, Leu-285, CHEBI:29997

subject: PR_000000325
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026794
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000326
type: Class
Object_term: activin receptor type-1-like sequence variant A306P (human)
Object_synonym: hACVRL1/var:A306P
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 18 (human)
Object_synonym: UniProtKB:P37023, Ala-306, CHEBI:50342

subject: PR_000000326
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026795
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000327
type: Class
Object_term: activin receptor type-1-like sequence variant H314Y (human)
Object_synonym: hACVRL1/var:H314Y
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 19 (human)
Object_synonym: UniProtKB:P37023, His-314, CHEBI:46858

subject: PR_000000327
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026796
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000328
type: Class
Object_term: activin receptor type-1-like sequence variant W50C (human)
Object_synonym: hACVRL1/var:W50C
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 2 (human)
Object_synonym: UniProtKB:P37023, Trp-50, CHEBI:29950

subject: PR_000000328
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10767348
Evidence_source: PMID:14684682
Evidence_source: PMID:9245985
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006204
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000328
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006204
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000328
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006204
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000329
type: Class
Object_term: activin receptor type-1-like sequence variant S333I (human)
Object_synonym: hACVRL1/var:S333I
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 20 (human)
Object_synonym: UniProtKB:P37023, Ser-333, CHEBI:30009

subject: PR_000000329
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10767348
Evidence_source: PMID:14684682
Evidence_source: PMID:9245985
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006210
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000329
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006210
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000329
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006210
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000330
type: Class
Object_term: activin receptor type-1-like sequence variant L337P (human)
Object_synonym: hACVRL1/var:L337P
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 21 (human)
Object_synonym: UniProtKB:P37023, Leu-337, CHEBI:50342

subject: PR_000000330
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026797
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000331
type: Class
Object_term: activin receptor type-1-like sequence variant C344Y (human)
Object_synonym: hACVRL1/var:C344Y
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 22 (human)
Object_synonym: UniProtKB:P37023, Cys-344, CHEBI:46858

subject: PR_000000331
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10767348
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026798
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000331
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026798
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000331
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026798
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000332
type: Class
Object_term: activin receptor type-1-like sequence variant A347P (human)
Object_synonym: hACVRL1/var:A347P
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 23 (human)
Object_synonym: UniProtKB:P37023, Ala-347, CHEBI:50342

subject: PR_000000332
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026799
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000333
type: Class
Object_term: activin receptor type-1-like sequence variant R374Q (human)
Object_synonym: hACVRL1/var:R374Q
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 24 (human)
Object_synonym: UniProtKB:P37023, Arg-374, CHEBI:30011

subject: PR_000000333
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026800
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000333
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026800
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000333
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026800
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000334
type: Class
Object_term: activin receptor type-1-like sequence variant R374W (human)
Object_synonym: hACVRL1/var:R374W
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 25 (human)
Object_synonym: UniProtKB:P37023, Arg-374, CHEBI:29954

subject: PR_000000334
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11170071
Evidence_source: PMID:14684682
Evidence_source: PMID:15712270
Evidence_source: PMID:9245985
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006211
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000335
type: Class
Object_term: activin receptor type-1-like sequence variant P378L (human)
Object_synonym: hACVRL1/var:P378L
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 26 (human)
Object_synonym: UniProtKB:P37023, Pro-378, CHEBI:30006

subject: PR_000000335
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026802
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000335
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026802
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000335
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026802
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000336
type: Class
Object_term: activin receptor type-1-like sequence variant E379K (human)
Object_synonym: hACVRL1/var:E379K
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 27 (human)
Object_synonym: UniProtKB:P37023, Glu-379, CHEBI:29967

subject: PR_000000336
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_source: PMID:15712270
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026803
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000337
type: Class
Object_term: activin receptor type-1-like sequence variant M376R (human)
Object_synonym: hACVRL1/var:M376R
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 28 (human)
Object_synonym: UniProtKB:P37023, Met-376, CHEBI:29952

subject: PR_000000337
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:8640225
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006212
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000338
type: Class
Object_term: activin receptor type-1-like sequence variant D397G (human)
Object_synonym: hACVRL1/var:D397G
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 29 (human)
Object_synonym: UniProtKB:P37023, Asp-397, CHEBI:29947

subject: PR_000000338
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026804
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000339
type: Class
Object_term: activin receptor type-1-like sequence variant C51Y (human)
Object_synonym: hACVRL1/var:C51Y
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 3 (human)
Object_synonym: UniProtKB:P37023, Cys-51, CHEBI:46858

subject: PR_000000339
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11170071
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006205
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000340
type: Class
Object_term: activin receptor type-1-like sequence variant I398N (human)
Object_synonym: hACVRL1/var:I398N
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 30 (human)
Object_synonym: UniProtKB:P37023, Ile-398, CHEBI:50347

subject: PR_000000340
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11170071
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026805
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000341
type: Class
Object_term: activin receptor type-1-like sequence variant W399S (human)
Object_synonym: hACVRL1/var:W399S
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 31 (human)
Object_synonym: UniProtKB:P37023, Trp-399, CHEBI:29999

subject: PR_000000341
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11170071
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026806
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000342
type: Class
Object_term: activin receptor type-1-like sequence variant E407D (human)
Object_synonym: hACVRL1/var:E407D
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 32 (human)
Object_synonym: UniProtKB:P37023, Glu-407, CHEBI:29958

subject: PR_000000342
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10767348
Evidence_source: PMID:15712270
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026807
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000343
type: Class
Object_term: activin receptor type-1-like sequence variant R411P (human)
Object_synonym: hACVRL1/var:R411P
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 33 (human)
Object_synonym: UniProtKB:P37023, Arg-411, CHEBI:50342

subject: PR_000000343
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026808
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000344
type: Class
Object_term: activin receptor type-1-like sequence variant R411Q (human)
Object_synonym: hACVRL1/var:R411Q
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 34 (human)
Object_synonym: UniProtKB:P37023, Arg-411, CHEBI:30011

subject: PR_000000344
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_source: PMID:15024723
Evidence_source: PMID:8640225
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006213
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000344
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006213
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000344
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006213
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000345
type: Class
Object_term: activin receptor type-1-like sequence variant R411W (human)
Object_synonym: hACVRL1/var:R411W
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 35 (human)
Object_synonym: UniProtKB:P37023, Arg-411, CHEBI:29954

subject: PR_000000345
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11484689
Evidence_source: PMID:15024723
Evidence_source: PMID:15712270
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026809
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000346
type: Class
Object_term: activin receptor type-1-like sequence variant P424T (human)
Object_synonym: hACVRL1/var:P424T
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 36 (human)
Object_synonym: UniProtKB:P37023, Pro-424, CHEBI:30013

subject: PR_000000346
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:9245985
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006214
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000347
type: Class
Object_term: activin receptor type-1-like sequence variant F425L (human)
Object_synonym: hACVRL1/var:F425L
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 37 (human)
Object_synonym: UniProtKB:P37023, Phe-425, CHEBI:30006

subject: PR_000000347
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026810
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000348
type: Class
Object_term: activin receptor type-1-like sequence variant F425V (human)
Object_synonym: hACVRL1/var:F425V
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 38 (human)
Object_synonym: UniProtKB:P37023, Phe-425, CHEBI:30015

subject: PR_000000348
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15712270
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026811
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000349
type: Class
Object_term: activin receptor type-1-like sequence variant F425del (human)
Object_synonym: hACVRL1/var:F425del
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 39 (human)
Object_synonym: UniProtKB:P37023, 22-423, 425-503

subject: PR_000000349
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: UniProtKB_VAR:VAR_026812
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026812
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000350
type: Class
Object_term: activin receptor type-1-like sequence variant R67Q (human)
Object_synonym: hACVRL1/var:R67Q
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 4 (human)
Object_synonym: UniProtKB:P37023, Arg-67, CHEBI:30011

subject: PR_000000350
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_source: PMID:9245985
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006206
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000350
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006206
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000350
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006206
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000351
type: Class
Object_term: activin receptor type-1-like sequence variant R479L (human)
Object_synonym: hACVRL1/var:R479L
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 40 (human)
Object_synonym: UniProtKB:P37023, Arg-479, CHEBI:30006

subject: PR_000000351
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026813
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000352
type: Class
Object_term: activin receptor type-1-like sequence variant A482V (human)
Object_synonym: hACVRL1/var:A482V
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 41 (human)
Object_synonym: UniProtKB:P37023, Ala-482, CHEBI:30015

subject: PR_000000352
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026814
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000353
type: Class
Object_term: activin receptor type-1-like sequence variant R484W (human)
Object_synonym: hACVRL1/var:R484W
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 42 (human)
Object_synonym: UniProtKB:P37023, Arg-484, CHEBI:29954

subject: PR_000000353
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:11484689
Evidence_source: PMID:15024723
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026815
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000354
type: Class
Object_term: activin receptor type-1-like sequence variant K487T (human)
Object_synonym: hACVRL1/var:K487T
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 43 (human)
Object_synonym: UniProtKB:P37023, Lys-487, CHEBI:30013

subject: PR_000000354
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026816
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000354
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026816
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000355
type: Class
Object_term: activin receptor type-1-like sequence variant GA48/49EP (human)
Object_synonym: hACVRL1/var:GA48/49EP
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 44 (human)
Object_synonym: UniProtKB:P37023, Gly-48, CHEBI:29972
Object_synonym: Ala-49, CHEBI:46217

subject: PR_000000355
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: UniProtKB_VAR:VAR_026784
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026784
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000356
type: Class
Object_term: activin receptor type-1-like sequence variant R67W (human)
Object_synonym: hACVRL1/var:R67W
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 5 (human)
Object_synonym: UniProtKB:P37023, Arg-67, CHEBI:29954

subject: PR_000000356
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:15712270
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026786
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000357
type: Class
Object_term: activin receptor type-1-like sequence variant C77W (human)
Object_synonym: hACVRL1/var:C77W
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 6 (human)
Object_synonym: UniProtKB:P37023, Cys-77, CHEBI:29954

subject: PR_000000357
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10694922
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006207
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000357
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006207
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000357
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006207
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000358
type: Class
Object_term: activin receptor type-1-like sequence variant N96D (human)
Object_synonym: hACVRL1/var:N96D
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 7 (human)
Object_synonym: UniProtKB:P37023, Asn-96, CHEBI:29958

subject: PR_000000358
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:10694922
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006208
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000359
type: Class
Object_term: activin receptor type-1-like sequence variant D179A (human)
Object_synonym: hACVRL1/var:D179A
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 8 (human)
Object_synonym: UniProtKB:P37023, Asp-179, CHEBI:46217

subject: PR_000000359
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026787
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000359
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026787
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000360
type: Class
Object_term: activin receptor type-1-like sequence variant G211D (human)
Object_synonym: hACVRL1/var:G211D
Object_synonym: serine/threonine-protein kinase receptor R3 sequence variant 9 (human)
Object_synonym: UniProtKB:P37023, Gly-211, CHEBI:29958

subject: PR_000000360
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:1270
  Ontology_term: hereditary hemorrhagic telangiectasia
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026788
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000360
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005783
  Ontology_term: endoplasmic reticulum
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026788
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000360
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004675
  Ontology_term: transmembrane receptor protein serine/threonine kinase activity
Modifier: NOT
Evidence_source: PMID:14684682
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026788
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000367
type: Class
Object_term: smad4 sequence variant E330G (human)
Object_synonym: hSMAD4/var:E330G
Object_synonym: smad4 sequence variant 1 (human)
Object_synonym: UniProtKB:Q13485, Glu-330, CHEBI:29947

subject: PR_000000367
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12417513
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_022833
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000368
type: Class
Object_term: smad4 sequence variant G352R (human)
Object_synonym: hSMAD4/var:G352R
Object_synonym: smad4 sequence variant 2 (human)
Object_synonym: UniProtKB:Q13485, Gly-352, CHEBI:29952

subject: PR_000000368
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:12417513
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019571
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000368
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4905
  Ontology_term: pancreatic carcinoma
Evidence_source: PMID:12417513
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019571
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000369
type: Class
Object_term: smad4 sequence variant R361C (human)
Object_synonym: hSMAD4/var:R361C
Object_synonym: smad4 sequence variant 3 (human)
Object_synonym: UniProtKB:Q13485, Arg-361, CHEBI:29950

subject: PR_000000369
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:9811934
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019572
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000370
type: Class
Object_term: smad4 sequence variant G386D (human)
Object_synonym: hSMAD4/var:G386D
Object_synonym: smad4 sequence variant 4 (human)
Object_synonym: UniProtKB:Q13485, Gly-386, CHEBI:29958

subject: PR_000000370
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050787
  Ontology_term: juvenile polyposis syndrome
Evidence_source: PMID:15031030
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019573
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000371
type: Class
Object_term: smad4 sequence variant D493H (human)
Object_synonym: hSMAD4/var:D493H
Object_synonym: smad4 sequence variant 5 (human)
Object_synonym: UniProtKB:Q13485, Asp-493, CHEBI:29979

subject: PR_000000371
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4905
  Ontology_term: pancreatic carcinoma
Evidence_source: PMID:8553070
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011380
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000398
type: Class
Object_term: TGF-beta 1 sequence variant L10P (human)
Object_synonym: hTGFB1/var:L10P
Object_synonym: TGF-beta 1 sequence variant 1 (human)
Object_synonym: UniProtKB:P01137, Leu-10, CHEBI:50342

subject: PR_000000398
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:9783545
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_016171
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000399
type: Class
Object_term: TGF-beta 1 sequence variant T81H (human)
Object_synonym: hTGFB1/var:T81H
Object_synonym: TGF-beta 1 sequence variant 2 (human)
Object_synonym: UniProtKB:P01137, Tyr-81, CHEBI:29979

subject: PR_000000399
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4997
  Ontology_term: Camurati-Engelmann disease
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000399
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001558
  Ontology_term: polypeptide_localization_variant
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000399
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11062463
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000400
type: Class
Object_term: TGF-beta 1 sequence variant R218C (human)
Object_synonym: hTGFB1/var:R218C
Object_synonym: TGF-beta 1 sequence variant 3 (human)
Object_synonym: UniProtKB:P01137, Arg-218, CHEBI:29950

subject: PR_000000400
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4997
  Ontology_term: Camurati-Engelmann disease
Evidence_source: PMID:10973241
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000400
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000400
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000400
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000002555
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000401
type: Class
Object_term: TGF-beta 1 sequence variant R218H (human)
Object_synonym: hTGFB1/var:R218H
Object_synonym: TGF-beta 1 sequence variant 4 (human)
Object_synonym: UniProtKB:P01137, Arg-218, CHEBI:29979

subject: PR_000000401
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4997
  Ontology_term: Camurati-Engelmann disease
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000402
type: Class
Object_term: TGF-beta 1 sequence variant H222D (human)
Object_synonym: hTGFB1/var:H222D
Object_synonym: TGF-beta 1 sequence variant 5 (human)
Object_synonym: UniProtKB:P01137, His-222, CHEBI:29958

subject: PR_000000402
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4997
  Ontology_term: Camurati-Engelmann disease
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000402
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000402
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000403
type: Class
Object_term: TGF-beta 1 sequence variant C225R (human)
Object_synonym: hTGFB1/var:C225R
Object_synonym: TGF-beta 1 sequence variant 6 (human)
Object_synonym: UniProtKB:P01137, Cys-225, CHEBI:29952

subject: PR_000000403
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:4997
  Ontology_term: Camurati-Engelmann disease
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000403
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000403
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000403
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000403
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000002555
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000437
type: Class
Object_term: growth/differentiation factor 5 sequence variant C400Y (human)
Object_synonym: growth/differentiation factor 5 sequence variant 1 (human)
Object_synonym: hGDF5/var:C400Y
Object_synonym: UniProtKB:P43026, Cys-400, CHEBI:46858

subject: PR_000000437
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0080052
  Ontology_term: acromesomelic dysplasia, Grebe type
Evidence_source: UniProtKB_VAR:VAR_017407
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017407
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000437
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR_000000164
Evidence_source: PMID:9288098
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017407
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000437
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005622
  Ontology_term: intracellular anatomical structure
Evidence_source: PMID:9288098
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017407
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000437
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: NOT
Evidence_source: PMID:9288098
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017407
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000438
type: Class
Object_term: growth/differentiation factor 5 sequence variant R438L (human)
Object_synonym: growth/differentiation factor 5 sequence variant 2 (human)
Object_synonym: hGDF5/var:R438L
Object_synonym: UniProtKB:P43026, Arg-438, CHEBI:30006

subject: PR_000000438
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050794
  Ontology_term: multiple synostoses syndrome
Evidence_source: PMID:16532400
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026545
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000438
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:16532400
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026545
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000439
type: Class
Object_term: growth/differentiation factor 5 sequence variant L441P (human)
Object_synonym: growth/differentiation factor 5 sequence variant 3 (human)
Object_synonym: hGDF5/var:L441P
Object_synonym: UniProtKB:P43026, Leu-441, CHEBI:50342

subject: PR_000000439
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050790
  Ontology_term: fibular hypoplasia and complex brachydactyly
Evidence_source: UniProtKB_VAR:VAR_017408
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017408
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000441
type: Class
Object_term: growth/differentiation factor 5 sequence variant 5 (mouse)
Object_synonym: mGDF5/var:5

subject: PR_000000441
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: MP:0006279
  Ontology_term: abnormal limb development
Evidence_source: PMID:8145850
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000452
type: Class
Object_term: lefty 2 sequence variant S342N (human)
Object_synonym: hLEFTY2/var:S342N
Object_synonym: lefty 2 sequence variant 1 (human)
Object_synonym: UniProtKB:O00292-1, Ser-342, CHEBI:50347

subject: PR_000000452
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050545
  Ontology_term: visceral heterotaxy
Evidence_source: PMID:10053005
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010385
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000470
type: Class
Object_term: smad2 sequence variant R133C (human)
Object_synonym: hSMAD2/var:R133C
Object_synonym: smad2 sequence variant 1 (human)
Object_synonym: UniProtKB:Q15796-1, Arg-133, CHEBI:29950

subject: PR_000000470
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:5672
  Ontology_term: large intestine cancer
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011375
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000470
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011375
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000470
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011375
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000471
type: Class
Object_term: smad2 sequence variant L440R (human)
Object_synonym: hSMAD2/var:L440R
Object_synonym: smad2 sequence variant 2 (human)
Object_synonym: UniProtKB:Q15796-1, Leu-440, CHEBI:29952

subject: PR_000000471
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:5672
  Ontology_term: large intestine cancer
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011377
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000472
type: Class
Object_term: smad2 sequence variant P445H (human)
Object_synonym: hSMAD2/var:P445H
Object_synonym: smad2 sequence variant 3 (human)
Object_synonym: UniProtKB:Q15796-1, Pro-445, CHEBI:29979

subject: PR_000000472
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:5672
  Ontology_term: large intestine cancer
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011378
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000472
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011378
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000473
type: Class
Object_term: smad2 sequence variant D450E (human)
Object_synonym: hSMAD2/var:D450E
Object_synonym: smad2 sequence variant 4 (human)
Object_synonym: UniProtKB:Q15796-1, Asp-450, CHEBI:29972

subject: PR_000000473
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:5672
  Ontology_term: large intestine cancer
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011379
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000473
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:8752209
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011379
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000474
type: Class
Object_term: smad2 sequence variant 5 (human)
Object_synonym: hSMAD2/var:5
Object_synonym: UniProtKB:Q15796-1, 2-343, 359-467

subject: PR_000000474
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:5672
  Ontology_term: large intestine cancer
Evidence_source: PMID:8673135
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011376
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000474
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:8673135
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_011376
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000619
type: Class
Object_term: TGF-beta 1 sequence variant T81H cleaved 1 (human)
Object_synonym: hTGFB1/var:T81H/Clv:1
Object_synonym: TGF-beta 1 sequence variant 2 cleaved 1 (human)
Object_synonym: UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979

subject: PR_000000619
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001558
  Ontology_term: polypeptide_localization_variant
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000620
type: Class
Object_term: TGF-beta 1 sequence variant T81H cleaved 2 (human)
Object_synonym: hTGFB1/var:T81H/Clv:2
Object_synonym: TGF-beta 1 sequence variant 2 cleaved 2 (human)
Object_synonym: UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979

subject: PR_000000620
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000621
type: Class
Object_term: TGF-beta 1 sequence variant R218C cleaved 1 (human)
Object_synonym: hTGFB1/var:R218C/Clv:1
Object_synonym: TGF-beta 1 sequence variant 3 cleaved 1 (human)
Object_synonym: UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950

subject: PR_000000621
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005160
  Ontology_term: transforming growth factor beta receptor binding
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000621
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000621
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000621
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000621
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000000616
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000622
type: Class
Object_term: TGF-beta 1 sequence variant R218C cleaved 2 (human)
Object_synonym: hTGFB1/var:R218C/Clv:2
Object_synonym: TGF-beta 1 sequence variant 3 cleaved 2 (human)
Object_synonym: UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950

subject: PR_000000622
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017608
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000623
type: Class
Object_term: TGF-beta 1 sequence variant H222D cleaved 1 (human)
Object_synonym: hTGFB1/var:H222D/Clv:1
Object_synonym: TGF-beta 1 sequence variant 5 cleaved 1 (human)
Object_synonym: UniProtKB:P01137, 279-390, His-222, CHEBI:29958

subject: PR_000000623
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000623
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000623
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000623
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000000616
Evidence_source: PMID:12493741
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000624
type: Class
Object_term: TGF-beta 1 sequence variant H222D cleaved 2 (human)
Object_synonym: hTGFB1/var:H222D/Clv:2
Object_synonym: TGF-beta 1 sequence variant 5 cleaved 2 (human)
Object_synonym: UniProtKB:P01137, 30-278, His-222, CHEBI:29958

subject: PR_000000624
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000624
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001601
  Ontology_term: conformational_change_variant
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017610
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000625
type: Class
Object_term: TGF-beta 1 sequence variant C225R cleaved 1 (human)
Object_synonym: hTGFB1/var:C225R/Clv:1
Object_synonym: TGF-beta 1 sequence variant 6 cleaved 1 (human)
Object_synonym: UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952

subject: PR_000000625
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000625
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000000616
Evidence_source: PMID:11062463
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000626
type: Class
Object_term: TGF-beta 1 sequence variant C225R cleaved 2 (human)
Object_synonym: hTGFB1/var:C225R/Clv:2
Object_synonym: TGF-beta 1 sequence variant 6 cleaved 2 (human)
Object_synonym: UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952

subject: PR_000000626
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017611
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000627
type: Class
Object_term: TGF-beta 1 sequence variant R218H cleaved 1 (human)
Object_synonym: hTGFB1/var:R218H/Clv:1
Object_synonym: TGF-beta 1 sequence variant 4 cleaved 1 (human)
Object_synonym: UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979

subject: PR_000000627
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005160
  Ontology_term: transforming growth factor beta receptor binding
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000627
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000627
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000627
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000627
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008083
  Ontology_term: growth factor activity
Modifier: increased
Relative_to: PR_000000616
Evidence_source: PMID:12493741
Evidence_source: PMID:12843182
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000628
type: Class
Object_term: TGF-beta 1 sequence variant R218H cleaved 2 (human)
Object_synonym: hTGFB1/var:R218H/Clv:2
Object_synonym: TGF-beta 1 sequence variant 4 cleaved 2 (human)
Object_synonym: UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979

subject: PR_000000628
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000000628
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001601
  Ontology_term: conformational_change_variant
Evidence_source: PMID:11278244
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_017607
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000647
type: Class
Object_term: smad1 isoform 1 phosphorylated 1
Object_synonym: BMP receptor-activated smad1
Object_synonym: SMAD1/iso:1/Phos:1

subject: PR_000000647
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0000981
  Ontology_term: DNA-binding transcription factor activity, RNA polymerase II-specific
Evidence_source: PMID:10708949
Evidence_code: TAS
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000678
type: Class
Object_term: sodium leak channel NALCN
Object_synonym: CanIon
Object_synonym: NALCN
Object_synonym: VGCNL1
Object_synonym: voltage gated channel-like protein 1

subject: PR_000000678
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006811
  Ontology_term: monoatomic ion transport
Evidence_source: PIRSF:PIRSF038547
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038547
DB_ID: PIRSF:PIRSF038547
DB_ID: UniProtKB:Q8BXR5
DB_ID: UniProtKB:Q8IZF0
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000678
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005216
  Ontology_term: monoatomic ion channel activity
Modifier: contributes_to
Evidence_source: PIRSF:PIRSF038547
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038547
DB_ID: PIRSF:PIRSF038547
DB_ID: UniProtKB:Q8BXR5
DB_ID: UniProtKB:Q8IZF0
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000682
type: Class
Object_term: voltage-gated potassium channel alpha subunit with PAS domain
Object_synonym: fam:Kchan_sub-a_PAS

subject: PR_000000682
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PIRSF:PIRSF038287
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038287
DB_ID: PIRSF:PIRSF038287
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000682
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: contributes_to
Evidence_source: PIRSF:PIRSF038287
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038287
DB_ID: PIRSF:PIRSF038287
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000684
type: Class
Object_term: voltage-gated potassium channel subunit KQT
Object_synonym: fam:Kchan_sub-KQT

subject: PR_000000684
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PIRSF:PIRSF038513
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038513
DB_ID: PIRSF:PIRSF038513
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000684
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: contributes_to
Evidence_source: PIRSF:PIRSF038513
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF038513
DB_ID: PIRSF:PIRSF038513
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000685
type: Class
Object_term: voltage-gated potassium channel alpha subunit
Object_synonym: fam:Kchan_sub-a

subject: PR_000000685
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PIRSF:PIRSF002449
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002449
DB_ID: PIRSF:PIRSF002449
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000685
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: contributes_to
Evidence_source: PIRSF:PIRSF002449
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002449
DB_ID: PIRSF:PIRSF002449
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000701
type: Class
Object_term: modulatory voltage-gated potassium channel subunit KCNG
Object_synonym: fam:Kchan_sub-KCNG
Object_synonym: silent subunit

subject: PR_000000701
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0015459
  Ontology_term: potassium channel regulator activity
Evidence_source: PIRSF:PIRSF500980
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500980
DB_ID: PIRSF:PIRSF500980
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000702
type: Class
Object_term: modulatory voltage-gated potassium channel subunit KCNS
Object_synonym: fam:Kchan_sub-KCNS
Object_synonym: silent subunit

subject: PR_000000702
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0015459
  Ontology_term: potassium channel regulator activity
Evidence_source: PIRSF:PIRSF500981
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF500981
DB_ID: PIRSF:PIRSF500981
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000000724
type: Class
Object_term: voltage-gated potassium channel KCNF1
Object_synonym: KCNF1
Object_synonym: kH1
Object_synonym: voltage-gated potassium channel subunit Kv5.1

subject: PR_000000724
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0015459
  Ontology_term: potassium channel regulator activity
Evidence_source: PMID:9696692
Evidence_code: IDA
DB_ID: UniProtKB:Q7TSH7
DB_ID: UniProtKB:Q9H3M0
Date: 2008-06-01
Assigned_by: PRO:CNA
Comments: Note=The organism source is uncertain.

subject: PR_000000724
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PMID:9696692
Evidence_code: IDA
DB_ID: UniProtKB:Q7TSH7
DB_ID: UniProtKB:Q9H3M0
Date: 2008-06-01
Assigned_by: PRO:CNA
Comments: Note=The organism source is uncertain.

subject: PR_000000724
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: contributes_to
Evidence_source: PMID:9696692
Evidence_code: IDA
DB_ID: UniProtKB:Q7TSH7
DB_ID: UniProtKB:Q9H3M0
Date: 2008-06-01
Assigned_by: PRO:CNA
Comments: Note=The organism source is uncertain.

PR_000000725
type: Class
Object_term: voltage-gated potassium channel KCNV1
Object_synonym: KCNV1
Object_synonym: neuronal potassium channel alpha subunit HNKA
Object_synonym: voltage-gated potassium channel subunit Kv8.1

subject: PR_000000725
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0015459
  Ontology_term: potassium channel regulator activity
Evidence_source: PANTHER:PTHR11537:SF38
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11537:SF38
DB_ID: PANTHER:PTHR11537:SF38
DB_ID: UniProtKB:Q6PIU1
DB_ID: UniProtKB:Q8BZN2
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000726
type: Class
Object_term: voltage-gated potassium channel KCNV2
Object_synonym: KCNV2
Object_synonym: voltage-gated potassium channel subunit Kv8.2

subject: PR_000000726
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0015459
  Ontology_term: potassium channel regulator activity
Evidence_source: PANTHER:PTHR11537:SF40
Evidence_code: ISS
Inferred_from: PANTHER:PTHR11537:SF39
DB_ID: PANTHER:PTHR11537:SF39
DB_ID: UniProtKB:Q8CFS6
DB_ID: UniProtKB:Q8TDN2
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000738
type: Class
Object_term: cyclic nucleotide-gated channel alpha-1 sequence variant S320F (human)
Object_synonym: cGMP-gated cation channel alpha-1 sequence variant 1 (human)
Object_synonym: hCNGA1/var:S320F
Object_synonym: UniProtKB:P29973-1, Ser-320, CHEBI:29997

subject: PR_000000738
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10584
  Ontology_term: retinitis pigmentosa
Evidence_source: PMID:7479749
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009297
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000738
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Modifier: NOT
Evidence_source: PMID:7479749
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009297
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000741
type: Class
Object_term: cyclic nucleotide-gated channel alpha-3 sequence variant R283Q (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 1 (human)
Object_synonym: hCNGA3/var:R283Q
Object_synonym: UniProtKB:Q16281-1, Arg-283, CHEBI:30011

subject: PR_000000741
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010904
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000742
type: Class
Object_term: cyclic nucleotide-gated channel alpha-3 sequence variant T291R (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 2 (human)
Object_synonym: hCNGA3/var:T291R
Object_synonym: UniProtKB:Q16281-1, Thr-291, CHEBI:29952

subject: PR_000000742
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010906
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000743
type: Class
Object_term: cyclic nucleotide-gated channel alpha-3 sequence variant G557R (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 3 (human)
Object_synonym: hCNGA3/var:G557R
Object_synonym: UniProtKB:Q16281-1, Gly-557, CHEBI:29952

subject: PR_000000743
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010909
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000744
type: Class
Object_term: cyclic nucleotide-gated channel alpha-3 sequence variant V529M (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 4 (human)
Object_synonym: hCNGA3/var:V529M
Object_synonym: UniProtKB:Q16281-1, Val-529, CHEBI:16044

subject: PR_000000744
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010907
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000745
type: Class
Object_term: cyclic nucleotide-gated channel alpha-3 sequence variant R283W (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 5 (human)
Object_synonym: hCNGA3/var:R283W
Object_synonym: UniProtKB:Q16281-1, Arg-283, CHEBI:29954

subject: PR_000000745
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010905
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000746
type: Class
Object_term: cyclic nucleotide-gated channel alpha-3 sequence variant F547L (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 6 (human)
Object_synonym: hCNGA3/var:F547L
Object_synonym: UniProtKB:Q16281-1, Phe-547, CHEBI:30006

subject: PR_000000746
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010908
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000747
type: Class
Object_term: cyclic nucleotide-gated channel alpha-3 sequence variant R410W (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 7 (human)
Object_synonym: hCNGA3/var:R410W
Object_synonym: UniProtKB:Q16281-1, Arg-410, CHEBI:29954

subject: PR_000000747
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010910
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000748
type: Class
Object_term: cyclic nucleotide-gated channel alpha-3 sequence variant P163L (human)
Object_synonym: cyclic nucleotide-gated cation channel alpha-3 sequence variant 8 (human)
Object_synonym: hCNGA3/var:P163L
Object_synonym: UniProtKB:Q16281-1, Pro-163, CHEBI:30006

subject: PR_000000748
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:9662398
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010903
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000752
type: Class
Object_term: cyclic nucleotide-gated channel beta-3 sequence variant S435F (human)
Object_synonym: cyclic nucleotide-gated cation channel beta-3 sequence variant 1 (human)
Object_synonym: hCNGB3/var:S435F
Object_synonym: UniProtKB:Q9NQW8-1, Ser-435, CHEBI:29997

subject: PR_000000752
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13911
  Ontology_term: achromatopsia
Evidence_source: PMID:10888875
Evidence_source: PMID:10958649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_018111
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000759
type: Class
Object_term: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human)
Object_synonym: hHCN4/var:D553N
Object_synonym: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 1 (human)
Object_synonym: UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347

subject: PR_000000759
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13884
  Ontology_term: sick sinus syndrome
Evidence_source: PMID:15123648
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026534
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000759
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Modifier: NOT
Evidence_source: PMID:15123648
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026534
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000760
type: Class
Object_term: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human)
Object_synonym: hHCN4/var:S672R
Object_synonym: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 2 (human)
Object_synonym: UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952

subject: PR_000000760
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:13884
  Ontology_term: sick sinus syndrome
Evidence_source: PMID:16407510
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026535
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000760
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005222
  Ontology_term: intracellularly cAMP-activated cation channel activity
Evidence_source: PMID:16407510
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026535
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000760
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0022843
  Ontology_term: voltage-gated monoatomic cation channel activity
Modifier: altered
Relative_to: PR_000002604
Evidence_source: PMID:16407510
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026535
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000803
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant G459D (human)
Object_synonym: hKCNV2/var:G459D
Object_synonym: UniProtKB:Q8TDN2, Gly-459, CHEBI:29958
Object_synonym: voltage-gated potassium channel KCNV2 sequence variant 1 (human)

subject: PR_000000803
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027637
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000804
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant A259V (human)
Object_synonym: hKCNV2/var:A259V
Object_synonym: UniProtKB:Q8TDN2, Ala-259, CHEBI:30015
Object_synonym: voltage-gated potassium channel KCNV2 sequence variant 2 (human)

subject: PR_000000804
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027635
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000805
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant L126Q (human)
Object_synonym: hKCNV2/var:L126Q
Object_synonym: UniProtKB:Q8TDN2, Leu-126, CHEBI:30011
Object_synonym: voltage-gated potassium channel KCNV2 sequence variant 3 (human)

subject: PR_000000805
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027632
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000806
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant 4 (human)
Object_synonym: hKCNV2/var:4
Object_synonym: UniProtKB:Q8TDN2, 1-338, 342-545

subject: PR_000000806
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027636
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000807
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant S256W (human)
Object_synonym: hKCNV2/var:S256W
Object_synonym: UniProtKB:Q8TDN2, Ser-256, CHEBI:29954
Object_synonym: voltage-gated potassium channel KCNV2 sequence variant 5 (human)

subject: PR_000000807
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027634
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000808
type: Class
Object_term: voltage-gated potassium channel KCNV2 sequence variant W188C (human)
Object_synonym: hKCNV2/var:W188C
Object_synonym: UniProtKB:Q8TDN2, Trp-188, CHEBI:29950
Object_synonym: voltage-gated potassium channel KCNV2 sequence variant 6 (human)

subject: PR_000000808
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050795
  Ontology_term: cone dystrophy
Evidence_source: PMID:16909397
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_027633
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000817
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant T587M (human)
Object_synonym: hKCNQ1/var:T587M
Object_synonym: UniProtKB:P51787-1, Thr-587, CHEBI:16044
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 1 (human)

subject: PR_000000817
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10024302
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008951
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000818
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant S373P (human)
Object_synonym: hKCNQ1/var:S373P
Object_synonym: UniProtKB:P51787-1, Ser-373, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 10 (human)

subject: PR_000000818
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008127
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000819
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R243C (human)
Object_synonym: hKCNQ1/var:R243C
Object_synonym: UniProtKB:P51787-1, Arg-243, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 11 (human)

subject: PR_000000819
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10409658
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010933
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000819
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: altered
Relative_to: PR_000002622
Evidence_source: PMID:10409658
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010933
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000820
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant D317N (human)
Object_synonym: hKCNQ1/var:D317N
Object_synonym: UniProtKB:P51787-1, Asp-317, CHEBI:50347
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 12 (human)

subject: PR_000000820
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9302275
Evidence_source: PMID:9482580
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001534
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000821
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant V310I (human)
Object_synonym: hKCNQ1/var:V310I
Object_synonym: UniProtKB:P51787-1, Val-310, CHEBI:30009
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 13 (human)

subject: PR_000000821
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009926
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000822
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant S566F (human)
Object_synonym: hKCNQ1/var:S566F
Object_synonym: UniProtKB:P51787-1, Ser-566, CHEBI:29997
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 14 (human)

subject: PR_000000822
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009932
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000823
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant Y315C (human)
Object_synonym: hKCNQ1/var:Y315C
Object_synonym: UniProtKB:P51787-1, Tyr-315, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 15 (human)

subject: PR_000000823
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9693036
Evidence_source: PMID:9927399
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008946
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000824
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant S225L (human)
Object_synonym: hKCNQ1/var:S225L
Object_synonym: UniProtKB:P51787-1, Ser-225, CHEBI:30006
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 16 (human)

subject: PR_000000824
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9927399
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009923
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000825
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A178P (human)
Object_synonym: hKCNQ1/var:A178P
Object_synonym: UniProtKB:P51787-1, Ala-178, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 17 (human)

subject: PR_000000825
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001518
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000825
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001518
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000825
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: NOT|contributes_to
Evidence_source: PMID:10704188
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001518
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000826
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A178T (human)
Object_synonym: hKCNQ1/var:A178T
Object_synonym: UniProtKB:P51787-1, Ala-178, CHEBI:30013
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 18 (human)

subject: PR_000000826
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9024139
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009920
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000827
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G189R (human)
Object_synonym: hKCNQ1/var:G189R
Object_synonym: UniProtKB:P51787-1, Gly-189, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 19 (human)

subject: PR_000000827
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001519
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000828
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant P448R (human)
Object_synonym: hKCNQ1/var:P448R
Object_synonym: UniProtKB:P51787-1, Pro-448, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 2 (human)

subject: PR_000000828
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009931
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000829
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant T309R (human)
Object_synonym: hKCNQ1/var:T309R
Object_synonym: UniProtKB:P51787-1, Thr-309, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 20 (human)

subject: PR_000000829
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001529
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000830
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R591H (human)
Object_synonym: hKCNQ1/var:R591H
Object_synonym: UniProtKB:P51787-1, Arg-591, CHEBI:29979
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 21 (human)

subject: PR_000000830
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10024302
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008953
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000831
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R366W (human)
Object_synonym: hKCNQ1/var:R366W
Object_synonym: UniProtKB:P51787-1, Arg-366, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 22 (human)

subject: PR_000000831
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9693036
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008948
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000832
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant I313M (human)
Object_synonym: hKCNQ1/var:I313M
Object_synonym: UniProtKB:P51787-1, Ile-313, CHEBI:16044
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 23 (human)

subject: PR_000000832
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9024139
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001531
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000833
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant Y111C (human)
Object_synonym: hKCNQ1/var:Y111C
Object_synonym: UniProtKB:P51787-1, Tyr-111, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 24 (human)

subject: PR_000000833
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009918
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000834
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R533W (human)
Object_synonym: hKCNQ1/var:R533W
Object_synonym: UniProtKB:P51787-1, Arg-533, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 25 (human)

subject: PR_000000834
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008949
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000834
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: altered
Relative_to: PR_000002622
Evidence_source: PMID:10704188
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008949
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000835
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G168R (human)
Object_synonym: hKCNQ1/var:G168R
Object_synonym: UniProtKB:P51787-1, Gly-168, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 26 (human)

subject: PR_000000835
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9693036
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001516
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000836
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant E261D (human)
Object_synonym: hKCNQ1/var:E261D
Object_synonym: UniProtKB:P51787-1, Glu-261, CHEBI:29958
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 27 (human)

subject: PR_000000836
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2842
  Ontology_term: Jervell-Lange Nielsen syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008944
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000837
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A371T (human)
Object_synonym: hKCNQ1/var:A371T
Object_synonym: UniProtKB:P51787-1, Ala-371, CHEBI:30013
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 28 (human)

subject: PR_000000837
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001544
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000838
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant 29 (human)
Object_synonym: hKCNQ1/var:29
Object_synonym: UniProtKB:P49747-1, 21-70, 74-757

subject: PR_000000838
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10511610
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009917
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000839
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A341V (human)
Object_synonym: hKCNQ1/var:A341V
Object_synonym: UniProtKB:P51787-1, Ala-341, CHEBI:30015
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 3 (human)

subject: PR_000000839
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:8818942
Evidence_source: PMID:8872472
Evidence_source: PMID:9570196
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001539
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000840
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant L250H (human)
Object_synonym: hKCNQ1/var:L250H
Object_synonym: UniProtKB:P51787-1, Leu-250, CHEBI:29979
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 30 (human)

subject: PR_000000840
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008943
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000841
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant S349W (human)
Object_synonym: hKCNQ1/var:S349W
Object_synonym: UniProtKB:P51787-1, Ser-349, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 31 (human)

subject: PR_000000841
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009928
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000842
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant T391I (human)
Object_synonym: hKCNQ1/var:T391I
Object_synonym: UniProtKB:P51787-1, Thr-391, CHEBI:30009
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 32 (human)

subject: PR_000000842
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009930
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000843
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant K318N (human)
Object_synonym: hKCNQ1/var:K318N
Object_synonym: UniProtKB:P51787-1, Lys-318, CHEBI:50347
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 33 (human)

subject: PR_000000843
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9693036
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008947
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000844
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A344V (human)
Object_synonym: hKCNQ1/var:A344V
Object_synonym: UniProtKB:P51787-1, Ala-344, CHEBI:30015
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 34 (human)

subject: PR_000000844
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001541
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000845
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A525T (human)
Object_synonym: hKCNQ1/var:A525T
Object_synonym: UniProtKB:P51787-1, Ala-525, CHEBI:30013
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 35 (human)

subject: PR_000000845
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10482963
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009181
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000846
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A341E (human)
Object_synonym: hKCNQ1/var:A341E
Object_synonym: UniProtKB:P51787-1, Ala-341, CHEBI:29972
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 36 (human)

subject: PR_000000846
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001538
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000846
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: MP:0003233
  Ontology_term: prolonged QT interval
Evidence_source: PMID:15498462
Evidence_code: IMP
Taxon: NCBITaxon:10090
DB_ID: MGI_allele:3056651
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000847
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R583C (human)
Object_synonym: hKCNQ1/var:R583C
Object_synonym: UniProtKB:P51787-1, Arg-583, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 37 (human)

subject: PR_000000847
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009933
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000848
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant D242N (human)
Object_synonym: hKCNQ1/var:D242N
Object_synonym: UniProtKB:P51787-1, Asp-242, CHEBI:50347
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 38 (human)

subject: PR_000000848
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008940
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000849
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant L342F (human)
Object_synonym: hKCNQ1/var:L342F
Object_synonym: UniProtKB:P51787-1, Leu-342, CHEBI:29997
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 39 (human)

subject: PR_000000849
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001540
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000850
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G306R (human)
Object_synonym: hKCNQ1/var:G306R
Object_synonym: UniProtKB:P51787-1, Gly-306, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 4 (human)

subject: PR_000000850
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001528
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000851
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant S140G (human)
Object_synonym: hKCNQ1/var:S140G
Object_synonym: UniProtKB:P51787-1, Ser-140, CHEBI:29947
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 40 (human)

subject: PR_000000851
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050650
  Ontology_term: familial atrial fibrillation
Evidence_source: PMID:12522251
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015742
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000851
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001557
  Ontology_term: polypeptide_gain_of_function_variant
Evidence_source: PMID:12522251
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015742
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000851
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005267
  Ontology_term: potassium channel activity
Modifier: increased
Relative_to: PR_000002622
Evidence_source: PMID:12522251
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_015742
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000852
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G269S (human)
Object_synonym: hKCNQ1/var:G269S
Object_synonym: UniProtKB:P51787-1, Gly-269, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 41 (human)

subject: PR_000000852
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009925
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000853
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R555C (human)
Object_synonym: hKCNQ1/var:R555C
Object_synonym: UniProtKB:P51787-1, Arg-555, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 42 (human)

subject: PR_000000853
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001545
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000854
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R539W (human)
Object_synonym: hKCNQ1/var:R539W
Object_synonym: UniProtKB:P51787-1, Arg-539, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 43 (human)

subject: PR_000000854
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008950
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000854
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: altered
Relative_to: PR_000002622
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008950
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000854
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Modifier: altered
Relative_to: PR_000002622
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008950
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000855
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant Y315S (human)
Object_synonym: hKCNQ1/var:Y315S
Object_synonym: UniProtKB:P51787-1, Tyr-315, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 44 (human)

subject: PR_000000855
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001533
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000856
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R174H (human)
Object_synonym: hKCNQ1/var:R174H
Object_synonym: UniProtKB:P51787-1, Arg-174, CHEBI:29979
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 45 (human)

subject: PR_000000856
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10367071
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008939
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000857
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A194P (human)
Object_synonym: hKCNQ1/var:A194P
Object_synonym: UniProtKB:P51787-1, Ala-194, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 46 (human)

subject: PR_000000857
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009922
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000858
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant Y184S (human)
Object_synonym: hKCNQ1/var:Y184S
Object_synonym: UniProtKB:P51787-1, Tyr-184, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 47 (human)

subject: PR_000000858
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008125
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000859
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G345E (human)
Object_synonym: hKCNQ1/var:G345E
Object_synonym: UniProtKB:P51787-1, Gly-345, CHEBI:29972
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 48 (human)

subject: PR_000000859
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001542
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000860
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R190Q (human)
Object_synonym: hKCNQ1/var:R190Q
Object_synonym: UniProtKB:P51787-1, Arg-190, CHEBI:30011
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 49 (human)

subject: PR_000000860
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001520
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000860
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:10704188
Evidence_source: PMID:9482580
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001520
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000860
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Modifier: NOT
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001520
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000860
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: NOT|contributes_to
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001520
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000861
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant T311I (human)
Object_synonym: hKCNQ1/var:T311I
Object_synonym: UniProtKB:P51787-1, Thr-311, CHEBI:30009
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 5 (human)

subject: PR_000000861
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9482580
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009927
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000862
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G314S (human)
Object_synonym: hKCNQ1/var:G314S
Object_synonym: UniProtKB:P51787-1, Gly-314, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 50 (human)

subject: PR_000000862
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:8872472
Evidence_source: PMID:9693036
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001532
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000863
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant W248R (human)
Object_synonym: hKCNQ1/var:W248R
Object_synonym: UniProtKB:P51787-1, Trp-248, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 51 (human)

subject: PR_000000863
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10409658
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008942
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000863
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:10409658
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008942
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000863
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008942
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000863
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: altered|contributes_to
Relative_to: PR_000002622
Evidence_source: PMID:10409658
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008942
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000864
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R366P (human)
Object_synonym: hKCNQ1/var:R366P
Object_synonym: UniProtKB:P51787-1, Arg-366, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 52 (human)

subject: PR_000000864
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_source: PMID:9024139
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001543
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000865
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R366Q (human)
Object_synonym: hKCNQ1/var:R366Q
Object_synonym: UniProtKB:P51787-1, Arg-366, CHEBI:30011
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 53 (human)

subject: PR_000000865
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009929
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000866
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant E160K (human)
Object_synonym: hKCNQ1/var:E160K
Object_synonym: UniProtKB:P51787-1, Glu-160, CHEBI:29967
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 54 (human)

subject: PR_000000866
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009919
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000867
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant V254M (human)
Object_synonym: hKCNQ1/var:V254M
Object_synonym: UniProtKB:P51787-1, Val-254, CHEBI:16044
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 55 (human)

subject: PR_000000867
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001522
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000868
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G345R (human)
Object_synonym: hKCNQ1/var:G345R
Object_synonym: UniProtKB:P51787-1, Gly-345, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 56 (human)

subject: PR_000000868
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008126
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000869
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant E261K (human)
Object_synonym: hKCNQ1/var:E261K
Object_synonym: UniProtKB:P51787-1, Glu-261, CHEBI:29967
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 57 (human)

subject: PR_000000869
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10409658
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001523
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000869
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Modifier: NOT
Evidence_source: PMID:8900283
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001523
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000869
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: NOT|contributes_to
Evidence_source: PMID:8900283
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001523
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000870
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant V307L (human)
Object_synonym: hKCNQ1/var:V307L
Object_synonym: UniProtKB:P51787-1, Val-307, CHEBI:30006
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 58 (human)

subject: PR_000000870
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050793
  Ontology_term: short QT syndrome
Evidence_source: PMID:15159330
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023841
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000870
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001557
  Ontology_term: polypeptide_gain_of_function_variant
Evidence_source: PMID:15159330
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023841
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000870
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005267
  Ontology_term: potassium channel activity
Modifier: increased
Relative_to: PR_000002622
Evidence_source: PMID:15159330
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_023841
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000871
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant F339del (human)
Object_synonym: deltaF339
Object_synonym: hKCNQ1/var:F339del
Object_synonym: UniProtKB:P49747-1, 21-338, 340-757
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 59 (human)

subject: PR_000000871
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:15159330
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001537
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000872
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R243H (human)
Object_synonym: hKCNQ1/var:R243H
Object_synonym: UniProtKB:P51787-1, Arg-243, CHEBI:29979
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 6 (human)

subject: PR_000000872
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2842
  Ontology_term: Jervell-Lange Nielsen syndrome
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008941
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000872
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0008076
  Ontology_term: voltage-gated potassium channel complex
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008941
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000872
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: decreased|contributes_to
Relative_to: PR_000002622
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008941
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000873
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G179S (human)
Object_synonym: hKCNQ1/var:G179S
Object_synonym: UniProtKB:P51787-1, Gly-179, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 60 (human)

subject: PR_000000873
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10728423
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009921
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000874
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant A300T (human)
Object_synonym: hKCNQ1/var:A300T
Object_synonym: UniProtKB:P51787-1, Ala-300, CHEBI:30013
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 61 (human)

subject: PR_000000874
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9641694
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001526
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000874
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: contributes_to
Evidence_source: PMID:9641694
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001526
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000875
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R174C (human)
Object_synonym: hKCNQ1/var:R174C
Object_synonym: UniProtKB:P51787-1, Arg-174, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 62 (human)

subject: PR_000000875
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001517
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000876
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant W305S (human)
Object_synonym: hKCNQ1/var:W305S
Object_synonym: UniProtKB:P51787-1, Trp-305, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 63 (human)

subject: PR_000000876
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2842
  Ontology_term: Jervell-Lange Nielsen syndrome
Evidence_source: PMID:9781056
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001527
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000877
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant L266P (human)
Object_synonym: hKCNQ1/var:L266P
Object_synonym: UniProtKB:P51787-1, Leu-266, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 64 (human)

subject: PR_000000877
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009924
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000878
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant R594Q (human)
Object_synonym: hKCNQ1/var:R594Q
Object_synonym: UniProtKB:P51787-1, Arg-594, CHEBI:30011
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 65 (human)

subject: PR_000000878
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009934
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000879
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant L273F (human)
Object_synonym: hKCNQ1/var:L273F
Object_synonym: UniProtKB:P51787-1, Leu-273, CHEBI:29997
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 66 (human)

subject: PR_000000879
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001525
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000879
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001561
  Ontology_term: polypeptide_partial_loss_of_function
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001525
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000879
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: contributes_to
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001525
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000880
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant Y281C (human)
Object_synonym: hKCNQ1/var:Y281C
Object_synonym: UniProtKB:P51787-1, Tyr-281, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 67 (human)

subject: PR_000000880
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9927399
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008945
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000881
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant P320A (human)
Object_synonym: hKCNQ1/var:P320A
Object_synonym: UniProtKB:P51787-1, Pro-320, CHEBI:46217
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 68 (human)

subject: PR_000000881
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001535
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000882
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant F157C (human)
Object_synonym: hKCNQ1/var:F157C
Object_synonym: UniProtKB:P51787-1, Phe-157, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 69 (human)

subject: PR_000000882
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220146
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008124
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000883
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant L353P (human)
Object_synonym: hKCNQ1/var:L353P
Object_synonym: UniProtKB:P51787-1, Leu-353, CHEBI:50342
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 7 (human)

subject: PR_000000883
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9693036
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_009180
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000884
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G325R (human)
Object_synonym: hKCNQ1/var:G325R
Object_synonym: UniProtKB:P51787-1, Gly-325, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 70 (human)

subject: PR_000000884
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9024139
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001536
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000885
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant W392R (human)
Object_synonym: hKCNQ1/var:W392R
Object_synonym: UniProtKB:P51787-1, Trp-392, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 71 (human)

subject: PR_000000885
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10220144
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008128
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000886
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G269D (human)
Object_synonym: hKCNQ1/var:G269D
Object_synonym: UniProtKB:P51787-1, Gly-269, CHEBI:29958
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 72 (human)

subject: PR_000000886
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001524
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000887
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G589D (human)
Object_synonym: hKCNQ1/var:G589D
Object_synonym: UniProtKB:P51787-1, Gly-589, CHEBI:29958
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 73 (human)

subject: PR_000000887
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008952
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000888
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant G216R (human)
Object_synonym: hKCNQ1/var:G216R
Object_synonym: UniProtKB:P51787-1, Gly-216, CHEBI:29952
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 74 (human)

subject: PR_000000888
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:9272155
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001521
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000889
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant V417M (human)
Object_synonym: hKCNQ1/var:V417M
Object_synonym: UniProtKB:P51787-1, Val-417, CHEBI:16044
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 8 (human)

subject: PR_000000889
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10704188
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010934
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000890
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ1 sequence variant T312I (human)
Object_synonym: hKCNQ1/var:T312I
Object_synonym: UniProtKB:P51787-1, Thr-312, CHEBI:30009
Object_synonym: voltage-gated potassium channel subunit KCNQ1 sequence variant 9 (human)

subject: PR_000000890
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:2843
  Ontology_term: long QT syndrome
Evidence_source: PMID:10409658
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001530
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000890
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:10409658
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001530
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000890
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005251
  Ontology_term: delayed rectifier potassium channel activity
Modifier: NOT|contributes_to
Evidence_source: PMID:10409658
Evidence_source: PMID:9323054
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001530
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000907
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant S247W (human)
Object_synonym: hKCNQ2/var:S247W
Object_synonym: UniProtKB:O43526-1, Ser-247, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 1 (human)

subject: PR_000000907
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:12742592
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026991
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000907
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: decreased
Relative_to: PR_000002632
Evidence_source: PMID:12742592
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026991
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000908
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant H228Q (human)
Object_synonym: hKCNQ2/var:H228Q
Object_synonym: UniProtKB:O43526-1, His-228, CHEBI:30011
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 10 (human)

subject: PR_000000908
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:14534157
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026989
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000909
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant R207W (human)
Object_synonym: hKCNQ2/var:R207W
Object_synonym: UniProtKB:O43526-1, Arg-207, CHEBI:29954
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 2 (human)

subject: PR_000000909
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:11572947
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026987
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000909
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: decreased
Relative_to: PR_000002632
Evidence_source: PMID:11572947
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026987
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000910
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant L243F (human)
Object_synonym: hKCNQ2/var:L243F
Object_synonym: UniProtKB:O43526-1, Leu-243, CHEBI:29997
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 3 (human)

subject: PR_000000910
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:14534157
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026990
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000911
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant 4 (human)
Object_synonym: hKCNQ2/var:4
Object_synonym: UniProtKB:O43526-1, Arg-214, CHEBI:29954

subject: PR_000000911
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:11175290
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010929
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000912
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant Y284C (human)
Object_synonym: hKCNQ2/var:Y284C
Object_synonym: UniProtKB:O43526-1, Tyr-284, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 5 (human)

subject: PR_000000912
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:10788442
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010930
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000912
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:10788442
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010930
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000913
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant A306T (human)
Object_synonym: hKCNQ2/var:A306T
Object_synonym: UniProtKB:O43526-1, Ala-306, CHEBI:30013
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 6 (human)

subject: PR_000000913
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:10788442
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010931
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000913
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:10788442
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010931
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000914
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant R333Q (human)
Object_synonym: hKCNQ2/var:R333Q
Object_synonym: UniProtKB:O43526-1, Arg-333, CHEBI:30011
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 7 (human)

subject: PR_000000914
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:14534157
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026992
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000915
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 sequence variant M208V (human)
Object_synonym: hKCNQ2/var:M208V
Object_synonym: UniProtKB:O43526-1, Met-208, CHEBI:30015
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 8 (human)

subject: PR_000000915
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:14534157
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026988
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000916
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human)
Object_synonym: hKCNQ2/iso:3/var:K526N
Object_synonym: UniProtKB:O43526-3, Lys-526, CHEBI:50347
Object_synonym: voltage-gated potassium channel subunit KCNQ2 sequence variant 9 (human)

subject: PR_000000916
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:14264
  Ontology_term: benign neonatal seizures
Evidence_source: PMID:15249611
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_026993
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000920
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant G285C (human)
Object_synonym: hKCNQ4/var:G285C
Object_synonym: UniProtKB:P56696-1, Gly-285, CHEBI:29950
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 1 (human)

subject: PR_000000920
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10369879
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008727
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000920
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: altered
Relative_to: PR_000000918
Evidence_source: PMID:10369879
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008727
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000921
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant L274H (human)
Object_synonym: hKCNQ4/var:L274H
Object_synonym: UniProtKB:P56696-1, Leu-274, CHEBI:29979
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 2 (human)

subject: PR_000000921
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10925378
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010936
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000922
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant G285S (human)
Object_synonym: hKCNQ4/var:G285S
Object_synonym: UniProtKB:P56696-1, Gly-285, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 3 (human)

subject: PR_000000922
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10025409
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001547
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000000922
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005249
  Ontology_term: voltage-gated potassium channel activity
Modifier: altered
Relative_to: PR_000000918
Evidence_source: PMID:10025409
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_001547
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000923
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant L281S (human)
Object_synonym: hKCNQ4/var:L281S
Object_synonym: UniProtKB:P56696-1, Leu-281, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 4 (human)

subject: PR_000000923
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10571947
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010937
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000924
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant W276S (human)
Object_synonym: hKCNQ4/var:W276S
Object_synonym: UniProtKB:P56696-1, Trp-276, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 5 (human)

subject: PR_000000924
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10369879
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008726
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000000925
type: Class
Object_term: voltage-gated potassium channel subunit KCNQ4 sequence variant G321S (human)
Object_synonym: hKCNQ4/var:G321S
Object_synonym: UniProtKB:P56696-1, Gly-321, CHEBI:29999
Object_synonym: voltage-gated potassium channel subunit KCNQ4 sequence variant 6 (human)

subject: PR_000000925
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050564
  Ontology_term: autosomal dominant nonsyndromic deafness
Evidence_source: PMID:10369879
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008728
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000001030
type: Class
Object_term: erm protein

subject: PR_000001030
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008092
  Ontology_term: cytoskeletal protein binding
Evidence_source: PIRSF:PIRSF002305
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF002305
DB_ID: PIRSF:PIRSF002305
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001092
type: Class
Object_term: interleukin-17
Object_synonym: fam:IL-17
Object_synonym: IL17

subject: PR_000001092
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0019221
  Ontology_term: cytokine-mediated signaling pathway
Evidence_source: PIRSF:PIRSF003430
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF003430
DB_ID: PIRSF:PIRSF003430
Date: 2008-09-22
Assigned_by: PRO:CNA

PR_000001124
type: Class
Object_term: calcium-independent alpha-latrotoxin receptor
Object_synonym: latrophilin

subject: PR_000001124
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007186
  Ontology_term: G protein-coupled receptor signaling pathway
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2008-09-15
Assigned_by: PRO:CNA

subject: PR_000001124
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0017157
  Ontology_term: regulation of exocytosis
Evidence_source: PIRSF:PIRSF010401
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF010401
DB_ID: PIRSF:PIRSF010401
Date: 2008-09-15
Assigned_by: PRO:CNA

PR_000002131
type: Class
Object_term: angiopoietin-1 receptor sequence variant R849W (human)
Object_synonym: angiopoietin-1 receptor sequence variant 1 (human)
Object_synonym: hTEK/var:R849W
Object_synonym: UniProtKB:Q02763-1, Arg-849, CHEBI:29954

subject: PR_000002131
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050792
  Ontology_term: multiple cutaneous and mucosal venous malformations
Evidence_source: PMID:10369874
Evidence_source: PMID:8980225
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006352
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000002131
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P27986-1
Evidence_source: PMID:10369874
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_006352
Date: 2009-03-09
Assigned_by: PRO:CNA
Comments: Note=Binding to SH2 domain (PF00017) of p85

PR_000002132
type: Class
Object_term: angiopoietin-1 receptor sequence variant Y897S (human)
Object_synonym: angiopoietin-1 receptor sequence variant 2 (human)
Object_synonym: hTEK/var:Y897S
Object_synonym: UniProtKB:Q02763-1, Tyr-897, CHEBI:29999

subject: PR_000002132
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050792
  Ontology_term: multiple cutaneous and mucosal venous malformations
Evidence_source: PMID:10369874
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008716
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000002132
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P27986-1
Evidence_source: PMID:10369874
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_008716
Date: 2009-03-09
Assigned_by: PRO:CNA
Comments: Note=Binding to SH2 domain (PF00017) of p85

PR_000002173
type: Class
Object_term: zinc finger protein Helios isoform 1
Object_synonym: IKZF2/iso:1
Object_synonym: zinc finger protein Helios isoform B

subject: PR_000002173
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046982
  Ontology_term: protein heterodimerization activity
Interaction_with: PR O08900
Interaction_with: PR Q03267-1
Evidence_source: MGI_ref:1203354
Evidence_source: PMID:9560339
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:1342541
Date: 2009-05-13
Assigned_by: MGI:MGI

PR_000002174
type: Class
Object_term: zinc finger protein Helios isoform 2
Object_synonym: IKZF2/iso:2
Object_synonym: zinc finger protein Helios isoform A

subject: PR_000002174
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046982
  Ontology_term: protein heterodimerization activity
Interaction_with: PR P81183-1
Interaction_with: PR P81183-2
Evidence_source: MGI_ref:1203354
Evidence_source: PMID:9560339
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:1342541
Date: 2011-12-16
Assigned_by: MGI:MGI

PR_000002684
type: Class
Object_term: voltage-gated potassium channel subunit KCNA5 isoform 2 unmodified form
Object_synonym: KCNA5/iso:2/UnMod

subject: PR_000002684
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: MGI_ref:63618
Evidence_source: PMID:8226976
Evidence_code: IC
Taxon: NCBITaxon:10090
Inferred_from: GO:0005249
DB_ID: MGI:96662
Date: 2014-04-25
Assigned_by: MGI:MGI

PR_000002988
type: Class
Object_term: zinc finger protein Eos isoform 1
Object_synonym: IKZF4/iso:1

subject: PR_000002988
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046982
  Ontology_term: protein heterodimerization activity
Interaction_with: PR Q03267-1
Evidence_source: MGI_ref:1333610
Evidence_source: PMID:10218586
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:1343139
Date: 2009-05-15
Assigned_by: MGI:MGI

PR_000002989
type: Class
Object_term: zinc finger protein Eos isoform 2
Object_synonym: IKZF4/iso:2

subject: PR_000002989
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Interaction_with: PR Q8C208-1
Evidence_source: MGI_ref:1333610
Evidence_source: PMID:10218586
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:1343139
Date: 2009-05-15
Assigned_by: MGI:MGI

PR_000022012
type: Class
Object_term: nucleolar transcription factor 1 isoform UBF2
Object_synonym: nucleolar transcription factor 1 isoform 2
Object_synonym: nucleolar transcription factor 1 isoform short
Object_synonym: UBTF/iso:UBF2

subject: PR_000022012
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005730
  Ontology_term: nucleolus
Evidence_source: MGI_ref:3836497
Evidence_source: PMID:19103806
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:98512
Date: 2009-12-15
Assigned_by: MGI:MGI

subject: PR_000022012
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0000183
  Ontology_term: rDNA heterochromatin formation
Evidence_source: MGI_ref:3836497
Evidence_source: PMID:19103806
Evidence_code: IMP
Taxon: NCBITaxon:10090
DB_ID: MGI:98512
Date: 2009-12-15
Assigned_by: MGI:MGI

PR_000022016
type: Class
Object_term: sphingolipid Delta(4)-desaturase/C4-monooxygenase DES2 isoform 1
Object_synonym: DEGS2/iso:1

subject: PR_000022016
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0000170
  Ontology_term: sphingosine hydroxylase activity
Evidence_source: MGI_ref:3056825
Evidence_source: PMID:15474011
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1917309
Date: 2010-02-02
Assigned_by: MGI:MGI

subject: PR_000022016
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0000170
  Ontology_term: sphingosine hydroxylase activity
Evidence_source: MGI_ref:3694278
Evidence_source: PMID:16571104
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1917309
Date: 2010-02-02
Assigned_by: MGI:MGI

subject: PR_000022016
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006667
  Ontology_term: sphinganine metabolic process
Evidence_source: MGI_ref:3694278
Evidence_source: PMID:16571104
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1917309
Date: 2010-02-02
Assigned_by: MGI:MGI

subject: PR_000022016
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0046513
  Ontology_term: ceramide biosynthetic process
Evidence_source: MGI_ref:3694278
Evidence_source: PMID:16571104
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1917309
Date: 2010-02-02
Assigned_by: MGI:MGI

PR_000024937
type: Class
Object_term: FUN30 homodimer (yeast)
Object_synonym: y(FUN30)*2

subject: PR_000024937
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Evidence_source: PMID:23779104
Evidence_code: IDA
Taxon: NCBITaxon:559292
Date: 2014-12-14
Assigned_by: PRO:CNA

subject: PR_000024937
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003682
  Ontology_term: chromatin binding
Evidence_source: PMID:23779104
Evidence_code: IDA
Taxon: NCBITaxon:559292
Date: 2014-01-14
Assigned_by: PRO:CNA

subject: PR_000024937
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004386
  Ontology_term: helicase activity
Evidence_source: PMID:23779104
Evidence_code: IDA
Taxon: NCBITaxon:559292
Date: 2014-01-14
Assigned_by: PRO:CNA

subject: PR_000024937
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008094
  Ontology_term: ATP-dependent activity, acting on DNA
Evidence_source: PMID:23779104
Evidence_code: IDA
Taxon: NCBITaxon:559292
Date: 2014-01-14
Assigned_by: PRO:CNA

subject: PR_000024937
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0140751
  Ontology_term: histone octamer slider activity
Evidence_source: PMID:23779104
Evidence_code: IDA
Taxon: NCBITaxon:559292
Date: 2014-01-14
Assigned_by: PRO:CNA
Comments: revised 2022-07-14 by PRO:DAN since original activity GO:0042766 'nucleosome mobilization' was made obsolete.

PR_000025509
type: Class
Object_term: synapsin-1 isoform 1b
Object_synonym: SYN1 isoform 2
Object_synonym: SYN1/iso:1b
Object_synonym: synapsin-1 isoform 2
Object_synonym: synapsin-1 isoform Ib

subject: PR_000025509
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P04925
Evidence_source: MGI_ref:2153789
Evidence_source: PMID:11571277
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:98460
Date: 2010-04-15
Assigned_by: MGI:MGI

PR_000025560
type: Class
Object_term: amyloid-beta precursor protein sequence variant D678N (human)
Object_synonym: hAPP/var:D678N
Object_synonym: Tottori APP
Object_synonym: UniProtKB:P05067-1, Asp-678, CHEBI:50347

subject: PR_000025560
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:15201367
Evidence_source: UniProtKB_VAR:VAR_044424
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_044424
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025561
type: Class
Object_term: amyloid-beta precursor protein sequence variant A692G (human)
Object_synonym: Flemish APP
Object_synonym: hAPP/var:A692G
Object_synonym: UniProtKB:P05067-1, Ala-692, CHEBI:29947

subject: PR_000025561
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:11311152
Evidence_source: PMID:1303239
Evidence_source: PMID:9754958
Evidence_source: UniProtKB_VAR:VAR_000016
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000016
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025562
type: Class
Object_term: amyloid-beta precursor protein sequence variant E693G (human)
Object_synonym: Arctic APP
Object_synonym: hAPP/var:E693G
Object_synonym: UniProtKB:P05067-1, Glu-693, CHEBI:29947

subject: PR_000025562
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:11528419
Evidence_source: PMID:1415269
Evidence_source: UniProtKB_VAR:VAR_014215
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_014215
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025563
type: Class
Object_term: amyloid-beta precursor protein sequence variant E693K (human)
Object_synonym: hAPP/var:E693K
Object_synonym: Italian APP
Object_synonym: UniProtKB:P05067-1, Glu-693, CHEBI:29967

subject: PR_000025563
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9246
  Ontology_term: cerebral amyloid angiopathy
Evidence_source: UniProtKB_VAR:VAR_014216
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_014216
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025564
type: Class
Object_term: amyloid-beta precursor protein sequence variant E693Q (human)
Object_synonym: Dutch APP
Object_synonym: hAPP/var:E693Q
Object_synonym: UniProtKB:P05067-1, Glu-693, CHEBI:30011

subject: PR_000025564
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9246
  Ontology_term: cerebral amyloid angiopathy
Evidence_source: PMID:2111584
Evidence_source: UniProtKB_VAR:VAR_000017
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000017
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025565
type: Class
Object_term: amyloid-beta precursor protein sequence variant D694N (human)
Object_synonym: hAPP/var:D694N
Object_synonym: Iowa APP
Object_synonym: UniProtKB:P05067-1, Asp-694, CHEBI:50347

subject: PR_000025565
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-d694n-iowa
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-d694n-iowa
Date: 2018-05-10
Assigned_by: PRO:DAN

subject: PR_000025565
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9246
  Ontology_term: cerebral amyloid angiopathy
Evidence_source: PMID:11409420
Evidence_source: PMID:12654973
Evidence_source: UniProtKB_VAR:VAR_014217
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_014217
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025566
type: Class
Object_term: amyloid-beta precursor protein sequence variant L705V (human)
Object_synonym: hAPP/var:L705V
Object_synonym: UniProtKB:P05067-1, Leu-705, CHEBI:30015

subject: PR_000025566
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9246
  Ontology_term: cerebral amyloid angiopathy
Evidence_source: PMID:16178030
Evidence_source: UniProtKB_VAR:VAR_032276
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_032276
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025567
type: Class
Object_term: amyloid-beta precursor protein sequence variant A713T (human)
Object_synonym: hAPP/var:A713T
Object_synonym: UniProtKB:P05067-1, Ala-713, CHEBI:30013

subject: PR_000025567
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:1303275
Evidence_source: PMID:15365148
Evidence_source: UniProtKB_VAR:VAR_000019
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000019
Date: 2012-04-12
Assigned_by: PRO:DAN

subject: PR_000025567
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9246
  Ontology_term: cerebral amyloid angiopathy
Evidence_source: Alzforum:app-a713t
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-a713t
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025568
type: Class
Object_term: amyloid-beta precursor protein sequence variant T714A (human)
Object_synonym: hAPP/var:T714A
Object_synonym: Iranian APP
Object_synonym: UniProtKB:P05067-1, Thr-714, CHEBI:46217

subject: PR_000025568
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:12034808
Evidence_source: UniProtKB_VAR:VAR_032277
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_032277
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025569
type: Class
Object_term: amyloid-beta precursor protein sequence variant T714I (human)
Object_synonym: Austrian APP
Object_synonym: hAPP/var:T714I
Object_synonym: UniProtKB:P05067-1, Thr-714, CHEBI:30009

subject: PR_000025569
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:11063718
Evidence_source: PMID:15668448
Evidence_source: UniProtKB_VAR:VAR_014218
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_014218
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025570
type: Class
Object_term: amyloid-beta precursor protein sequence variant V715M (human)
Object_synonym: French APP
Object_synonym: hAPP/var:V715M
Object_synonym: UniProtKB:P05067-1, Val-715, CHEBI:16044

subject: PR_000025570
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:10097173
Evidence_source: UniProtKB_VAR:VAR_010108
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010108
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025571
type: Class
Object_term: amyloid-beta precursor protein sequence variant I716V (human)
Object_synonym: Florida APP
Object_synonym: hAPP/var:I716V
Object_synonym: UniProtKB:P05067-1, Ile-716, CHEBI:30015

subject: PR_000025571
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:9328472
Evidence_source: UniProtKB_VAR:VAR_000020
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000020
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025572
type: Class
Object_term: amyloid-beta precursor protein sequence variant V717F (human)
Object_synonym: hAPP/var:V717F
Object_synonym: Indiana APP
Object_synonym: UniProtKB:P05067-1, Val-717, CHEBI:29997

subject: PR_000025572
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:1925564
Evidence_source: PMID:8267572
Evidence_source: PMID:8290042
Evidence_source: PMID:8476439
Evidence_source: UniProtKB_VAR:VAR_000023
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000023
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025573
type: Class
Object_term: amyloid-beta precursor protein sequence variant V717G (human)
Object_synonym: hAPP/var:V717G
Object_synonym: UniProtKB:P05067-1, Val-717, CHEBI:29947

subject: PR_000025573
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:1944558
Evidence_source: PMID:8476439
Evidence_source: UniProtKB_VAR:VAR_000022
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000022
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025574
type: Class
Object_term: amyloid-beta precursor protein sequence variant V717I (human)
Object_synonym: hAPP/var:V717I
Object_synonym: London APP
Object_synonym: UniProtKB:P05067-1, Val-717, CHEBI:30009

subject: PR_000025574
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:10631141
Evidence_source: PMID:1671712
Evidence_source: PMID:1678058
Evidence_source: PMID:1908231
Evidence_source: PMID:8267572
Evidence_source: PMID:8476439
Evidence_source: PMID:8577393
Evidence_source: UniProtKB_VAR:VAR_000021
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000021
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025575
type: Class
Object_term: amyloid-beta precursor protein sequence variant V717L (human)
Object_synonym: hAPP/var:V717L
Object_synonym: UniProtKB:P05067-1, Val-717, CHEBI:30006

subject: PR_000025575
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:10867787
Evidence_source: UniProtKB_VAR:VAR_014219
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_014219
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025576
type: Class
Object_term: amyloid-beta precursor protein sequence variant L723P (human)
Object_synonym: Australian APP
Object_synonym: hAPP/var:L723P
Object_synonym: UniProtKB:P05067-1, Leu-723, CHEBI:50342

subject: PR_000025576
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: PMID:10665499
Evidence_source: UniProtKB_VAR:VAR_010109
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_010109
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025591
type: Class
Object_term: amyloid-beta precursor protein sequence variant A673T (human)
Object_synonym: hAPP/var:A673T
Object_synonym: Icelandic APP
Object_synonym: UniProtKB:P05067-1, Ala-673, CHEBI:30013

subject: PR_000025591
predicate:
  Relation: associated_with_disease_suppression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-a673t-icelandic
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-a673t-icelandic
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025594
type: Class
Object_term: amyloid-beta precursor protein sequence variant V715A (human)
Object_synonym: German APP
Object_synonym: hAPP/var:V715A
Object_synonym: UniProtKB:P05067-1, Val-715, CHEBI:46217

subject: PR_000025594
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-v715a-german
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-v715a-german
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025595
type: Class
Object_term: amyloid-beta precursor protein sequence variant I716F (human)
Object_synonym: hAPP/var:I716F
Object_synonym: Iberian APP
Object_synonym: UniProtKB:P05067-1, Ile-716, CHEBI:29997

subject: PR_000025595
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-i716f-iberian
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-i716f-iberian
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025596
type: Class
Object_term: amyloid-beta precursor protein sequence variant I716T (human)
Object_synonym: hAPP/var:I716T
Object_synonym: UniProtKB:P05067-1, Ile-716, CHEBI:30013

subject: PR_000025596
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-i716t
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-i716t
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025597
type: Class
Object_term: amyloid-beta precursor protein sequence variant T719P (human)
Object_synonym: hAPP/var:T719P
Object_synonym: UniProtKB:P05067-1, Thr-719, CHEBI:50342

subject: PR_000025597
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-t719p
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-t719p
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025598
type: Class
Object_term: amyloid-beta precursor protein sequence variant K724N (human)
Object_synonym: Belgian APP
Object_synonym: hAPP/var:K724N
Object_synonym: UniProtKB:P05067-1, Lys-724, CHEBI:50347

subject: PR_000025598
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-k724n-belgian
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-k724n-belgian
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025599
type: Class
Object_term: amyloid-beta precursor protein sequence variant E682K (human)
Object_synonym: hAPP/var:E682K
Object_synonym: Leuven APP
Object_synonym: UniProtKB:P05067-1, Glu-682, CHEBI:29967

subject: PR_000025599
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-e682k-leuven
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-e682k-leuven
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025601
type: Class
Object_term: amyloid-beta precursor protein sequence variant KM670/671NL (human)
Object_synonym: hAPP/var:KM670/671NL
Object_synonym: Swedish APP
Object_synonym: UniProtKB:P05067-1, Lys-670, CHEBI:50347
Object_synonym: Met-671, CHEBI:30006

subject: PR_000025601
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: UniProtKB_VAR:VAR_000015
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_000015
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000025602
type: Class
Object_term: amyloid-beta precursor protein sequence variant E693del (human)
Object_synonym: APP deltaGlu693
Object_synonym: APP E693delta
Object_synonym: hAPP/var:E693del
Object_synonym: Osaka APP
Object_synonym: UniProtKB:P05067-1, 1-692, 694-770

subject: PR_000025602
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:10652
  Ontology_term: Alzheimer's disease
Evidence_source: Alzforum:app-e693del-osaka
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:app-e693del-osaka
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000025633
type: Class
Object_term: mediator of RNA polymerase II transcription subunit 28 isoform 1 phosphorylated 1 (human)
Object_synonym: hMED28/iso:1/Phos:1
Object_synonym: UniProtKB:Q9H204-1, Tyr-64, MOD:00048

subject: PR_000025633
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P62993
Evidence_source: PMID:16899217
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9H204-1
Date: 2010-05-10
Assigned_by: PRO:JAN

PR_000025637
type: Class
Object_term: G1/S-specific cyclin-E1 isoform 3 phosphorylated 1 (human)
Object_synonym: hCCNE1/iso:3/Phos:1
Object_synonym: UniProtKB:P24864-3, Ser-384, MOD:00046

subject: PR_000025637
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q13526
Evidence_source: PMID:16223725
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P24864-3
Date: 2010-05-10
Assigned_by: PRO:JAN

PR_000025639
type: Class
Object_term: platelet endothelial aggregation receptor 1 isoform 1 phosphorylated 1 (human)
Object_synonym: hPEAR1/iso:1/Phos:1
Object_synonym: UniProtKB:Q5VY43-1, Tyr-925, MOD:00048
Object_synonym: Ser-953/Ser-1029, MOD:00046

subject: PR_000025639
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P29353
Evidence_source: PMID:15851471
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q5VY43-1
Date: 2010-05-15
Assigned_by: PRO:CNA

subject: PR_000025639
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P98077
Evidence_source: PMID:15851471
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q5VY43-1
Date: 2010-05-15
Assigned_by: PRO:CNA

subject: PR_000025639
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:15851471
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q5VY43-1
Date: 2010-05-15
Assigned_by: PRO:CNA

PR_000025641
type: Class
Object_term: E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human)
Object_synonym: hSIAH1/iso:1/Phos:1
Object_synonym: UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048

subject: PR_000025641
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043525
  Ontology_term: positive regulation of neuron apoptotic process
Evidence_source: PMID:16230351
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8IUQ4-1
Date: 2010-05-15
Assigned_by: PRO:CNA

subject: PR_000025641
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0070304
  Ontology_term: positive regulation of stress-activated protein kinase signaling cascade
Evidence_source: PMID:16230351
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8IUQ4-1
Date: 2010-05-15
Assigned_by: PRO:CNA

subject: PR_000025641
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000045369
Interaction_with: PR Q69ZI1-1
Evidence_source: PMID:16230351
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8IUQ4-1
Date: 2015-11-05
Assigned_by: PRO:CNA

PR_000025712
type: Class
Object_term: alpha-actinin-1 isoform 1 phosphorylated 1 (human)
Object_synonym: hACTN1/iso:1/Phos:1
Object_synonym: UniProtKB:P12814-1, Tyr-12, MOD:00048

subject: PR_000025712
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P12931
Evidence_source: PMID:16291744
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12814-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025712
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0019903
  Ontology_term: protein phosphatase binding
Interaction_with: PR P18031
Evidence_source: PMID:16291744
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12814-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025712
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0016477
  Ontology_term: cell migration
Evidence_source: PMID:16291744
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12814-1
Date: 2010-05-20
Assigned_by: PRO:JAN

PR_000025714
type: Class
Object_term: B-cell lymphoma/leukemia 10 isoform 1 phosphorylated 1 (human)
Object_synonym: hBCL10/iso:1/Phos:1
Object_synonym: UniProtKB:O95999-1, Ser-218/Ser-231, MOD:00046

subject: PR_000025714
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P20749
Evidence_source: PMID:16280327
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O95999-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025714
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:16280327
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O95999-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025714
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0032996
  Ontology_term: Bcl3-Bcl10 complex
Evidence_source: PMID:16280327
Evidence_code: EXP
Taxon: NCBITaxon:9606
Inferred_from: UniProtKB:P20749
DB_ID: UniProtKB:O95999-1
Date: 2010-05-20
Assigned_by: PRO:JAN

PR_000025723
type: Class
Object_term: heat shock factor protein 1 isoform Long phosphorylated 1 (human)
Object_synonym: hHSF1/iso:Long/Phos:1
Object_synonym: UniProtKB:Q00613-1, Ser-121, MOD:00046

subject: PR_000025723
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P07900
Evidence_source: PMID:16278218
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q00613-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025723
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P08238
Evidence_source: PMID:16278218
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q00613-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025723
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0000976
  Ontology_term: transcription cis-regulatory region binding
Modifier: NOT
Evidence_source: PMID:16278218
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q00613-1
Date: 2015-08-20
Assigned_by: PRO:JAN

PR_000025725
type: Class
Object_term: heat shock factor protein 1 isoform Long phosphorylated 2 (human)
Object_synonym: hHSF1/iso:Long/Phos:2
Object_synonym: UniProtKB:Q00613-1, Ser-303/Ser-307, MOD:00046

subject: PR_000025725
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P62258
Evidence_source: PMID:12917326
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q00613-1
Date: 2015-05-04
Assigned_by: PRO:CNA

subject: PR_000025725
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:12917326
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q00613-1
Date: 2015-05-04
Assigned_by: PRO:CNA

PR_000025727
type: Class
Object_term: Bcl-2-like protein 11 isoform 1 phosphorylated 1 (human)
Object_synonym: hBCL2L11/iso:1/Phos:1
Object_synonym: UniProtKB:O43521-1, Ser-87, MOD:00046

subject: PR_000025727
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P31946
Evidence_source: PMID:16282323
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43521-1
Date: 2010-05-20
Assigned_by: PRO:JAN

subject: PR_000025727
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:16282323
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43521-1
Date: 2010-05-20
Assigned_by: PRO:JAN

PR_000025750
type: Class
Object_term: cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 (human)
Object_synonym: hCDKN1B/iso:1/Phos:2
Object_synonym: UniProtKB:P46527-1, Tyr-88, MOD:00048

subject: PR_000025750
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P20248
Evidence_source: PMID:17254966
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

subject: PR_000025750
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P24385
Evidence_source: PMID:17254966
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

subject: PR_000025750
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P24864
Evidence_source: PMID:17254966
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

subject: PR_000025750
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0044877
  Ontology_term: protein-containing complex binding
Interaction_with: PR_000026741
Evidence_source: PMID:17254966
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

subject: PR_000025750
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051318
  Ontology_term: G1 phase
Evidence_source: PMID:17254966
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

subject: PR_000025750
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004861
  Ontology_term: cyclin-dependent protein serine/threonine kinase inhibitor activity
Modifier: decreased
Relative_to: PR_000045370
Evidence_source: PMID:17254966
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P46527-1
Date: 2010-07-10
Assigned_by: PRO:CNA

PR_000025763
type: Class
Object_term: interferon regulatory factor 3 isoform 1 phosphorylated 1 (human)
Object_synonym: hIRF3/iso:1/Phos:1
Object_synonym: IRF3-P (human)
Object_synonym: UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046

subject: PR_000025763
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR O14980
Evidence_source: PMID:10805757
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7149
Date: 2011-05-13
Assigned_by: PRO:CNA
Comments: Evidence=Fig4f

subject: PR_000025763
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: Reactome:REACT_7149
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q14653-1
Date: 2010-07-18
Assigned_by: PRO:CNA

PR_000025765
type: Class
Object_term: IRF3-P:IRF3-P complex (human)

subject: PR_000025765
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:10805757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7444
Date: 2011-05-13
Assigned_by: PRO:CNA

subject: PR_000025765
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005654
  Ontology_term: nucleoplasm
Evidence_source: Reactome:REACT_7444
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7444
Date: 2010-07-18
Assigned_by: PRO:CNA

subject: PR_000025765
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: Reactome:REACT_7146
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7146
Date: 2010-07-18
Assigned_by: PRO:CNA

subject: PR_000025765
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

subject: PR_000025765
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: Reactome:REACT_6894

subject: PR_000025765
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034340
  Ontology_term: response to type I interferon
Evidence_source: PMID:10805757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7444
Date: 2011-05-13
Assigned_by: PRO:CNA

subject: PR_000025765
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002753
  Ontology_term: cytoplasmic pattern recognition receptor signaling pathway
Evidence_source: Reactome:REACT_7146
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

PR_000025773
type: Class
Object_term: lipopolysaccharide receptor complex 3 (human)
Object_synonym: h(LPSR:3)
Object_synonym: TLR4:MD2:LPS:CD14 (human)

subject: PR_000025773
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2015-05-13
Assigned_by: PRO:CNA

PR_000025780
type: Class
Object_term: CD3 gamma isoform 1, signal peptide removed phosphorylated 1 (human)
Object_synonym: CD3 gamma with phosphorylated ITAM (human)
Object_synonym: hCD3G/iso:1/SigPep-/Phos:1
Object_synonym: PRO_0000014615, Tyr-160/Tyr-171, MOD:00048
Object_synonym: UniProtKB:P09693-1, 23-182, Tyr-160/Tyr-171, MOD:00048

subject: PR_000025780
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_13072
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P09693-1
Date: 2010-07-18
Assigned_by: PRO:CNA

PR_000025782
type: Class
Object_term: CD3 epsilon:CD3 gamma with phosphorylated ITAM (human)
Object_synonym: h(CD3E:CD3G)

subject: PR_000025782
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_13214
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_13214
Date: 2010-07-18
Assigned_by: PRO:CNA

PR_000025786
type: Class
Object_term: lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
Object_synonym: hLY96/iso:1/SigPep-/NGlyco:1
Object_synonym: MD-2 glycosylated
Object_synonym: PRO_0000018619, Asn-26/Asn-114, MOD:00160
Object_synonym: UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160

subject: PR_000025786
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0001530
  Ontology_term: lipopolysaccharide binding
Evidence_source: PMID:17569869
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Y9-1
Date: 2014-05-14
Assigned_by: PRO:CNA
Comments: Occurs_in=PR:000025773.

subject: PR_000025786
predicate:
  Relation: enables
object:
  Ontology_ID: GO:1990458
  Ontology_term: lipooligosaccharide binding
Evidence_source: PMID:19783674
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Y9-1
Date: 2014-08-14
Assigned_by: PRO:CNA
Comments: Target=lipooligosaccharide (CHEBI:35371).

subject: PR_000025786
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11593030
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Y9-1
Date: 2010-07-18
Assigned_by: PRO:CNA

subject: PR_000025786
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:19783674
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Y9-1
Date: 2014-08-14
Assigned_by: PRO:CNA

subject: PR_000025786
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_7660
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Y9-1
Date: 2013-05-20
Assigned_by: PRO:CNA

PR_000025790
type: Class
Object_term: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
Object_synonym: hCD28/iso:1/SigPep-/Phos:1
Object_synonym: PRO_0000014652, Tyr-191, MOD:00048
Object_synonym: UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048

subject: PR_000025790
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_20178
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P10747-1
Date: 2010-07-18
Assigned_by: PRO:CNA

PR_000025792
type: Class
Object_term: phospho CD28 homodimer (human)
Object_synonym: h(CD28/iso:1/SigPep-/Phos:1)*2

subject: PR_000025792
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_20268
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_20268
Date: 2010-07-18
Assigned_by: PRO:CNA

PR_000025800
type: Class
Object_term: eukaryotic translation initiation factor 3 subunit F isoform 1 CDK11-phosphorylated 1 (human)
Object_synonym: hEIF3F/iso:1/Phos:1
Object_synonym: UniProtKB:O00303-1, Ser-46, MOD:00046
Object_synonym: Thr-119, MOD:00047

subject: PR_000025800
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0005852
  Ontology_term: eukaryotic translation initiation factor 3 complex
Evidence_source: PMID:19245811
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O00303-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025800
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0017148
  Ontology_term: negative regulation of translation
Evidence_source: PMID:19245811
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O00303-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025800
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043065
  Ontology_term: positive regulation of apoptotic process
Evidence_source: PMID:19245811
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O00303-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025800
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0031369
  Ontology_term: translation initiation factor binding
Modifier: increased
Relative_to: PR_000025839
Interaction_with: PR P55884
Evidence_source: PMID:19245811
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O00303-1
Date: 2010-08-04
Assigned_by: PRO:JAN

PR_000025834
type: Class
Object_term: tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)
Object_synonym: mSYK/iso:1/Phos:1
Object_synonym: UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048

subject: PR_000025834
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0019901
  Ontology_term: protein kinase binding
Interaction_with: PR P09769
Evidence_source: PMID:15536084
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P48025-1
Date: 2010-08-04
Assigned_by: PRO:JAN
Comments: Note=SH2 domain (PF00017) of p85is involved in binding

subject: PR_000025834
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0031625
  Ontology_term: ubiquitin protein ligase binding
Interaction_with: PR P09769
Evidence_source: PMID:15536084
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P48025-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025834
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0043548
  Ontology_term: phosphatidylinositol 3-kinase binding
Interaction_with: PR P27986
Evidence_source: PMID:15536084
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P48025-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025834
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002433
  Ontology_term: immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Evidence_source: PMID:15536084
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P48025-1
Date: 2010-08-04
Assigned_by: PRO:JAN

PR_000025837
type: Class
Object_term: protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 (human)
Object_synonym: hMDM4/iso:1/PhosUbiq:1
Object_synonym: UniProtKB:O15151-1, Ser-367, MOD:00046
Object_synonym: MOD:01148

subject: PR_000025837
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P27348
Evidence_source: PMID:16511560
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O15151-1
Date: 2015-05-04
Assigned_by: PRO:JAN

subject: PR_000025837
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P61981
Evidence_source: PMID:16511572
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O15151-1
Date: 2015-05-04
Assigned_by: PRO:CNA

subject: PR_000025837
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:16511560
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O15151-1
Date: 2010-08-04
Assigned_by: PRO:JAN

subject: PR_000025837
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043516
  Ontology_term: regulation of DNA damage response, signal transduction by p53 class mediator
Evidence_source: PMID:16511560
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O15151-1
Date: 2010-08-04
Assigned_by: PRO:JAN

PR_000025873
type: Class
Object_term: glutaminase 1 tetramer (Escherichia coli K-12)

subject: PR_000025873
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004359
  Ontology_term: glutaminase activity
Evidence_source: PMID:18459799
Evidence_code: EXP
Taxon: NCBITaxon:83333
Date: 2010-09-21
Assigned_by: PRO:CNA

PR_000025874
type: Class
Object_term: glutaminase 1 tetramer (Bacillus subtilis subsp. subtilis str. 168)

subject: PR_000025874
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004359
  Ontology_term: glutaminase activity
Evidence_source: PMID:18459799
Evidence_code: EXP
Taxon: NCBITaxon:1423
Date: 2010-09-21
Assigned_by: PRO:CNA

PR_000025882
type: Class
Object_term: siroheme synthase cysG phosphorylated 1 (Salmonella typhimurium)
Object_synonym: cysG/Phos:1 (SALTM)
Object_synonym: UniProtKB:P25924, Ser-128, MOD:00046

subject: PR_000025882
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0043115
  Ontology_term: precorrin-2 dehydrogenase activity
Modifier: decreased
Relative_to: PR_000025884
Evidence_source: PDB:1PJQ
Evidence_source: PMID:14595395
Evidence_code: EXP
Taxon: NCBITaxon:99287
DB_ID: UniProtKB:P25924-1
Date: 2010-09-21
Assigned_by: PRO:CNA
Comments: Note=Strain information inferred from PDB sequence [PRO:DAN]

PR_000025884
type: Class
Object_term: siroheme synthase cysG unmodified form (Salmonella typhimurium)
Object_synonym: cysG/UnMod (SALTM)

subject: PR_000025884
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0043115
  Ontology_term: precorrin-2 dehydrogenase activity
Evidence_source: PDB:1PJQ
Evidence_source: PMID:14595395
Evidence_code: EXP
Taxon: NCBITaxon:99287
DB_ID: UniProtKB:P25924-1
Date: 2015-11-04
Assigned_by: PRO:CNA
Comments: Note=Strain information inferred from PDB sequence [PRO:DAN]

PR_000025892
type: Class
Object_term: transcription factor Jun isoform 1 phosphorylated 1 (mouse)
Object_synonym: mJUN/iso:1/Phos:1
Object_synonym: UniProtKB:P05627-1, Ser-63/Ser-73, MOD:00046
Object_synonym: MOD:00696

subject: PR_000025892
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q60739-1
Evidence_source: PMID:20516211
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P05627-1
Date: 2010-08-25
Assigned_by: PRO:HJD

PR_000025906
type: Class
Object_term: phosphocarrier protein HPr isoform 1 phosphorylated 1 (Escherichia coli K-12)
Object_synonym: Ec-ptsH/iso:1/Phos:1
Object_synonym: phosphocarrier protein HPr isoform 1 P-Ser-HPr (Escherichia coli K-12)
Object_synonym: UniProtKB:P0AA04-1, His-15, MOD:00890

subject: PR_000025906
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P0AC86
Evidence_source: PMID:9334229
Evidence_code: IPI
Taxon: NCBITaxon:83333
DB_ID: UniProtKB:P0AA04-1
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025906
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0009927
  Ontology_term: histidine phosphotransfer kinase activity
Evidence_source: PMID:12963714
Evidence_code: EXP
Taxon: NCBITaxon:83333
DB_ID: UniProtKB:P0AA04-1
Date: 2010-09-25
Assigned_by: PRO:CNA

subject: PR_000025906
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009401
  Ontology_term: phosphoenolpyruvate-dependent sugar phosphotransferase system
Evidence_source: PMID:12963714
Evidence_code: EXP
Taxon: NCBITaxon:83333
DB_ID: UniProtKB:P0AA04-1
Date: 2010-09-25
Assigned_by: PRO:CNA

subject: PR_000025906
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006109
  Ontology_term: regulation of carbohydrate metabolic process
Evidence_source: PMID:9334229
Evidence_code: EXP
Taxon: NCBITaxon:83333
DB_ID: UniProtKB:P0AA04-1
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025907
type: Class
Object_term: phosphocarrier protein HPr isoform 1 phosphorylated 1 (Bacillus subtilis subsp. subtilis str. 168)
Object_synonym: ptsH/iso:1/Phos:1 (BACSU)
Object_synonym: UniProtKB:P08877-1, His-15, MOD:00890

subject: PR_000025907
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0009927
  Ontology_term: histidine phosphotransfer kinase activity
Evidence_source: PMID:14527945
Evidence_code: EXP
Taxon: NCBITaxon:1423
DB_ID: UniProtKB:P08877-1
Date: 2010-09-25
Assigned_by: PRO:CNA

subject: PR_000025907
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009401
  Ontology_term: phosphoenolpyruvate-dependent sugar phosphotransferase system
Evidence_source: PMID:14527945
Evidence_code: EXP
Taxon: NCBITaxon:1423
DB_ID: UniProtKB:P08877-1
Date: 2010-09-25
Assigned_by: PRO:CNA

PR_000025921
type: Class
Object_term: protein max isoform short acetylated 1 (human)
Object_synonym: hMAX/iso:short/Ac:1
Object_synonym: UniProtKB:P61244-2, Lys-57/Lys-144/Lys-145, MOD:00064

subject: PR_000025921
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:17217336
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P61244-2
Date: 2010-09-25
Assigned_by: PRO:CNA

PR_000025924
type: Class
Object_term: Max homodimer acetylated 1 (human)
Object_synonym: h(MAX/iso:short/AcRes+)*2

subject: PR_000025924
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:17217336
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025924
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008134
  Ontology_term: transcription factor binding
Modifier: NOT
Interaction_with: PR Q13105
Evidence_source: PMID:16126174
Evidence_code: IPI
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025927
type: Class
Object_term: TGF-beta 1 isoform 1 mature form (human)
Object_synonym: hTGFB1/iso:1/mature
Object_synonym: PRO_0000033763
Object_synonym: UniProtKB:P01137-1, 279-390

subject: PR_000025927
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:3162913
Evidence_source: PMID:8471846
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025927
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: PMID:8294500
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025927
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:8471846
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025927
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:9918798
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025928
type: Class
Object_term: TGF-beta 1 isoform 1 mature form (mouse)
Object_synonym: mTGFB1/iso:1/mature
Object_synonym: PRO_0000033767
Object_synonym: UniProtKB:P04202-1, 279-390

subject: PR_000025928
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005160
  Ontology_term: transforming growth factor beta receptor binding
Evidence_source: PMID:14764882
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P04202-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025928
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: PMID:9008713
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P04202-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025928
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030879
  Ontology_term: mammary gland development
Evidence_source: PMID:1821856
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P04202-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025929
type: Class
Object_term: TGF-beta 1 isoform 1 mature form (rat)
Object_synonym: PRO_0000033771
Object_synonym: rTGFB1/iso:1/mature
Object_synonym: UniProtKB:P17246-1, 279-390

subject: PR_000025929
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: PMID:11907708
Evidence_code: IDA
Taxon: NCBITaxon:10116
DB_ID: UniProtKB:P17246-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025930
type: Class
Object_term: TGF-beta 1 isoform 1 mature form (green monkey)
Object_synonym: GrMonkey-TGFB1/iso:1/mature
Object_synonym: PRO_0000033761
Object_synonym: UniProtKB:P09533-1, 279-390

subject: PR_000025930
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:3185545
Evidence_code: IDA
Taxon: NCBITaxon:9534
DB_ID: UniProtKB:P09533-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025930
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: PMID:3185545
Evidence_code: IDA
Taxon: NCBITaxon:9534
DB_ID: UniProtKB:P09533-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025930
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:3185545
Evidence_code: IDA
Taxon: NCBITaxon:9534
DB_ID: UniProtKB:P09533-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025933
type: Class
Object_term: smad2-smad4 protein complex 1 (human)
Object_synonym: h(pSMAD2:SMAD4):1

subject: PR_000025933
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005654
  Ontology_term: nucleoplasm
Evidence_source: Reactome:REACT_7382
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025933
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: Reactome:REACT_7344
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025933
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:8752209
Evidence_source: PMID:8980228
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025934
type: Class
Object_term: smad2 isoform Long phosphorylated 1 (human)
Object_synonym: hSMAD2/iso:Long/Phos:1
Object_synonym: UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046

subject: PR_000025934
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Evidence_source: PMID:9689110
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0000981
  Ontology_term: DNA-binding transcription factor activity, RNA polymerase II-specific
Evidence_source: PMID:8980228
Evidence_source: PMID:9346966
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Interaction_with: PR Q13485
Evidence_source: PMID:9311995
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:9006934
Evidence_source: PMID:9346966
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of DNA-templated transcription
Evidence_source: PMID:15690394
Evidence_source: PMID:9689110
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:8752209
Evidence_source: PMID:8980228
Evidence_source: PMID:9346966
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:8752209
Evidence_source: PMID:8980228
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025934
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0060395
  Ontology_term: SMAD protein signal transduction
Evidence_source: PMID:9346966
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025935
type: Class
Object_term: smad2 isoform Long phosphorylated 2 (human)
Object_synonym: hSMAD2/iso:Long/Phos:2
Object_synonym: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047
Object_synonym: Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046

subject: PR_000025935
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0000981
  Ontology_term: DNA-binding transcription factor activity, RNA polymerase II-specific
Evidence_source: PMID:12193595
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003712
  Ontology_term: transcription coregulator activity
Evidence_source: PMID:12193595
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Interaction_with: PR Q13485
Evidence_source: PMID:12193595
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:12193595
Evidence_source: PMID:17074053
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006355
  Ontology_term: regulation of DNA-templated transcription
Evidence_source: PMID:12193595
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:12193595
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

subject: PR_000025935
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0060395
  Ontology_term: SMAD protein signal transduction
Evidence_source: PMID:12193595
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2010-10-04
Assigned_by: PRO:CNA

PR_000025936
type: Class
Object_term: smad2 isoform Long phosphorylated 3 (human)
Object_synonym: hSMAD2/iso:Long/Phos:3
Object_synonym: UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046

subject: PR_000025936
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Interaction_with: PR Q13485
Evidence_source: PMID:11027280
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025936
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:11027280
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025936
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:11027280
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025936
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0060395
  Ontology_term: SMAD protein signal transduction
Evidence_source: PMID:11027280
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025936
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:11027280
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025937
type: Class
Object_term: smad2 isoform Long phosphorylated 4 (human)
Object_synonym: hSMAD2/iso:Long/Phos:4
Object_synonym: UniProtKB:Q15796-1, Thr-220, MOD:00047
Object_synonym: Ser-245/Ser-250/Ser-255, MOD:00046

subject: PR_000025937
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:10197981
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025937
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: NOT
Evidence_source: PMID:10197981
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025938
type: Class
Object_term: smad2 isoform Short phosphorylated 1 (human)
Object_synonym: hSMAD2/iso:Short/Phos:1
Object_synonym: UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046

subject: PR_000025938
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Evidence_source: PMID:14701940
Evidence_source: PMID:9873005
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025938
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PMID:9873005
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025938
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003712
  Ontology_term: transcription coregulator activity
Evidence_source: PMID:14701940
Evidence_source: PMID:9873005
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025938
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:9873005
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15796-2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025942
type: Class
Object_term: smad2 isoform Long phosphorylated 1 (mouse)
Object_synonym: mSMAD2/iso:Long/Phos:1
Object_synonym: UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046

subject: PR_000025942
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Evidence_source: PMID:15282343
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025942
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Interaction_with: PR P97471
Evidence_source: PMID:11043574
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025942
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:11557747
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025942
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:11262418
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025942
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11262418
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025943
type: Class
Object_term: smad2 isoform Short phosphorylated 1 (mouse)
Object_synonym: mSMAD2/iso:Short/Phos:1
Object_synonym: UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046

subject: PR_000025943
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PMID:15630024
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000025943
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:15630024
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q62432-2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000025944
type: Class
Object_term: smad2-smad4 protein complex 1 (mouse)
Object_synonym: m(SMAD2:SMAD4):1

subject: PR_000025944
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:12672795
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025944
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12672795
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025946
type: Class
Object_term: smad2-smad4 protein complex 3 (human)
Object_synonym: h(SMAD2:SMAD4):3

subject: PR_000025946
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:12193595
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025946
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030511
  Ontology_term: positive regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12193595
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025947
type: Class
Object_term: smad2-smad4 protein complex 4 (human)
Object_synonym: h(SMAD2:SMAD4):4

subject: PR_000025947
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:11027280
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025947
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11027280
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025950
type: Class
Object_term: smad2-smad4-ski protein complex

subject: PR_000025950
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:10705283
Evidence_source: PMID:15107821
Evidence_code: EXP
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025951
type: Class
Object_term: smad2-smad4-ski protein complex 1 (human)

subject: PR_000025951
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:10485843
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Note=Conflicting information with data for complex 2

subject: PR_000025951
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:10485843
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Note=Conflicting information with data for complex 2

PR_000025952
type: Class
Object_term: smad2-smad4-ski protein complex 2 (human)

subject: PR_000025952
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:12732634
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Note=Conflicting information with data for complex 1

subject: PR_000025952
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:12732634
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Note=Conflicting information with data for complex 1

PR_000025958
type: Class
Object_term: mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human)
Object_synonym: hSMAD4/iso:1/MonoUbiq:2
Object_synonym: UniProtKB:Q13485-1, Lys-519, MOD:01148

subject: PR_000025958
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030512
  Ontology_term: negative regulation of transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:19135894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13485-1
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000025958
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Modifier: NOT
Evidence_source: PMID:19135894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13485-1
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025959
type: Class
Object_term: TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
Object_synonym: hTGFBR1/iso:1/SigPep-/Phos:1
Object_synonym: PRO_0000024423, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046
Object_synonym: Thr-185/Thr-186, MOD:00047
Object_synonym: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046

subject: PR_000025959
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005025
  Ontology_term: transforming growth factor beta receptor activity, type I
Evidence_source: PMID:7774578
Evidence_source: PMID:8947046
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36897-1
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000025959
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: PMID:8947046
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36897-1
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000025959
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PMID:7774578
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36897-1
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000025959
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:8242743
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36897-1
Date: 2009-03-09
Assigned_by: PRO:CNA

subject: PR_000025959
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007181
  Ontology_term: transforming growth factor beta receptor complex assembly
Evidence_source: PMID:8947046
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36897-1
Date: 2009-03-09
Assigned_by: PRO:CNA

PR_000025981
type: Class
Object_term: ccap-HPr-Ser46-P-cre operator complex (Priestia megaterium)

subject: PR_000025981
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045013
  Ontology_term: carbon catabolite repression of transcription
Evidence_source: PMID:15369672
Evidence_code: EXP
Taxon: NCBITaxon:1404
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000025982
type: Class
Object_term: ccap-HPr-Ser46-P-cre operator complex (Bacillus subtilis subsp. subtilis str. 168)

subject: PR_000025982
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045013
  Ontology_term: carbon catabolite repression of transcription
Evidence_source: PMID:15885105
Evidence_code: EXP
Taxon: NCBITaxon:1423
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026021
type: Class
Object_term: Max-binding protein MNT isoform 1 phosphorylated 1 (human)
Object_synonym: hMNT/iso:1/Phos:1

subject: PR_000026021
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051726
  Ontology_term: regulation of cell cycle
Evidence_source: PMID:16103876
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q99583-1
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026022
type: Class
Object_term: Max-binding protein MNT isoform 1 phosphorylated 1 (mouse)
Object_synonym: mMNT/iso:1/Phos:1

subject: PR_000026022
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051726
  Ontology_term: regulation of cell cycle
Evidence_source: PMID:16103876
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:O08789-1
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000026022
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0140297
  Ontology_term: DNA-binding transcription factor binding
Modifier: NOT
Interaction_with: PR Q62141
Evidence_source: PMID:16103876
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:O08789-1
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026023
type: Class
Object_term: mnt-msin3-hdac1 complex

subject: PR_000026023
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004407
  Ontology_term: histone deacetylase activity
Evidence_source: PMID:16103876
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA

subject: PR_000026023
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of DNA-templated transcription
Evidence_source: PMID:16103876
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2015-08-20
Assigned_by: PRO:CNA

subject: PR_000026023
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Evidence_source: PMID:16103876
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026030
type: Class
Object_term: mnt-max complex (human)

subject: PR_000026030
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Evidence_source: PMID:9184233
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026033
type: Class
Object_term: c-myc protein isoform 1 acetylated 1 (human)
Object_synonym: hMYC/iso:1/Ac:1
Object_synonym: UniProtKB:P01106-1, Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394

subject: PR_000026033
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PMID:16126174
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026033
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:16126174
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026033
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0005667
  Ontology_term: transcription factor complex
Evidence_source: PMID:16126174
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026035
type: Class
Object_term: Myc-max acetylated complex (human)

subject: PR_000026035
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008134
  Ontology_term: transcription factor binding
Interaction_with: PR Q13105
Evidence_source: PMID:16126174
Evidence_code: IPI
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Evidence=Fig6. Evidence for max short isoform comes from cited sources PMID:15003254, PMID:9162900.

subject: PR_000026035
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Evidence_source: PMID:16126174
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Evidence=Fig6. Evidence for max short isoform comes from cited source PMID:9162900.

PR_000026039
type: Class
Object_term: Myc-max complex 1 (human)

subject: PR_000026039
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Evidence_source: PMID:15003254
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Evidence for max short isoform comes from cited source PMID:9162900.

PR_000026046
type: Class
Object_term: mga-max complex (mouse)

subject: PR_000026046
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0043565
  Ontology_term: sequence-specific DNA binding
Evidence_source: PMID:10601024
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA
Comments: Note=T-box DNA binding

subject: PR_000026046
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Evidence_source: PMID:10601024
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2010-10-05
Assigned_by: PRO:CNA

PR_000026051
type: Class
Object_term: c-myc protein isoform 1 O-glycosylated 1 (human)
Object_synonym: hMYC/iso:1/OGlyco:1
Object_synonym: UniProtKB:P01106-1, Thr-58, MOD:00806

subject: PR_000026051
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0000981
  Ontology_term: DNA-binding transcription factor activity, RNA polymerase II-specific
Evidence_source: PMID:11904304
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026051
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006357
  Ontology_term: regulation of transcription by RNA polymerase II
Evidence_source: PMID:11904304
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026052
type: Class
Object_term: c-myc protein isoform 1 phosphorylated 1 (mouse)
Object_synonym: mMYC/iso:1/Phos:1
Object_synonym: UniProtKB:P01108-1, Ser-62, MOD:00046

subject: PR_000026052
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0000981
  Ontology_term: DNA-binding transcription factor activity, RNA polymerase II-specific
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026052
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026052
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0005667
  Ontology_term: transcription factor complex
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026052
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006357
  Ontology_term: regulation of transcription by RNA polymerase II
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026052
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008283
  Ontology_term: cell population proliferation
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026052
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006879
  Ontology_term: intracellular iron ion homeostasis
Evidence_source: PMID:11018017
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026053
type: Class
Object_term: c-myc protein isoform 1 phosphorylated 2 (mouse)
Object_synonym: mMYC/iso:1/Phos:2
Object_synonym: UniProtKB:P01108-1, Thr-58, MOD:00047
Object_synonym: Ser-62, MOD:00046

subject: PR_000026053
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:14563837
Evidence_source: PMID:15503302
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01108-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026054
type: Class
Object_term: c-myc protein isoform 1 phosphorylated 2 (human)
Object_synonym: hMYC/iso:1/Phos:2
Object_synonym: UniProtKB:P01106-1, Thr-58, MOD:00047
Object_synonym: Ser-62, MOD:00046

subject: PR_000026054
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Modifier: NOT
Evidence_source: PMID:7623799
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026055
type: Class
Object_term: c-myc protein isoform 1 phosphorylated 3 (human)
Object_synonym: hMYC/iso:1/Phos:3
Object_synonym: UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046

subject: PR_000026055
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:12676581
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026055
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045766
  Ontology_term: positive regulation of angiogenesis
Evidence_source: PMID:12676581
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01106-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026111
type: Class
Object_term: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA D532H (human)
Object_synonym: hMCCC1/var:MCCA D532H

subject: PR_000026111
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe form of disease.

subject: PR_000026111
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001630
  Ontology_term: splice_region_variant
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026112
type: Class
Object_term: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA L437P (human)
Object_synonym: hMCCC1/var:MCCA L437P
Object_synonym: UniProtKB:Q96RQ3, Leu-437, CHEBI:50342

subject: PR_000026112
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012788
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe form of disease.

subject: PR_000026112
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012788
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026113
type: Class
Object_term: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA R385S (human)
Object_synonym: hMCCC1/var:MCCA R385S
Object_synonym: UniProtKB:Q96RQ3, Arg-385, CHEBI:29999

subject: PR_000026113
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012787
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe form of disease.

subject: PR_000026113
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012787
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026114
type: Class
Object_term: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA A289V (human)
Object_synonym: hMCCC1/var:MCCA A289V
Object_synonym: UniProtKB:Q96RQ3, Ala-289, CHEBI:30015

subject: PR_000026114
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012785
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Mild form of disease

subject: PR_000026114
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001559
  Ontology_term: polypeptide_loss_of_function_variant
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012785
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026118
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB S173L (human)
Object_synonym: hMCCC2/var:MCCB S173L
Object_synonym: UniProtKB:Q9HCC0-1, Ser-173, CHEBI:30006

subject: PR_000026118
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012795
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe form of disease.

PR_000026119
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB E99Q (human)
Object_synonym: hMCCC2/var:MCCB E99Q
Object_synonym: UniProtKB:Q9HCC0-1, Glu-99, CHEBI:30011

subject: PR_000026119
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012792
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe and mild forms of disease

PR_000026120
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB V339M (human)
Object_synonym: hMCCC2/var:MCCB V339M
Object_synonym: UniProtKB:Q9HCC0-1, Val-339, CHEBI:16044

subject: PR_000026120
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_012800
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Severe form of disease

PR_000026121
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB I437V (human)
Object_synonym: hMCCC2/var:MCCB I437V

subject: PR_000026121
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA
Comments: Note=Mild form of disease

subject: PR_000026121
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001569
  Ontology_term: cryptic_splice_site_variant
Evidence_source: PMID:11181649
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026122
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant D172fs (human)
Object_synonym: hMCCC2/var:D172fs
Object_synonym: MCC beta D172fs (human)
Object_synonym: MCCB D172fs (human)
Object_synonym: UniProtKB:Q9HCC0, 1-172
Object_synonym: UniProtKB:Q9HCC0-1, 1-172

subject: PR_000026122
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11170888
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026123
type: Class
Object_term: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial sequence variant MCCB IVS3+5G->T (human)
Object_synonym: hMCCC2/var:MCCB IVS3+5G->T

subject: PR_000026123
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:0050710
  Ontology_term: 3-methylcrotonyl-CoA carboxylase deficiency
Evidence_source: PMID:11170888
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-11-30
Assigned_by: PRO:CNA

PR_000026130
type: Class
Object_term: bacterial-type serine palmitoyltransferase complex (Sphingomonas paucimobilis)
Object_synonym: SPT complex (SPHPI)

subject: PR_000026130
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004758
  Ontology_term: serine C-palmitoyltransferase activity
Evidence_source: PMID:17559874
Evidence_code: EXP
Taxon: NCBITaxon:13689
Date: 2010-12-06
Assigned_by: PRO:CNA

subject: PR_000026130
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:11279212
Evidence_source: PMID:17559874
Evidence_code: EXP
Taxon: NCBITaxon:13689
Date: 2015-08-20
Assigned_by: PRO:CNA

PR_000026132
type: Class
Object_term: bacterial-type serine palmitoyltransferase complex (Rhizorhabdus wittichii RW1)
Object_synonym: SPT complex (SPHWW)

subject: PR_000026132
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004758
  Ontology_term: serine C-palmitoyltransferase activity
Evidence_source: PMID:17559874
Evidence_code: EXP
Taxon: NCBITaxon:392499
Date: 2010-12-06
Assigned_by: PRO:CNA

subject: PR_000026132
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:17559874
Evidence_code: IC
Taxon: NCBITaxon:392499
Date: 2015-08-20
Assigned_by: PRO:CNA

PR_000026133
type: Class
Object_term: Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 (mouse)
Object_synonym: mBAD/iso:1/Phos:2
Object_synonym: UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046

subject: PR_000026133
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR_000003237
Evidence_source: PMID:16403219
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2014-09-03
Assigned_by: PRO:KER

subject: PR_000026133
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P63101-1
Evidence_source: PMID:10949026
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-08-10
Assigned_by: PRO:JAN

subject: PR_000026133
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:10949026
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-08-10
Assigned_by: PRO:JAN

subject: PR_000026133
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: decreased
Relative_to: PR_000037809
Interaction_with: PR Q64373-1
Evidence_source: PMID:16403219
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2014-09-03
Assigned_by: PRO:KER

subject: PR_000026133
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: NOT
Interaction_with: PR Q07817-1
Evidence_source: PMID:10949026
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-08-10
Assigned_by: PRO:JAN

PR_000026134
type: Class
Object_term: Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 (rat)
Object_synonym: rBAD/iso:1/Phos:3
Object_synonym: UniProtKB:O35147-1, Ser-112, MOD:00046

subject: PR_000026134
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0019902
  Ontology_term: phosphatase binding
Interaction_with: PR P63329
Evidence_source: PMID:10195903
Evidence_code: IPI
Taxon: NCBITaxon:10116
DB_ID: UniProtKB:O35147-1
Date: 2009-09-18
Assigned_by: PRO:JAN

subject: PR_000026134
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: PMID:10195903
Evidence_code: EXP
Taxon: NCBITaxon:10116
DB_ID: UniProtKB:O35147-1
Date: 2009-09-18
Assigned_by: PRO:JAN

subject: PR_000026134
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: decreased
Relative_to: PR_000002843
Interaction_with: PR P53563-1
Evidence_source: PMID:10195903
Evidence_code: IPI
Taxon: NCBITaxon:10116
DB_ID: UniProtKB:O35147-1
Date: 2009-09-18
Assigned_by: PRO:JAN

PR_000026135
type: Class
Object_term: Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 (mouse)
Object_synonym: mBAD/iso:1/Phos:4
Object_synonym: UniProtKB:Q61337-1, Thr-201, MOD:00047

subject: PR_000026135
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:14967141
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-09-18
Assigned_by: PRO:JAN

subject: PR_000026135
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: decreased
Relative_to: PR_000002843
Interaction_with: PR Q64373-1
Evidence_source: PMID:14967141
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-09-18
Assigned_by: PRO:JAN

PR_000026136
type: Class
Object_term: Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 (mouse)
Object_synonym: mBAD/iso:1/Phos:5
Object_synonym: UniProtKB:Q61337-1, Ser-136, MOD:00046

subject: PR_000026136
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P63101
Evidence_source: PMID:12049737
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-09-18
Assigned_by: PRO:JAN

PR_000026137
type: Class
Object_term: Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 (mouse)
Object_synonym: mBAD/iso:1/Phos:6
Object_synonym: UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046

subject: PR_000026137
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051402
  Ontology_term: neuron apoptotic process
Evidence_source: PMID:12049737
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-09-18
Assigned_by: PRO:JAN

PR_000026139
type: Class
Object_term: Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 (mouse)
Object_synonym: mBAD/iso:1/Phos:8
Object_synonym: UniProtKB:Q61337-1, Ser-155, MOD:00046

subject: PR_000026139
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P61982
Evidence_source: PMID:10880354
Evidence_code: IPI
Taxon: NCBITaxon:10090
Date: 2010-12-06
Assigned_by: PRO:CNA
Comments: Note=GST-BAD is mouse: Cell signaling #9294 pEBG-MBad DNA. Fig8

PR_000026140
type: Class
Object_term: Bcl2-associated agonist of cell death isoform 2 phosphorylated 1 (human)
Object_synonym: hBAD/iso:2/Phos:1
Object_synonym: UniProtKB:Q92934-1, Ser-75/Ser-99, MOD:00046

subject: PR_000026140
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: PMID:16932738
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q92934-1
Date: 2009-08-10
Assigned_by: PRO:JAN

subject: PR_000026140
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0019902
  Ontology_term: phosphatase binding
Interaction_with: PR Q08209
Evidence_source: PMID:10195903
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q92934-1
Date: 2009-09-18
Assigned_by: PRO:JAN

subject: PR_000026140
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P63101
Evidence_source: PMID:16932738
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q92934-1
Date: 2010-12-06
Assigned_by: PRO:JAN

subject: PR_000026140
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: PMID:10195903
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q92934-1
Date: 2009-09-18
Assigned_by: PRO:JAN

subject: PR_000026140
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: decreased
Relative_to: PR_000002844
Interaction_with: PR Q07817-1
Evidence_source: PMID:10195903
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q92934-1
Date: 2009-09-18
Assigned_by: PRO:JAN

PR_000026144
type: Class
Object_term: serine palmitoyltransferase complex core 1 (human)
Object_synonym: 3-oxosphinganine synthetase, acyl-CoA:serine C-2 acyltransferase decarboxylating (human)
Object_synonym: SPT (human)

subject: PR_000026144
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004758
  Ontology_term: serine C-palmitoyltransferase activity
Evidence_source: PMID:19416851
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-12-06
Assigned_by: PRO:CNA
Comments: Evidence=Fig6. Evidence=7.

PR_000026153
type: Class
Object_term: serine palmitoyltransferase complex 5 (human)

subject: PR_000026153
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004758
  Ontology_term: serine C-palmitoyltransferase activity
Modifier: increased
Relative_to: PR_000026144
Evidence_source: PMID:19416851
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-12-06
Assigned_by: PRO:CNA
Comments: Evidence=Fig6. Evidence=Fig7. Strong preference for C16-CoA substrate.

PR_000026154
type: Class
Object_term: serine palmitoyltransferase complex 6 (human)

subject: PR_000026154
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004758
  Ontology_term: serine C-palmitoyltransferase activity
Modifier: increased
Relative_to: PR_000026144
Evidence_source: PMID:19416851
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2010-12-06
Assigned_by: PRO:CNA
Comments: Evidence=Fig6. Evidence=Fig7. Strong preference for C16-CoA substrate.

PR_000026167
type: Class
Object_term: Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 (mouse)
Object_synonym: mBAD/iso:1/Phos:1
Object_synonym: UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046

subject: PR_000026167
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P62258-1
Evidence_source: PMID:10490655
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-08-10
Assigned_by: PRO:JAN
Comments: Note=Binding between proteins from heterogeneous species

subject: PR_000026167
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q07817-1
Evidence_source: PMID:10949026
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-08-10
Assigned_by: PRO:JAN

subject: PR_000026167
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9CQV8
Evidence_source: PMID:10490655
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-08-10
Assigned_by: PRO:JAN

subject: PR_000026167
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: decreased
Relative_to: PR_000026136
Interaction_with: PR P63101
Evidence_source: PMID:12049737
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q61337-1
Date: 2009-09-18
Assigned_by: PRO:JAN

PR_000026169
type: Class
Object_term: bacterial-type serine palmitoyltransferase complex (Sphingobacterium multivorum)
Object_synonym: SPT complex (SPHMU)

subject: PR_000026169
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004758
  Ontology_term: serine C-palmitoyltransferase activity
Evidence_source: PMID:17557831
Evidence_source: PMID:19564159
Evidence_code: EXP
Taxon: NCBITaxon:28454
Date: 2010-12-06
Assigned_by: PRO:CNA

PR_000026189
type: Class
Object_term: mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human)
Object_synonym: activated ERK1
Object_synonym: activated MAPK3
Object_synonym: hMAPK3/iso:1/Phos:1
Object_synonym: UniProtKB:P27361-1, Thr-202, MOD:00047
Object_synonym: Tyr-204, MOD:00048

subject: PR_000026189
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PMID:16581800
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P27361-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026189
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PMID:7687743
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P27361-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026189
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051726
  Ontology_term: regulation of cell cycle
Evidence_source: PMID:7687743
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P27361-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026225
type: Class
Object_term: induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1 cleaved 1 (mouse)
Object_synonym: mMCL1/iso:1/Clv:1
Object_synonym: UniProtKB:P97287-1, 34-331

subject: PR_000026225
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005759
  Ontology_term: mitochondrial matrix
Evidence_source: MGI_ref:4822083
Evidence_source: PMID:20627101
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:101769
Date: 2010-12-20
Assigned_by: MGI:MGI

PR_000026333
type: Class
Object_term: smad3 isoform 1 phosphorylated 1 (human)
Object_synonym: hSMAD3/iso:1/Phos:1
Object_synonym: UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046

subject: PR_000026333
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0000981
  Ontology_term: DNA-binding transcription factor activity, RNA polymerase II-specific
Evidence_source: PMID:10823886
Evidence_source: PMID:12943993
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P84022-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026333
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008134
  Ontology_term: transcription factor binding
Evidence_source: PMID:15084259
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P84022-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026333
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Interaction_with: PR Q13485
Evidence_source: PMID:15350224
Evidence_source: PMID:9311995
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P84022-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026333
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:10846168
Evidence_source: PMID:15280432
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P84022-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026333
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0005667
  Ontology_term: transcription factor complex
Evidence_source: PMID:12374795
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P84022-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026333
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006366
  Ontology_term: transcription by RNA polymerase II
Evidence_source: PMID:10823886
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P84022-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026333
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:8774881
Evidence_source: PMID:9380693
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P84022-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026334
type: Class
Object_term: smad1 isoform 1 phosphorylated 1 (human)
Object_synonym: hSMAD1/iso:1/Phos:1
Object_synonym: phospho-R-smad1 (human)
Object_synonym: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046

subject: PR_000026334
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Interaction_with: PR Q13485
Evidence_source: PMID:9136927
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15797-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026334
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:11509558
Evidence_source: PMID:9759503
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15797-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026334
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:9759503
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15797-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026334
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030509
  Ontology_term: BMP signaling pathway
Evidence_source: PMID:8653785
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q15797-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026335
type: Class
Object_term: TGF-beta 1 isoform 1 inactive form (human)
Object_synonym: hTGFB1/iso:1/inactive
Object_synonym: PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160
Object_synonym: UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160

subject: PR_000026335
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:3162913
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026335
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: PMID:17015622
Evidence_source: PMID:8294500
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026335
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0032991
  Ontology_term: protein-containing complex
Evidence_source: PMID:3162913
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026335
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:3162913
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026335
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005160
  Ontology_term: transforming growth factor beta receptor binding
Modifier: NOT
Evidence_source: PMID:2677679
Evidence_source: PMID:3162913
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01137-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026336
type: Class
Object_term: bone morphogenetic protein 2 isoform 1, mature form (human)
Object_synonym: hBMP2/iso:1/mature
Object_synonym: PRO_0000033825
Object_synonym: UniProtKB:P12643-1, 283-396

subject: PR_000026336
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005102
  Ontology_term: signaling receptor binding
Evidence_source: PMID:2315314
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12643-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026336
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:10074410
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12643-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026336
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:2315314
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12643-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026336
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0001501
  Ontology_term: skeletal system development
Evidence_source: PMID:2315314
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12643-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026336
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007267
  Ontology_term: cell-cell signaling
Evidence_source: PMID:2315314
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P12643-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026337
type: Class
Object_term: thrombospondin-4 isoform 1, signal peptide removed form (human)
Object_synonym: hTHBS4/iso:1/SigPep-
Object_synonym: PRO_0000035852
Object_synonym: UniProtKB:P35443-1, 27-961

subject: PR_000026337
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005509
  Ontology_term: calcium ion binding
Evidence_source: PMID:7852353
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35443-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026337
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008201
  Ontology_term: heparin binding
Evidence_source: PMID:7852353
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35443-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026337
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: PMID:7490284
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35443-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026337
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006930
  Ontology_term: substrate-dependent cell migration, cell extension
Evidence_source: PMID:7490284
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35443-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026338
type: Class
Object_term: thrombospondin-1 isoform 1, signal peptide removed form (human)
Object_synonym: hTHBS1/iso:1/SigPep-
Object_synonym: PRO_0000035842
Object_synonym: UniProtKB:P07996-1, 19-1170

subject: PR_000026338
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004866
  Ontology_term: endopeptidase inhibitor activity
Evidence_source: PMID:8751720
Evidence_code: TAS
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P07996-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026338
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:15662972
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P07996-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026340
type: Class
Object_term: Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)
Object_synonym: hROCK1/iso:1/Clv:1
Object_synonym: UniProtKB:Q13464-1, 1-1113

subject: PR_000026340
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PMID:11283607
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13464-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026340
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Modifier: increased
Relative_to: PR_000002529
Evidence_source: PMID:11283607
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13464-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026341
type: Class
Object_term: mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)
Object_synonym: hMAPK1/iso:1/Phos:1
Object_synonym: UniProtKB:P28482-1, Thr-185, MOD:00047
Object_synonym: Tyr-187, MOD:00048

subject: PR_000026341
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PMID:10706854
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P28482-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026341
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004707
  Ontology_term: MAP kinase activity
Evidence_source: PMID:10706854
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P28482-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026341
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PMID:16291755
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P28482-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026341
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006915
  Ontology_term: apoptotic process
Evidence_source: PMID:10958679
Evidence_code: TAS
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P28482-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026341
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006935
  Ontology_term: chemotaxis
Evidence_source: PMID:10706854
Evidence_code: TAS
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P28482-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026341
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007165
  Ontology_term: signal transduction
Evidence_source: PMID:1540184
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P28482-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026350
type: Class
Object_term: unique cartilage matrix-associated protein isoform 1
Object_synonym: UCMA/iso:1

subject: PR_000026350
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031012
  Ontology_term: extracellular matrix
Evidence_source: MGI_ref:3772275
Evidence_source: PMID:17707622
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1915777
Date: 2011-01-26
Assigned_by: MGI:MGI

subject: PR_000026350
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: MGI_ref:4421086
Evidence_source: PMID:19819238
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1915777
Date: 2011-01-26
Assigned_by: MGI:MGI
Comments: part_of(CL:0000138)

PR_000026457
type: Class
Object_term: IkappaB kinase complex (human)
Object_synonym: IKK complex (human)
Object_synonym: inhibitor of KappaB kinase (IKK) complex (human)

subject: PR_000026457
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: Reactome:REACT_6894

PR_000026480
type: Class
Object_term: transcription factor PML isoform 1 phosphorylated 1 (human)
Object_synonym: hPML/iso:1/Phos:1
Object_synonym: UniProtKB:P29590-1, Ser-403, MOD:00046
Object_synonym: Thr-409, MOD:00047

subject: PR_000026480
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:20832753
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P29590-1
Date: 2011-02-14
Assigned_by: PRO:CNA
Comments: Note=This phosphoform is not involved in cell proliferation (GO:0008283).

PR_000026481
type: Class
Object_term: mitogen-activated protein kinase 7 isoform 1 phosphorylated 1 (human)
Object_synonym: BMK1 active form
Object_synonym: hMAPK7/iso:1/Phos:1
Object_synonym: UniProtKB:Q13164-1, Thr-28/Thr-219/Thr-733, MOD:00047
Object_synonym: Ser-421/Ser-433/Ser-496/Ser-731, MOD:00046
Object_synonym: Tyr-221, MOD:00048

subject: PR_000026481
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004707
  Ontology_term: MAP kinase activity
Evidence_source: PMID:20832753
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13164-1
Date: 2011-02-14
Assigned_by: PRO:CNA

subject: PR_000026481
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P29590-1
Evidence_source: PMID:20832753
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13164-1
Date: 2011-02-14
Assigned_by: PRO:CNA

subject: PR_000026481
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:20832753
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13164-1
Date: 2011-02-14
Assigned_by: PRO:CNA

subject: PR_000026481
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008284
  Ontology_term: positive regulation of cell population proliferation
Evidence_source: PMID:20832753
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13164-1
Date: 2011-02-14
Assigned_by: PRO:CNA

PR_000026724
type: Class
Object_term: smad1 isoform 1 phosphorylated 1 (mouse)
Object_synonym: mSMAD1/iso:1/Phos:1
Object_synonym: UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046

subject: PR_000026724
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q04211
Evidence_source: PMID:15542835
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P70340-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026724
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q8BGV5
Evidence_source: PMID:12370310
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P70340-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026724
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9QZH6
Evidence_source: PMID:14633973
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P70340-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026724
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:10504300
Evidence_source: PMID:12151307
Evidence_source: PMID:12370310
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P70340-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026724
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005769
  Ontology_term: early endosome
Evidence_source: PMID:17592637
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P70340-1
Date: 2009-03-05
Assigned_by: PRO:CNA

subject: PR_000026724
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0005667
  Ontology_term: transcription factor complex
Evidence_source: PMID:14633973
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P70340-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000026724
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008285
  Ontology_term: negative regulation of cell population proliferation
Evidence_source: PMID:15899870
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P70340-1
Date: 2013-02-05
Assigned_by: PRO:CNA

subject: PR_000026724
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030509
  Ontology_term: BMP signaling pathway
Evidence_source: PMID:12370310
Evidence_source: PMID:15198985
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P70340-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000026785
type: Class
Object_term: BH3-interacting domain death agonist isoform 1 cleaved 1 (mouse)
Object_synonym: mBID/iso:1/Clv:1
Object_synonym: p15 (mouse)
Object_synonym: PRO_0000223236
Object_synonym: UniProtKB:P70444-1, 61-195

subject: PR_000026785
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031966
  Ontology_term: mitochondrial membrane
Evidence_source: MGI_ref:4940333
Evidence_source: PMID:9873064
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:108093
Date: 2011-03-14
Assigned_by: MGI:MGI

subject: PR_000026785
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0001836
  Ontology_term: release of cytochrome c from mitochondria
Evidence_source: MGI_ref:4940333
Evidence_source: PMID:9873064
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:108093
Date: 2011-03-14
Assigned_by: MGI:MGI

subject: PR_000026785
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008637
  Ontology_term: apoptotic mitochondrial changes
Evidence_source: MGI_ref:1277505
Evidence_source: PMID:9727492
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:108093
Date: 2011-03-14
Assigned_by: MGI:MGI

PR_000026848
type: Class
Object_term: E3 ubiquitin-protein ligase COP1 phosphorylated 1 (human)
Object_synonym: hCOP1/Phos:1
Object_synonym: phospho-COP1(Ser 387) (human)
Object_synonym: UniProtKB:Q8NHY2-1, Ser-387, MOD:00046

subject: PR_000026848
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR O70456
Evidence_source: PMID:20843328
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8NHY2-1
Date: 2015-05-04
Assigned_by: PRO:CNA
Comments: Note=Binding between proteins from heterogeneous species. Species information from cited reference PMID:10767298

PR_000027057
type: Class
Object_term: dual specificity mitogen-activated protein kinase kinase 2 autophosphorylated form (human)
Object_synonym: hMAP2K2/Phos:auto
Object_synonym: human phospho-MEK2

subject: PR_000027057
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PMID:8388392
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36507-1
Date: 2011-05-03
Assigned_by: PRO:CNA

subject: PR_000027057
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: Reactome:REACT_3571
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36507-1
Date: 2011-05-03
Assigned_by: PRO:CNA

PR_000027058
type: Class
Object_term: E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated 1 (human)
Object_synonym: hPELI2/Phos:1
Object_synonym: UniProtKB:Q9HAT8, Thr-290, MOD:00047

subject: PR_000027058
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: Reactome:REACT_22715
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9HAT8-1
Date: 2011-05-03
Assigned_by: PRO:CNA

PR_000027086
type: Class
Object_term: IRF7-P:IRF7-P complex (human)
Object_synonym: h(pIRF7)*2

subject: PR_000027086
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Evidence_source: PMID:11073981
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-07-18
Assigned_by: PRO:CNA
Comments: Note=Triggered by viral infection.

subject: PR_000027086
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005654
  Ontology_term: nucleoplasm
Evidence_source: Reactome:REACT_21689
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-07-18
Assigned_by: PRO:CNA

subject: PR_000027086
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

subject: PR_000027086
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: Reactome:REACT_6894

subject: PR_000027086
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002753
  Ontology_term: cytoplasmic pattern recognition receptor signaling pathway
Evidence_source: Reactome:REACT_7146
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

PR_000027111
type: Class
Object_term: double-stranded RNA-activated factor 1 complex (human)
Object_synonym: human draf1 complex
Object_synonym: human dsRNA-activated factor 1
Object_synonym: human IRF3-P dimer:CBP/p300

subject: PR_000027111
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0043565
  Ontology_term: sequence-specific DNA binding
Evidence_source: PMID:10805757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_26303
Date: 2011-05-13
Assigned_by: PRO:CNA

subject: PR_000027111
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:10805757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_26303
Date: 2011-05-13
Assigned_by: PRO:CNA

subject: PR_000027111
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034340
  Ontology_term: response to type I interferon
Evidence_source: PMID:10805757
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_26303
Date: 2011-05-13
Assigned_by: PRO:CNA

PR_000027132
type: Class
Object_term: G1/S-specific cyclin-D1 phosphorylated 1 (human)
Object_synonym: hCCND1/Phos:1
Object_synonym: p-T286-CCND1 (human)
Object_synonym: UniProtKB:P24385, Thr-286, MOD:00047

subject: PR_000027132
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000037511
Interaction_with: PR_000037513
Evidence_source: PMID:17407548
Evidence_code: IPI
Taxon: NCBITaxon:9606
Date: 2014-09-03
Assigned_by: PRO:KER

PR_000027171
type: Class
Object_term: lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
Object_synonym: mLY96/iso:1/SigPep-/NGlyco:1
Object_synonym: PRO_0000018620, Asn-26/Asn-114/Asn-150, MOD:00160
Object_synonym: UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160

subject: PR_000027171
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:19783674
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q9JHF9-1
Date: 2014-08-14
Assigned_by: PRO:CNA

subject: PR_000027171
predicate:
  Relation: enables
object:
  Ontology_ID: GO:1990458
  Ontology_term: lipooligosaccharide binding
Modifier: NOT
Evidence_source: PMID:19783674
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q9JHF9-1
Date: 2014-08-14
Assigned_by: PRO:CNA
Comments: Target=lipooligosaccharide (CHEBI:35371).

PR_000027174
type: Class
Object_term: MYD88s:TIRAP:activated TLR4 receptor (mouse)
Object_synonym: MYD88s:Mal:activated TLR4 receptor (mouse)
Object_synonym: TLR4MD2LPSditms

subject: PR_000027174
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034125
  Ontology_term: negative regulation of MyD88-dependent toll-like receptor signaling pathway
Evidence_source: PMID:12538665
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2014-04-28
Assigned_by: TLR:AMM

PR_000027183
type: Class
Object_term: IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
Object_synonym: IRAK4:MyD88:Mal:activated TLR4 (human)

subject: PR_000027183
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: Reactome:REACT_6894

PR_000027192
type: Class
Object_term: pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
Object_synonym: pIRAK4:MyD88:Mal:activated TLR4 (human)

subject: PR_000027192
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: Reactome:REACT_6894

PR_000027196
type: Class
Object_term: TIRAP:PIP2:activated TLR4 (mouse)
Object_synonym: Mal:activated TLR4 complex (mouse)
Object_synonym: TIRAP:PIP2:MD2:LPS:TLR4 complex (mouse)
Object_synonym: TLR4MD2LPSditirap'

subject: PR_000027196
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: PMID:12447442
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2014-07-18
Assigned_by: TLR:AMM

PR_000027204
type: Class
Object_term: ticam2:activated TLR4 complex (mouse)
Object_synonym: TLR4MD2LPSditram'
Object_synonym: TRAM:activated TLR4 (mouse)

subject: PR_000027204
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: PMID:18222170
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-01-29
Assigned_by: PRO:CNA

subject: PR_000027204
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: PMID:18222170
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-01-29
Assigned_by: PRO:CNA

PR_000027207
type: Class
Object_term: ticam1:ticam2:activated TLR4 complex (mouse)
Object_synonym: TLR4MD2LPSditt
Object_synonym: TRIF:TRAM:activated TLR4 (mouse)

subject: PR_000027207
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: PMID:18222170
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-01-29
Assigned_by: PRO:CNA

subject: PR_000027207
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: PMID:18222170
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-01-29
Assigned_by: PRO:CNA

subject: PR_000027207
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: PMID:18222170
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2014-05-14
Assigned_by: PRO:CNA

PR_000027208
type: Class
Object_term: ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: TRIF:TRAM:activated TLR4 (human)

subject: PR_000027208
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_7861
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-01-29
Assigned_by: PRO:CNA

subject: PR_000027208
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-01-29
Assigned_by: PRO:CNA

subject: PR_000027208
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-05-14
Assigned_by: PRO:CNA

PR_000027223
type: Class
Object_term: CALCA gene translation product (mouse)
Object_synonym: mCALCA

subject: PR_000027223
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: MGI_ref:3028786
Evidence_source: PMID:14765981
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:2151253
Date: 2011-06-21
Assigned_by: MGI:MGI
Comments: part_of(MA:0000792),part_of(CL:0000150)
Comments: part_of(MA:0000792),part_of(CL:0000167)

PR_000027273
type: Class
Object_term: Toll-like receptor 1-Toll-like receptor 2 protein complex (human)
Object_synonym: TLR1-TLR2 protein complex (human)

subject: PR_000027273
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: Reactome:REACT_6894

PR_000027461
type: Class
Object_term: apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)
Object_synonym: hBCL2/iso:1/Phos:2
Object_synonym: UniProtKB:P10415-1, Thr-74, MOD:00047

subject: PR_000027461
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:12039864
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P10415-1
Date: 2011-07-01
Assigned_by: PRO:PD
Comments: Note=In context of glucocorticoid induced apoptosis

PR_000027463
type: Class
Object_term: apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)
Object_synonym: hBCL2/iso:1/Phos:3
Object_synonym: UniProtKB:P10415-1, Thr-69, MOD:00047
Object_synonym: Ser-70/Ser-87, MOD:00046

subject: PR_000027463
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0016239
  Ontology_term: positive regulation of macroautophagy
Evidence_source: PMID:18570871
Evidence_source: PMID:19029119
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P10415-1
Date: 2011-07-01
Assigned_by: PRO:PD
Comments: Kinase=JNK1 [PR:P45983]. Disrupts Bcl-2 (unmodified)/Beclin 1 complex. Induced in response to ceramide (19029119).

subject: PR_000027463
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: NOT
Interaction_with: PR Q14457
Evidence_source: PMID:18570871
Evidence_source: PMID:19029119
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P10415-1
Date: 2011-07-01
Assigned_by: PRO:PD
Comments: Kinase=JNK1 [PR:P45983]. Disrupts Bcl-2 (unmodified)/Beclin 1 complex. Induced in response to ceramide (19029119).

PR_000027465
type: Class
Object_term: apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)
Object_synonym: hBCL2/iso:1/Phos:4
Object_synonym: UniProtKB:P10415-1, Thr-69, MOD:00047
Object_synonym: Ser-87, MOD:00046

subject: PR_000027465
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043065
  Ontology_term: positive regulation of apoptotic process
Evidence_source: PMID:15703383
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P10415-1
Date: 2011-07-01
Assigned_by: PRO:PD
Comments: Kinase=JNK [PR:P45983]. Inducing agent: Cephalostatin 1

PR_000027467
type: Class
Object_term: apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)
Object_synonym: hBCL2/iso:1/Phos:5
Object_synonym: UniProtKB:P10415-1, Thr-56, MOD:00047

subject: PR_000027467
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045839
  Ontology_term: negative regulation of mitotic nuclear division
Evidence_source: PMID:10766756
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P10415-1
Date: 2011-07-01
Assigned_by: PRO:PD
Comments: Kinase=CDC2 [PR:P06493]. Induced by okadaic acid.

PR_000027471
type: Class
Object_term: beclin-1 isoform 1 phosphorylated 1 (human)
Object_synonym: hBECN1/iso:1/Phos:1
Object_synonym: UniProtKB:Q14457-1, Thr-119, MOD:00047

subject: PR_000027471
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0010508
  Ontology_term: positive regulation of autophagy
Evidence_source: PMID:19180116
Evidence_source: PMID:19395874
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q14457-1
Date: 2011-07-01
Assigned_by: PRO:PD
Comments: Kinase=DAPK (DAPK family: DAPK1/2/3 [PR:000006276, PR:000006277, PR:000006278]

subject: PR_000027471
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: decreased
Relative_to: PR_000027487
Interaction_with: PR P10415
Evidence_source: PMID:19395874
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q14457-1
Date: 2011-07-01
Assigned_by: PRO:PD

subject: PR_000027471
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: decreased
Relative_to: PR_000027487
Interaction_with: PR Q07817-1
Evidence_source: PMID:19180116
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q14457-1
Date: 2011-07-01
Assigned_by: PRO:PD

PR_000027473
type: Class
Object_term: RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)
Object_synonym: hAKT1/iso:1/Phos:2
Object_synonym: UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047
Object_synonym: Ser-246/Ser-473, MOD:00046

subject: PR_000027473
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: PMID:16549426
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P31749-1
Date: 2011-07-01
Assigned_by: PRO:PD
Comments: Note=Autophosphorylation sites are situated in characteristic Akt substrate motif (RXRXX(S/T)

PR_000027479
type: Class
Object_term: epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human)
Object_synonym: hEGFR/iso:1/SigPep-/Phos:1
Object_synonym: PRO_0000016665, Tyr-869, MOD:00048
Object_synonym: UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048

subject: PR_000027479
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:18789131
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P00533-1
Date: 2011-07-01
Assigned_by: PRO:PD
Comments: Kinase=Src [PR:P12931; PR:000027234]. Authors did not consider the signal peptide of EGFR (residue 1-24) hence paper refers to Y845 (instead of Y869). Inducing agent: Ionizing radiation.Activates DNA-PK by inducing phosphorylation at T2609

subject: PR_000027479
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034504
  Ontology_term: protein localization to nucleus
Evidence_source: PMID:18789131
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P00533-1
Date: 2011-07-01
Assigned_by: PRO:PD
Comments: Kinase=Src [PR:P12931; PR:000027234]. Authors did not consider the signal peptide of EGFR (residue 1-24) hence paper refers to Y845 (instead of Y869). Inducing agent: Ionizing radiation.Activates DNA-PK by inducing phosphorylation at T2609

PR_000027492
type: Class
Object_term: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)
Object_synonym: hIRAK1/iso:1/Phos:3
Object_synonym: pp-IRAK1 (human)
Object_synonym: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047

subject: PR_000027492
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PMID:14625308
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P51617-1
Date: 2010-02-08
Assigned_by: PRO:CNA

subject: PR_000027492
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0070498
  Ontology_term: interleukin-1-mediated signaling pathway
Evidence_source: PMID:14625308
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P51617-1
Date: 2010-02-08
Assigned_by: PRO:CNA

PR_000027493
type: Class
Object_term: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)
Object_synonym: hIRAK1/iso:1/Phos:4
Object_synonym: hp-IRAK1 (human)
Object_synonym: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047
Object_synonym: MOD:00046

subject: PR_000027493
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PMID:14625308
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P51617-1
Date: 2010-02-08
Assigned_by: PRO:CNA

subject: PR_000027493
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9Y4K3
Evidence_source: PMID:14625308
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P51617-1
Date: 2010-02-08
Assigned_by: PRO:CNA

subject: PR_000027493
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0070498
  Ontology_term: interleukin-1-mediated signaling pathway
Evidence_source: PMID:14625308
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P51617-1
Date: 2010-02-08
Assigned_by: PRO:CNA

subject: PR_000027493
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: NOT
Interaction_with: PR Q99836
Evidence_source: PMID:14625308
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P51617-1
Date: 2010-02-08
Assigned_by: PRO:CNA
Comments: Note=Dissociation from ILR complex. Phosphorylated in PTS domain.

PR_000027494
type: Class
Object_term: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
Object_synonym: hIRAK1/iso:1/Phos:1
Object_synonym: UniProtKB:P51617-1, Thr-209, MOD:00047

subject: PR_000027494
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9NWZ3
Evidence_source: PMID:11960013
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P51617-1
Date: 2010-02-08
Assigned_by: PRO:CNA

subject: PR_000027494
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0016301
  Ontology_term: kinase activity
Evidence_source: PMID:11960013
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P51617-1
Date: 2010-02-08
Assigned_by: PRO:CNA

PR_000027495
type: Class
Object_term: pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
Object_synonym: pIRAK1:IRAK4:MyD88:Mal:activated TLR4 (human)

subject: PR_000027495
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: Reactome:REACT_6894

PR_000027692
type: Class
Object_term: nuclear receptor coactivator 3 isoform 1 phosphorylated 1 (human)
Object_synonym: hNCOA3/iso:1/Phos:1
Object_synonym: UniProtKB:Q9Y6Q9-1, Ser-101/Ser-102, MOD:00046

subject: PR_000027692
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR O43791
Evidence_source: PMID:21577200
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Q9-1
Date: 2011-07-20
Assigned_by: PRO:PD

PR_000027694
type: Class
Object_term: nuclear receptor coactivator 3 isoform 1 phosphorylated 2 (human)
Object_synonym: hNCOA3/iso:1/Phos:2
Object_synonym: UniProtKB:Q9Y6Q9-1, Ser-601, MOD:00046

subject: PR_000027694
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Evidence_source: PMID:19339517
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Q9-1
Date: 2011-07-20
Assigned_by: PRO:PD

subject: PR_000027694
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030374
  Ontology_term: nuclear receptor coactivator activity
Evidence_source: PMID:19339517
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Q9-1
Date: 2011-07-20
Assigned_by: PRO:PD

PR_000027696
type: Class
Object_term: nuclear receptor coactivator 3 isoform 1 phosphorylated 3 (human)
Object_synonym: hNCOA3/iso:1/Phos:3
Object_synonym: UniProtKB:Q9Y6Q9-1, Tyr-1357, MOD:00048

subject: PR_000027696
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0030331
  Ontology_term: nuclear estrogen receptor binding
Interaction_with: PR_000007204
Evidence_source: PMID:18765637
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Q9-1
Date: 2011-07-20
Assigned_by: PRO:PD
Comments: Kinase=c-Abl tyrosine kinase [PR:P00519]. Induced by insulin-like growth factor 1, epidermal growth factor, or estrogen treatment in breast cancer cells

subject: PR_000027696
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0035035
  Ontology_term: histone acetyltransferase binding
Interaction_with: PR_000027108
Evidence_source: PMID:18765637
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Q9-1
Date: 2011-07-20
Assigned_by: PRO:PD
Comments: Kinase=c-Abl tyrosine kinase [PR:P00519]. Induced by insulin-like growth factor 1, epidermal growth factor, or estrogen treatment in breast cancer cells

subject: PR_000027696
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030374
  Ontology_term: nuclear receptor coactivator activity
Evidence_source: PMID:18765637
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Q9-1
Date: 2011-07-20
Assigned_by: PRO:PD
Comments: Kinase=c-Abl tyrosine kinase [PR:P00519]. Induced by insulin-like growth factor 1, epidermal growth factor, or estrogen treatment in breast cancer cells

PR_000027724
type: Class
Object_term: estrogen receptor isoform 1 phosphorylated 1 (human)
Object_synonym: hESR1/iso:1/Phos:1
Object_synonym: phospho-ERalpha-Ser-167
Object_synonym: UniProtKB:P03372-1, Ser-167, MOD:00046

subject: PR_000027724
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045893
  Ontology_term: positive regulation of DNA-templated transcription
Evidence_source: PMID:19940156
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P03372-1
Date: 2011-09-01
Assigned_by: PRO:PD
Comments: Kinase=IKKepsilon [PR:Q14164; PR:000001778]

PR_000027726
type: Class
Object_term: estrogen receptor isoform 1 phosphorylated 2 (human)
Object_synonym: hESR1/iso:1/Phos:2
Object_synonym: UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048

subject: PR_000027726
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:20101225
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P03372-1
Date: 2011-09-01
Assigned_by: PRO:CNA
Comments: Kinase=c-Abl tyrosine kinase [PR:P00519; PR:000003582]. interaction mediated by two PXXP motifs of ERalpha and the c-Abl SH3 domain

subject: PR_000027726
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:20101225
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P03372-1
Date: 2011-09-01
Assigned_by: PRO:CNA
Comments: Kinase=c-Abl tyrosine kinase [PR:P00519; PR:000003582]. interaction mediated by two PXXP motifs of ERalpha and the c-Abl SH3 domain

subject: PR_000027726
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0010628
  Ontology_term: positive regulation of gene expression
Evidence_source: PMID:20101225
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P03372-1
Date: 2011-09-01
Assigned_by: PRO:PD
Comments: Kinase=c-Abl tyrosine kinase [PR:P00519; PR:000003582]. interaction mediated by two PXXP motifs of ERalpha and the c-Abl SH3 domain

PR_000027756
type: Class
Object_term: estrogen receptor isoform 1 acetylated 1 (human)
Object_synonym: AcK266/268-ERalpha (human)
Object_synonym: ERalpha acetylated (human)
Object_synonym: hESR1/iso:1/Ac:1
Object_synonym: UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064

subject: PR_000027756
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Evidence_source: PMID:16497729
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P03372-1
Date: 2011-09-09
Assigned_by: PRO:PD
Comments: Acetylase=EP300 [PR:Q09472; PR:000007102]

PR_000027766
type: Class
Object_term: cellular tumor antigen p53 isoform 1 dimethylated 1 (human)
Object_synonym: hTP53/iso:1/Me2:1
Object_synonym: p53K382me2
Object_synonym: UniProtKB:P04637-1, Lys-382, MOD:00084

subject: PR_000027766
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q12888
Evidence_source: PMID:18840612
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2011-09-19
Assigned_by: PRO:PD

PR_000027774
type: Class
Object_term: cellular tumor antigen p53 isoform 1 acetylated 1 (human)
Object_synonym: hTP53/iso:1/Ac:1
Object_synonym: p53-acLys120
Object_synonym: UniProtKB:P04637-1, Lys-120, MOD:00064

subject: PR_000027774
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043065
  Ontology_term: positive regulation of apoptotic process
Evidence_source: PMID:17189187
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2011-09-20
Assigned_by: PRO:PD
Comments: Acetylase=hMOF.

PR_000027776
type: Class
Object_term: estrogen receptor isoform 1 phosphorylated 4 (human)
Object_synonym: hESR1/iso:1/Phos:4
Object_synonym: pERalpha-Thr311
Object_synonym: UniProtKB:P03372-1, Thr-311, MOD:00047

subject: PR_000027776
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:12138194
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P03372-1
Date: 2011-09-20
Assigned_by: PRO:PD
Comments: Kinase=p38 MAPK [PR:Q16539; PR:000003107].

subject: PR_000027776
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0010628
  Ontology_term: positive regulation of gene expression
Evidence_source: PMID:12138194
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P03372-1
Date: 2011-09-20
Assigned_by: PRO:PD
Comments: Kinase=p38 MAPK [PR:Q16539; PR:000003107].

PR_000027808
type: Class
Object_term: cellular tumor antigen p53 isoform 1 methylated 3 (human)
Object_synonym: hTP53/iso:1/Me:3
Object_synonym: p53-mLys372
Object_synonym: UniProtKB:P04637-1, Lys-372, MOD:00663

subject: PR_000027808
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:15525938
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2011-09-29
Assigned_by: PRO:PD

subject: PR_000027808
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045893
  Ontology_term: positive regulation of DNA-templated transcription
Evidence_source: PMID:15525938
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2011-09-29
Assigned_by: PRO:PD

PR_000027810
type: Class
Object_term: cellular tumor antigen p53 isoform 1 methylated 4 (human)
Object_synonym: hTP53/iso:1/Me:4
Object_synonym: p53-mLys370
Object_synonym: UniProtKB:P04637-1, Lys-370, MOD:00663

subject: PR_000027810
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of DNA-templated transcription
Evidence_source: PMID:17108971
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2011-09-29
Assigned_by: PRO:PD
Comments: Lysine methyltransferase, SMYD2 [PR:Q9NRG4].

PR_000027812
type: Class
Object_term: cellular tumor antigen p53 isoform 1 acetylated 2 (human)
Object_synonym: hTP53/iso:1/Ac:2
Object_synonym: p53-acLys382
Object_synonym: UniProtKB:P04637-1, Lys-382, MOD:00064

subject: PR_000027812
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045893
  Ontology_term: positive regulation of DNA-templated transcription
Evidence_source: PMID:20228809
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2011-09-29
Assigned_by: PRO:PD
Comments: Acetylace=Acetyltransferase EP300 [PR:Q09472; PR:000007102].

PR_000027814
type: Class
Object_term: cellular tumor antigen p53 isoform 1 phosphorylated 12 (human)
Object_synonym: hTP53/iso:1/Phos:12
Object_synonym: p53-pSer15-pSer392
Object_synonym: UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046

subject: PR_000027814
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:21317932
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2011-09-29
Assigned_by: PRO:PD
Comments: Kinase=NUAK1 [PR:O60285; PR:000011473]. NUAK1 gets activated upon phosphorylation by LKB1.

subject: PR_000027814
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045893
  Ontology_term: positive regulation of DNA-templated transcription
Evidence_source: PMID:21317932
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2011-09-29
Assigned_by: PRO:PD
Comments: Kinase=NUAK1 [PR:O60285; PR:000011473]. NUAK1 gets activated upon phosphorylation by LKB1.

PR_000027818
type: Class
Object_term: zinc finger protein ZFPM1 isoform 2 (mouse)
Object_synonym: FOG1S (mouse)
Object_synonym: mZFPM1/iso:2
Object_synonym: UniProtKB:O35615-1, 19-995

subject: PR_000027818
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: MGI_ref:4422158
Evidence_source: PMID:19654328
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1095400
Date: 2011-08-10
Assigned_by: MGI:MGI

subject: PR_000027818
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: MGI_ref:4422158
Evidence_source: PMID:19654328
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1095400
Date: 2011-08-10
Assigned_by: MGI:MGI

PR_000027833
type: Class
Object_term: cellular tumor antigen p53 isoform 1 phosphorylated 9 (human)
Object_synonym: hTP53/iso:1/Phos:9
Object_synonym: p53-pSer15-pSer37
Object_synonym: UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046

subject: PR_000027833
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0010468
  Ontology_term: regulation of gene expression
Evidence_source: PMID:14712210
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2011-09-29
Assigned_by: PRO:PD

PR_000027839
type: Class
Object_term: cellular tumor antigen p53 isoform 1 phosphorylated 11 (human)
Object_synonym: hTP53/iso:1/Phos:11
Object_synonym: p53-pSer183-pSer269-pThr284
Object_synonym: UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046
Object_synonym: Thr-284, MOD:00047

subject: PR_000027839
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0010629
  Ontology_term: negative regulation of gene expression
Evidence_source: PMID:20959462
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2011-10-29
Assigned_by: PRO:PD
Comments: Kinase=AURKB [PR:Q96GD4]

PR_000027844
type: Class
Object_term: p53 complex sumoylated 1 (human)
Object_synonym: Sup53

subject: PR_000027844
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of DNA-templated transcription
Evidence_source: PMID:19339993
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2011-09-29
Assigned_by: PRO:PD
Comments: Evidence=Fig3. Evidence=7.

subject: PR_000027844
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Modifier: NOT
Evidence_source: PMID:19339993
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2011-09-29
Assigned_by: PRO:PD
Comments: Evidence=Fig3.

PR_000027885
type: Class
Object_term: nuclear receptor coactivator 3 isoform 1 acetylated 1 (human)
Object_synonym: hNCOA3/iso:1/Ac:1
Object_synonym: NCOA3-acLys619-acLys620
Object_synonym: UniProtKB:Q9Y6Q9-1, Lys-619/Lys-620, MOD:00064

subject: PR_000027885
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0016922
  Ontology_term: nuclear receptor binding
Modifier: NOT
Evidence_source: PMID:10490106
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y6Q9-1
Date: 2011-11-27
Assigned_by: PRO:PD

PR_000027889
type: Class
Object_term: signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 (human)
Object_synonym: hSTAT1/iso:1/Phos:3
Object_synonym: STAT1-pSer727
Object_synonym: UniProtKB:P42224-1, Ser-727, MOD:00046

subject: PR_000027889
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:15322115
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P42224-1
Date: 2011-11-27
Assigned_by: PRO:PD

subject: PR_000027889
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043065
  Ontology_term: positive regulation of apoptotic process
Evidence_source: PMID:15322115
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P42224-1
Date: 2011-11-27
Assigned_by: PRO:PD

PR_000027894
type: Class
Object_term: forkhead box protein O1 isoform 1 phosphorylated 1 (human)
Object_synonym: FOXO1-pSer249
Object_synonym: hFOXO1/iso:1/Phos:1
Object_synonym: UniProtKB:Q12778-1, Ser-249, MOD:00046

subject: PR_000027894
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:18356527
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12778-1
Date: 2011-11-27
Assigned_by: PRO:PD

subject: PR_000027894
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0010628
  Ontology_term: positive regulation of gene expression
Evidence_source: PMID:18356527
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12778-1
Date: 2011-11-27
Assigned_by: PRO:PD

subject: PR_000027894
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Modifier: NOT
Evidence_source: PMID:18356527
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12778-1
Date: 2011-11-27
Assigned_by: PRO:PD

PR_000027930
type: Class
Object_term: myocyte-specific enhancer factor 2C isoform 2 acetylated 1 (mouse)
Object_synonym: MEF2C-AcLys4
Object_synonym: mMEF2C/iso:2/Ac:1
Object_synonym: UniProtKB:Q8CFN5-2, Lys-4, MOD:00064

subject: PR_000027930
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0035914
  Ontology_term: skeletal muscle cell differentiation
Evidence_source: PMID:18086704
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q8CFN5-2
Date: 2011-11-29
Assigned_by: PRO:CNA

subject: PR_000027930
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Modifier: increased
Relative_to: PR_000027940
Evidence_source: PMID:18086704
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q8CFN5-2
Date: 2011-11-29
Assigned_by: PRO:CNA
Comments: Evidence=Fig4

PR_000027938
type: Class
Object_term: acetylated STAT3 homodimer (human)
Object_synonym: h(STAT3/AcRes+)*2

subject: PR_000027938
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:19506034
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2011-11-29
Assigned_by: PRO:CNA

PR_000027943
type: Class
Object_term: CDK9:cyclin-T1 (human)
Object_synonym: CDK9-cyclin T1 (human)
Object_synonym: CDK9-cyclinT1 (human)
Object_synonym: dimeric P-TEFb human

subject: PR_000027943
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0097472
  Ontology_term: cyclin-dependent protein kinase activity
Evidence_source: PMID:17452463
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2011-11-29
Assigned_by: PRO:CNA
Comments: Evidence=Fig5

subject: PR_000027943
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:17452463
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2011-11-29
Assigned_by: PRO:CNA
Comments: Evidence=HeLa nuclear extracts.

subject: PR_000027943
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006354
  Ontology_term: DNA-templated transcription elongation
Evidence_source: PMID:17452463
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2011-11-29
Assigned_by: PRO:CNA
Comments: Evidence=Fig7

subject: PR_000027943
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PMID:17452463
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2011-11-29
Assigned_by: PRO:CNA

PR_000028337
type: Class
Object_term: serine/threonine-protein kinase CDG1 isoform 1 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-CDG1/iso:1/Phos:1
Object_synonym: pCDG1 (Arabidopsis thaliana)
Object_synonym: UniProtKB:Q9LSE1-1, Ser-44/Ser-47/Ser-234, MOD:00046

subject: PR_000028337
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PMID:21855796
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LSE1-1
Date: 2013-02-05
Assigned_by: PRO:LVM
Comments: Target=PR:Q9LR78-1.

subject: PR_000028337
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9LR78-1
Evidence_source: PMID:21855796
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LSE1-1
Date: 2013-02-05
Assigned_by: PRO:LVM

subject: PR_000028337
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: PMID:21855796
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LSE1-1
Date: 2013-02-05
Assigned_by: PRO:LVM

subject: PR_000028337
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900459
  Ontology_term: positive regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:21855796
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LSE1-1
Date: 2013-02-05
Assigned_by: PRO:LVM

PR_000028342
type: Class
Object_term: serine/threonine-protein phosphatase BSU1 isoform 1 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-BSU1/iso:1/Phos:1
Object_synonym: pBSU1 (Arabidopsis thaliana)
Object_synonym: UniProtKB:Q9LR78-1, Ser-395/Ser-444/Ser-764, MOD:00046

subject: PR_000028342
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004721
  Ontology_term: phosphoprotein phosphatase activity
Evidence_source: PMID:21855796
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LR78-1
Date: 2013-02-05
Assigned_by: PRO:LVM
Comments: Target=PR:000035742.

subject: PR_000028342
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR_000035742
Evidence_source: PMID:21855796
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LR78-1
Date: 2013-02-05
Assigned_by: PRO:LVM

subject: PR_000028342
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900459
  Ontology_term: positive regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:21855796
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LR78-1
Date: 2013-02-05
Assigned_by: PRO:LVM

PR_000028347
type: Class
Object_term: BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 isoform 1 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-plantBAK1/iso:1/Phos:1
Object_synonym: UniProtKB:Q94F62-1, Tyr-610, MOD:00048
Object_synonym: MOD:00046
Object_synonym: MOD:00047

subject: PR_000028347
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004712
  Ontology_term: protein serine/threonine/tyrosine kinase activity
Evidence_source: PMID:20876109
Evidence_source: PMID:21350342
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q94F62-1
Date: 2011-12-19
Assigned_by: PRO:CNA
Comments: Target=PR:Q94F62-1.

subject: PR_000028347
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009742
  Ontology_term: brassinosteroid mediated signaling pathway
Evidence_source: PMID:20876109
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q94F62-1
Date: 2011-12-19
Assigned_by: PRO:CNA

subject: PR_000028347
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900459
  Ontology_term: positive regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:21350342
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q94F62-1
Date: 2013-02-06
Assigned_by: PRO:LVM

PR_000028352
type: Class
Object_term: protein BRASSINAZOLE-RESISTANT 1 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-BZR1/Phos:1
Object_synonym: AtBZR1 phosphorylated
Object_synonym: pAtBZR1
Object_synonym: phospho-AtBZR1
Object_synonym: UniProtKB:Q8S307, Ser-173, MOD:00046
Object_synonym: Thr-177, MOD:00047
Object_synonym: (Ser-130, MOD:00046 and/or Ser-134, MOD:00046 and/or Ser-118, MOD:00046 and/or Ser-114, MOD:00046 and/or Ser-110, MOD:00046 and/or Ser-122, MOD:00046 and/or Ser-126, MOD:00046 and/or Ser-138, MOD:00046)

subject: PR_000028352
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Evidence_source: PMID:17873094
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q8S307
Date: 2013-02-05
Assigned_by: PRO:LVM

subject: PR_000028352
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:17873094
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q8S307
Date: 2013-02-05
Assigned_by: PRO:LVM

PR_000028357
type: Class
Object_term: protein BRASSINOSTEROID INSENSITIVE 1 isoform 1 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-BRI1/iso:1/Phos:1
Object_synonym: pAtBRI1
Object_synonym: phospho-AtBRI1
Object_synonym: UniProtKB:O22476-1, Tyr-831/Tyr-956/Tyr-1052/Tyr-1057/Tyr-1072, MOD:00048

subject: PR_000028357
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009742
  Ontology_term: brassinosteroid mediated signaling pathway
Evidence_source: PMID:19124768
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O22476-1
Date: 2013-04-12
Assigned_by: PRO:LVM

PR_000028410
type: Class
Object_term: thrombospondin-1, signal peptide removed form (human)
Object_synonym: hTHBS1/SigPep-
Object_synonym: PRO_0000035842
Object_synonym: UniProtKB:P07996-1, 19-1170

subject: PR_000028410
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:15662972
Evidence_code: IDA
Taxon: NCBITaxon:9606
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000028458
type: Class
Object_term: SCF(TIR1) complex (Arabidopsis thaliana)

subject: PR_000028458
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009734
  Ontology_term: auxin-activated signaling pathway
Evidence_source: PMID:21370976
Evidence_code: TAS
Taxon: NCBITaxon:3702
Date: 2011-12-19
Assigned_by: PRO:CNA

PR_000028460
type: Class
Object_term: auxin-IAA7-SCF(TIR1) complex (Arabidopsis thaliana)

subject: PR_000028460
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009734
  Ontology_term: auxin-activated signaling pathway
Evidence_source: PMID:21370976
Evidence_code: TAS
Taxon: NCBITaxon:3702
Date: 2011-12-19
Assigned_by: PRO:CNA

PR_000028465
type: Class
Object_term: SCF(COI1) complex (Arabidopsis thaliana)

subject: PR_000028465
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009867
  Ontology_term: jasmonic acid mediated signaling pathway
Evidence_source: PMID:21370976
Evidence_code: TAS
Taxon: NCBITaxon:3702
Date: 2011-12-19
Assigned_by: PRO:CNA

PR_000028483
type: Class
Object_term: serine/threonine-protein kinase BIK1 isoform 1 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-BIK1/iso:1/Phos:1
Object_synonym: UniProtKB:O48814-1, Thr-237, MOD:00047

subject: PR_000028483
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0042742
  Ontology_term: defense response to bacterium
Evidence_source: PMID:20018686
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O48814-1
Date: 2011-12-19
Assigned_by: PRO:CNA

subject: PR_000028483
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002221
  Ontology_term: pattern recognition receptor signaling pathway
Evidence_source: PMID:20018686
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O48814-1
Date: 2011-12-19
Assigned_by: PRO:CNA

PR_000028503
type: Class
Object_term: FLS2:BAK1 complex (Arabidopsis thaliana)
Object_synonym: Flg22:AtFls2:AtBak1 complex

subject: PR_000028503
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PMID:20018686
Evidence_code: EXP
Taxon: NCBITaxon:3702
Date: 2011-12-19
Assigned_by: PRO:CNA
Comments: Target=PR:000028483.

subject: PR_000028503
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PMID:27884939
Evidence_code: EXP
Taxon: NCBITaxon:3702
Date: 2016-11-28
Assigned_by: PRO:CNA
Comments: Target=PR:000049767.

subject: PR_000028503
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0042742
  Ontology_term: defense response to bacterium
Evidence_source: PMID:17625569
Evidence_code: EXP
Taxon: NCBITaxon:3702
Date: 2011-12-19
Assigned_by: PRO:CNA

subject: PR_000028503
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002221
  Ontology_term: pattern recognition receptor signaling pathway
Evidence_source: PMID:17625569
Evidence_source: PMID:20103591
Evidence_code: EXP
Taxon: NCBITaxon:3702
Date: 2011-12-19
Assigned_by: PRO:CNA

PR_000028505
type: Class
Object_term: BRI1:BAK1 complex (Arabidopsis thaliana)
Object_synonym: AtBRI1/BAK1 complex

subject: PR_000028505
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004712
  Ontology_term: protein serine/threonine/tyrosine kinase activity
Evidence_source: PMID:18694562
Evidence_code: EXP
Taxon: NCBITaxon:3702
Date: 2011-12-19
Assigned_by: PRO:CNA

subject: PR_000028505
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009742
  Ontology_term: brassinosteroid mediated signaling pathway
Evidence_source: PMID:18694562
Evidence_code: EXP
Taxon: NCBITaxon:3702
Date: 2011-12-19
Assigned_by: PRO:CNA

PR_000028510
type: Class
Object_term: zona pellucida receptor complex 1 (mouse)
Object_synonym: sperm protein complex

subject: PR_000028510
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007339
  Ontology_term: binding of sperm to zona pellucida
Evidence_source: PMID:21880732
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2012-11-13
Assigned_by: PRO:KC
Comments: Note=Purified zona pellucida receptor binding complex shown to bind to solubilized zona pellucida proteins

PR_000028569
type: Class
Object_term: C-terminal-binding protein 2 isoform 1 acetylated 1 (human)
Object_synonym: CtBP2 acetylated (human)
Object_synonym: hCTBP2/iso:1/Ac:1
Object_synonym: UniProtKB:P56545-1, Lys-6/Lys-8/Lys-10, MOD:00064

subject: PR_000028569
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:16356938
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P56545-1
Date: 2012-02-14
Assigned_by: PRO:CNA

PR_000028573
type: Class
Object_term: ETS translocation variant 1 isoform 1 acetylated 1 (human)
Object_synonym: hETV1/iso:1/Ac:1
Object_synonym: UniProtKB:P50549-1, Lys-33/Lys-116, MOD:00064

subject: PR_000028573
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Modifier: increased
Relative_to: PR_000028622
Evidence_source: PMID:12917345
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P50549-1
Date: 2012-02-14
Assigned_by: PRO:CNA

PR_000028592
type: Class
Object_term: endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)
Object_synonym: hNEIL2/iso:1/InitMet-/Ac:1
Object_synonym: NEIL2 acetylated (human)
Object_synonym: UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064

subject: PR_000028592
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0019104
  Ontology_term: DNA N-glycosylase activity
Modifier: decreased
Relative_to: PR_000045372
Evidence_source: PMID:15175427
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q969S2-1
Date: 2012-02-14
Assigned_by: PRO:CNA

PR_000028600
type: Class
Object_term: N-glycosylase/DNA lyase isoform 1 acetylated 1 (human)
Object_synonym: hOGG1/iso:1/Ac:1
Object_synonym: human 8-oxoguanine-DNA glycosylase acetylated
Object_synonym: human AcOGG1
Object_synonym: human OGG1 acetylated
Object_synonym: UniProtKB:O15527-1, Lys-338/Lys-341, MOD:00064

subject: PR_000028600
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:16478987
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O15527-1
Date: 2012-02-14
Assigned_by: PRO:CNA
Comments: Evidence=Fig4.

PR_000028604
type: Class
Object_term: DNA polymerase beta acetylated 1 (human)
Object_synonym: hPOLB/Ac:1
Object_synonym: UniProtKB:P06746, Lys-72, MOD:00064

subject: PR_000028604
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0016829
  Ontology_term: lyase activity
Modifier: decreased
Relative_to: PR_000045373
Evidence_source: PMID:12453427
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P06746-1
Date: 2012-02-14
Assigned_by: PRO:CNA

PR_000028616
type: Class
Object_term: transcription factor Jun isoform 1 acetylated 1 (human)
Object_synonym: hJUN/iso:1/Ac:1
Object_synonym: UniProtKB:P05412-1, Lys-268/Lys-271/Lys-273, MOD:00064

subject: PR_000028616
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:18793328
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P05412-1
Date: 2012-02-14
Assigned_by: PRO:CNA

subject: PR_000028616
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0042692
  Ontology_term: muscle cell differentiation
Evidence_source: PMID:18793328
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P05412-1
Date: 2012-02-14
Assigned_by: PRO:CNA

PR_000028678
type: Class
Object_term: ticam2:activated TLR4 complex (human)
Object_synonym: TRAM:activated TLR4 (human)
Object_synonym: TRAM:TLR4:MD2:LPS:CD14 (human)

subject: PR_000028678
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_7083
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-01-29
Assigned_by: PRO:CNA

subject: PR_000028678
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-01-29
Assigned_by: PRO:CNA

subject: PR_000028678
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-05-14
Assigned_by: PRO:CNA

PR_000028680
type: Class
Object_term: traf6:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRAM:TRIF:TRAF6 (human)
Object_synonym: traf6:trif:tram:activated TLR4 complex (human)

subject: PR_000028680
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_25948
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: PRO:CNA

subject: PR_000028680
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: PRO:CNA

subject: PR_000028680
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-05-14
Assigned_by: PRO:CNA

PR_000028683
type: Class
Object_term: traf3:ticam1:ticam2:activated TLR4 complex (mouse)
Object_synonym: TRAF3:TRIF:TRAM:activated TLR4 (mouse)

subject: PR_000028683
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: PMID:16306937
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-01-29
Assigned_by: PRO:CNA

subject: PR_000028683
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: PMID:16306937
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2014-05-14
Assigned_by: PRO:CNA

PR_000028709
type: Class
Object_term: microtubule-associated protein tau sequence variant R5H (human)
Object_synonym: hMAPT/var:R5H
Object_synonym: UniProtKB:P10636-8, Arg-5, CHEBI:29979

subject: PR_000028709
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:9255
  Ontology_term: frontotemporal dementia
Evidence_source: PMID:11921059
Evidence_source: UniProtKB_VAR:VAR_019660
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019660
Date: 2012-04-12
Assigned_by: PRO:DAN

PR_000028710
type: Class
Object_term: microtubule-associated protein tau sequence variant R5L (human)
Object_synonym: hMAPT/var:R5L
Object_synonym: UniProtKB:P10636-8, Arg-5, CHEBI:29967

subject: PR_000028710
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:678
  Ontology_term: progressive supranuclear palsy
Evidence_source: PMID:12325083
Evidence_source: UniProtKB_VAR:VAR_019661
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019661
Date: 2012-04-12
Assigned_by: PRO:DAN

subject: PR_000028710
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:680
  Ontology_term: tauopathy
Evidence_source: Alzforum:mapt-r5l
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:mapt-r5l
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000028724
type: Class
Object_term: microtubule-associated protein tau sequence variant N296del (human)
Object_synonym: hMAPT/var:N296del
Object_synonym: UniProtKB:P10636-1, 1-612, 614-758
Object_synonym: UniProtKB:P10636-8, 1-295, 297-441

subject: PR_000028724
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:678
  Ontology_term: progressive supranuclear palsy
Evidence_source: PMID:11220749
Evidence_source: PMID:11906000
Evidence_source: PMID:14991828
Evidence_source: PMID:14991829
Evidence_source: UniProtKB_VAR:VAR_019664
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB_VAR:VAR_019664
Date: 2012-04-12
Assigned_by: PRO:DAN

subject: PR_000028724
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: DOID:680
  Ontology_term: tauopathy
Evidence_source: Alzforum:mapt-n296del-dn296
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Alzforum:mapt-n296del-dn296
Date: 2018-05-10
Assigned_by: PRO:DAN

PR_000028845
type: Class
Object_term: SH3 domain and tetratricopeptide repeat-containing protein 2 isoform 1 myristoylated 1 (mouse)
Object_synonym: mSH3TC2/iso:1/Myr:1
Object_synonym: UniProtKB:Q80VA5-1, 2-1289, Gly-2, MOD:00068

subject: PR_000028845
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: MGI_ref:4366127
Evidence_source: PMID:19805030
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:2444417
Date: 2012-05-07
Assigned_by: MGI:MGI

subject: PR_000028845
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0055037
  Ontology_term: recycling endosome
Evidence_source: PMID:19805030
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q80VA5-1
Date: 2012-07-02
Assigned_by: PRO:HJD

PR_000028854
type: Class
Object_term: 1-aminocyclopropane-1-carboxylate synthase 6 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-ACS6/Phos:1
Object_synonym: AtACS6 phosphorylated
Object_synonym: UniProtKB:Q9SAR0, Ser-480/Ser-483/Ser-488, MOD:00046

subject: PR_000028854
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009693
  Ontology_term: ethylene biosynthetic process
Evidence_source: PMID:15539472
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9SAR0-1
Date: 2012-05-22
Assigned_by: PRO:PD
Comments: Kinase=MPK6 [PR:Q39026]. Phosphorylation promotes protein stability [PMID:18182027]

subject: PR_000028854
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0010365
  Ontology_term: positive regulation of ethylene biosynthetic process
Evidence_source: PMID:15539472
Evidence_source: PMID:18182027
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9SAR0-1
Date: 2014-04-02
Assigned_by: PRO:LVM

PR_000028859
type: Class
Object_term: 1-aminocyclopropane-1-carboxylate synthase 2 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-ACS2/Phos:1
Object_synonym: AtACS2 phosphorylated
Object_synonym: UniProtKB:Q06402-1, Ser-483/Ser-488/Ser-491, MOD:00046

subject: PR_000028859
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009693
  Ontology_term: ethylene biosynthetic process
Evidence_source: PMID:15539472
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q06402-1
Date: 2012-05-22
Assigned_by: PRO:PD
Comments: Kinase=MPK6 [PR:Q39026]. Phosphorylation promotes protein stability.

subject: PR_000028859
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0010365
  Ontology_term: positive regulation of ethylene biosynthetic process
Evidence_source: PMID:15539472
Evidence_source: PMID:18182027
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q06402-1
Date: 2014-04-02
Assigned_by: PRO:LVM

PR_000028874
type: Class
Object_term: mitogen-activated protein kinase 6 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: activated atMPK6
Object_synonym: At-MPK6/Phos:1
Object_synonym: atMPK6 phosphorylated
Object_synonym: UniProtKB:Q39026, Thr-221, MOD:00047
Object_synonym: Tyr-223, MOD:00048

subject: PR_000028874
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004707
  Ontology_term: MAP kinase activity
Evidence_source: PMID:18273012
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39026-1
Date: 2014-04-15
Assigned_by: PRO:CNA
Comments: Target=PR:O24606, Thr-174.

subject: PR_000028874
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004707
  Ontology_term: MAP kinase activity
Evidence_source: PMID:20870959
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39026-1
Date: 2014-04-15
Assigned_by: PRO:CNA
Comments: Target=PR:P11035. Evidence=ECO:0000181.

subject: PR_000028874
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009873
  Ontology_term: ethylene-activated signaling pathway
Evidence_source: PMID:18273012
Evidence_code: IC
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39026-1
Date: 2014-04-15
Assigned_by: PRO:CNA

PR_000028971
type: Class
Object_term: histone acetyltransferase KAT2A isoform 1
Object_synonym: KAT2A/iso:1

subject: PR_000028971
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0140672
  Ontology_term: ATAC complex
Evidence_source: MGI_ref:4462751
Evidence_source: PMID:20508642
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1343101
Date: 2012-06-11
Assigned_by: MGI:MGI

PR_000028994
type: Class
Object_term: RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)
Object_synonym: Akt1 active form (human)
Object_synonym: hAKT1/iso:1/Phos:1
Object_synonym: UniProtKB:P31749-1, Thr-308, MOD:00047
Object_synonym: Ser-473, MOD:00046

subject: PR_000028994
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PMID:8978681
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P31749-1
Date: 2012-07-16
Assigned_by: PRO:CNA
Comments: Note=Species information in Materials and methods

subject: PR_000028994
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PMID:12138205
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P31749-1
Date: 2009-07-09
Assigned_by: PRO:JAN

subject: PR_000028994
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR O14746-1
Evidence_source: PMID:12586360
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P31749-1
Date: 2009-07-09
Assigned_by: PRO:JAN

subject: PR_000028994
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P41279-1
Evidence_source: PMID:12138205
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P31749-1
Date: 2009-07-09
Assigned_by: PRO:JAN

subject: PR_000028994
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0032869
  Ontology_term: cellular response to insulin stimulus
Evidence_source: PMID:8978681
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P31749-1
Date: 2012-07-16
Assigned_by: PRO:CNA
Comments: Note=Species information in Materials and methods

subject: PR_000028994
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051092
  Ontology_term: positive regulation of NF-kappaB transcription factor activity
Evidence_source: PMID:12138205
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P31749-1
Date: 2009-07-09
Assigned_by: PRO:JAN

PR_000028998
type: Class
Object_term: myogenic factor 6 isoform 1 phosphorylated 1 (rat)
Object_synonym: MRF4 inactive (rat)
Object_synonym: rMYF6/iso:1/Phos:1
Object_synonym: UniProtKB:P19335-1, Thr-99, MOD:00047
Object_synonym: Ser-220/Ser-221, MOD:00046

subject: PR_000028998
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0070888
  Ontology_term: E-box binding
Modifier: NOT
Evidence_source: PMID:8413199
Evidence_code: EXP
Taxon: NCBITaxon:10116
DB_ID: UniProtKB:P19335-1
Date: 2012-07-16
Assigned_by: PRO:CNA
Comments: Note=Species information in Materials and methods

PR_000029002
type: Class
Object_term: histone deacetylase 4 isoform 1 phosphorylated 1 (human)
Object_synonym: HDAC4 phosphorylated (human)
Object_synonym: hHDAC4/iso:1/Phos:1
Object_synonym: UniProtKB:P56524-1, Ser-210/Ser-246, MOD:00046

subject: PR_000029002
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Evidence_source: PMID:17179159
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P56524-1
Date: 2012-07-27
Assigned_by: PRO:CNA

subject: PR_000029002
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:17179159
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P56524-1
Date: 2012-07-27
Assigned_by: PRO:CNA

PR_000029006
type: Class
Object_term: histone deacetylase 5 isoform 1 phosphorylated 1 (human)
Object_synonym: HDAC5 phosphorylated (human)
Object_synonym: hHDAC5/iso:1/Phos:1
Object_synonym: UniProtKB:Q9UQL6-1, Ser-259/Ser-498, MOD:00046

subject: PR_000029006
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Evidence_source: PMID:11114197
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9UQL6-1
Date: 2012-07-27
Assigned_by: PRO:CNA

subject: PR_000029006
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:11114197
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9UQL6-1
Date: 2012-07-27
Assigned_by: PRO:CNA

subject: PR_000029006
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007519
  Ontology_term: skeletal muscle tissue development
Evidence_source: PMID:11509672
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9UQL6-1
Date: 2012-07-27
Assigned_by: PRO:CNA

PR_000029010
type: Class
Object_term: myocyte-specific enhancer factor 2A isoform 1 phosphorylated 1 (human)
Object_synonym: hMEF2A/iso:1/Phos:1
Object_synonym: MEF2A phosphorylated (human)
Object_synonym: UniProtKB:Q02078-1, Thr-312/Thr-319, MOD:00047
Object_synonym: Ser-355, MOD:00046

subject: PR_000029010
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0001070
  Ontology_term: RNA-binding transcription regulator activity
Evidence_source: PMID:10849446
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q02078-1
Date: 2012-07-27
Assigned_by: PRO:CNA

subject: PR_000029010
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007173
  Ontology_term: epidermal growth factor receptor signaling pathway
Evidence_source: PMID:10849446
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q02078-1
Date: 2012-07-27
Assigned_by: PRO:CNA

PR_000029016
type: Class
Object_term: myocyte-specific enhancer factor 2D isoform 2 phosphorylated 1 (mouse)
Object_synonym: mMEF2D/iso:2/Phos:1
Object_synonym: UniProtKB:Q63943-2, Ser-179, MOD:00046

subject: PR_000029016
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0001070
  Ontology_term: RNA-binding transcription regulator activity
Evidence_source: PMID:10849446
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q63943-2
Date: 2012-07-27
Assigned_by: PRO:CNA

subject: PR_000029016
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007173
  Ontology_term: epidermal growth factor receptor signaling pathway
Evidence_source: PMID:10849446
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q63943-2
Date: 2012-07-27
Assigned_by: PRO:CNA

PR_000029018
type: Class
Object_term: eukaryotic translation initiation factor 4E-binding protein 1 isoform 1 phosphorylated 2 (rat)
Object_synonym: PHAS-I phosphorylated (rat)
Object_synonym: rEIF4EBP1/iso:1/Phos:2
Object_synonym: UniProtKB:Q62622-1, Ser-64, MOD:00046

subject: PR_000029018
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0031369
  Ontology_term: translation initiation factor binding
Modifier: NOT
Evidence_source: PMID:7939721
Evidence_code: EXP
Taxon: NCBITaxon:10116
DB_ID: UniProtKB:Q62622-1
Date: 2012-07-27
Assigned_by: PRO:CNA

PR_000029022
type: Class
Object_term: histone H1.5, initiator methionine removed phosphorylated 1 (human)
Object_synonym: hHIST1H1B/InitMet-/Phos:1
Object_synonym: PRO_0000195909, Thr-11, MOD:00047
Object_synonym: MOD:00696
Object_synonym: UniProtKB:P16401, 2-226, Thr-11, MOD:00047

subject: PR_000029022
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003682
  Ontology_term: chromatin binding
Evidence_source: PMID:19136008
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P16401-1
Date: 2012-07-27
Assigned_by: PRO:CNA

subject: PR_000029022
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:19136008
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P16401-1
Date: 2012-07-27
Assigned_by: PRO:CNA

subject: PR_000029022
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0140014
  Ontology_term: mitotic nuclear division
Evidence_source: PMID:19136008
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P16401-1
Date: 2012-07-27
Assigned_by: PRO:CNA

PR_000029162
type: Class
Object_term: myoblast determination protein 1 phosphorylated 1 (mouse)
Object_synonym: mMYOD1/Phos:1
Object_synonym: myod phosphorylated (mouse)
Object_synonym: myod1 phosphorylated (mouse)
Object_synonym: UniProtKB:P10085, Ser-199/Ser-200, MOD:00046

subject: PR_000029162
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003700
  Ontology_term: DNA-binding transcription factor activity
Modifier: decreased
Relative_to: PR_000029164
Evidence_source: PMID:20026657
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P10085-1
Date: 2012-08-15
Assigned_by: PRO:CNA
Comments: Kinase=MAPK12 [PR:O08911; PR:000010153]

subject: PR_000029162
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0001046
  Ontology_term: core promoter sequence-specific DNA binding
Modifier: increased
Relative_to: PR_000029164
Evidence_source: PMID:20026657
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P10085-1
Date: 2012-08-15
Assigned_by: PRO:CNA
Comments: Kinase=MAPK12 [PR:O08911; PR:000010153]

PR_000029187
type: Class
Object_term: ribosomal protein S6 kinase alpha
Object_synonym: MAPK-activated protein kinase-1
Object_synonym: MAPKAP-K1
Object_synonym: p90 ribosomal S6 kinase
Object_synonym: p90RSK
Object_synonym: ribosomal protein S6 kinase II

subject: PR_000029187
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006468
  Ontology_term: protein phosphorylation
Evidence_source: PIRSF:PIRSF000606
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000606
DB_ID: PIRSF:PIRSF000606
Date: 2012-08-20
Assigned_by: PRO:CNA

subject: PR_000029187
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0070371
  Ontology_term: ERK1 and ERK2 cascade
Evidence_source: PIRSF:PIRSF000606
Evidence_code: ISS
Inferred_from: PIRSF:PIRSF000606
DB_ID: PIRSF:PIRSF000606
Date: 2012-08-20
Assigned_by: PRO:CNA

PR_000029911
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (frog)
Object_synonym: frog-BUB1/Phos:1
Object_synonym: xBUB1 phosphorylated

subject: PR_000029911
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0016301
  Ontology_term: kinase activity
Modifier: increased
Relative_to: PR_000029917
Evidence_source: PMID:11231148
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q98UH3
Date: 2012-09-12
Assigned_by: PRO:KER
Comments: Timing=Meiosis I (prophase I, metaphase I, anaphase I, telophase I), Meiosis II (prophase II, metaphase II).

PR_000029956
type: Class
Object_term: small conductance calcium-activated potassium channel protein 3 sequence variant 1 (human)
Object_synonym: hKCNN3/var:1
Object_synonym: SKCa3Delta (human)

subject: PR_000029956
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:11395478
Evidence_code: IDA
Taxon: NCBITaxon:9606
Date: 2008-06-01
Assigned_by: PRO:CNA

subject: PR_000029956
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0015269
  Ontology_term: calcium-activated potassium channel activity
Modifier: NOT
Evidence_source: PMID:11395478
Evidence_code: IDA
Taxon: NCBITaxon:9606
Date: 2008-06-01
Assigned_by: PRO:CNA

PR_000029959
type: Class
Object_term: smad9 isoform 3 (human)
Object_synonym: hSMAD9/iso:3
Object_synonym: SMAD8b (human)

subject: PR_000029959
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Evidence_source: PMID:10583507
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: HGNC:6774
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Sequence not deposited in any database

subject: PR_000029959
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:10583507
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: HGNC:6774
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Sequence not deposited in any database

subject: PR_000029959
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030514
  Ontology_term: negative regulation of BMP signaling pathway
Evidence_source: PMID:10583507
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: HGNC:6774
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Sequence not deposited in any database

PR_000029962
type: Class
Object_term: smad5 isoform 2 (human)
Object_synonym: hSMAD5/iso:2

subject: PR_000029962
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0046332
  Ontology_term: SMAD binding
Modifier: NOT
Evidence_source: PMID:10845932
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: HGNC:6771
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000030192
type: Class
Object_term: catenin beta-1 isoform 1 phosphorylated 1 (human)
Object_synonym: hCTNNB1/iso:1/Phos:1
Object_synonym: UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046

subject: PR_000030192
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0016055
  Ontology_term: Wnt signaling pathway
Evidence_source: PMID:22369945
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35222-1
Date: 2012-10-16
Assigned_by: PRO:IC
Comments: Note=Phosphorylation at Ser-663 found in human colon cancer cells and tissues, which display a high PAK1 activity, or in response to Wnt3a stimulation.

subject: PR_000030192
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003713
  Ontology_term: transcription coactivator activity
Modifier: increased
Relative_to: PR_000002862
Evidence_source: PMID:22369945
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35222-1
Date: 2012-10-16
Assigned_by: PRO:IC
Comments: Note=Phosphorylation at Ser-663 found in human colon cancer cells and tissues, which display a high PAK1 activity, or in response to Wnt3a stimulation.

PR_000035362
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (human)
Object_synonym: BUBR1 phosphorylated (human)
Object_synonym: hBUB1B/Phos:1
Object_synonym: hBUBR1 phosphorylated
Object_synonym: UniProtKB:O60566-1, Thr-620, MOD:00047

subject: PR_000035362
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035373
Interaction_with: PR P53350
Evidence_source: PMID:17785528
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-10-23
Assigned_by: PRO:KER

PR_000035369
type: Class
Object_term: cell division cycle protein 20 homolog unphosphorylated form (human)
Object_synonym: cdc20 unphosphorylated (human)
Object_synonym: hCDC20/PhosRes-

subject: PR_000035369
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004842
  Ontology_term: ubiquitin-protein transferase activity
Evidence_source: PMID:15525512
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-10-23
Assigned_by: PRO:KER

subject: PR_000035369
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR O60566
Evidence_source: PMID:15525512
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-10-23
Assigned_by: PRO:KER
Comments: Timing=Spindle disruption (nocodazole).

subject: PR_000035369
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q13257
Evidence_source: PMID:15525512
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-10-23
Assigned_by: PRO:KER
Comments: Timing=Spindle disruption (nocodazole).

subject: PR_000035369
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:15525512
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-10-23
Assigned_by: PRO:KER
Comments: Timing=Spindle disruption (nocodazole).

subject: PR_000035369
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Evidence_source: PMID:15525512
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-10-23
Assigned_by: PRO:KER

PR_000035371
type: Class
Object_term: cell division cycle protein 20 homolog phosphorylated 1 (human)
Object_synonym: cdc20 phosphorylated (human)
Object_synonym: hCDC20/Phos:1
Object_synonym: UniProtKB:Q12834, Ser-41/Ser-72/Ser-92/Ser-153/Ser-161, MOD:00046
Object_synonym: Thr-157, MOD:00047

subject: PR_000035371
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR O60566
Evidence_source: PMID:15525512
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-10-23
Assigned_by: PRO:KER
Comments: Timing=Spindle disruption (nocodazole).

subject: PR_000035371
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q13257
Evidence_source: PMID:15525512
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-10-23
Assigned_by: PRO:KER
Comments: Timing=Spindle disruption (nocodazole).

subject: PR_000035371
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:15525512
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-10-23
Assigned_by: PRO:KER
Comments: Timing=Spindle disruption (nocodazole).

subject: PR_000035371
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004842
  Ontology_term: ubiquitin-protein transferase activity
Modifier: decreased
Relative_to: PR_000035369
Evidence_source: PMID:15525512
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-10-23
Assigned_by: PRO:KER

subject: PR_000035371
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Modifier: increased
Relative_to: PR_000035369
Evidence_source: PMID:15525512
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-10-23
Assigned_by: PRO:KER

PR_000035373
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (human)
Object_synonym: hBUB1B/PhosRes-

subject: PR_000035373
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR_000035669
Evidence_source: PMID:19503101
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2013-01-02
Assigned_by: PRO:KER

subject: PR_000035373
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:22801780
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2013-01-02
Assigned_by: PRO:KER

subject: PR_000035373
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005813
  Ontology_term: centrosome
Evidence_source: PMID:19503101
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2013-01-02
Assigned_by: PRO:KER

subject: PR_000035373
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0001933
  Ontology_term: negative regulation of protein phosphorylation
Evidence_source: PMID:22801780
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2013-01-02
Assigned_by: PRO:KER
Comments: Target=PR:O14777.

subject: PR_000035373
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0010826
  Ontology_term: negative regulation of centrosome duplication
Evidence_source: PMID:19503101
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2013-01-02
Assigned_by: PRO:KER

subject: PR_000035373
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0033673
  Ontology_term: negative regulation of kinase activity
Evidence_source: PMID:19503101
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2013-01-02
Assigned_by: PRO:KER
Comments: Target=PR:P53350.

PR_000035386
type: Class
Object_term: GerQ cross-linked complex (Bacillus subtilis subsp. subtilis str. 168)

subject: PR_000035386
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0031160
  Ontology_term: spore wall
Evidence_source: PMID:16936016
Evidence_code: EXP
Taxon: NCBITaxon:224308
DB_ID: UniProtKB:P39620
Date: 2012-10-01
Assigned_by: PRO:KL

PR_000035391
type: Class
Object_term: protein BRASSINAZOLE-RESISTANT 2 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-BZR2/Phos:1
Object_synonym: AtBES1-p
Object_synonym: UniProtKB:Q9LN63-1, Ser-101/Ser-109/Ser-113/Ser-117/Ser-121/Ser-125/Ser-129/Ser-133/Ser-137/Ser-171, MOD:00046
Object_synonym: Thr-105/Thr-175, MOD:00047

subject: PR_000035391
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P48348
Evidence_source: PMID:20387034
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LN63
Date: 2012-10-31
Assigned_by: PRO:LVM

subject: PR_000035391
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:20387034
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LN63
Date: 2012-10-31
Assigned_by: PRO:LVM

subject: PR_000035391
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009742
  Ontology_term: brassinosteroid mediated signaling pathway
Modifier: decreased
Relative_to: PR_000035745
Evidence_source: PMID:20387034
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LN63
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000035398
type: Class
Object_term: BUB1B:APC:EB1 complex (frog)
Object_synonym: BUBR1:APC:EB1 complex

subject: PR_000035398
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051310
  Ontology_term: metaphase chromosome alignment
Evidence_source: PMID:17709426
Evidence_code: EXP
Taxon: NCBITaxon:8355
Date: 2012-11-21
Assigned_by: PRO:KER

PR_000035404
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog)
Object_synonym: frog-BUB1/Phos:3
Object_synonym: UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047
Object_synonym: Ser-500/Ser-634, MOD:00046
Object_synonym: xBUB1 hyperphosphorylated

subject: PR_000035404
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Evidence_source: PMID:15241477
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q6GPC9-1
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035404
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Evidence_source: PMID:15241477
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q6GPC9-1
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:P79935.

subject: PR_000035404
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Evidence_source: PMID:15241477
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q6GPC9-1
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:Q6GPD1.

subject: PR_000035404
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Evidence_source: PMID:15241477
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q6GPC9-1
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:Q9YGY3-2.

subject: PR_000035404
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: increased
Relative_to: PR_000029917
Evidence_source: PMID:15241477
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q6GPC9-1
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035405
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human)
Object_synonym: hBUB1/PhosRes-

subject: PR_000035405
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:16760428
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43683
Date: 2013-01-02
Assigned_by: PRO:KER
Comments: Timing=spindle disruption (nocodazole).

subject: PR_000035405
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: NOT
Interaction_with: PR P53350
Evidence_source: PMID:16760428
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43683
Date: 2013-01-02
Assigned_by: PRO:KER
Comments: Timing=spindle disruption (nocodazole).

PR_000035407
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human)
Object_synonym: hBUB1 phosphorylated
Object_synonym: hBUB1/Phos:4

subject: PR_000035407
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: increased
Relative_to: PR_000035405
Evidence_source: PMID:15525512
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43683
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035410
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 (Schizosaccharomyces pombe 972h-)
Object_synonym: Spom972h-BUB1/Phos:5

subject: PR_000035410
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007094
  Ontology_term: mitotic spindle assembly checkpoint signaling
Evidence_source: PMID:12606573
Evidence_code: EXP
Taxon: NCBITaxon:284812
DB_ID: UniProtKB:O94751
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035410
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045143
  Ontology_term: homologous chromosome segregation
Evidence_source: PMID:12606573
Evidence_code: EXP
Taxon: NCBITaxon:284812
DB_ID: UniProtKB:O94751
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035411
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 6 (Schizosaccharomyces pombe 972h-)
Object_synonym: Spom972h-BUB1/Phos:6
Object_synonym: UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)

subject: PR_000035411
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:12606573
Evidence_code: EXP
Taxon: NCBITaxon:284812
DB_ID: UniProtKB:O94751
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Timing=spindle disruption.

subject: PR_000035411
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007094
  Ontology_term: mitotic spindle assembly checkpoint signaling
Evidence_source: PMID:12606573
Evidence_code: EXP
Taxon: NCBITaxon:284812
DB_ID: UniProtKB:O94751
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035411
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045143
  Ontology_term: homologous chromosome segregation
Evidence_source: PMID:12606573
Evidence_code: EXP
Taxon: NCBITaxon:284812
DB_ID: UniProtKB:O94751
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035412
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human)
Object_synonym: hBUB1/Phos:7
Object_synonym: UniProtKB:O43683-1, Ser-593, MOD:00046
Object_synonym: Thr-609, MOD:00047

subject: PR_000035412
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Evidence_source: PMID:16760428
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43683
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:Q9NQS7.

subject: PR_000035412
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035414
Interaction_with: PR Q9NQS7
Evidence_source: PMID:16760428
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43683
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Timing=Mitosis and spindle disruption (nocodazole).

PR_000035419
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 1 (yeast)
Object_synonym: BUB1p phosphorylated
Object_synonym: UniProtKB:P41695, Thr-566, MOD:00047
Object_synonym: yBUB1/Phos:CDK-1

subject: PR_000035419
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Modifier: NOT
Evidence_source: PMID:21298086
Evidence_code: EXP
Taxon: NCBITaxon:559292
DB_ID: UniProtKB:P41695
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035421
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human)
Object_synonym: hBUB1 phosphorylated
Object_synonym: hBUB1/Phos:10
Object_synonym: UniProtKB:O43683-1, Ser-314, MOD:00046

subject: PR_000035421
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0035861
  Ontology_term: site of double-strand break
Evidence_source: PMID:22071147
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43683
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035421
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006281
  Ontology_term: DNA repair
Evidence_source: PMID:22071147
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43683
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035421
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Evidence_source: PMID:22099307
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43683
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035421
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: increased
Relative_to: PR_000035405
Evidence_source: PMID:22071147
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43683
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:000044898.

PR_000035423
type: Class
Object_term: serine-protein kinase ATM phosphorylated 2 (human)
Object_synonym: hATM/Phos:2
Object_synonym: UniProtKB:Q13315, Ser-1403/Ser-1981, MOD:00046

subject: PR_000035423
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000779
  Ontology_term: condensed chromosome, centromeric region
Evidence_source: PMID:22099307
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13315
Date: 2013-01-17
Assigned_by: PRO:KER
Comments: Timing=Metaphase.

subject: PR_000035423
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000922
  Ontology_term: spindle pole
Evidence_source: PMID:22099307
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13315
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Timing=Prometaphase and metaphase.

subject: PR_000035423
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005694
  Ontology_term: chromosome
Evidence_source: PMID:22099307
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13315
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Timing=Prophase.

subject: PR_000035423
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0030496
  Ontology_term: midbody
Evidence_source: PMID:22099307
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13315
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Timing=Telophase.

subject: PR_000035423
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0051233
  Ontology_term: spindle midzone
Evidence_source: PMID:22099307
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13315
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Timing=Snaphase.

subject: PR_000035423
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: increased
Relative_to: PR_000035452
Evidence_source: PMID:22099307
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13315
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035423
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Modifier: increased
Relative_to: PR_000035452
Evidence_source: PMID:22099307
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13315
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035426
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (frog)
Object_synonym: BUBR1 phosphorylated (frog)
Object_synonym: frog-BUB1B/Phos:1
Object_synonym: UniProtKB:Q8JGT8, Thr-605, MOD:00047
Object_synonym: xBUBR1 phosphorylated

subject: PR_000035426
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Evidence_source: PMID:17998400
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q8JGT8
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035426
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Evidence_source: PMID:17998400
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q8JGT8
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:P70032.

subject: PR_000035426
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Evidence_source: PMID:17998400
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q8JGT8
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:P79935.

subject: PR_000035426
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035425
Interaction_with: PR P70032
Evidence_source: PMID:17998400
Evidence_code: IPI
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q8JGT8
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035428
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)
Object_synonym: BUBR1 phosphorylated (human)
Object_synonym: hBUB1B/Phos:2
Object_synonym: hBUBR1 phosphorylated
Object_synonym: UniProtKB:O60566, Thr-620, MOD:00047
Object_synonym: (Ser-676, MOD:00046 and/or Thr-680, MOD:00047)
Object_synonym: (Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)

subject: PR_000035428
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q12834
Evidence_source: PMID:11030144
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035428
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:17785528
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2013-01-17
Assigned_by: PRO:KER

subject: PR_000035428
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006974
  Ontology_term: DNA damage response
Evidence_source: PMID:18440313
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035428
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: increased
Relative_to: PR_000035425
Evidence_source: PMID:17376779
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035428
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035425
Interaction_with: PR O43683
Evidence_source: PMID:11792804
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035428
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035425
Interaction_with: PR Q15172
Evidence_source: PMID:23079597
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2013-02-01
Assigned_by: PRO:KER

subject: PR_000035428
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008608
  Ontology_term: attachment of spindle microtubules to kinetochore
Modifier: increased
Relative_to: PR_000035425
Evidence_source: PMID:17785528
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035428
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051310
  Ontology_term: metaphase chromosome alignment
Modifier: increased
Relative_to: PR_000035425
Evidence_source: PMID:17376779
Evidence_source: PMID:17785528
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035430
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form (frog)
Object_synonym: frog-BUB1B/Phos:2
Object_synonym: UniProtKB:Q8JGT8, Thr-605, MOD:00047
Object_synonym: MOD:00696

subject: PR_000035430
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: increased
Relative_to: PR_000035425
Evidence_source: PMID:17998400
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q8JGT8
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035432
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human)
Object_synonym: BUBR1 phosphorylated (human)
Object_synonym: hBUB1B/Phos:3
Object_synonym: hBUBR1 phosphorylated
Object_synonym: UniProtKB:O60566-1, Thr-608, MOD:00047

subject: PR_000035432
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:22801780
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035432
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0001933
  Ontology_term: negative regulation of protein phosphorylation
Modifier: decreased
Relative_to: PR_000035373
Evidence_source: PMID:22801780
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:O14777.

subject: PR_000035432
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007059
  Ontology_term: chromosome segregation
Modifier: increased
Relative_to: PR_000035373
Evidence_source: PMID:22801780
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035432
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Modifier: increased
Relative_to: PR_000035373
Evidence_source: PMID:22801780
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035432
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Modifier: increased
Relative_to: PR_000035373
Evidence_source: PMID:22801780
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:Q13257.

subject: PR_000035432
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Modifier: increased
Relative_to: PR_000035373
Evidence_source: PMID:22801780
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:Q9Y6D9.

subject: PR_000035432
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051310
  Ontology_term: metaphase chromosome alignment
Modifier: increased
Relative_to: PR_000035373
Evidence_source: PMID:22801780
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035435
type: Class
Object_term: mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human)
Object_synonym: BUBR1 phosphorylated (human)
Object_synonym: hBUB1B/Phos:4
Object_synonym: hBUBR1 phosphorylated
Object_synonym: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046

subject: PR_000035435
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:19015317
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Timing=prophase, prometaphase, metaphase.

subject: PR_000035435
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008608
  Ontology_term: attachment of spindle microtubules to kinetochore
Modifier: increased
Relative_to: PR_000035373
Evidence_source: PMID:19015317
Evidence_source: PMID:20016069
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035435
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051310
  Ontology_term: metaphase chromosome alignment
Modifier: increased
Relative_to: PR_000035373
Evidence_source: PMID:20016069
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O60566
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035437
type: Class
Object_term: mitotic checkpoint protein BUB3 phosphorylated 1 (human)
Object_synonym: hBUB3/Phos:1
Object_synonym: UniProtKB:O43684, Ser-18, MOD:00046

subject: PR_000035437
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0012501
  Ontology_term: programmed cell death
Modifier: increased
Relative_to: PR_000035454
Evidence_source: PMID:20057499
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O43684
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035442
type: Class
Object_term: cell division cycle protein 20 homolog phosphorylated 3 (human)
Object_synonym: cdc20 phosphorylated (human)
Object_synonym: hCDC20/Phos:3
Object_synonym: p55CDC phsphorylated (human)

subject: PR_000035442
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: decreased
Relative_to: PR_000035369
Interaction_with: PR O60566
Evidence_source: PMID:22566641
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q12834
Date: 2012-11-05
Assigned_by: PRO:KER

PR_000035444
type: Class
Object_term: cell division cycle protein 20 homolog phosphorylated 4 (frog)
Object_synonym: Fizzy1 phosphorylated (frog)
Object_synonym: frog-CDC20/Phos:4
Object_synonym: UniProtKB:Q6DFD4, Ser-50, MOD:00046
Object_synonym: Thr-64/Thr-68/Thr-79, MOD:00047

subject: PR_000035444
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035628
Interaction_with: PR O60566
Evidence_source: PMID:12855955
Evidence_code: IPI
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:O93289
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035444
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035628
Interaction_with: PR P79935
Evidence_source: PMID:12855955
Evidence_code: IPI
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:O93289
Date: 2012-11-05
Assigned_by: PRO:KER

subject: PR_000035444
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Modifier: increased
Relative_to: PR_000035628
Evidence_source: PMID:12855955
Evidence_code: EXP
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:O93289
Date: 2012-11-05
Assigned_by: PRO:KER
Comments: Target=PR:000035369.

PR_000035446
type: Class
Object_term: cellular tumor antigen p53 isoform 1 phosphorylated 1 (human)
Object_synonym: hTP53/iso:1/Phos:1
Object_synonym: p53S15 (human)
Object_synonym: UniProtKB:P04637-1, Ser-15, MOD:00046

subject: PR_000035446
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:11602639
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2009-07-17
Assigned_by: PRO:CL
Comments: Note=HIV-1-Env-induced syncytium formation leads to apoptosis via a pathway that involves p53S15 phosphorylation by mTOR/FRAP.

subject: PR_000035446
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006915
  Ontology_term: apoptotic process
Evidence_source: PMID:11602639
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P04637-1
Date: 2009-07-17
Assigned_by: PRO:CL
Comments: Note=HIV-1-Env-induced syncytium formation leads to apoptosis via a pathway that involves p53S15 phosphorylation by mTOR/FRAP.

PR_000035449
type: Class
Object_term: cell division cycle protein 27 phosphorylated 1 (human)
Object_synonym: hCDC27/Phos:1

subject: PR_000035449
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035450
Interaction_with: PR O60566
Evidence_source: PMID:11030144
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P30260
Date: 2012-11-24
Assigned_by: PRO:KER

PR_000035458
type: Class
Object_term: T-complex protein 1 subunit epsilon isoform 1 phosphorylated 1 (mouse)
Object_synonym: mCCT5/iso:1/Phos:1
Object_synonym: UniProtKB:P80316-1, Ser-270, MOD:00046

subject: PR_000035458
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0002199
  Ontology_term: zona pellucida receptor complex
Evidence_source: MGI_ref:5295912
Evidence_source: PMID:21880732
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:107185
Date: 2012-11-09
Assigned_by: MGI:MGI

PR_000035460
type: Class
Object_term: T-complex protein 1 subunit eta isoform 1 phosphorylated 1 (mouse)
Object_synonym: mCCT7/iso:1/Phos:1
Object_synonym: UniProtKB:P80313-1, Thr-57, MOD:00047
Object_synonym: Ser-59, MOD:00046

subject: PR_000035460
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0002199
  Ontology_term: zona pellucida receptor complex
Evidence_source: MGI_ref:5295912
Evidence_source: PMID:21880732
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:107184
Date: 2012-11-09
Assigned_by: MGI:MGI

PR_000035483
type: Class
Object_term: Purkinje cell protein 2 isoform 2
Object_synonym: PCP2/iso:2

subject: PR_000035483
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0043025
  Ontology_term: neuronal cell body
Evidence_source: MGI_ref:3817370
Evidence_source: PMID:18768681
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:97508
Date: 2012-11-14
Assigned_by: MGI:MGI
Comments: part_of(MA:0000276),part_of(CL:0000749)

PR_000035486
type: Class
Object_term: breast cancer type 2 susceptibility protein phosphorylated 1 (human)
Object_synonym: hBRCA2/Phos:1

subject: PR_000035486
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:10749118
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P51587
Date: 2012-11-12
Assigned_by: PRO:KER

PR_000035503
type: Class
Object_term: spindle assembly checkpoint component MAD3 phosphorylated 2 (yeast)
Object_synonym: UniProtKB:P47074, Ser-303/Ser-337, MOD:00046
Object_synonym: yMAD3/Phos:2

subject: PR_000035503
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Modifier: increased
Relative_to: PR_000035506
Evidence_source: PMID:17504936
Evidence_code: EXP
Taxon: NCBITaxon:4932
DB_ID: UniProtKB:P47074
Date: 2012-11-20
Assigned_by: PRO:KER

PR_000035509
type: Class
Object_term: interleukin-24 isoform 2
Object_synonym: IL24/iso:2

subject: PR_000035509
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043066
  Ontology_term: negative regulation of apoptotic process
Evidence_source: MGI_ref:3821693
Evidence_source: PMID:18708357
Evidence_code: IGI
Taxon: NCBITaxon:10090
Inferred_from: UniProtKB:Q925S4-1
DB_ID: MGI:2135548
Date: 2013-06-24
Assigned_by: MGI:MGI

subject: PR_000035509
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:2000117
  Ontology_term: negative regulation of cysteine-type endopeptidase activity
Evidence_source: MGI_ref:3821693
Evidence_source: PMID:18708357
Evidence_code: IGI
Taxon: NCBITaxon:10090
Inferred_from: UniProtKB:Q925S4-1
DB_ID: MGI:2135548
Date: 2013-06-24
Assigned_by: MGI:MGI

PR_000035521
type: Class
Object_term: serine/threonine-protein kinase haspin phosphorylated 1 (human)
Object_synonym: hHASPIN/Phos:1
Object_synonym: UniProtKB:Q8TF76, Ser-93/Ser-108/Ser-143, MOD:00046

subject: PR_000035521
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PMID:21658950
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8TF76
Date: 2012-11-21
Assigned_by: PRO:KER

subject: PR_000035521
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005694
  Ontology_term: chromosome
Evidence_source: PMID:21658950
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8TF76
Date: 2012-11-21
Assigned_by: PRO:KER

subject: PR_000035521
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: increased
Relative_to: PR_000035523
Evidence_source: PMID:21658950
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8TF76
Date: 2012-11-21
Assigned_by: PRO:KER
Comments: Target=PR:000035524.

subject: PR_000035521
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034502
  Ontology_term: protein localization to chromosome
Modifier: increased
Relative_to: PR_000035523
Evidence_source: PMID:21658950
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8TF76
Date: 2012-11-21
Assigned_by: PRO:KER
Comments: Target=PR:Q96GD4.

PR_000035525
type: Class
Object_term: histone H3, initiator methionine removed phosphorylated 1 (human)
Object_synonym: hH3(any)/InitMet-/Phos:1
Object_synonym: hH3T3ph
Object_synonym: human histone H3 Thr-3

subject: PR_000035525
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000779
  Ontology_term: condensed chromosome, centromeric region
Evidence_source: PMID:21658950
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-01-16
Assigned_by: PRO:KER

subject: PR_000035525
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035690
Interaction_with: PR O15392
Evidence_source: PMID:21658950
Evidence_code: IPI
Taxon: NCBITaxon:9606
Date: 2013-01-16
Assigned_by: PRO:KER

subject: PR_000035525
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0071459
  Ontology_term: protein localization to chromosome, centromeric region
Modifier: increased
Relative_to: PR_000035690
Evidence_source: PMID:21658950
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-01-16
Assigned_by: PRO:KER
Comments: Target=PR:Q96GD4. Target=PR:Q9NQS7. Target=PR:O15392. Target=PR:Q53HL2.

PR_000035527
type: Class
Object_term: inner centromere protein phosphorylated 1 (human)
Object_synonym: hINCENP/Phos:1
Object_synonym: UniProtKB:Q9NQS7, Thr-892, MOD:00047
Object_synonym: Ser-893/Ser-894, MOD:00046

subject: PR_000035527
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0033674
  Ontology_term: positive regulation of kinase activity
Modifier: increased
Relative_to: PR_000035529
Evidence_source: PMID:22024163
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9NQS7
Date: 2012-11-21
Assigned_by: PRO:KER
Comments: Target=PR:Q96GD4.

PR_000035536
type: Class
Object_term: outer kinetochore KNL1 complex subunit SPC105 phosphorylated 1 (yeast)
Object_synonym: UniProtKB:P53148, Thr-149/Thr-172/Thr-235, MOD:00047
Object_synonym: ySPC105/Phos:1

subject: PR_000035536
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035538
Interaction_with: PR P26449
Evidence_source: PMID:22521787
Evidence_code: IPI
Taxon: NCBITaxon:4932
DB_ID: UniProtKB:P53148
Date: 2012-11-21
Assigned_by: PRO:KER

subject: PR_000035536
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000035538
Interaction_with: PR P41695
Evidence_source: PMID:22521787
Evidence_code: IPI
Taxon: NCBITaxon:4932
DB_ID: UniProtKB:P53148
Date: 2012-11-21
Assigned_by: PRO:KER

subject: PR_000035536
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007059
  Ontology_term: chromosome segregation
Modifier: increased
Relative_to: PR_000035538
Evidence_source: PMID:22521787
Evidence_code: EXP
Taxon: NCBITaxon:4932
DB_ID: UniProtKB:P53148
Date: 2012-11-21
Assigned_by: PRO:KER

subject: PR_000035536
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Modifier: increased
Relative_to: PR_000035538
Evidence_source: PMID:22521787
Evidence_code: EXP
Taxon: NCBITaxon:4932
DB_ID: UniProtKB:P53148
Date: 2012-11-21
Assigned_by: PRO:KER

subject: PR_000035536
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Modifier: increased
Relative_to: PR_000035538
Evidence_source: PMID:22521787
Evidence_code: EXP
Taxon: NCBITaxon:4932
DB_ID: UniProtKB:P53148
Date: 2012-11-21
Assigned_by: PRO:KER
Comments: Target=PR:P26449.

subject: PR_000035536
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Modifier: increased
Relative_to: PR_000035538
Evidence_source: PMID:22521787
Evidence_code: EXP
Taxon: NCBITaxon:4932
DB_ID: UniProtKB:P53148
Date: 2012-11-21
Assigned_by: PRO:KER
Comments: Target=PR:P41695.

PR_000035549
type: Class
Object_term: segment polarity protein dishevelled homolog DVL-2 phosphorylated 1 (human)
Object_synonym: hDVL2/Phos:1
Object_synonym: UniProtKB:O14641, Thr-206, MOD:00047

subject: PR_000035549
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Evidence_source: PMID:20823832
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O14641
Date: 2012-11-24
Assigned_by: PRO:KER

subject: PR_000035549
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051294
  Ontology_term: establishment of spindle orientation
Modifier: increased
Relative_to: PR_000035550
Evidence_source: PMID:20823832
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O14641
Date: 2012-11-24
Assigned_by: PRO:KER

PR_000035550
type: Class
Object_term: segment polarity protein dishevelled homolog DVL-2 unphosphorylated form (human)
Object_synonym: hDVL2/PhosRes-

subject: PR_000035550
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:20823832
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O14641
Date: 2013-01-02
Assigned_by: PRO:KER

subject: PR_000035550
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Evidence_source: PMID:20823832
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:O14641
Date: 2013-01-02
Assigned_by: PRO:KER

PR_000035558
type: Class
Object_term: outer kinetochore KNL1 complex subunit KNL1 isoform 2 phosphorylated 1 (human)
Object_synonym: hKNL1/iso:2/Phos:1
Object_synonym: UniProtKB:Q8NG31-2, Thr-875/Thr-1075/Thr-1089/Thr-1129/Thr-1154/Thr-1167, MOD:00047
Object_synonym: Ser-1022/Ser-1037, MOD:00046

subject: PR_000035558
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034501
  Ontology_term: protein localization to kinetochore
Modifier: increased
Relative_to: PR_000035560
Evidence_source: PMID:22660415
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q8NG31-2
Date: 2012-11-24
Assigned_by: PRO:KER
Comments: Target=PR:O43683.

PR_000035602
type: Class
Object_term: disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 (mouse)
Object_synonym: DISC1 phosphorylated
Object_synonym: mDISC1/iso:1/Phos:1
Object_synonym: UniProtKB:Q811T9-1, Ser-710, MOD:00046

subject: PR_000035602
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q3V3N7
Evidence_source: MGI_ref:5002731
Evidence_source: PMID:21471969
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:2447658
Date: 2012-12-05
Assigned_by: MGI:MGI
Comments: occurs_in(EMAP:11619)

subject: PR_000035602
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005813
  Ontology_term: centrosome
Evidence_source: MGI_ref:5002731
Evidence_source: PMID:21471969
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:2447658
Date: 2012-12-05
Assigned_by: MGI:MGI
Comments: part_of(CL:0000530)

subject: PR_000035602
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0008104
  Ontology_term: protein localization
Evidence_source: MGI_ref:5002731
Evidence_source: PMID:21471969
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:2447658
Date: 2012-12-05
Assigned_by: MGI:MGI

PR_000035640
type: Class
Object_term: glutamate receptor-interacting protein 1 isoform 2 palmitoylated 1 (mouse)
Object_synonym: mGRIP1/iso:2/Palm:1
Object_synonym: UniProtKB:Q925T6-2, Cys-11, MOD:00115

subject: PR_000035640
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0055037
  Ontology_term: recycling endosome
Evidence_source: MGI_ref:5315188
Evidence_source: PMID:22325201
Evidence_code: IMP
Taxon: NCBITaxon:10090
DB_ID: MGI:1921303
Date: 2012-12-14
Assigned_by: MGI:MGI
Comments: part_of(CL:0002608)

PR_000035652
type: Class
Object_term: cystin-1 isoform 1, N-terminal myristoylated form (mouse)
Object_synonym: mCYS1/iso:1/MyrRes+
Object_synonym: PRO_0000261178, Gly-2, MOD:00068
Object_synonym: UniProtKB:Q8R4T1-1, 2-145, Gly-2, MOD:00068

subject: PR_000035652
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005930
  Ontology_term: axoneme
Evidence_source: MGI_ref:4461844
Evidence_source: PMID:19850956
Evidence_code: IMP
Taxon: NCBITaxon:10090
DB_ID: MGI:2177632
Date: 2012-12-26
Assigned_by: MGI:MGI

subject: PR_000035652
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0045121
  Ontology_term: membrane raft
Evidence_source: MGI_ref:4461844
Evidence_source: PMID:19850956
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:2177632
Date: 2012-12-20
Assigned_by: MGI:MGI

PR_000035654
type: Class
Object_term: disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form (mouse)
Object_synonym: mDISC1/iso:1/PhosRes-

subject: PR_000035654
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9WV60
Evidence_source: MGI_ref:5002731
Evidence_source: PMID:21471969
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:2447658
Date: 2012-12-05
Assigned_by: MGI:MGI
Comments: occurs_in(EMAP:6018)

subject: PR_000035654
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0060070
  Ontology_term: canonical Wnt signaling pathway
Evidence_source: MGI_ref:5002731
Evidence_source: PMID:21471969
Evidence_code: IMP
Taxon: NCBITaxon:10090
DB_ID: MGI:2447658
Date: 2012-12-05
Assigned_by: MGI:MGI
Comments: occurs_in(EMAP:6018)

PR_000035661
type: Class
Object_term: aurora kinase B unphosphorylated form (human)
Object_synonym: hAURKB/PhosRes-

subject: PR_000035661
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9NQS7
Evidence_source: PMID:22024163
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q96GD4
Date: 2013-01-16
Assigned_by: PRO:KER

subject: PR_000035661
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:22024163
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q96GD4
Date: 2013-01-16
Assigned_by: PRO:KER

PR_000035663
type: Class
Object_term: aurora kinase B phosphorylated 1 (human)
Object_synonym: hAURKB active form
Object_synonym: hAURKB/Phos:1
Object_synonym: UniProtKB:Q96GD4, Ser-331, MOD:00046

subject: PR_000035663
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9NQS7
Evidence_source: PMID:22024163
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q96GD4
Date: 2013-01-16
Assigned_by: PRO:KER

subject: PR_000035663
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0000776
  Ontology_term: kinetochore
Evidence_source: PMID:22024163
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q96GD4
Date: 2013-01-16
Assigned_by: PRO:KER
Comments: Timing=prometaphase and metaphase.

subject: PR_000035663
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: increased
Relative_to: PR_000035661
Evidence_source: PMID:17276342
Evidence_source: PMID:22024163
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q96GD4
Date: 2013-01-16
Assigned_by: PRO:KER

subject: PR_000035663
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007059
  Ontology_term: chromosome segregation
Modifier: increased
Relative_to: PR_000035661
Evidence_source: PMID:22024163
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q96GD4
Date: 2013-01-16
Assigned_by: PRO:KER

subject: PR_000035663
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0031577
  Ontology_term: spindle checkpoint signaling
Modifier: increased
Relative_to: PR_000035661
Evidence_source: PMID:22024163
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q96GD4
Date: 2013-01-16
Assigned_by: PRO:KER

subject: PR_000035663
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0051310
  Ontology_term: metaphase chromosome alignment
Modifier: increased
Relative_to: PR_000035661
Evidence_source: PMID:22024163
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q96GD4
Date: 2013-01-16
Assigned_by: PRO:KER

PR_000035696
type: Class
Object_term: serine/threonine-protein kinase LMTK1 isoform 2 palmitoylated 1 (mouse)
Object_synonym: AATYK1A palmitoylated 1 (mouse)
Object_synonym: mAATK/iso:2/Palm:1
Object_synonym: UniProtKB:Q80YE4-2, Cys-4/Cys-6/Cys-7, MOD:00115

subject: PR_000035696
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P12931
Evidence_source: MGI_ref:3820458
Evidence_source: PMID:18691334
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: MGI:1197518
Date: 2013-01-25
Assigned_by: MGI:MGI

subject: PR_000035696
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0055037
  Ontology_term: recycling endosome
Evidence_source: MGI_ref:3820458
Evidence_source: PMID:18691334
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1197518
Date: 2013-01-18
Assigned_by: MGI:MGI

PR_000035700
type: Class
Object_term: serine/threonine-protein kinase LMTK1 isoform 2 phosphorylated 1 (mouse)
Object_synonym: AATYK1A phosphorylated 1 (mouse)
Object_synonym: mAATK/iso:2/Phos:1
Object_synonym: UniProtKB:Q80YE4-2, Ser-34, MOD:00046

subject: PR_000035700
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0044295
  Ontology_term: axonal growth cone
Evidence_source: MGI_ref:5426470
Evidence_source: PMID:22573681
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1197518
Date: 2013-01-22
Assigned_by: MGI:MGI
Comments: part_of(CL:0002609)

subject: PR_000035700
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0048471
  Ontology_term: perinuclear region of cytoplasm
Evidence_source: MGI_ref:5426470
Evidence_source: PMID:22573681
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1197518
Date: 2013-01-22
Assigned_by: MGI:MGI
Comments: part_of(CL:0002609)

subject: PR_000035700
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0055037
  Ontology_term: recycling endosome
Evidence_source: MGI_ref:5426470
Evidence_source: PMID:22573681
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:1197518
Date: 2013-01-22
Assigned_by: MGI:MGI
Comments: part_of(CL:0002609)

subject: PR_000035700
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030517
  Ontology_term: negative regulation of axon extension
Evidence_source: MGI_ref:5426470
Evidence_source: PMID:22573681
Evidence_code: IGI
Taxon: NCBITaxon:10090
Inferred_from: MGI:101764
DB_ID: MGI:1197518
Date: 2013-01-24
Assigned_by: MGI:MGI
Comments: regulates_o_occurs_in(CL:0002609)

subject: PR_000035700
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030517
  Ontology_term: negative regulation of axon extension
Evidence_source: MGI_ref:5426470
Evidence_source: PMID:22573681
Evidence_code: IMP
Taxon: NCBITaxon:10090
DB_ID: MGI:1197518
Date: 2013-01-22
Assigned_by: MGI:MGI
Comments: regulates_o_occurs_in(CL:0002609)

PR_000035701
type: Class
Object_term: lipopolysaccharide-binding protein, signal peptide removed form (human)
Object_synonym: hLBP/SigPep-
Object_synonym: LBP
Object_synonym: PRO_0000017158
Object_synonym: UniProtKB:P18428, 26-481

subject: PR_000035701
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005576
  Ontology_term: extracellular region
Evidence_source: Reactome:REACT_7385
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P18428
Date: 2013-01-25
Assigned_by: PRO:CNA

subject: PR_000035701
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P18428
Date: 2013-01-25
Assigned_by: PRO:CNA

PR_000035702
type: Class
Object_term: CD14 molecule cleaved 2 GPI-anchored form (human)
Object_synonym: GPI-anchored form of CD14 (human)
Object_synonym: GPI-N345-CD14 (human)
Object_synonym: hCD14/iso:1/Clv:2/anchored
Object_synonym: PRO_0000020885, Asn-345, MOD:00167
Object_synonym: UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167

subject: PR_000035702
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: PMID:2779588
Evidence_source: PMID:3385210
Evidence_source: PMID:9665271
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P08571-1
Date: 2013-01-25
Assigned_by: PRO:CNA

subject: PR_000035702
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_7740
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P08571-1
Date: 2013-01-25
Assigned_by: PRO:CNA

subject: PR_000035702
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P08571-1
Date: 2013-01-25
Assigned_by: PRO:CNA

PR_000035703
type: Class
Object_term: CD14 molecule cleaved 2 soluble form (human)
Object_synonym: hCD14/iso:1/Clv:2/soluble
Object_synonym: PRO_0000020885
Object_synonym: Secreted form of CD14 (human)
Object_synonym: UniProtKB:P08571-1, 20-345

subject: PR_000035703
predicate:
  Relation: expressed_in
object:
  Ontology_ID: CL:0000129
  Ontology_term: microglial cell
Evidence_source: PMID:24659539
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P08571-1
Date: 2014-05-14
Assigned_by: PRO:CNA
Comments: Note=Expressed in supernatant of microglial cells

subject: PR_000035703
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0001530
  Ontology_term: lipopolysaccharide binding
Evidence_source: PMID:9464818
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P08571-1
Date: 2014-05-14
Assigned_by: PRO:CNA

subject: PR_000035703
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005576
  Ontology_term: extracellular region
Evidence_source: PMID:2779588
Evidence_source: PMID:9665271
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P08571-1
Date: 2013-01-25
Assigned_by: PRO:CNA

subject: PR_000035703
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P08571-1
Date: 2013-01-25
Assigned_by: PRO:CNA

PR_000035707
type: Class
Object_term: interferon regulatory factor 8 isoform 1 sumoylated 1 (mouse)
Object_synonym: mIRF8/iso:1/Sumo:1
Object_synonym: SUMOylated IRF8
Object_synonym: UniProtKB:P23611-1, Lys-310, MOD:01149

subject: PR_000035707
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: MGI_ref:5448615
Evidence_source: PMID:22942423
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:96395
Date: 2013-01-30
Assigned_by: MGI:MGI

subject: PR_000035707
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0060261
  Ontology_term: positive regulation of transcription initiation by RNA polymerase II
Modifier: NOT
Evidence_source: MGI_ref:5448615
Evidence_source: PMID:22942423
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:96395
Date: 2013-01-30
Assigned_by: MGI:MGI

PR_000035709
type: Class
Object_term: interferon regulatory factor 8 isoform 1 unsumoylated form (mouse)
Object_synonym: mIRF8/iso:1/SumoRes-

subject: PR_000035709
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: MGI_ref:5448615
Evidence_source: PMID:22942423
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:96395
Date: 2013-01-30
Assigned_by: MGI:MGI

subject: PR_000035709
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0060261
  Ontology_term: positive regulation of transcription initiation by RNA polymerase II
Evidence_source: MGI_ref:5448615
Evidence_source: PMID:22942423
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:96395
Date: 2013-01-30
Assigned_by: MGI:MGI

PR_000035710
type: Class
Object_term: traf6:ticam1:ticam2:activated TLR4 complex (mouse)
Object_synonym: traf6:trif:tram:activated TLR4 complex (mouse)

subject: PR_000035710
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: PMID:14530355
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-04-12
Assigned_by: PRO:CNA

PR_000035714
type: Class
Object_term: TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
Object_synonym: hTRAF6/K63polyUbiq:1
Object_synonym: K63-pUb-TRAF6
Object_synonym: UniProtKB:Q9Y4K3, Lys-124, PR:000044772

subject: PR_000035714
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q9Y4K3
Date: 2013-04-12
Assigned_by: PRO:CNA

PR_000035715
type: Class
Object_term: pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRIF:K63-pUb-TRAF6 (human)

subject: PR_000035715
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_25867
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-01-30
Assigned_by: PRO:CNA

subject: PR_000035715
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-01-30
Assigned_by: PRO:CNA

PR_000035730
type: Class
Object_term: TAK1 kinase complex (human)
Object_synonym: TAB1:TAB2,TAB3:TAK1 (human)

subject: PR_000035730
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002755
  Ontology_term: MyD88-dependent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_25222
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

subject: PR_000035730
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

subject: PR_000035730
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0038095
  Ontology_term: Fc-epsilon receptor signaling pathway
Evidence_source: Reactome:REACT_163936
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

PR_000035734
type: Class
Object_term: free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRIF:K63-pUb-TRAF6:free K63-linked pUb:TAK1complex (human)

subject: PR_000035734
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: Reactome:REACT_26036
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-02-04
Assigned_by: PRO:CNA

subject: PR_000035734
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_26036
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-02-04
Assigned_by: PRO:CNA

subject: PR_000035734
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000035738
type: Class
Object_term: free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRIF:TRAF:K63-pUb-TRAF6:free K63-linked pUb:activated TAK1 complex (human)

subject: PR_000035738
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_26039
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000035738
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000035740
type: Class
Object_term: free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
Object_synonym: K63-pUb-TRAF6:free K63-linked pUb:activated TAK1 complex (human)
Object_synonym: pUb-TRAF6:TAB1:TAB2/TAB3:free polyubiquitin chain : phospho-TAK1 (human)

subject: PR_000035740
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: Reactome:REACT_23131
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-02-04
Assigned_by: PRO:CNA

subject: PR_000035740
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002755
  Ontology_term: MyD88-dependent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_23131
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

subject: PR_000035740
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_23131
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2014-04-28
Assigned_by: PRO:VS

PR_000035742
type: Class
Object_term: shaggy-related protein kinase eta phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-ASK7/Phos:1
Object_synonym: Tyr200 BIN2
Object_synonym: UniProtKB:Q39011-1, Tyr-200, MOD:00048

subject: PR_000035742
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PMID:21855796
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39011
Date: 2013-02-05
Assigned_by: PRO:CNA

subject: PR_000035742
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q8L7U5
Evidence_source: PMID:19734888
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39011
Date: 2013-04-29
Assigned_by: PRO:LVM

subject: PR_000035742
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0019903
  Ontology_term: protein phosphatase binding
Interaction_with: PR_000028342
Evidence_source: PMID:21855796
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39011
Date: 2013-02-05
Assigned_by: PRO:CNA

subject: PR_000035742
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0019903
  Ontology_term: protein phosphatase binding
Interaction_with: PR Q9LR78
Evidence_source: PMID:19734888
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39011
Date: 2013-04-29
Assigned_by: PRO:LVM

subject: PR_000035742
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900458
  Ontology_term: negative regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:19734888
Evidence_source: PMID:21855796
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39011
Date: 2012-04-29
Assigned_by: PRO:LVM

PR_000035749
type: Class
Object_term: receptor-like serine/threonine-protein kinase SD1-7 isoform 1 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-SD17/iso:1/Phos:1
Object_synonym: AtpARK1

subject: PR_000035749
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PMID:8811866
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39086-1
Date: 2013-02-06
Assigned_by: PRO:CNA

subject: PR_000035749
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0046777
  Ontology_term: protein autophosphorylation
Evidence_source: PMID:8811866
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39086-1
Date: 2013-02-06
Assigned_by: PRO:CNA

PR_000035770
type: Class
Object_term: catenin beta-1 isoform 1 phosphorylated 2 (human)
Object_synonym: hCTNNB1/iso:1/Phos:2
Object_synonym: UniProtKB:P35222-1, Tyr-64, MOD:00048
Object_synonym: Tyr-142, MOD:00048
Object_synonym: (Tyr-331, MOD:00048 or Tyr-333, MOD:00048)

subject: PR_000035770
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:20026641
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35222-1
Date: 2013-10-30
Assigned_by: PRO:IC

PR_000035772
type: Class
Object_term: catenin beta-1 isoform 1 phosphorylated 3 (human)
Object_synonym: hCTNNB1/iso:1/Phos:3
Object_synonym: UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046
Object_synonym: Thr-41, MOD:00047

subject: PR_000035772
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9Y297
Evidence_source: PMID:10074433
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35222-1
Date: 2013-10-30
Assigned_by: PRO:IC

subject: PR_000035772
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: NOT
Interaction_with: PR Q9UKB1
Evidence_source: PMID:10074433
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35222-1
Date: 2013-10-30
Assigned_by: PRO:IC

PR_000035774
type: Class
Object_term: catenin beta-1 isoform 1 phosphorylated 4 (human)
Object_synonym: hCTNNB1/iso:1/Phos:4
Object_synonym: UniProtKB:P35222-1, Ser-45, MOD:00046

subject: PR_000035774
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR P12830
Evidence_source: PMID:20419129
Evidence_source: PMID:21152425
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35222-1
Date: 2014-09-03
Assigned_by: PRO:KER

subject: PR_000035774
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:20419129
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35222-1
Date: 2014-09-03
Assigned_by: PRO:KER

subject: PR_000035774
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Modifier: increased
Relative_to: PR_000037813
Interaction_with: PR P49841
Evidence_source: PMID:12051714
Evidence_source: PMID:20419129
Evidence_source: PMID:23606879
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P35222-1
Date: 2014-09-03
Assigned_by: PRO:KER

PR_000035776
type: Class
Object_term: serine/threonine-protein kinase PAK 1 phosphorylated 1 (human)
Object_synonym: hPAK1/Phos:1
Object_synonym: UniProtKB:Q13153, Thr-423, MOD:00047

subject: PR_000035776
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PMID:22369945
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13153
Date: 2013-02-25
Assigned_by: PRO:IC
Comments: Target=PR:000002319.

subject: PR_000035776
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008013
  Ontology_term: beta-catenin binding
Evidence_source: PMID:22369945
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13153
Date: 2013-02-25
Assigned_by: PRO:IC
Comments: Target=PR:000002319.

PR_000035786
type: Class
Object_term: protein BRASSINOSTEROID INSENSITIVE 1 isoform 1 phosphorylated 5 (Arabidopsis thaliana)
Object_synonym: At protein BRASSINOSTEROID INSENSITIVE 1 isoform 1 phosphorylated 4
Object_synonym: At-BRI1/iso:1/Phos:5
Object_synonym: UniProtKB:O22476-1, Ser-858/Ser-891, MOD:00046
Object_synonym: Thr-872, MOD:00047

subject: PR_000035786
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q94F62-1
Evidence_source: PMID:22184234
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O22476-1
Date: 2013-03-04
Assigned_by: PRO:LVM

subject: PR_000035786
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0040015
  Ontology_term: negative regulation of multicellular organism growth
Evidence_source: PMID:22184234
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O22476-1
Date: 2013-03-04
Assigned_by: PRO:LVM

subject: PR_000035786
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900458
  Ontology_term: negative regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:22184234
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O22476-1
Date: 2013-03-04
Assigned_by: PRO:LVM

subject: PR_000035786
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: decreased
Relative_to: PR_000035788
Evidence_source: PMID:22184234
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O22476-1
Date: 2013-03-04
Assigned_by: PRO:LVM

PR_000035792
type: Class
Object_term: BRI1 kinase inhibitor 1 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-BKI1/Phos:1
Object_synonym: AtBKI1 phosphorylated
Object_synonym: UniProtKB:Q9FMZ0, Ser-270/Ser-274, MOD:00046

subject: PR_000035792
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P48348
Evidence_source: PMID:22075146
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9FMZ0
Date: 2013-03-05
Assigned_by: PRO:LVM

subject: PR_000035792
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P48349
Evidence_source: PMID:22075146
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9FMZ0
Date: 2013-03-05
Assigned_by: PRO:LVM

subject: PR_000035792
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:22075146
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9FMZ0
Date: 2013-03-05
Assigned_by: PRO:LVM

subject: PR_000035792
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900459
  Ontology_term: positive regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:22075146
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9FMZ0
Date: 2013-03-05
Assigned_by: PRO:LVM

PR_000035794
type: Class
Object_term: BRI1 kinase inhibitor 1 unphosphorylated form (Arabidopsis thaliana)
Object_synonym: At-BKI1/PhosRes-
Object_synonym: AtBKI1 unphosphorylated form

subject: PR_000035794
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: PMID:21289069
Evidence_source: PMID:22075146
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9FMZ0
Date: 2013-03-18
Assigned_by: PRO:LVM

subject: PR_000035794
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900458
  Ontology_term: negative regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:22075146
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9FMZ0
Date: 2013-03-05
Assigned_by: PRO:CNA

PR_000035833
type: Class
Object_term: activated IkappaB kinase complex (human)
Object_synonym: activated IKK complex (human)

subject: PR_000035833
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-12
Assigned_by: Reactome:REACT_6894

PR_000035834
type: Class
Object_term: nuclear factor NF-kappa-B p50 subunit (human)
Object_synonym: hNFKBp50
Object_synonym: NF-KAPPA-B P50 (human)
Object_synonym: NFKB1 p50 (human)
Object_synonym: p50 (human)
Object_synonym: PRO_0000030311
Object_synonym: UniProtKB:P19838-1, 1-433

subject: PR_000035834
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P18939-1
Date: 2013-04-12
Assigned_by: Reactome:REACT_6894

PR_000035846
type: Class
Object_term: BRI1 kinase inhibitor 1 phosphorylated 2 (Arabidopsis thaliana)
Object_synonym: At-BKI1/Phos:2
Object_synonym: UniProtKB:Q9FMZ0, Tyr-211, MOD:00048

subject: PR_000035846
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005829
  Ontology_term: cytosol
Evidence_source: PMID:21289069
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9FMZ0
Date: 2013-03-29
Assigned_by: PRO:LVM

subject: PR_000035846
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900458
  Ontology_term: negative regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:21289069
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9FMZ0
Date: 2013-03-18
Assigned_by: PRO:LVM

PR_000035857
type: Class
Object_term: uric acid degradation bifunctional protein TTL phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-TTL(ALNS)/Phos:1

subject: PR_000035857
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0040015
  Ontology_term: negative regulation of multicellular organism growth
Evidence_source: PMID:15319482
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LVM5
Date: 2013-03-29
Assigned_by: PRO:LVM

subject: PR_000035857
predicate:
  Relation: enables
object:
  Ontology_ID: GO:1900458
  Ontology_term: negative regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:15319482
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LVM5
Date: 2013-03-29
Assigned_by: PRO:LVM

subject: PR_000035857
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: PMID:15319482
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LVM5
Date: 2013-03-29
Assigned_by: PRO:LVM

PR_000035860
type: Class
Object_term: transcription factor MYBL2(At1g71030) phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-MYBL2(At1g71030)/Phos:1

subject: PR_000035860
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9LN63
Evidence_source: PMID:23169658
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9C9A5
Date: 2013-03-29
Assigned_by: PRO:LVM

subject: PR_000035860
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0010629
  Ontology_term: negative regulation of gene expression
Evidence_source: PMID:23169658
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9C9A5
Date: 2013-03-29
Assigned_by: PRO:LVM

subject: PR_000035860
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900459
  Ontology_term: positive regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:23169658
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9C9A5
Date: 2013-03-29
Assigned_by: PRO:LVM

PR_000035886
type: Class
Object_term: chorion-specific transcription factor GCMa acetylated 1 (mouse)
Object_synonym: Gcm1 acetylated 1 (mouse)
Object_synonym: mGCM1/Ac:1
Object_synonym: UniProtKB:P70348, Lys-367/Lys-406, MOD:00064

subject: PR_000035886
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0060143
  Ontology_term: positive regulation of syncytium formation by plasma membrane fusion
Evidence_source: MGI_ref:5049808
Evidence_source: PMID:21558372
Evidence_code: IMP
Taxon: NCBITaxon:10090
DB_ID: MGI:108045
Date: 2013-04-08
Assigned_by: MGI:MGI
Comments: regulates_o_occurs_in(CL:0000351)

PR_000035889
type: Class
Object_term: shaggy-related protein kinase theta phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-ASKtheta/Phos:1
Object_synonym: atASKtheta phosphorylated

subject: PR_000035889
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:20128883
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q96287
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035889
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009704
  Ontology_term: de-etiolation
Evidence_source: PMID:20128883
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q96287
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035889
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009910
  Ontology_term: negative regulation of flower development
Evidence_source: PMID:20128883
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q96287
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035889
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0048366
  Ontology_term: leaf development
Evidence_source: PMID:20128883
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q96287
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035889
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0048640
  Ontology_term: negative regulation of developmental growth
Evidence_source: PMID:20128883
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q96287
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035889
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900458
  Ontology_term: negative regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:20128883
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q96287
Date: 2013-04-12
Assigned_by: PRO:LVM

PR_000035891
type: Class
Object_term: protein BRASSINAZOLE-RESISTANT 2 phosphorylated 2 (Arabidopsis thaliana)
Object_synonym: At-BZR2/Phos:2

subject: PR_000035891
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:20128883
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9LN63
Date: 2013-04-12
Assigned_by: PRO:LVM
Comments: Evidence=Fig4.

PR_000035896
type: Class
Object_term: BES1/BZR1 homolog protein 2 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-BEH2/Phos:1

subject: PR_000035896
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:20128883
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q94A43
Date: 2013-04-12
Assigned_by: PRO:LVM

PR_000035898
type: Class
Object_term: shaggy-related protein kinase theta unphosphorylated form (Arabidopsis thaliana)
Object_synonym: At-ASKtheta/PhosRes-
Object_synonym: atASKtheta unphosphorylated

subject: PR_000035898
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0046777
  Ontology_term: protein autophosphorylation
Evidence_source: PMID:20128883
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q96287
Date: 2013-04-12
Assigned_by: PRO:LVM

PR_000035954
type: Class
Object_term: BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-plantBAK1/Phos:1
Object_synonym: UniProtKB:Q94F62, Ser-290, MOD:00046
Object_synonym: Thr-312/Thr-446/Thr-449/Thr-455, MOD:00047

subject: PR_000035954
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PMID:18694562
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q94F62
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035954
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0040018
  Ontology_term: positive regulation of multicellular organism growth
Evidence_source: PMID:18694562
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q94F62
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035954
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900459
  Ontology_term: positive regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:18694562
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q94F62
Date: 2013-04-12
Assigned_by: PRO:LVM

PR_000035956
type: Class
Object_term: protein BRASSINOSTEROID INSENSITIVE 1 isoform 1 phosphorylated 6 (Arabidopsis thaliana)
Object_synonym: At-BRI1/iso:1/Phos:6
Object_synonym: UniProtKB:O22476-1, Ser-1162, MOD:00046
Object_synonym: Thr-1180, MOD:00047

subject: PR_000035956
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0006469
  Ontology_term: negative regulation of protein kinase activity
Evidence_source: PMID:15935775
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O22476-1
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035956
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900458
  Ontology_term: negative regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:15935775
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O22476-1
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035956
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: decreased
Relative_to: PR_000035788
Evidence_source: PMID:15935775
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O22476-1
Date: 2013-04-12
Assigned_by: PRO:LVM

PR_000035958
type: Class
Object_term: protein BRASSINAZOLE-RESISTANT 1 phosphorylated 3 (Arabidopsis thaliana)
Object_synonym: At-BZR1/Phos:3
Object_synonym: UniProtKB:Q8S307, Ser-173, MOD:00046

subject: PR_000035958
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0009911
  Ontology_term: positive regulation of flower development
Evidence_source: PMID:17681130
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q8S307
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035958
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0071889
  Ontology_term: 14-3-3 protein binding
Interaction_with: PR P48349
Evidence_source: PMID:17681130
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q8S307
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035958
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:17681130
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q8S307
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035958
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0048366
  Ontology_term: leaf development
Evidence_source: PMID:17681130
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q8S307
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035958
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900458
  Ontology_term: negative regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:17681130
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q8S307
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035958
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Modifier: decreased
Relative_to: PR_000035950
Evidence_source: PMID:17681130
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q8S307
Date: 2013-04-12
Assigned_by: PRO:LVM

PR_000035961
type: Class
Object_term: U-box domain-containing protein 13 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-PUB13/Phos:1

subject: PR_000035961
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004842
  Ontology_term: ubiquitin-protein transferase activity
Evidence_source: PMID:21680842
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9SNC6
Date: 2013-04-12
Assigned_by: PRO:LVM
Comments: Target=PR:Q9FL28.

subject: PR_000035961
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9FL28
Evidence_source: PMID:21680842
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9SNC6
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035961
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9ZV31
Evidence_source: PMID:21680842
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9SNC6
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035961
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0000151
  Ontology_term: ubiquitin ligase complex
Evidence_source: PMID:21680842
Evidence_code: IDA
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9SNC6
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035961
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900425
  Ontology_term: negative regulation of defense response to bacterium
Evidence_source: PMID:21680842
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9SNC6
Date: 2013-04-12
Assigned_by: PRO:LVM

PR_000035966
type: Class
Object_term: mitogen-activated protein kinase kinase 4 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-MKK4/Phos:1
Object_synonym: UniProtKB:O80397, Ser-6, MOD:00046
Object_synonym: Thr-234, MOD:00047
Object_synonym: (Ser-230 or 231, MOD:00046)

subject: PR_000035966
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:23341468
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O80397
Date: 2013-04-12
Assigned_by: PRO:LVM
Comments: Evidence=Fig6.

subject: PR_000035966
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:23341468
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O80397
Date: 2013-04-12
Assigned_by: PRO:LVM
Comments: Evidence=Fig6.

subject: PR_000035966
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:2000037
  Ontology_term: regulation of stomatal complex patterning
Evidence_source: PMID:23341468
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O80397
Date: 2013-04-12
Assigned_by: PRO:LVM

subject: PR_000035966
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Modifier: decreased
Relative_to: PR_000035968
Evidence_source: PMID:23341468
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O80397
Date: 2013-04-12
Assigned_by: PRO:LVM
Comments: Target=PR:000028877.

PR_000035971
type: Class
Object_term: shaggy-related protein kinase eta unphosphorylated form (Arabidopsis thaliana)
Object_synonym: At-ASK7/PhosRes-

subject: PR_000035971
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0046777
  Ontology_term: protein autophosphorylation
Evidence_source: PMID:19734888
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q39011
Date: 2013-04-29
Assigned_by: PRO:LVM

PR_000035974
type: Class
Object_term: serine/threonine-protein kinase BSK1 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-BSK1/Phos:1
Object_synonym: UniProtKB:Q944A7, Ser-230, MOD:00046

subject: PR_000035974
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:18653891
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q944A7
Date: 2013-04-29
Assigned_by: PRO:LVM
Comments: Note=phosphorylation experiment in vitro.

subject: PR_000035974
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900459
  Ontology_term: positive regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:18653891
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q944A7
Date: 2013-04-29
Assigned_by: PRO:LVM
Comments: Note=phosphorylation experiment in vitro.

PR_000035976
type: Class
Object_term: protein BRASSINOSTEROID INSENSITIVE 1 isoform 1 phosphorylated 7 (Arabidopsis thaliana)
Object_synonym: At-BRI1/iso:1/Phos:7
Object_synonym: UniProtKB:O22476-1, Tyr-831/Tyr-956/Tyr-1072, MOD:00048
Object_synonym: Ser-858/Ser-891, MOD:00046
Object_synonym: Thr-872, MOD:00047

subject: PR_000035976
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004672
  Ontology_term: protein kinase activity
Evidence_source: PMID:22891071
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O22476-1
Date: 2013-04-29
Assigned_by: PRO:LVM

PR_000035979
type: Class
Object_term: U-box domain-containing protein 12 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-PUB12/Phos:1

subject: PR_000035979
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004842
  Ontology_term: ubiquitin-protein transferase activity
Evidence_source: PMID:21680842
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9ZV31
Date: 2013-04-29
Assigned_by: PRO:LVM
Comments: Target=PR:Q9FL28.

subject: PR_000035979
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9FL28
Evidence_source: PMID:21680842
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9ZV31
Date: 2013-04-29
Assigned_by: PRO:LVM

subject: PR_000035979
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q9SNC6
Evidence_source: PMID:21680842
Evidence_code: IPI
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9ZV31
Date: 2013-04-29
Assigned_by: PRO:LVM

subject: PR_000035979
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0000151
  Ontology_term: ubiquitin ligase complex
Evidence_source: PMID:21680842
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9ZV31
Date: 2013-04-29
Assigned_by: PRO:LVM

subject: PR_000035979
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900425
  Ontology_term: negative regulation of defense response to bacterium
Evidence_source: PMID:21680842
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q9ZV31
Date: 2013-04-29
Assigned_by: PRO:LVM

PR_000035992
type: Class
Object_term: peptidyl-prolyl cis-trans isomerase CYP18-3 unphosphorylated form (Arabidopsis thaliana)
Object_synonym: At-CYP18-3/PhosRes-

subject: PR_000035992
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009704
  Ontology_term: de-etiolation
Evidence_source: PMID:22463079
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:P34790
Date: 2013-04-30
Assigned_by: PRO:LVM

subject: PR_000035992
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0009742
  Ontology_term: brassinosteroid mediated signaling pathway
Evidence_source: PMID:22463079
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:P34790
Date: 2013-04-30
Assigned_by: PRO:LVM

PR_000035995
type: Class
Object_term: auxin response factor 2 phosphorylated 1 (Arabidopsis thaliana)
Object_synonym: At-ARF2/Phos:1

subject: PR_000035995
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0045892
  Ontology_term: negative regulation of DNA-templated transcription
Evidence_source: PMID:18599455
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q94JM3
Date: 2013-04-30
Assigned_by: PRO:LVM

subject: PR_000035995
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:1900458
  Ontology_term: negative regulation of brassinosteroid mediated signaling pathway
Evidence_source: PMID:18599455
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q94JM3
Date: 2013-04-30
Assigned_by: PRO:LVM

subject: PR_000035995
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Modifier: decreased
Relative_to: PR_000035997
Evidence_source: PMID:18599455
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:Q94JM3
Date: 2013-04-30
Assigned_by: PRO:LVM

PR_000035999
type: Class
Object_term: protein BRASSINOSTEROID INSENSITIVE 1 isoform 1 phosphorylated 8 (Arabidopsis thaliana)
Object_synonym: At-BRI1/iso:1/Phos:8
Object_synonym: UniProtKB:O22476-1, Ser-838, MOD:00046
Object_synonym: Thr-842, MOD:00047
Object_synonym: Thr-846, MOD:00047
Object_synonym: Ser-858, MOD:00046
Object_synonym: Thr-872, MOD:00047
Object_synonym: (Ser-887, MOD:00046 or Ser-891, MOD:00046)
Object_synonym: (Ser-981, MOD:00046 or Thr-982, MOD:00047)
Object_synonym: (Thr-1039, MOD:00047 or Ser-1042, MOD:00046 or Ser-1044, MOD:00046 or Thr-1045, MOD:00047 or Thr-1049, MOD:00047 or Ser-1060, MOD:00046)
Object_synonym: (Ser-1166, MOD:00046 or Ser-1168, MOD:00046 or Thr-1169, MOD:00047)
Object_synonym: (Ser-1172, MOD:00046 or Ser-1179, MOD:00046 or Thr-1180, MOD:00047 or Ser-1187, MOD:00046)

subject: PR_000035999
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PMID:11027724
Evidence_code: EXP
Taxon: NCBITaxon:3702
DB_ID: UniProtKB:O22476-1
Date: 2013-04-30
Assigned_by: PRO:LVM

PR_000036004
type: Class
Object_term: LY96:TLR4 complex (human)
Object_synonym: h(LY96:TLR4)
Object_synonym: MD2:TLR4 complex (human)
Object_synonym: TLR4MD2 complex (human)

subject: PR_000036004
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_7105
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036004
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036005
type: Class
Object_term: LY96:TLR4 complex (mouse)
Object_synonym: m(LY96:TLR4)
Object_synonym: MD2:TLR4 complex (mouse)
Object_synonym: TLR4MD2 complex (mouse)

subject: PR_000036005
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: PMID:17803912
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2014-08-14
Assigned_by: PRO:CNA

PR_000036007
type: Class
Object_term: TIRAP:PIP2 complex (mouse)
Object_synonym: MAL:PIP2
Object_synonym: TIRAPPIP2

subject: PR_000036007
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002755
  Ontology_term: MyD88-dependent toll-like receptor signaling pathway
Evidence_source: PMID:11544529
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: TLR:AMM

PR_000036014
type: Class
Object_term: TIRAP:PIP2 complex (human)
Object_synonym: MAL:PI(4,5)P2
Object_synonym: MAL:PIP2 human
Object_synonym: TIRAP:PIP2 human

subject: PR_000036014
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_151450
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036014
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002755
  Ontology_term: MyD88-dependent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_25222
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036022
type: Class
Object_term: traf3:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: TRAF3:TRIF:TRAM:activated TLR4 (human)

subject: PR_000036022
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004842
  Ontology_term: ubiquitin-protein transferase activity
Evidence_source: Reactome:REACT_124037
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036022
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_124037
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036022
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_124037
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036024
type: Class
Object_term: rip1:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: RIP1:TRIF:activated TLR4 (human)
Object_synonym: RIP1:trif:tram:activated TLR4 complex (human)

subject: PR_000036024
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_25948
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-05-21
Assigned_by: PRO:CNA

subject: PR_000036024
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-05-21
Assigned_by: PRO:CNA

PR_000036027
type: Class
Object_term: sarm:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: SARM:TRIF:TRAM:activated TLR4 (human)

subject: PR_000036027
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_151758
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036027
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034128
  Ontology_term: negative regulation of MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_151758
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036030
type: Class
Object_term: IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-TBK1:IRF3 (human)

subject: PR_000036030
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: Reactome:REACT_27000
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036030
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_27000
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036030
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036034
type: Class
Object_term: IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-TBK1:IRF7 (human)

subject: PR_000036034
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: Reactome:REACT_27000
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036034
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_27000
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036034
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036036
type: Class
Object_term: IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-IKKE:IRF3 (human)

subject: PR_000036036
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: Reactome:REACT_27000
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036036
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_27000
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036036
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036038
type: Class
Object_term: IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-IKKE:IRF7 (human)

subject: PR_000036038
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: Reactome:REACT_27000
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036038
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_27000
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036038
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036041
type: Class
Object_term: K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: K63-poly-Ub-TRAF3:TRIF:TRAM:activated TLR4 (human)

subject: PR_000036041
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_124855
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036041
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036043
type: Class
Object_term: IRF3-P:p65 complex (mouse)

subject: PR_000036043
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005634
  Ontology_term: nucleus
Evidence_source: PMID:14557267
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-04-30
Assigned_by: TLR:AMM

subject: PR_000036043
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034142
  Ontology_term: toll-like receptor 4 signaling pathway
Evidence_source: PMID:14557267
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036045
type: Class
Object_term: IRF3:XPO1 complex (human)
Object_synonym: IRF3pIRF3pIMP4alpha human
Object_synonym: IRF3pIRF3pQip1 human

subject: PR_000036045
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: PMID:10805757
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036049
type: Class
Object_term: K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRIF:K63-pUb-RIP1 (human)

subject: PR_000036049
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_25755
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036049
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036051
type: Class
Object_term: receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (human)
Object_synonym: hRIPK1/K63polyUbiq:1
Object_synonym: K-63 polyubiquitinated RIP1 (human)
Object_synonym: K63-linked polyUb - RIP1 (human)
Object_synonym: K63polyUb-RIP1 (human)
Object_synonym: K63polyUb-RIPK1 (human)
Object_synonym: UniProtKB:Q13546, Lys-377, PR:000044772

subject: PR_000036051
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005737
  Ontology_term: cytoplasm
Evidence_source: Reactome:REACT_26236
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13546
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036053
type: Class
Object_term: IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRIF:K63-pUb-RIP1:IKKcomplex (human)

subject: PR_000036053
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_26016
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036053
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036056
type: Class
Object_term: rip3:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: RIP3:TRIF:activated TLR4 (human)

subject: PR_000036056
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_152149
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036056
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036058
type: Class
Object_term: rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: RIP3:RIP1:TRIF:activated TLR4 (human)

subject: PR_000036058
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_151344
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036058
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036060
type: Class
Object_term: pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
Object_synonym: activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 (human)

subject: PR_000036060
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004197
  Ontology_term: cysteine-type endopeptidase activity
Evidence_source: Reactome:REACT_151344
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036060
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_151344
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036060
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036077
type: Class
Object_term: activated TLR4 complex (mouse)
Object_synonym: LY96:LPS:TLR4 complex (mouse)
Object_synonym: MD2:LPS:TLR4 complex (mouse)
Object_synonym: mTLR4actv
Object_synonym: TLR4MD2LPS complex dimer (mouse)

subject: PR_000036077
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: PMID:23565187
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2014-07-18
Assigned_by: TLR:AMM

PR_000036101
type: Class
Object_term: rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
Object_synonym: rip1:traf6:trif:tram:activated TLR4 complex (mouse)

subject: PR_000036101
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036123
type: Class
Object_term: p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
Object_synonym: activated TLR4:TRAM:TRIF:K63-poly-Ub-TRAF3:p-TBK1 (human)

subject: PR_000036123
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_26959
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-05-15
Assigned_by: PRO:CNA

subject: PR_000036123
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-05-15
Assigned_by: PRO:CNA

PR_000036124
type: Class
Object_term: p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
Object_synonym: activated TLR4:TRAM:TRIF:K63-poly-Ub-TRAF3:p-IKK epsilon (human)

subject: PR_000036124
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_26959
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-05-15
Assigned_by: PRO:CNA

subject: PR_000036124
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-05-15
Assigned_by: PRO:CNA

PR_000036135
type: Class
Object_term: TIRAP:PIP2:activated TLR4 complex (human)
Object_synonym: Mal:activated TLR4 complex (human)

subject: PR_000036135
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_152404
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036135
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002755
  Ontology_term: MyD88-dependent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_25222
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036136
type: Class
Object_term: lipopolysaccharide receptor complex 3; plasma membrane (human)
Object_synonym: h(LPSR:3)pm
Object_synonym: TLR4:MD2:LPS:CD14 [plasma membrane] (human)

subject: PR_000036136
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7465
Date: 2013-04-30
Assigned_by: PRO:CNA

subject: PR_000036136
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002755
  Ontology_term: MyD88-dependent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_7465
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036137
type: Class
Object_term: lipopolysaccharide receptor complex 3; endosome membrane (human)
Object_synonym: h(LPSR:3)endosome
Object_synonym: TLR4:MD2:LPS:CD14 [endosome membrane] (human)

subject: PR_000036137
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0010008
  Ontology_term: endosome membrane
Evidence_source: Reactome:REACT_6894
Evidence_code: EXP
Taxon: NCBITaxon:9606
DB_ID: Reactome:REACT_124771
Date: 2014-05-21
Assigned_by: PRO:CNA

subject: PR_000036137
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0002756
  Ontology_term: MyD88-independent toll-like receptor signaling pathway
Evidence_source: Reactome:REACT_6809
Evidence_code: EXP
Taxon: NCBITaxon:9606
Date: 2013-04-30
Assigned_by: PRO:CNA

PR_000036149
type: Class
Object_term: tbk1:tank:ikke complex (mouse)
Object_synonym: tbk1tankikke (mouse)

subject: PR_000036149
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0034138
  Ontology_term: toll-like receptor 3 signaling pathway
Evidence_source: PMID:17823124
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2014-02-24
Assigned_by: TLR:AMM

PR_000036150
type: Class
Object_term: doublesex- and mab-3-related transcription factor 1 homodimer (mouse)
Object_synonym: Dmrt1 homodimer (mouse)

subject: PR_000036150
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0043565
  Ontology_term: sequence-specific DNA binding
Evidence_source: PMID:17605809
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-05-28
Assigned_by: PRO:KRC

PR_000036151
type: Class
Object_term: doublesex and mab-3 related transcription factor 2 homodimer (mouse)
Object_synonym: Dmrt2 homodimer (mouse)

subject: PR_000036151
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0043565
  Ontology_term: sequence-specific DNA binding
Evidence_source: PMID:17605809
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-05-28
Assigned_by: PRO:KRC

PR_000036152
type: Class
Object_term: doublesex- and mab-3-related transcription factor A1 homodimer (mouse)
Object_synonym: Dmrta1 homodimer (mouse)

subject: PR_000036152
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0043565
  Ontology_term: sequence-specific DNA binding
Evidence_source: PMID:17605809
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-05-28
Assigned_by: PRO:KRC

PR_000036153
type: Class
Object_term: doublesex- and mab-3-related transcription factor A2 homodimer (mouse)
Object_synonym: Dmrta2 homodimer (mouse)

subject: PR_000036153
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0043565
  Ontology_term: sequence-specific DNA binding
Evidence_source: PMID:17605809
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-05-28
Assigned_by: PRO:KRC

PR_000036154
type: Class
Object_term: doublesex- and mab-3-related transcription factor C2 homodimer (mouse)
Object_synonym: Dmrtc2 homodimer (mouse)

subject: PR_000036154
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0043565
  Ontology_term: sequence-specific DNA binding
Evidence_source: PMID:17605809
Evidence_code: EXP
Taxon: NCBITaxon:10090
Date: 2013-05-28
Assigned_by: PRO:KRC

PR_000036294
type: Class
Object_term: pituitary homeobox 2 isoform 4 (human)
Object_synonym: hPITX2/iso:4

subject: PR_000036294
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q99697-2
Evidence_source: PMID:11948188
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: HGNC:9005
Date: 2015-02-23
Assigned_by: PRO:CNA
Comments: Note=Sequence not deposited in any database

subject: PR_000036294
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR Q99697-3
Evidence_source: PMID:11948188
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: HGNC:9005
Date: 2015-02-23
Assigned_by: PRO:CNA
Comments: Note=Sequence not deposited in any database

subject: PR_000036294
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0043433
  Ontology_term: negative regulation of DNA-binding transcription factor activity
Evidence_source: PMID:11948188
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: HGNC:9005
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Sequence not deposited in any database

subject: PR_000036294
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0003677
  Ontology_term: DNA binding
Modifier: NOT
Evidence_source: PMID:11948188
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: HGNC:9005
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Sequence not deposited in any database

PR_000036395
type: Class
Object_term: interleukin-15 receptor subunit alpha isoform 1
Object_synonym: IL15RA/iso:1

subject: PR_000036395
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005886
  Ontology_term: plasma membrane
Evidence_source: MGI_ref:4461380
Evidence_source: PMID:20374432
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: MGI:104644
Date: 2013-06-10
Assigned_by: MGI:MGI

PR_000036407
type: Class
Object_term: interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
Object_synonym: mIFNG/iso:1/SigPep-/GlycoRes+
Object_synonym: PRO_0000016453, MOD:00693
Object_synonym: UniProtKB:P01580-1, 23-155, MOD:00693

subject: PR_000036407
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005125
  Ontology_term: cytokine activity
Evidence_source: PMID:11027433
Evidence_source: PMID:12925700
Evidence_source: PMID:15240719
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01580-1
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Mature IFGN is heterogeneous in its C-terminus

subject: PR_000036407
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11057672
Evidence_source: PMID:11728336
Evidence_source: PMID:15240714
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01580-1
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Mature IFGN is heterogeneous in its C-terminus

subject: PR_000036407
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0050776
  Ontology_term: regulation of immune response
Evidence_source: PMID:12882831
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01580-1
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Mature IFGN is heterogeneous in its C-terminus

PR_000036408
type: Class
Object_term: TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
Object_synonym: hTGFBR2/iso:1/SigPep-
Object_synonym: hTGFBR2/iso:RII-1/SigPep-
Object_synonym: PRO_0000024426
Object_synonym: TGF-beta receptor type-2 isoform 1, signal peptide removed form (human)
Object_synonym: UniProtKB:P37173-1, 23-567

subject: PR_000036408
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005026
  Ontology_term: transforming growth factor beta receptor activity, type II
Evidence_source: PMID:11483955
Evidence_code: TAS
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P37173-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036408
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR_000000616
Evidence_source: PMID:1310899
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P37173-1
Date: 2009-03-03
Assigned_by: PRO:CNA

subject: PR_000036408
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR_000000634
Evidence_source: PMID:1850637
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P37173-1
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=The binding is shown to the ectodomain. The form is inferred by curator.

subject: PR_000036408
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0050431
  Ontology_term: transforming growth factor beta binding
Evidence_source: PMID:11850637
Evidence_source: PMID:1310899
Evidence_code: IC
Taxon: NCBITaxon:9606
Inferred_from: PMID:11850637
Inferred_from: PMID:1310899
DB_ID: UniProtKB:P37173-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036408
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0016020
  Ontology_term: membrane
Evidence_source: PMID:1310899
Evidence_code: TAS
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P37173-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036408
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007179
  Ontology_term: transforming growth factor beta receptor signaling pathway
Evidence_source: PMID:11483955
Evidence_code: TAS
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P37173-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036408
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0007181
  Ontology_term: transforming growth factor beta receptor complex assembly
Evidence_source: PMID:1310899
Evidence_source: PMID:8774881
Evidence_code: IC
Taxon: NCBITaxon:9606
Inferred_from: PMID:1310899
Inferred_from: PMID:8774881
DB_ID: UniProtKB:P37173-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036409
type: Class
Object_term: chordin isoform 1, signal peptide removed form (mouse)
Object_synonym: mCHRD/iso:1/SigPep-
Object_synonym: PRO_0000005365
Object_synonym: UniProtKB:Q9Z0E2-1, 27-948

subject: PR_000036409
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Evidence_source: PMID:15381701
Evidence_code: IPI
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q9Z0E2-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036409
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0008201
  Ontology_term: heparin binding
Evidence_source: PMID:15381701
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q9Z0E2-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036409
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:15780974
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q9Z0E2-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036409
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0001501
  Ontology_term: skeletal system development
Evidence_source: PMID:11784076
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q9Z0E2-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036409
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030514
  Ontology_term: negative regulation of BMP signaling pathway
Evidence_source: PMID:10479448
Evidence_source: PMID:15780974
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q9Z0E2-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036410
type: Class
Object_term: chordin isoform 1, signal peptide removed form (frog)
Object_synonym: frog-CHRD/iso:1/SigPep-
Object_synonym: PRO_0000005367
Object_synonym: UniProtKB:Q91713-1, 20-941

subject: PR_000036410
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:8752213
Evidence_code: IDA
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q91713-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036410
predicate:
  Relation: part_of
object:
  Ontology_ID: GO:0032991
  Ontology_term: protein-containing complex
Evidence_source: PMID:8752213
Evidence_code: IDA
Taxon: NCBITaxon:8355
DB_ID: UniProtKB:Q91713-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036411
type: Class
Object_term: chordin isoform 1 cleaved 2 (mouse)
Object_synonym: mCHRD/iso:1/Clv:2
Object_synonym: UniProtKB:Q9Z0E2-1, 154-861

subject: PR_000036411
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:10479448
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q9Z0E2-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036411
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0001501
  Ontology_term: skeletal system development
Evidence_source: PMID:10479448
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:Q9Z0E2-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036412
type: Class
Object_term: follistatin isoform 1, signal peptide removed glycosylated form (human)
Object_synonym: hFST/iso:1/SigPep-/GlycoRes+
Object_synonym: PRO_0000010103, MOD:00693
Object_synonym: UniProtKB:P19883-1, 30-344, MOD:00693

subject: PR_000036412
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:16150905
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P19883-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036413
type: Class
Object_term: follistatin isoform 1 cleaved and N-glycosylated 2 (pig)
Object_synonym: pig-FST/iso:1/ClvNGlyco:2
Object_synonym: PRO_0000419163, Asn-124/Asn-288, MOD:00160
Object_synonym: UniProtKB:P10669-1, 30-332, Asn-124/Asn-288, MOD:00160

subject: PR_000036413
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0032926
  Ontology_term: negative regulation of activin receptor signaling pathway
Evidence_source: PMID:8340384
Evidence_code: IDA
Taxon: NCBITaxon:9823
DB_ID: UniProtKB:P10669-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036414
type: Class
Object_term: follistatin isoform 1 cleaved and N-glycosylated 2 (human)
Object_synonym: hFST/iso:1/ClvNGlyco:2
Object_synonym: UniProtKB:P19883-1, 30-332, Asn-124/Asn-288, MOD:00160

subject: PR_000036414
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:16150905
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P19883-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036415
type: Class
Object_term: follistatin isoform 2, signal peptide removed N-glycosylated 1 (human)
Object_synonym: hFST/iso:2/SigPep-/NGlyco:1
Object_synonym: UniProtKB:P19883-2, 30-317, Asn-124/Asn-288, MOD:00160

subject: PR_000036415
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:16150905
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P19883-2
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036415
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0032926
  Ontology_term: negative regulation of activin receptor signaling pathway
Evidence_source: PMID:1906804
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P19883-2
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036417
type: Class
Object_term: growth/differentiation factor 5 sequence variant V186* (mouse)
Object_synonym: bp-3J (mouse)
Object_synonym: mGDF5/var:V186*
Object_synonym: UniProtKB:P43027, 1-185

subject: PR_000036417
predicate:
  Relation: associated_with_disease_progression
object:
  Ontology_ID: MP:0006279
  Ontology_term: abnormal limb development
Evidence_source: PMID:8145850
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P43027-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036417
predicate:
  Relation: has_agent
object:
  Ontology_ID: SO:0001587
  Ontology_term: stop_gained
Evidence_source: PMID:8145850
Evidence_code: EXP
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P43027-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036418
type: Class
Object_term: interferon gamma isoform 1, signal peptide removed form (mouse)
Object_synonym: mIFNG/iso:1/SigPep-
Object_synonym: PRO_0000016453
Object_synonym: UniProtKB:P01580-1, 23-155

subject: PR_000036418
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005125
  Ontology_term: cytokine activity
Evidence_source: PMID:11441112
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01580-1
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Recombinant mature protein not glycosylated

subject: PR_000036418
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0050776
  Ontology_term: regulation of immune response
Evidence_source: PMID:11441112
Evidence_code: IDA
Taxon: NCBITaxon:10090
DB_ID: UniProtKB:P01580-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036419
type: Class
Object_term: interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
Object_synonym: hIFNG/iso:1/SigPep-/NGlyco:1
Object_synonym: UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160

subject: PR_000036419
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005133
  Ontology_term: type II interferon receptor binding
Evidence_source: PMID:10986460
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01579-1
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Glycosylation sites by similarity but shown to be glycoprotein [PMIDs:10823661, 2434486]

subject: PR_000036419
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:3109913
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01579-1
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Glycosylation sites by similarity but shown to be glycoprotein [PMIDs:10823661, 2434486]

subject: PR_000036419
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:6427223
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01579-1
Date: 2008-03-01
Assigned_by: PRO:CNA
Comments: Note=Glycosylation sites by similarity but shown to be glycoprotein [PMIDs:10823661, 2434486]

PR_000036420
type: Class
Object_term: interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
Object_synonym: hIFNG/iso:1/ClvNGlyco:2
Object_synonym: PRO_0000016444, Asn-48/Asn-120, MOD:00160
Object_synonym: UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160

subject: PR_000036420
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0042803
  Ontology_term: protein homodimerization activity
Evidence_source: PMID:1902591
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P01579-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036421
type: Class
Object_term: noggin isoform 1, signal peptide removed form (human)
Object_synonym: hNOG/iso:1/SigPep-
Object_synonym: PRO_0000019813
Object_synonym: UniProtKB:Q13253-1, 28-232

subject: PR_000036421
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0005515
  Ontology_term: protein binding
Interaction_with: PR_000036517
Evidence_source: PMID:12478285
Evidence_code: IPI
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13253-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036421
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0005615
  Ontology_term: extracellular space
Evidence_source: PMID:11562478
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13253-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036421
predicate:
  Relation: acts_upstream_of_or_within
object:
  Ontology_ID: GO:0030514
  Ontology_term: negative regulation of BMP signaling pathway
Evidence_source: PMID:12478285
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:Q13253-1
Date: 2008-03-01
Assigned_by: PRO:CNA

PR_000036422
type: Class
Object_term: BMP receptor type-1A isoform 1 phosphorylated 1 (human)
Object_synonym: hBMPR1A/iso:1/Phos:1

subject: PR_000036422
predicate:
  Relation: enables
object:
  Ontology_ID: GO:0004674
  Ontology_term: protein serine/threonine kinase activity
Evidence_source: PMID:12829744
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36894-1
Date: 2008-03-01
Assigned_by: PRO:CNA

subject: PR_000036422
predicate:
  Relation: located_in
object:
  Ontology_ID: GO:0009986
  Ontology_term: cell surface
Evidence_source: PMID:10712517
Evidence_code: IDA
Taxon: NCBITaxon:9606
DB_ID: UniProtKB:P36894-1
Date: 2008-03-01
Assigned_by: PRO:CNA

Relation: part_of